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Protein

L-lactate dehydrogenase

Gene

dl4665w

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (dl4665w), L-lactate dehydrogenase, L-lactate dehydrogenase (LDH1), L-lactate dehydrogenase (At4g17260), L-lactate dehydrogenase (AXX17_At4g20330)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei126SubstrateUniRule annotation1
Binding sitei158SubstrateUniRule annotation1
Binding sitei189SubstrateUniRule annotation1
Active sitei213Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

ReactomeiR-ATH-70268 Pyruvate metabolism
UniPathwayi
UPA00554;UER00611

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Gene namesi
Name:dl4665wImported
Ordered Locus Names:At4g17260Imported
ORF Names:Dl4665WImported, FCAALL.172Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G17260
TAIRilocus:2130764 AT4G17260

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiO23569

Expressioni

Gene expression databases

ExpressionAtlasiO23569 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G17260.1

Structurei

3D structure databases

SMRiO23569
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 180Ldh_1_NInterPro annotationAdd BLAST140
Domaini183 – 346Ldh_1_CInterPro annotationAdd BLAST164

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1495 Eukaryota
COG0039 LUCA
HOGENOMiHOG000213793
KOiK00016
OMAiMDLMQTA
OrthoDBiEOG09360DKP

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064 L_LDH, 1 hit

Sequencei

Sequence statusi: Complete.

O23569-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKNASTSSL KDLGPSGLDL TSAFFKPIHN SDPSLPSNRR TKVSVVGVGN
60 70 80 90 100
VGMAIAQTIL TQDLADEIAL VDAKPDKLRG EMLDLQHAAA FLPRTKITAS
110 120 130 140 150
VDYEVTAGSD LCIVTAGARQ NPGESRLNLL QRNVALFRHI IPPLAKASPD
160 170 180 190 200
SILIIVSNPV DVLTYVAWKL SGFPVNRVLG SGTNLDSSRF RFLIADHLDV
210 220 230 240 250
NAQDVQAFIV GEHGDSSVAL WSSISVGGIP VLSFLEKNQI AYEKQTLEDI
260 270 280 290 300
HQAVVGSAYE VIGLKGYTSW AIGYSVANLA RTILRDQRKI HPVTVLARGF
310 320 330 340 350
YGVDGGDVFL SLPALLGRNG VVAVTNVHMT DEEAEKLQKS AKTILEMQSQ

LGL
Length:353
Mass (Da):37,950
Last modified:January 1, 1998 - v1
Checksum:iF8467FD4BC298F2F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT028958 mRNA Translation: ABI54333.1
CP002687 Genomic DNA Translation: AEE83871.1
Z97343 Genomic DNA Translation: CAB10507.1
AL161546 Genomic DNA Translation: CAB78729.1
PIRiF71441
RefSeqiNP_193459.1, NM_117832.4
UniGeneiAt.27760

Genome annotation databases

EnsemblPlantsiAT4G17260.1; AT4G17260.1; AT4G17260
GeneIDi827440
GrameneiAT4G17260.1; AT4G17260.1; AT4G17260
KEGGiath:AT4G17260

Similar proteinsi

Entry informationi

Entry nameiO23569_ARATH
AccessioniPrimary (citable) accession number: O23569
Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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