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Protein

RGG repeats nuclear RNA binding protein A

Gene

RGGA

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds RNA. Regulates responses to abscisic acid (ABA). Promotes stomata closure in drought conditions. Involved in resistance to salt and drought stresses via the accumulation of Pro.1 Publication

GO - Molecular functioni

  • mRNA binding Source: TAIR

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processAbscisic acid signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
RGG repeats nuclear RNA binding protein A1 Publication
Short name:
AtRGGA1 Publication
Gene namesi
Name:RGGA1 Publication
Ordered Locus Names:At4g16830Imported
ORF Names:dl4440wImported, FCAALL.13Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G16830
TAIRilocus:2129191 AT4G16830

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Larger rosettes and delayed flowering in long days (16 h of light/8 h of darkness). Higher sensitivity to salt (NaCl). Hypersensitivity to the presence of abscisic acid (ABA).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00004383162 – 355RGG repeats nuclear RNA binding protein AAdd BLAST354

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei268PhosphoserineBy similarity1
Modified residuei351PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiO23523
PRIDEiO23523

PTM databases

iPTMnetiO23523

Expressioni

Tissue specificityi

Expressed in seedlings, leaves, roots, inflorescences, and siliques (PubMed:25783413). Constitutively expressed in seedlings and roots (PubMed:11905967).2 Publications

Developmental stagei

In leaves, especially present in stomata guard cells. In reproductive organs, expressed in pollen grains and tubes of germinating pollen, as well as in funiculi attaching seeds to siliques.1 Publication

Inductioni

By abscisic acid (ABA), and osmotic stress (e.g. polyethylene glycol PEG). Slight transient repression by salt (NaCl).1 Publication

Gene expression databases

ExpressionAtlasiO23523 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G16830.1

Structurei

3D structure databases

ProteinModelPortaliO23523
SMRiO23523
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini234 – 289FFPROSITE-ProRule annotationAdd BLAST56

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi132 – 139Nuclear localization signalPROSITE-ProRule annotation8
Motifi145 – 155Arginine-rich RNA-binding motif E-R-P-R-R-X-[F/Y]-[E/D]-R-R-S1 PublicationAdd BLAST11

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi68 – 177Gly-richPROSITE-ProRule annotationAdd BLAST110
Compositional biasi306 – 334Gly-richPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the RGGA protein family.Curated

Phylogenomic databases

eggNOGiKOG2945 Eukaryota
ENOG410YBHR LUCA
HOGENOMiHOG000238039
KOiK13199
OMAiDGNNGYS
OrthoDBiEOG09360Q6Q
PhylomeDBiO23523

Family and domain databases

InterProiView protein in InterPro
IPR006861 HABP4_PAIRBP1-bd
IPR019084 Stm1-like_N
PfamiView protein in Pfam
PF04774 HABP4_PAI-RBP1, 1 hit
PF09598 Stm1_N, 1 hit
SMARTiView protein in SMART
SM01233 HABP4_PAI-RBP1, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O23523-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATLNPFDLL DDDAEDPSQL AVAIEKIDKS KKSGQVSSLP AKSAPKLPSK
60 70 80 90 100
PLPPAQAVRE ARSDAPRGGG GRGGFNRGRG GYNRDDGNNG YSGGYTKPSG
110 120 130 140 150
EGDVSKSSYE RRGGGGAPRG SFRGEGGGPG GGRRGGFSNE GGDGERPRRA
160 170 180 190 200
FERRSGTGRG SDFKRDGSGR GNWGTPGEEI AAETEAVAGV ETEKDVGEKP
210 220 230 240 250
AVDDVAADAN KEDTVVEEKE PEDKEMTLDE YEKILEEKKK ALQSLTTSER
260 270 280 290 300
KVDTKVFESM QQLSNKKSND EIFIKLGSDK DKRKDDKEEK AKKAVSINEF
310 320 330 340 350
LKPAEGGNYY RGGRGGRGRG GRGRGGVSSG ESGGYRNEAA PAIGDAAQFP

SLGGK
Length:355
Mass (Da):37,468
Last modified:January 1, 1998 - v1
Checksum:iA7F1D63DA96B7C2C
GO
Isoform 2 (identifier: O23523-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-140: MATLNPFDLL...GGRRGGFSNE → MLHVVVEAVE...FQSLLTRGVA

Note: Derived from EST data. No experimental confirmation available.Imported
Show »
Length:265
Mass (Da):28,676
Checksum:iB8BCE49A3EF16DF0
GO
Isoform 3 (identifier: O23523-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-57: ATLNPFDLLD...PSKPLPPAQA → MMLRIQASSL...HRSHFLLLKP

Note: Derived from EST data. No experimental confirmation available.Imported
Show »
Length:345
Mass (Da):37,062
Checksum:i25E3950629DD4DDD
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0586431 – 140MATLN…GFSNE → MLHVVVEAVEDLTVVVVVTT VMMVTMDIQGDTLNPQVKEM FQSLLTRGVA in isoform 2. Add BLAST140
Alternative sequenceiVSP_0586442 – 57ATLNP…PPAQA → MMLRIQASSLLPSRRLISPR NLDRFRACLLSQLLSFHRSH FLLLKP in isoform 3. Add BLAST56

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110227 Genomic DNA Translation: AAF14243.1
Z97342 Genomic DNA Translation: CAB10456.1
AL161545 Genomic DNA Translation: CAB80954.1
CP002687 Genomic DNA Translation: AEE83809.1
CP002687 Genomic DNA Translation: AEE83810.1
CP002687 Genomic DNA Translation: AEE83811.1
AY063896 mRNA Translation: AAL36252.1
AY096500 mRNA Translation: AAM20150.1
AY127018 mRNA Translation: AAM83242.1
BT000559 mRNA Translation: AAN18128.1
PIRiF71435
RefSeqiNP_001078399.1, NM_001084930.1 [O23523-2]
NP_001078400.1, NM_001084931.1 [O23523-3]
NP_193416.1, NM_117785.5 [O23523-1]
UniGeneiAt.24459

Genome annotation databases

EnsemblPlantsiAT4G16830.1; AT4G16830.1; AT4G16830 [O23523-1]
AT4G16830.2; AT4G16830.2; AT4G16830 [O23523-2]
AT4G16830.3; AT4G16830.3; AT4G16830 [O23523-3]
GeneIDi827389
GrameneiAT4G16830.1; AT4G16830.1; AT4G16830 [O23523-1]
AT4G16830.2; AT4G16830.2; AT4G16830 [O23523-2]
AT4G16830.3; AT4G16830.3; AT4G16830 [O23523-3]
KEGGiath:AT4G16830

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRGGA_ARATH
AccessioniPrimary (citable) accession number: O23523
Secondary accession number(s): A8MQG3, A8MQJ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 30, 2016
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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