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UniProtKB - O24145 (4CL1_TOBAC)
Protein
4-coumarate--CoA ligase 1
Gene
4CL1
Organism
Nicotiana tabacum (Common tobacco)
Status
Functioni
Catalytic activityi
- EC:6.2.1.12
: 3,4',5-trihydroxystilbene biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes 3,4',5-trihydroxystilbene from trans-4-coumarate. This subpathway is part of the pathway 3,4',5-trihydroxystilbene biosynthesis, which is itself part of Phytoalexin biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes 3,4',5-trihydroxystilbene from trans-4-coumarate, the pathway 3,4',5-trihydroxystilbene biosynthesis and in Phytoalexin biosynthesis.
GO - Molecular functioni
- 4-coumarate-CoA ligase activity Source: UniProtKB-EC
- ATP binding Source: UniProtKB-KW
- CoA-ligase activity Source: GO_Central
GO - Biological processi
- phenylpropanoid metabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Ligase |
Biological process | Phenylpropanoid metabolism |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
UniPathwayi | UPA00372;UER00547 |
Names & Taxonomyi
Protein namesi | Recommended name: 4-coumarate--CoA ligase 1 (EC:6.2.1.12)Short name: 4CL 1 Alternative name(s): 4-coumaroyl-CoA synthase 1 |
Gene namesi | Name:4CL1 |
Organismi | Nicotiana tabacum (Common tobacco) |
Taxonomic identifieri | 4097 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › asterids › lamiids › Solanales › Solanaceae › Nicotianoideae › Nicotianeae › Nicotiana |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000193040 | 1 – 547 | 4-coumarate--CoA ligase 1Add BLAST | 547 |
Family & Domainsi
Sequence similaritiesi
Belongs to the ATP-dependent AMP-binding enzyme family.Curated
Phylogenomic databases
OMAi | NARASWW |
PhylomeDBi | O24145 |
Family and domain databases
Gene3Di | 3.30.300.30, 1 hit 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR025110, AMP-bd_C IPR045851, AMP-bd_C_sf IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, ANL_N_sf |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
i Sequence
Sequence statusi: Complete.
O24145-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPMETTTETK QSGDLIFRSK LPDIYIPKHL PLHSYCFENI SEFSSRPCLI
60 70 80 90 100
NGANDQIYTY AEVELTCRKV AVGLNKLGIQ QKDTIMILLP NSPEFVFAFM
110 120 130 140 150
GASYLGAIST MANPLFTPAE VVKQAKASSA KIIITQSCFV GKVKDYASEN
160 170 180 190 200
DVKVICIDSA PEGCLHFSEL TQSDEHEIPE VKIQPDDVVA LPYSSGTTGL
210 220 230 240 250
PKGVMLTHKG LVTSVAQQVD GENANLYMHS EDVLMCVLPL FHIYSLNSIL
260 270 280 290 300
LCGLRVGAAI LIMQKFDIAP FLELIQKYKV SIGPFVPPIV LAIAKSPIVD
310 320 330 340 350
SYDLSSVRTV MSGAAPLGKE LEDAVRTKFP NAKLGQGYGM TEAGPVLAMC
360 370 380 390 400
LAFAKEPFDI KSGACGTVVR NAEMKIVDPD TGCSLPRNQP GEICIRGDQI
410 420 430 440 450
MKGYLNDPEA TTRTIDKEGW LHTGDIGFID EDDELFIVDR LKELIKYKGF
460 470 480 490 500
QVAPAEIEAL LLNHPNISDA AVVPMKDEQA GEVPVAFVVR SNGSAITEDE
510 520 530 540
VKDFISKQVI FYKRVKRVFF VETVPKSPSG KILRKDLRAR LAAGVPN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U50845 mRNA Translation: AAB18637.1 |
RefSeqi | NP_001312667.1, NM_001325738.1 |
Genome annotation databases
GeneIDi | 107803673 |
KEGGi | nta:107803673 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U50845 mRNA Translation: AAB18637.1 |
RefSeqi | NP_001312667.1, NM_001325738.1 |
3D structure databases
SMRi | O24145 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 4097.O24145 |
Genome annotation databases
GeneIDi | 107803673 |
KEGGi | nta:107803673 |
Phylogenomic databases
OMAi | NARASWW |
PhylomeDBi | O24145 |
Enzyme and pathway databases
UniPathwayi | UPA00372;UER00547 |
Family and domain databases
Gene3Di | 3.30.300.30, 1 hit 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR025110, AMP-bd_C IPR045851, AMP-bd_C_sf IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, ANL_N_sf |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit PF13193, AMP-binding_C, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | 4CL1_TOBAC | |
Accessioni | O24145Primary (citable) accession number: O24145 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | January 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 76 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families