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Entry version 147 (17 Jun 2020)
Sequence version 1 (01 Jan 1998)
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Protein

Serine hydroxymethyltransferase 4

Gene

SHM4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the interconversion of serine and glycine with the conversion of tetrahydrofolate (THF) into 5,10-methylene-THF.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pyridoxal 5'-phosphate1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by the antifolate drugs methotrexate and pemetrexed.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=2.56 mM for L-serine (at pH 6.5 and 30 degrees Celsius)1 Publication
  2. KM=0.54 mM for L-serine (at pH 7.0 and 30 degrees Celsius)1 Publication
  3. KM=0.30 mM for L-serine (at pH 8.0 and 30 degrees Celsius)1 Publication
  4. KM=0.24 mM for L-serine (at pH 8.5 and 30 degrees Celsius)1 Publication
  5. KM=0.20 mM for L-serine (at pH 9.5 and 30 degrees Celsius)1 Publication
  6. KM=7.87 µM for (6S)-5,6,7,8-tetrahydrofolate (at pH 6.5 and 30 degrees Celsius)1 Publication
  7. KM=14.97 µM for (6S)-5,6,7,8-tetrahydrofolate (at pH 7.0 and 30 degrees Celsius)1 Publication
  8. KM=23.83 µM for (6S)-5,6,7,8-tetrahydrofolate (at pH 8.0 and 30 degrees Celsius)1 Publication
  9. KM=33.75 µM for (6S)-5,6,7,8-tetrahydrofolate (at pH 8.5 and 30 degrees Celsius)1 Publication
  10. KM=49.24 µM for (6S)-5,6,7,8-tetrahydrofolate (at pH 9.5 and 30 degrees Celsius)1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: tetrahydrofolate interconversion

    This protein is involved in the pathway tetrahydrofolate interconversion, which is part of One-carbon metabolism.Curated
    View all proteins of this organism that are known to be involved in the pathway tetrahydrofolate interconversion and in One-carbon metabolism.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei39L-serineBy similarity1
    Binding sitei39PemetrexedCombined sources1 Publication1
    Binding sitei59PemetrexedCombined sources1 Publication1
    Binding sitei61L-serineBy similarity1
    Binding sitei61PemetrexedCombined sources1 Publication1
    Binding sitei69L-serineBy similarity1
    Binding sitei134PemetrexedCombined sources1 Publication1
    Binding sitei190PemetrexedCombined sources1 Publication1
    Binding sitei218L-serineBy similarity1
    Binding sitei218PemetrexedCombined sources1 Publication1
    Binding sitei244L-serineBy similarity1
    Binding sitei290Pemetrexed; via amide nitrogenCombined sources1 Publication1
    Binding sitei373MethotrexateCombined sources1 Publication1
    Binding sitei389L-serineBy similarity1
    Binding sitei389PemetrexedCombined sources1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionTransferase
    Biological processOne-carbon metabolism
    LigandPyridoxal phosphate

    Enzyme and pathway databases

    BioCyc Collection of Pathway/Genome Databases

    More...
    BioCyci
    ARA:AT4G13930-MONOMER

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00193

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Serine hydroxymethyltransferase 41 Publication (EC:2.1.2.11 Publication)
    Short name:
    AtSHMT41 Publication
    Alternative name(s):
    Glycine hydroxymethyltransferase 4Curated
    Serine methylase 4Curated
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:SHM41 Publication
    Synonyms:SHMT41 Publication
    Ordered Locus Names:At4g13930Imported
    ORF Names:dl3005cImported, FCAALL.160Imported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

    Organism-specific databases

    Arabidopsis Information Portal

    More...
    Araporti
    AT4G13930

    The Arabidopsis Information Resource

    More...
    TAIRi
    locus:2129251 AT4G13930

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004223491 – 471Serine hydroxymethyltransferase 4Add BLAST471

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
    Modified residuei244N6-(pyridoxal phosphate)lysineBy similarity1

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    O23254

    PRoteomics IDEntifications database

    More...
    PRIDEi
    O23254

    Protein Mass spectra EXtraction

    More...
    ProMEXi
    O23254

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    248430

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    O23254

    MetOSite database of methionine sulfoxide sites

    More...
    MetOSitei
    O23254

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Mostly expressed in flowers, less abundant in roots, inflorescence stems, and siliques, and barely detectable in leaves.1 Publication

    <p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Circadian-regulation.1 Publication

    Gene expression databases

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    O23254 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    O23254 AT

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homotetramer (PubMed:31873125).

    Interacts with UBP16 (PubMed:23232097).

    2 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    12324, 3 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    O23254, 3 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    3702.AT4G13930.1

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1471
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    O23254

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni105 – 107Pemetrexed bindingCombined sources1 Publication3

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the SHMT family.Curated

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG2467 Eukaryota
    COG0112 LUCA

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_022477_0_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    O23254

    KEGG Orthology (KO)

    More...
    KOi
    K00600

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    VTNRNAI

    Database of Orthologous Groups

    More...
    OrthoDBi
    372408at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    O23254

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd00378 SHMT, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.40.640.10, 1 hit
    3.90.1150.10, 1 hit

    HAMAP database of protein families

    More...
    HAMAPi
    MF_00051 SHMT, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR015424 PyrdxlP-dep_Trfase
    IPR015422 PyrdxlP-dep_Trfase_dom1
    IPR015421 PyrdxlP-dep_Trfase_major
    IPR001085 Ser_HO-MeTrfase
    IPR019798 Ser_HO-MeTrfase_PLP_BS
    IPR039429 SHMT-like_dom

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11680 PTHR11680, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00464 SHMT, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF000412 SHMT, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF53383 SSF53383, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00096 SHMT, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    O23254-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MEPVSSWGNT SLVSVDPEIH DLIEKEKRRQ CRGIELIASE NFTSFAVIEA
    60 70 80 90 100
    LGSALTNKYS EGIPGNRYYG GNEFIDEIEN LCRSRALEAF HCDPAAWGVN
    110 120 130 140 150
    VQPYSGSPAN FAAYTALLQP HDRIMGLDLP SGGHLTHGYY TSGGKKISAT
    160 170 180 190 200
    SIYFESLPYK VNFTTGYIDY DKLEEKALDF RPKLLICGGS AYPRDWDYAR
    210 220 230 240 250
    FRAIADKVGA LLLCDMAHIS GLVAAQEAAN PFEYCDVVTT TTHKSLRGPR
    260 270 280 290 300
    AGMIFYRKGP KPPKKGQPEG AVYDFEDKIN FAVFPALQGG PHNHQIGALA
    310 320 330 340 350
    VALKQANTPG FKVYAKQVKA NAVALGNYLM SKGYQIVTNG TENHLVLWDL
    360 370 380 390 400
    RPLGLTGNKV EKLCDLCSIT LNKNAVFGDS SALAPGGVRI GAPAMTSRGL
    410 420 430 440 450
    VEKDFEQIGE FLSRAVTLTL DIQKTYGKLL KDFNKGLVNN KDLDQLKADV
    460 470
    EKFSASYEMP GFLMSEMKYK D
    Length:471
    Mass (Da):51,718
    Last modified:January 1, 1998 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5F5D997042CBD425
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti53S → R in AAG40343 (PubMed:14593172).Curated1
    Sequence conflicti84S → P in AAG40343 (PubMed:14593172).Curated1
    Sequence conflicti147I → T in AAM64493 (Ref. 5) Curated1
    Sequence conflicti470K → Q in AAM64493 (Ref. 5) Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    Z97335 Genomic DNA Translation: CAB10172.1
    AL161537 Genomic DNA Translation: CAB78435.1
    CP002687 Genomic DNA Translation: AEE83344.1
    AF324991 mRNA Translation: AAG40343.1
    AF361589 mRNA Translation: AAK32757.1
    AY093987 mRNA Translation: AAM16248.1
    AY086929 mRNA Translation: AAM64493.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    B71400

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_193129.1, NM_117467.4

    Genome annotation databases

    Ensembl plant genome annotation project

    More...
    EnsemblPlantsi
    AT4G13930.1; AT4G13930.1; AT4G13930

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    827027

    Gramene; a comparative resource for plants

    More...
    Gramenei
    AT4G13930.1; AT4G13930.1; AT4G13930

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    ath:AT4G13930

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    Z97335 Genomic DNA Translation: CAB10172.1
    AL161537 Genomic DNA Translation: CAB78435.1
    CP002687 Genomic DNA Translation: AEE83344.1
    AF324991 mRNA Translation: AAG40343.1
    AF361589 mRNA Translation: AAK32757.1
    AY093987 mRNA Translation: AAM16248.1
    AY086929 mRNA Translation: AAM64493.1
    PIRiB71400
    RefSeqiNP_193129.1, NM_117467.4

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    6SMRX-ray2.12A/B/C/D1-471[»]
    SMRiO23254
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGRIDi12324, 3 interactors
    IntActiO23254, 3 interactors
    STRINGi3702.AT4G13930.1

    PTM databases

    iPTMnetiO23254
    MetOSiteiO23254

    Proteomic databases

    PaxDbiO23254
    PRIDEiO23254
    ProMEXiO23254
    ProteomicsDBi248430

    Genome annotation databases

    EnsemblPlantsiAT4G13930.1; AT4G13930.1; AT4G13930
    GeneIDi827027
    GrameneiAT4G13930.1; AT4G13930.1; AT4G13930
    KEGGiath:AT4G13930

    Organism-specific databases

    AraportiAT4G13930
    TAIRilocus:2129251 AT4G13930

    Phylogenomic databases

    eggNOGiKOG2467 Eukaryota
    COG0112 LUCA
    HOGENOMiCLU_022477_0_0_1
    InParanoidiO23254
    KOiK00600
    OMAiVTNRNAI
    OrthoDBi372408at2759
    PhylomeDBiO23254

    Enzyme and pathway databases

    UniPathwayiUPA00193
    BioCyciARA:AT4G13930-MONOMER

    Miscellaneous databases

    Protein Ontology

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    PROi
    PR:O23254

    Gene expression databases

    ExpressionAtlasiO23254 baseline and differential
    GenevisibleiO23254 AT

    Family and domain databases

    CDDicd00378 SHMT, 1 hit
    Gene3Di3.40.640.10, 1 hit
    3.90.1150.10, 1 hit
    HAMAPiMF_00051 SHMT, 1 hit
    InterProiView protein in InterPro
    IPR015424 PyrdxlP-dep_Trfase
    IPR015422 PyrdxlP-dep_Trfase_dom1
    IPR015421 PyrdxlP-dep_Trfase_major
    IPR001085 Ser_HO-MeTrfase
    IPR019798 Ser_HO-MeTrfase_PLP_BS
    IPR039429 SHMT-like_dom
    PANTHERiPTHR11680 PTHR11680, 1 hit
    PfamiView protein in Pfam
    PF00464 SHMT, 1 hit
    PIRSFiPIRSF000412 SHMT, 1 hit
    SUPFAMiSSF53383 SSF53383, 1 hit
    PROSITEiView protein in PROSITE
    PS00096 SHMT, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

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    ProtoNeti
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    MobiDB: a database of protein disorder and mobility annotations

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    MobiDBi
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    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGLYC4_ARATH
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O23254
    Secondary accession number(s): Q8LBY1, Q9FPJ3
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2013
    Last sequence update: January 1, 1998
    Last modified: June 17, 2020
    This is version 147 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families
    4. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
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