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Entry version 127 (07 Apr 2021)
Sequence version 2 (03 Mar 2009)
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Protein

Baruol synthase

Gene

BARS1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Converts oxidosqualene to baruol (90%) and 22 minor products.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei493Proton donorBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:AT4G15370-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Baruol synthase (EC:5.4.99.57)
Short name:
AtBARS1
Alternative name(s):
Pentacyclic triterpene synthase 2
Short name:
AtPEN2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BARS1
Synonyms:PEN2
Ordered Locus Names:At4g15370
ORF Names:dl3730c, FCAALL.279
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT4G15370

The Arabidopsis Information Resource

More...
TAIRi
locus:2130040, AT4G15370

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003661371 – 759Baruol synthaseAdd BLAST759

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O23390

PRoteomics IDEntifications database

More...
PRIDEi
O23390

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
240847

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O23390, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O23390, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT4G15370.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O23390

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati149 – 190PFTB 1Add BLAST42
Repeati522 – 564PFTB 2Add BLAST43
Repeati641 – 682PFTB 3Add BLAST42

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the terpene cyclase/mutase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0497, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009074_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O23390

Identification of Orthologs from Complete Genome Data

More...
OMAi
FTHEHRI

Database of Orthologous Groups

More...
OrthoDBi
365003at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O23390

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02892, SQCY_1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032696, SQ_cyclase_C
IPR032697, SQ_cyclase_N
IPR018333, Squalene_cyclase
IPR002365, Terpene_synthase_CS
IPR008930, Terpenoid_cyclase/PrenylTrfase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13243, SQHop_cyclase_C, 1 hit
PF13249, SQHop_cyclase_N, 1 hit

Structure-Function Linkage Database

More...
SFLDi
SFLDG01016, Prenyltransferase_Like_2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48239, SSF48239, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01787, squalene_cyclas, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01074, TERPENE_SYNTHASES, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O23390-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWRLRIGAKA KDNTHLFTTN NYVGRQIWEF DANAGSPEEL AEVEEARRNF
60 70 80 90 100
SNNRSRFKAS ADLLWRMQFL REKKFEQKIP RVIVEDAEKI TYEDAKTALR
110 120 130 140 150
RGLLYFTALQ ADDGHWPAEN AGSIFFNAPF VICLYITGHL EKIFTHEHRV
160 170 180 190 200
ELLRYMYNHQ NEDGGWGLHV ESPSNMFCSV INYICLRILG VEAGHDDKGS
210 220 230 240 250
ACARARKWIL DHGGATYSPL IGKAWLSVLG VYDWSGCKPI PPEFWFLPSF
260 270 280 290 300
FPVNGGTLWI YLRDIFMGLS YLYGKNFVAT STPLILQLRE EIYPEPYTNI
310 320 330 340 350
SWRQARNRCA KEDLYYPQSF LQDLFWKGVH VFSENILNRW PFNNLIRQRA
360 370 380 390 400
LRTTMELVHY HDEATRYITG GSVPKVIAVF HMLACWVEDP ESDYFKKHLA
410 420 430 440 450
RVPDFIWIGE DGLKIQSFGS QVWDTALSLH VFIDGFDDDV DEEIRSTLLK
460 470 480 490 500
GYDYLEKSQV TENPPGDYMK MFRHMAKGGW TFSDQDQGWP VSDCTAESLE
510 520 530 540 550
CCLFFESMSS EFIGKKMDVE KLYDAVDFLL YLQSDNGGIT AWQPADGKLV
560 570 580 590 600
EFIEDAVVEH EYVECTGSAI VALAQFNKQF PGYKKEEVER FITKGVKYIE
610 620 630 640 650
DLQMVDGSWY GNWGVCFIYG TFFAVRGLVA AGKCYNNCEA IRRAVRFILD
660 670 680 690 700
TQNTEGGWGE SYLSCPRKKY IPLIGNKTNV VNTGQALMVL IMGNQMKRDP
710 720 730 740 750
LPVHRAAKVL INSQMDNGDF PQQEIMGVFK MNVMLHFPTY RNMFTLWALT

HYTKALRGL
Length:759
Mass (Da):87,455
Last modified:March 3, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i620E96D9085213C1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1P8B819A0A1P8B819_ARATH
Terpene cyclase/mutase family membe...
BARS1 baruol synthase 1, PEN2, At4g15370, Dl3730c, FCAALL.279
756Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB10316 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB78579 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z97338 Genomic DNA Translation: CAB10316.1 Sequence problems.
AL161541 Genomic DNA Translation: CAB78579.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE83589.1

Protein sequence database of the Protein Information Resource

More...
PIRi
B71418

NCBI Reference Sequences

More...
RefSeqi
NP_193272.1, NM_117625.2

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT4G15370.1; AT4G15370.1; AT4G15370

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
827203

Gramene; a comparative resource for plants

More...
Gramenei
AT4G15370.1; AT4G15370.1; AT4G15370

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT4G15370

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z97338 Genomic DNA Translation: CAB10316.1 Sequence problems.
AL161541 Genomic DNA Translation: CAB78579.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE83589.1
PIRiB71418
RefSeqiNP_193272.1, NM_117625.2

3D structure databases

SMRiO23390
ModBaseiSearch...

Protein-protein interaction databases

STRINGi3702.AT4G15370.1

Proteomic databases

PaxDbiO23390
PRIDEiO23390
ProteomicsDBi240847

Genome annotation databases

EnsemblPlantsiAT4G15370.1; AT4G15370.1; AT4G15370
GeneIDi827203
GrameneiAT4G15370.1; AT4G15370.1; AT4G15370
KEGGiath:AT4G15370

Organism-specific databases

AraportiAT4G15370
TAIRilocus:2130040, AT4G15370

Phylogenomic databases

eggNOGiKOG0497, Eukaryota
HOGENOMiCLU_009074_2_0_1
InParanoidiO23390
OMAiFTHEHRI
OrthoDBi365003at2759
PhylomeDBiO23390

Enzyme and pathway databases

BioCyciMetaCyc:AT4G15370-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O23390

Gene expression databases

ExpressionAtlasiO23390, baseline and differential
GenevisibleiO23390, AT

Family and domain databases

CDDicd02892, SQCY_1, 1 hit
InterProiView protein in InterPro
IPR032696, SQ_cyclase_C
IPR032697, SQ_cyclase_N
IPR018333, Squalene_cyclase
IPR002365, Terpene_synthase_CS
IPR008930, Terpenoid_cyclase/PrenylTrfase
PfamiView protein in Pfam
PF13243, SQHop_cyclase_C, 1 hit
PF13249, SQHop_cyclase_N, 1 hit
SFLDiSFLDG01016, Prenyltransferase_Like_2, 1 hit
SUPFAMiSSF48239, SSF48239, 2 hits
TIGRFAMsiTIGR01787, squalene_cyclas, 1 hit
PROSITEiView protein in PROSITE
PS01074, TERPENE_SYNTHASES, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBARS1_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O23390
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: March 3, 2009
Last modified: April 7, 2021
This is version 127 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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