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Entry version 88 (18 Sep 2019)
Sequence version 1 (01 Jan 1998)
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Protein

Pleiotropic drug resistance protein TUR2

Gene

TUR2

Organism
Spirodela polyrhiza (Giant duckweed) (Lemna polyrhiza)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be a general defense protein (By similarity). Seems involved in turion (dormant buds) formation. Confers resistance to the diterpenoid antifungal agent sclareol.By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi191 – 198ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi888 – 895ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processPlant defense, Transport
LigandATP-binding, Nucleotide-binding

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.1.205.20 the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pleiotropic drug resistance protein TUR2
Short name:
Protein Turion 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TUR2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSpirodela polyrhiza (Giant duckweed) (Lemna polyrhiza)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri29656 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaLiliopsidaAraceaeLemnoideaeSpirodela

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei526 – 546HelicalSequence analysisAdd BLAST21
Transmembranei559 – 579HelicalSequence analysisAdd BLAST21
Transmembranei614 – 634HelicalSequence analysisAdd BLAST21
Transmembranei646 – 666HelicalSequence analysisAdd BLAST21
Transmembranei671 – 691HelicalSequence analysisAdd BLAST21
Transmembranei756 – 776HelicalSequence analysisAdd BLAST21
Transmembranei1187 – 1207HelicalSequence analysisAdd BLAST21
Transmembranei1215 – 1235HelicalSequence analysisAdd BLAST21
Transmembranei1275 – 1295HelicalSequence analysisAdd BLAST21
Transmembranei1302 – 1322HelicalSequence analysisAdd BLAST21
Transmembranei1332 – 1352HelicalSequence analysisAdd BLAST21
Transmembranei1363 – 1383HelicalSequence analysisAdd BLAST21
Transmembranei1413 – 1433HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002346571 – 1441Pleiotropic drug resistance protein TUR2Add BLAST1441

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
O24367

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced by abiotic stresses such as cold-stress, cycloheximide and sodium chloride (NaCl). Induction by abscisic acid (ABA) is repressed by cytokinin such as kinetin (at protein level).2 Publications

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O24367

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini158 – 430ABC transporter 1PROSITE-ProRule annotationAdd BLAST273
Domaini508 – 721ABC transmembrane type-2 1Add BLAST214
Domaini843 – 1095ABC transporter 2PROSITE-ProRule annotationAdd BLAST253
Domaini1168 – 1382ABC transmembrane type-2 2Add BLAST215

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03233 ABCG_PDR_domain1, 1 hit
cd03232 ABCG_PDR_domain2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR013525 ABC_2_trans
IPR029481 ABC_trans_N
IPR003439 ABC_transporter-like
IPR034001 ABCG_PDR_1
IPR034003 ABCG_PDR_2
IPR027417 P-loop_NTPase
IPR013581 PDR_assoc

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01061 ABC2_membrane, 2 hits
PF00005 ABC_tran, 2 hits
PF14510 ABC_trans_N, 1 hit
PF08370 PDR_assoc, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O24367-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEIAGYRGGS LRGSLQGSLR RSVSAWRSPS TSDVFGRSSR EEDDEEALKW
60 70 80 90 100
AALEKLPTYD RLRKGIMTGD GGEIQEVDIQ GLGFQERKNL LEKLVRNAEE
110 120 130 140 150
DNERFLLKLR NRMERVGIDN PTIEVRFEHL NINAEAFVGN RGVPTLVNFF
160 170 180 190 200
VNKAIWILSA LHLMPSGKRP ISILHDVSGI IKPCRMTLLL GPPGAGKTTL
210 220 230 240 250
LLALAGKLDN TLKVTGNVTY NGHGMHEFVP QRTSAYISQH DVHIGEMTVR
260 270 280 290 300
ETLAFSSRCQ GVGTRYEMLT ELSRREKEAN IKPDPDVDVY MKAVAVEGQE
310 320 330 340 350
SVVTDYILKI LGLDICADTM VGDGMIRGIS GGQKKRVTTG EMLVGPSKAL
360 370 380 390 400
FMDEISTGLD SSTTFQIVNS LRQSVHILGG TALIALLQPA PETYDLFDDI
410 420 430 440 450
LLLSDGQIVY QGPRENVLEF FESMGFKCPE RKGVADFLQE VTSRKDQQQY
460 470 480 490 500
WVRENEPYRF VPVNEFSEAF KSFHVGAKLH EELSTPFDRS RNHPAALTTS
510 520 530 540 550
KYGISKMELL KACIDREWLL MKRNSFVYIF KVVQLIVLAL IAMTVFFRTK
560 570 580 590 600
LPRNGLEDAT IFFGAMFLGL VTHLFNGFAE LAMSIAKLPV FYKQRDLLFY
610 620 630 640 650
PPWAYALPTW ILKIPISFVE CGVWIAMTYY VIGFDPNVVR MFRHYLLLVL
660 670 680 690 700
ISQVASGLFR LLAAVGRDMV VADTFGAFAQ LVLLVLGGFI IAREKIKKFW
710 720 730 740 750
IWGYWSSPLM YAQNAIAVNE FLGHSWNKLV DATGQTLGER FLRNRGIFVD
760 770 780 790 800
KNWYWIGVGA LIGYMVLFNF LFILFLEWLD PLGKGQTTVS EEALQEKEAN
810 820 830 840 850
RTGANVELAT RGSAATSDGG SVEIRKDGNR KKGMVLPFTP LSITFDNVKY
860 870 880 890 900
SVDMPQEMKD RGVTEDKLLL LKGVSGAFRP GVLTALMGVS GRGKTTLMDV
910 920 930 940 950
LAGRKTGGYI EGDIRISGYP KNQETFARIS GYCEQNDIHS PHVTVYESLL
960 970 980 990 1000
YSAWLRLPAE VDEKQRKMFV DEVMDLVELN SLRGSLVGLP GVTGLSTEQR
1010 1020 1030 1040 1050
KRLTIAVELV ANPSIIFMDE PTSGLDARAA AIVMRAVRNT VDTGRTVVCT
1060 1070 1080 1090 1100
IHQPSIDIFE AFDELFLMKR GGEEIYVGPL GRQSSHLIKY FESIDGVKKI
1110 1120 1130 1140 1150
KERYNPATWM LEVTTISQEE ILGLNFAEVY RNSDLYKRNK DLIKELSTPP
1160 1170 1180 1190 1200
PGSKDLFFAT QFSQSFVMQC LACLWKQHKS YWRNPSYTAT RLFFTVVIAL
1210 1220 1230 1240 1250
IFGTIFWDLG KKRSTSLDLI NAMGSMYAAV LFIGIQNAQT VQPIVDVERT
1260 1270 1280 1290 1300
VFYREKAAGM YSALPYAYAQ VLIEVPHILV QTLLYGLLVY SMIGFDWTAA
1310 1320 1330 1340 1350
KFLWYMFFMF FTFLYFTYYG MMAVAMTPNS DIAAIVAAAF YAIWNIFAGF
1360 1370 1380 1390 1400
IIPRPRIPIW WRWYYWACPV AWTLYGLVVS QFGEYTDTMS DVDETVKDFL
1410 1420 1430 1440
RRFLGFRHDF LPVVGVMVVV FTVLFASIFA FSIKTLNFQR R
Length:1,441
Mass (Da):162,698
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i62D6A8DE0923EB76
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z70524 mRNA Translation: CAA94437.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70524 mRNA Translation: CAA94437.1

3D structure databases

SMRiO24367
ModBaseiSearch...

Protein family/group databases

TCDBi3.A.1.205.20 the atp-binding cassette (abc) superfamily

Proteomic databases

PRIDEiO24367

Family and domain databases

CDDicd03233 ABCG_PDR_domain1, 1 hit
cd03232 ABCG_PDR_domain2, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR013525 ABC_2_trans
IPR029481 ABC_trans_N
IPR003439 ABC_transporter-like
IPR034001 ABCG_PDR_1
IPR034003 ABCG_PDR_2
IPR027417 P-loop_NTPase
IPR013581 PDR_assoc
PfamiView protein in Pfam
PF01061 ABC2_membrane, 2 hits
PF00005 ABC_tran, 2 hits
PF14510 ABC_trans_N, 1 hit
PF08370 PDR_assoc, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTUR2_SPIPO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O24367
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: January 1, 1998
Last modified: September 18, 2019
This is version 88 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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