We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - O24146 (4CL2_TOBAC)
Protein
4-coumarate--CoA ligase 2
Gene
4CL2
Organism
Nicotiana tabacum (Common tobacco)
Status
Functioni
Catalytic activityi
- EC:6.2.1.12
: 3,4',5-trihydroxystilbene biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes 3,4',5-trihydroxystilbene from trans-4-coumarate. This subpathway is part of the pathway 3,4',5-trihydroxystilbene biosynthesis, which is itself part of Phytoalexin biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes 3,4',5-trihydroxystilbene from trans-4-coumarate, the pathway 3,4',5-trihydroxystilbene biosynthesis and in Phytoalexin biosynthesis.
GO - Molecular functioni
- 4-coumarate-CoA ligase activity Source: UniProtKB-EC
- ATP binding Source: UniProtKB-KW
- CoA-ligase activity Source: GO_Central
GO - Biological processi
- phenylpropanoid metabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Ligase |
Biological process | Phenylpropanoid metabolism |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 6.2.1.12, 3645 |
UniPathwayi | UPA00372;UER00547 |
Names & Taxonomyi
Protein namesi | Recommended name: 4-coumarate--CoA ligase 2 (EC:6.2.1.12)Short name: 4CL 2 Alternative name(s): 4-coumaroyl-CoA synthase 2 |
Gene namesi | Name:4CL2 |
Organismi | Nicotiana tabacum (Common tobacco) |
Taxonomic identifieri | 4097 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › asterids › lamiids › Solanales › Solanaceae › Nicotianoideae › Nicotianeae › Nicotiana |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000193041 | 1 – 542 | 4-coumarate--CoA ligase 2Add BLAST | 542 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O24146 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the ATP-dependent AMP-binding enzyme family.Curated
Family and domain databases
Gene3Di | 3.30.300.30, 1 hit 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR025110, AMP-bd_C IPR045851, AMP-bd_C_sf IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, ANL_N_sf |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
i Sequence
Sequence statusi: Complete.
O24146-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEKDTKQVDI IFRSKLPDIY IPNHLPLHSY CFENISEFSS RPCLINGANK
60 70 80 90 100
QIYTYADVEL NSRKVAAGLH KQGIQPKDTI MILLPNSPEF VFAFIGASYL
110 120 130 140 150
GAISTMANPL FTPAEVVKQA KASSAKIIVT QACHVNKVKD YAFENDVKII
160 170 180 190 200
CIDSAPEGCL HFSVLTQANE HDIPEVEIQP DDVVALPYSS GTTGLPKGVM
210 220 230 240 250
LTHKGLVTSV AQQVDGENPN LYIHSEDVML CVLPLFHIYS LNSVLLCGLR
260 270 280 290 300
VGAAILIMQK FDIVSFLELI QRYKVTIGPF VPPIVLAIAK SPMVDDYDLS
310 320 330 340 350
SVRTVMSGAA PLGKELEDTV RAKFPNAKLG QGYGMTEAGP VLAMCLAFAK
360 370 380 390 400
EPFEIKSGAC GTVVRNAEMK IVDPKTGNSL PRNQSGEICI RGDQIMKGYL
410 420 430 440 450
NDPEATARTI DKEGWLYTGD IGYIDDDDEL FIVDRLKELI KYKGFQVAPA
460 470 480 490 500
ELEALLLNHP NISDAAVVPM KDEQAGEVPV AFVVRSNGST ITEDEVKDFI
510 520 530 540
SKQVIFYKRI KRVFFVDAIP KSPSGKILRK DLRAKLAAGL PN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U50846 mRNA Translation: AAB18638.1 |
PIRi | T03789 |
RefSeqi | NP_001312554.1, NM_001325625.1 |
Genome annotation databases
GeneIDi | 107797004 |
KEGGi | nta:107797004 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U50846 mRNA Translation: AAB18638.1 |
PIRi | T03789 |
RefSeqi | NP_001312554.1, NM_001325625.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5BSM | X-ray | 2.32 | A/B | 1-542 | [»] | |
5BSR | X-ray | 1.50 | A | 1-542 | [»] | |
5BST | X-ray | 1.61 | A | 1-542 | [»] | |
5BSU | X-ray | 1.75 | A | 1-542 | [»] | |
5BSV | X-ray | 1.70 | A | 1-542 | [»] | |
5BSW | X-ray | 2.10 | A/B | 1-542 | [»] | |
5U95 | X-ray | 2.25 | A/B/C/D | 1-542 | [»] | |
SMRi | O24146 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 4097.O24146 |
Genome annotation databases
GeneIDi | 107797004 |
KEGGi | nta:107797004 |
Enzyme and pathway databases
UniPathwayi | UPA00372;UER00547 |
BRENDAi | 6.2.1.12, 3645 |
Family and domain databases
Gene3Di | 3.30.300.30, 1 hit 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR025110, AMP-bd_C IPR045851, AMP-bd_C_sf IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, ANL_N_sf |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | 4CL2_TOBAC | |
Accessioni | O24146Primary (citable) accession number: O24146 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | January 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 83 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families