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Protein

Pantoate--beta-alanine ligase

Gene

PANC

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the condensation of pantoate with beta-alanine to form pantothenate. Essential for panthotenate biosynthesis (Probable).1 Publication

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.

Pathwayi: (R)-pantothenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine.
Proteins known to be involved in this subpathway in this organism are:
  1. Pantoate--beta-alanine ligase (PANC)
This subpathway is part of the pathway (R)-pantothenate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-pantothenate from (R)-pantoate and beta-alanine, the pathway (R)-pantothenate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei43Proton donorBy similarity1
Binding sitei71Beta-alanineBy similarity1
Binding sitei71PantoateBy similarity1
Binding sitei184PantoateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi36 – 43ATPBy similarity8
Nucleotide bindingi178 – 181ATPBy similarity4
Nucleotide bindingi215 – 218ATPBy similarity4

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • pantoate-beta-alanine ligase activity Source: GO_Central
  • protein homodimerization activity Source: EnsemblPlants

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPantothenate biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi6.3.2.1 4460
UniPathwayi
UPA00028;UER00005

Names & Taxonomyi

Protein namesi
Recommended name:
Pantoate--beta-alanine ligase (EC:6.3.2.1)
Alternative name(s):
Pantoate-activating enzyme
Pantothenate synthetase
Gene namesi
Name:PANC
Ordered Locus Names:Os03g0851800, LOC_Os03g63490
ORF Names:OSJNBa0015N08.21
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001283001 – 313Pantoate--beta-alanine ligaseAdd BLAST313

Proteomic databases

PaxDbiO24210

Expressioni

Gene expression databases

ExpressionAtlasiO24210 differential
GenevisibleiO24210 OS

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi39947.LOC_Os03g63490.1

Structurei

3D structure databases

ProteinModelPortaliO24210
SMRiO24210
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.Curated

Phylogenomic databases

eggNOGiKOG3042 Eukaryota
COG0414 LUCA
HOGENOMiHOG000175516
InParanoidiO24210
OMAiGEKACEK
OrthoDBiEOG09360G9W

Family and domain databases

CDDicd00560 PanC, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00158 PanC, 1 hit
InterProiView protein in InterPro
IPR003721 Pantoate_ligase
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR21299:SF1 PTHR21299:SF1, 1 hit
PfamiView protein in Pfam
PF02569 Pantoate_ligase, 1 hit
TIGRFAMsiTIGR00018 panC, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O24210-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAPREPEVI RDKAAMRAWS RRRRAEGKTV AVVPTMGYLH QGHLSLISAA
60 70 80 90 100
AAAASADPVA IVVTIYVNPS QFAPSEDLAT YPSDFAGDLR KLASTGVVDA
110 120 130 140 150
VFNPPDLYVR GAGRRGAASG GAISCLEEAA GDGHETWVRV ERLEKGMCGA
160 170 180 190 200
SRPVFFRGVA TIVSKLFNII EPDVAVFGKK DYQQWRVICR MVRDLDFAIE
210 220 230 240 250
IIGSEIVREA DGLAMSSRNV HLSREEREKA LSISRSLVDA RTGALKGNTD
260 270 280 290 300
CKQIKNKIVQ TLTETGGQVD YVEIVEQESL VPVEQIDGPV VICVAAWFGK
310
VRLIDNIEID TRS
Length:313
Mass (Da):34,039
Last modified:May 30, 2006 - v2
Checksum:i8079519175263FDF
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0P0W5J4A0A0P0W5J4_ORYSJ
Os03g0851800 protein
Os03g0851800 OSNPB_030851800
308Annotation score:

Sequence cautioni

The sequence CAA71303 differs from that shown. Sequencing errors.Curated
The sequence CAA71303 differs from that shown. Reason: Frameshift at several positions.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10253 mRNA Translation: CAA71303.1 Sequence problems.
AC096688 Genomic DNA Translation: AAO20059.1
DP000009 Genomic DNA Translation: ABF99935.1
AP008209 Genomic DNA Translation: BAF13832.1
AP014959 Genomic DNA Translation: BAS87394.1
AK066656 mRNA Translation: BAG90070.1
PIRiT03924
UniGeneiOs.4531

Genome annotation databases

EnsemblPlantsiOs03t0851800-01; Os03t0851800-01; Os03g0851800
GrameneiOs03t0851800-01; Os03t0851800-01; Os03g0851800

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10253 mRNA Translation: CAA71303.1 Sequence problems.
AC096688 Genomic DNA Translation: AAO20059.1
DP000009 Genomic DNA Translation: ABF99935.1
AP008209 Genomic DNA Translation: BAF13832.1
AP014959 Genomic DNA Translation: BAS87394.1
AK066656 mRNA Translation: BAG90070.1
PIRiT03924
UniGeneiOs.4531

3D structure databases

ProteinModelPortaliO24210
SMRiO24210
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi39947.LOC_Os03g63490.1

Proteomic databases

PaxDbiO24210

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiOs03t0851800-01; Os03t0851800-01; Os03g0851800
GrameneiOs03t0851800-01; Os03t0851800-01; Os03g0851800

Phylogenomic databases

eggNOGiKOG3042 Eukaryota
COG0414 LUCA
HOGENOMiHOG000175516
InParanoidiO24210
OMAiGEKACEK
OrthoDBiEOG09360G9W

Enzyme and pathway databases

UniPathwayi
UPA00028;UER00005

BRENDAi6.3.2.1 4460

Gene expression databases

ExpressionAtlasiO24210 differential
GenevisibleiO24210 OS

Family and domain databases

CDDicd00560 PanC, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00158 PanC, 1 hit
InterProiView protein in InterPro
IPR003721 Pantoate_ligase
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR21299:SF1 PTHR21299:SF1, 1 hit
PfamiView protein in Pfam
PF02569 Pantoate_ligase, 1 hit
TIGRFAMsiTIGR00018 panC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPANC_ORYSJ
AccessioniPrimary (citable) accession number: O24210
Secondary accession number(s): A0A0P0W5L1, Q10AH8, Q851Y0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 30, 2006
Last modified: November 7, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
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