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Protein

Pyruvate, phosphate dikinase 1, chloroplastic

Gene

PPDK

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Formation of phosphoenolpyruvate. May be involved in regulating the flux of carbon into starch and fatty acids of seeds and in the remobilization of nitrogen reserves in senescing leaves.4 Publications

Miscellaneous

The reaction takes place in three steps, mediated by a phosphocarrier histidine residue located on the surface of the central domain. The two first partial reactions are catalyzed at an active site located on the N-terminal domain, and the third partial reaction is catalyzed at an active site located on the C-terminal domain. For catalytic turnover, the central domain swivels from the concave surface of the N-terminal domain to that of the C-terminal domain.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Activated by light-induced dephosphorylation. Inhibited by dark-induced phosphorylation. Both reactions are catalyzed by PDRP1.By similarity

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=17 µM for pyruvate1 Publication
  2. KM=292 µM for phosphoenolpyruvate1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei545Tele-phosphohistidine intermediateBy similarity1
    <p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei651SubstrateBy similarity1
    Binding sitei707SubstrateBy similarity1
    <p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi836MagnesiumBy similarity1
    Binding sitei836SubstrateBy similarity1
    Binding sitei857Substrate; via carbonyl oxygenBy similarity1
    Binding sitei858Substrate; via amide nitrogenBy similarity1
    Binding sitei859SubstrateBy similarity1
    Metal bindingi860MagnesiumBy similarity1
    Binding sitei860Substrate; via amide nitrogenBy similarity1
    Active sitei922Proton donorBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionKinase, Transferase
    Biological processPhotosynthesis
    LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Pyruvate

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    ARA:AT4G15530-MONOMER

    BRENDA Comprehensive Enzyme Information System

    More...
    BRENDAi
    2.7.11.32 399

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Pyruvate, phosphate dikinase 1, chloroplastic (EC:2.7.9.1)
    Alternative name(s):
    Pyruvate, orthophosphate dikinase 1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:PPDK
    Ordered Locus Names:At4g15530
    ORF Names:dl3805c, FCAALL.325
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

    Organism-specific databases

    Arabidopsis Information Portal

    More...
    Araporti
    AT4G15530

    The Arabidopsis Information Resource

    More...
    TAIRi
    locus:2130324 AT4G15530

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Chloroplast, Cytoplasm, Plastid

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi543T → D: Loss of phosphorylation. 1 Publication1

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 76ChloroplastCombined sourcesAdd BLAST76
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000034351577 – 963Pyruvate, phosphate dikinase 1, chloroplasticAdd BLAST887

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei543Phosphothreonine; by PDRP1Combined sources1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Phosphorylation of Thr-543 in the dark inactivates the enzyme. Dephosphorylation upon light stimulation reactivates the enzyme.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    O23404

    PRoteomics IDEntifications database

    More...
    PRIDEi
    O23404

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    O23404

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Isoform 1 is expressed in leaves, flowers and siliques. Isoform 2 is found in cotyledons, rosette and cauline leaves, petioles, flowers and siliques.1 Publication

    <p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

    Both isoforms 1 and 2 increase up to 7 days after sowing, but then decline.1 Publication

    <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Isoform 2, but not isoform 1, is induced during darkness.2 Publications

    Gene expression databases

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    O23404 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    O23404 AT

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homotetramer. Interacts with RP1 and RP2.By similarity1 Publication

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    12523, 4 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    3702.AT4G15530.5

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    O23404

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    O23404

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    The catalytic core domain alone is sufficient for the binding to PDRP1 but not for the binding to PDRP2.1 Publication
    The N-terminal domain contains the ATP/Pi binding site, the central domain the pyrophosphate/phosphate carrier histidine, and the C-terminal domain the pyruvate binding site.By similarity

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the PEP-utilizing enzyme family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG410IIM3 Eukaryota
    COG0574 LUCA

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000039664

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    O23404

    KEGG Orthology (KO)

    More...
    KOi
    K01006

    Database of Orthologous Groups

    More...
    OrthoDBi
    EOG0936014R

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    O23404

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.30.1490.20, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR013815 ATP_grasp_subdomain_1
    IPR008279 PEP-util_enz_mobile_dom
    IPR018274 PEP_util_AS
    IPR000121 PEP_util_C
    IPR023151 PEP_util_CS
    IPR036637 Phosphohistidine_dom_sf
    IPR002192 PPDK_PEP-bd
    IPR010121 Pyruvate_phosphate_dikinase
    IPR015813 Pyrv/PenolPyrv_Kinase-like_dom

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR22931:SF9 PTHR22931:SF9, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00391 PEP-utilizers, 1 hit
    PF02896 PEP-utilizers_C, 1 hit
    PF01326 PPDK_N, 3 hits

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF000853 PPDK, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF51621 SSF51621, 1 hit
    SSF52009 SSF52009, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR01828 pyru_phos_dikin, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00742 PEP_ENZYMES_2, 1 hit
    PS00370 PEP_ENZYMES_PHOS_SITE, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket
    Note: One additional alternative promoter may be used. According to EST data.
    Isoform 1 (identifier: O23404-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MLYIRKKMTS MIVKTTPELF KGNGVFRTDH LGENRMVSRS NRLGDGSNRF
    60 70 80 90 100
    PRTGTIHCQR LSIAKTGLHR ETKARAILSP VSDPAASIAQ KRVFTFGKGR
    110 120 130 140 150
    SEGNKGMKSL LGGKGANLAE MASIGLSVPP GLTISTEACQ QYQIAGKKLP
    160 170 180 190 200
    EGLWEEILEG LSFIERDIGA SLADPSKPLL LSVRSGAAIS MPGMMDTVLN
    210 220 230 240 250
    LGLNDQVVVG LAAKSGERFA YDSFRRFLDM FGDVVMGIPH AKFEEKLERM
    260 270 280 290 300
    KERKGVKNDT DLSAADLKEL VEQYKSVYLE AKGQEFPSDP KKQLELAIEA
    310 320 330 340 350
    VFDSWDSPRA NKYRSINQIT GLKGTAVNIQ CMVFGNMGDT SGTGVLFTRN
    360 370 380 390 400
    PSTGEKKLYG EFLVNAQGED VVAGIRTPED LDTMKRFMPE AYAELVENCN
    410 420 430 440 450
    ILERHYKDMM DIEFTVQEER LWMLQCRAGK RTGKGAVKIA VDMVGEGLVE
    460 470 480 490 500
    KSSAIKMVEP QHLDQLLHPQ FHDPSGYREK VVAKGLPASP GAAVGQVVFT
    510 520 530 540 550
    AEEAEAWHSQ GKTVILVRTE TSPDDVGGMH AAEGILTARG GMTSHAAVVA
    560 570 580 590 600
    RGWGKCCIAG CSEIRVDENH KVLLIGDLTI NEGEWISMNG STGEVILGKQ
    610 620 630 640 650
    ALAPPALSPD LETFMSWADA IRRLKVMANA DTPEDAIAAR KNGAQGIGLC
    660 670 680 690 700
    RTEHMFFGAD RIKAVRKMIM AVTTEQRKAS LDILLPYQRS DFEGIFRAMD
    710 720 730 740 750
    GLPVTIRLLD PPLHEFLPEG DLDNIVHELA EETGVKEDEV LSRIEKLSEV
    760 770 780 790 800
    NPMLGFRGCR LGISYPELTE MQARAIFEAA ASMQDQGVTV IPEIMVPLVG
    810 820 830 840 850
    TPQELGHQVD VIRKVAKKVF AEKGHTVSYK VGTMIEIPRA ALIADEIAKE
    860 870 880 890 900
    AEFFSFGTND LTQMTFGYSR DDVGKFLPIY LAKGILQHDP FEVLDQQGVG
    910 920 930 940 950
    QLIKMATEKG RAARPSLKVG ICGEHGGDPS SVGFFAEAGL DYVSCSPFRV
    960
    PIARLAAAQV VVA
    Note: Translation of the sequence shown in PubMed:16915520 was N-terminally extended.
    Length:963
    Mass (Da):105,138
    Last modified:July 1, 2008 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i239263180A836FE2
    GO
    Isoform 2 (identifier: O23404-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-88: Missing.
         89-91: AQK → MMQ

    Note: Produced by alternative promoter usage. Cytoplasmic.
    Show »
    Length:875
    Mass (Da):95,393
    Checksum:iF8929AE2403188EA
    GO
    Isoform 3 (identifier: O23404-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-7: Missing.

    Note: Produced by alternative splicing of isoform 1. Derived from EST data. No experimental confirmation available.
    Show »
    Length:956
    Mass (Da):104,205
    Checksum:i42BDE83BC6B979FF
    GO
    Isoform 4 (identifier: O23404-4) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-106: Missing.

    Note: Produced by alternative splicing of isoform 1. Derived from EST data. No experimental confirmation available.
    Show »
    Length:857
    Mass (Da):93,380
    Checksum:iA843A22058F89E7E
    GO

    <p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

    The sequence CAB10331 differs from that shown. Reason: Erroneous gene model prediction.Curated
    The sequence CAB78595 differs from that shown. Reason: Erroneous gene model prediction.Curated

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0346031 – 106Missing in isoform 4. CuratedAdd BLAST106
    Alternative sequenceiVSP_0346041 – 88Missing in isoform 2. 1 PublicationAdd BLAST88
    Alternative sequenceiVSP_0346051 – 7Missing in isoform 3. 1 Publication7
    Alternative sequenceiVSP_03460689 – 91AQK → MMQ in isoform 2. 1 Publication3

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    Z97339 Genomic DNA Translation: CAB10331.1 Sequence problems.
    AL161541 Genomic DNA Translation: CAB78595.1 Sequence problems.
    CP002687 Genomic DNA Translation: AEE83616.1
    CP002687 Genomic DNA Translation: AEE83617.1
    CP002687 Genomic DNA Translation: AEE83618.1
    CP002687 Genomic DNA Translation: AEE83619.1
    CP002687 Genomic DNA Translation: AEE83620.1
    CP002687 Genomic DNA Translation: AEE83621.1
    CP002687 Genomic DNA Translation: ANM67012.1
    AK317187 mRNA Translation: BAH19872.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    A71420

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001031647.1, NM_001036570.1 [O23404-4]
    NP_001078395.1, NM_001084926.1 [O23404-3]
    NP_001078396.1, NM_001084927.2 [O23404-1]
    NP_001118987.1, NM_001125515.1 [O23404-1]
    NP_001328869.1, NM_001341051.1 [O23404-4]
    NP_193288.2, NM_117643.4 [O23404-2]
    NP_849391.2, NM_179060.4 [O23404-3]

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    At.23286
    At.44851

    Genome annotation databases

    Ensembl plant genome annotation project

    More...
    EnsemblPlantsi
    AT4G15530.1; AT4G15530.1; AT4G15530 [O23404-3]
    AT4G15530.2; AT4G15530.2; AT4G15530 [O23404-2]
    AT4G15530.3; AT4G15530.3; AT4G15530 [O23404-4]
    AT4G15530.4; AT4G15530.4; AT4G15530 [O23404-3]
    AT4G15530.5; AT4G15530.5; AT4G15530 [O23404-1]
    AT4G15530.6; AT4G15530.6; AT4G15530 [O23404-1]
    AT4G15530.7; AT4G15530.7; AT4G15530 [O23404-4]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    827226

    Gramene; a comparative resource for plants

    More...
    Gramenei
    AT4G15530.1; AT4G15530.1; AT4G15530 [O23404-3]
    AT4G15530.2; AT4G15530.2; AT4G15530 [O23404-2]
    AT4G15530.3; AT4G15530.3; AT4G15530 [O23404-4]
    AT4G15530.4; AT4G15530.4; AT4G15530 [O23404-3]
    AT4G15530.5; AT4G15530.5; AT4G15530 [O23404-1]
    AT4G15530.6; AT4G15530.6; AT4G15530 [O23404-1]
    AT4G15530.7; AT4G15530.7; AT4G15530 [O23404-4]

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ath:AT4G15530

    Keywords - Coding sequence diversityi

    Alternative promoter usage, Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    Z97339 Genomic DNA Translation: CAB10331.1 Sequence problems.
    AL161541 Genomic DNA Translation: CAB78595.1 Sequence problems.
    CP002687 Genomic DNA Translation: AEE83616.1
    CP002687 Genomic DNA Translation: AEE83617.1
    CP002687 Genomic DNA Translation: AEE83618.1
    CP002687 Genomic DNA Translation: AEE83619.1
    CP002687 Genomic DNA Translation: AEE83620.1
    CP002687 Genomic DNA Translation: AEE83621.1
    CP002687 Genomic DNA Translation: ANM67012.1
    AK317187 mRNA Translation: BAH19872.1
    PIRiA71420
    RefSeqiNP_001031647.1, NM_001036570.1 [O23404-4]
    NP_001078395.1, NM_001084926.1 [O23404-3]
    NP_001078396.1, NM_001084927.2 [O23404-1]
    NP_001118987.1, NM_001125515.1 [O23404-1]
    NP_001328869.1, NM_001341051.1 [O23404-4]
    NP_193288.2, NM_117643.4 [O23404-2]
    NP_849391.2, NM_179060.4 [O23404-3]
    UniGeneiAt.23286
    At.44851

    3D structure databases

    ProteinModelPortaliO23404
    SMRiO23404
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi12523, 4 interactors
    STRINGi3702.AT4G15530.5

    PTM databases

    iPTMnetiO23404

    Proteomic databases

    PaxDbiO23404
    PRIDEiO23404

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsemblPlantsiAT4G15530.1; AT4G15530.1; AT4G15530 [O23404-3]
    AT4G15530.2; AT4G15530.2; AT4G15530 [O23404-2]
    AT4G15530.3; AT4G15530.3; AT4G15530 [O23404-4]
    AT4G15530.4; AT4G15530.4; AT4G15530 [O23404-3]
    AT4G15530.5; AT4G15530.5; AT4G15530 [O23404-1]
    AT4G15530.6; AT4G15530.6; AT4G15530 [O23404-1]
    AT4G15530.7; AT4G15530.7; AT4G15530 [O23404-4]
    GeneIDi827226
    GrameneiAT4G15530.1; AT4G15530.1; AT4G15530 [O23404-3]
    AT4G15530.2; AT4G15530.2; AT4G15530 [O23404-2]
    AT4G15530.3; AT4G15530.3; AT4G15530 [O23404-4]
    AT4G15530.4; AT4G15530.4; AT4G15530 [O23404-3]
    AT4G15530.5; AT4G15530.5; AT4G15530 [O23404-1]
    AT4G15530.6; AT4G15530.6; AT4G15530 [O23404-1]
    AT4G15530.7; AT4G15530.7; AT4G15530 [O23404-4]
    KEGGiath:AT4G15530

    Organism-specific databases

    AraportiAT4G15530
    TAIRilocus:2130324 AT4G15530

    Phylogenomic databases

    eggNOGiENOG410IIM3 Eukaryota
    COG0574 LUCA
    HOGENOMiHOG000039664
    InParanoidiO23404
    KOiK01006
    OrthoDBiEOG0936014R
    PhylomeDBiO23404

    Enzyme and pathway databases

    BioCyciARA:AT4G15530-MONOMER
    BRENDAi2.7.11.32 399

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:O23404

    Gene expression databases

    ExpressionAtlasiO23404 baseline and differential
    GenevisibleiO23404 AT

    Family and domain databases

    Gene3Di3.30.1490.20, 1 hit
    InterProiView protein in InterPro
    IPR013815 ATP_grasp_subdomain_1
    IPR008279 PEP-util_enz_mobile_dom
    IPR018274 PEP_util_AS
    IPR000121 PEP_util_C
    IPR023151 PEP_util_CS
    IPR036637 Phosphohistidine_dom_sf
    IPR002192 PPDK_PEP-bd
    IPR010121 Pyruvate_phosphate_dikinase
    IPR015813 Pyrv/PenolPyrv_Kinase-like_dom
    PANTHERiPTHR22931:SF9 PTHR22931:SF9, 1 hit
    PfamiView protein in Pfam
    PF00391 PEP-utilizers, 1 hit
    PF02896 PEP-utilizers_C, 1 hit
    PF01326 PPDK_N, 3 hits
    PIRSFiPIRSF000853 PPDK, 1 hit
    SUPFAMiSSF51621 SSF51621, 1 hit
    SSF52009 SSF52009, 1 hit
    TIGRFAMsiTIGR01828 pyru_phos_dikin, 1 hit
    PROSITEiView protein in PROSITE
    PS00742 PEP_ENZYMES_2, 1 hit
    PS00370 PEP_ENZYMES_PHOS_SITE, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPDK1_ARATH
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O23404
    Secondary accession number(s): B9DGK5
    , Q27GJ5, Q2V3I1, Q3EA16
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: July 1, 2008
    Last modified: December 5, 2018
    This is version 142 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
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