UniProtKB - O23968 (GPX4_HELAN)
Protein
Probable phospholipid hydroperoxide glutathione peroxidase
Gene
GPXHA-2
Organism
Helianthus annuus (Common sunflower)
Status
Functioni
Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.By similarity
Catalytic activityi
- a hydroperoxy polyunsaturated fatty acid + 2 glutathione = a hydroxy polyunsaturated fatty acid + glutathione disulfide + H2OBy similarityEC:1.11.1.12By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 54 | By similarity | 1 |
GO - Molecular functioni
- glutathione peroxidase activity Source: InterPro
- phospholipid-hydroperoxide glutathione peroxidase activity Source: UniProtKB-EC
GO - Biological processi
- response to oxidative stress Source: InterPro
Keywordsi
Molecular function | Oxidoreductase, Peroxidase |
Protein family/group databases
PeroxiBasei | 2650, HaGPx06 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable phospholipid hydroperoxide glutathione peroxidase (EC:1.11.1.12)Short name: PHGPx Alternative name(s): Glutathione peroxidase 2 |
Gene namesi | Name:GPXHA-2 |
Organismi | Helianthus annuus (Common sunflower) |
Taxonomic identifieri | 4232 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › asterids › campanulids › Asterales › Asteraceae › Asteroideae › Heliantheae alliance › Heliantheae › Helianthus |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm Curated
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000066630 | 1 – 180 | Probable phospholipid hydroperoxide glutathione peroxidaseAdd BLAST | 180 |
Family & Domainsi
Sequence similaritiesi
Belongs to the glutathione peroxidase family.Curated
Family and domain databases
CDDi | cd00340, GSH_Peroxidase, 1 hit |
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR000889, Glutathione_peroxidase IPR029759, GPX_AS IPR029760, GPX_CS IPR036249, Thioredoxin-like_sf |
PANTHERi | PTHR11592, PTHR11592, 1 hit |
Pfami | View protein in Pfam PF00255, GSHPx, 1 hit |
PIRSFi | PIRSF000303, Glutathion_perox, 1 hit |
PRINTSi | PR01011, GLUTPROXDASE |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS00460, GLUTATHIONE_PEROXID_1, 1 hit PS00763, GLUTATHIONE_PEROXID_2, 1 hit PS51355, GLUTATHIONE_PEROXID_3, 1 hit |
i Sequence
Sequence statusi: Complete.
O23968-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATQTVFDFP DDVLQQPPMP ADNAFSDKDV KGQDVELSKY KGKVLLIVNV
60 70 80 90 100
ASQCGFTNSN YPELTTLYQK YKDQGFEILA FPCNQFGGQE PGSNEEIQVF
110 120 130 140 150
ACTRFKAEYP VFSKVNVNGK EADPLYKFLK SSKGGFLGDS IKWNFTKFLV
160 170 180
DREGKVVDRY APTTSPLSIE KDIKKLLNVA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y14707 mRNA Translation: CAA75009.1 |
PIRi | T12633 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y14707 mRNA Translation: CAA75009.1 |
PIRi | T12633 |
3D structure databases
SMRi | O23968 |
ModBasei | Search... |
Protein family/group databases
PeroxiBasei | 2650, HaGPx06 |
Family and domain databases
CDDi | cd00340, GSH_Peroxidase, 1 hit |
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR000889, Glutathione_peroxidase IPR029759, GPX_AS IPR029760, GPX_CS IPR036249, Thioredoxin-like_sf |
PANTHERi | PTHR11592, PTHR11592, 1 hit |
Pfami | View protein in Pfam PF00255, GSHPx, 1 hit |
PIRSFi | PIRSF000303, Glutathion_perox, 1 hit |
PRINTSi | PR01011, GLUTPROXDASE |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS00460, GLUTATHIONE_PEROXID_1, 1 hit PS00763, GLUTATHIONE_PEROXID_2, 1 hit PS51355, GLUTATHIONE_PEROXID_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GPX4_HELAN | |
Accessioni | O23968Primary (citable) accession number: O23968 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | January 1, 1998 | |
Last modified: | October 7, 2020 | |
This is version 87 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |