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Protein

Peroxidase 49

Gene

PER49

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Removal of H2O2, oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.

Miscellaneous

There are 73 peroxidase genes in A.thaliana.

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.PROSITE-ProRule annotation
  • Ca2+PROSITE-ProRule annotationNote: Binds 2 calcium ions per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei66Transition state stabilizerPROSITE-ProRule annotation1
Active sitei70Proton acceptorPROSITE-ProRule annotation1
Metal bindingi71Calcium 1PROSITE-ProRule annotation1
Metal bindingi74Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi76Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi78Calcium 1PROSITE-ProRule annotation1
Metal bindingi80Calcium 1PROSITE-ProRule annotation1
Binding sitei167Substrate; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi197Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi198Calcium 2PROSITE-ProRule annotation1
Metal bindingi249Calcium 2PROSITE-ProRule annotation1
Metal bindingi252Calcium 2PROSITE-ProRule annotation1
Metal bindingi257Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandCalcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT4G36430-MONOMER

Protein family/group databases

PeroxiBasei215 AtPrx49

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxidase 49 (EC:1.11.1.7)
Short name:
Atperox P49
Alternative name(s):
ATP31
Gene namesi
Name:PER49
Synonyms:DIDI 6G-3B, P49
Ordered Locus Names:At4g36430
ORF Names:AP22.54, C7A10.930
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G36430
TAIRilocus:2115335 AT4G36430

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000002371423 – 331Peroxidase 49Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi39 ↔ 119PROSITE-ProRule annotation
Disulfide bondi72 ↔ 77PROSITE-ProRule annotation
Disulfide bondi125 ↔ 326PROSITE-ProRule annotation
Glycosylationi170N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi204 ↔ 236PROSITE-ProRule annotation
Glycosylationi213N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO23237
PRIDEiO23237

PTM databases

SwissPalmiO23237

Expressioni

Gene expression databases

ExpressionAtlasiO23237 baseline and differential
GenevisibleiO23237 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G36430.1

Structurei

3D structure databases

ProteinModelPortaliO23237
SMRiO23237
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIQM Eukaryota
ENOG410YA1B LUCA
HOGENOMiHOG000237557
InParanoidiO23237
KOiK00430
OMAiSPGFYAH
OrthoDBiEOG09360H0D
PhylomeDBiO23237

Family and domain databases

CDDicd00693 secretory_peroxidase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR000823 Peroxidase_pln
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
IPR033905 Secretory_peroxidase
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PRINTSiPR00458 PEROXIDASE
PR00461 PLPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O23237-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARLTSFLLL LSLICFVPLC LCDKSYGGKL FPGYYAHSCP QVNEIVRSVV
60 70 80 90 100
AKAVARETRM AASLLRLHFH DCFVQGCDGS LLLDSSGRVA TEKNSNPNSK
110 120 130 140 150
SARGFDVVDQ IKAELEKQCP GTVSCADVLT LAARDSSVLT GGPSWVVPLG
160 170 180 190 200
RRDSRSASLS QSNNNIPAPN NTFQTILSKF NRQGLDITDL VALSGSHTIG
210 220 230 240 250
FSRCTSFRQR LYNQSGNGSP DMTLEQSFAA NLRQRCPKSG GDQILSVLDI
260 270 280 290 300
ISAASFDNSY FKNLIENKGL LNSDQVLFSS NEKSRELVKK YAEDQGEFFE
310 320 330
QFAESMIKMG NISPLTGSSG EIRKNCRKIN S
Length:331
Mass (Da):36,164
Last modified:May 1, 1999 - v2
Checksum:iE9C0130D77406624
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ286345 mRNA Translation: CAB71009.1
AF452384 mRNA Translation: AAL40848.1
Z99708 Genomic DNA Translation: CAB16848.1
AL161589 Genomic DNA Translation: CAB80309.1
CP002687 Genomic DNA Translation: AEE86655.1
AY074296 mRNA Translation: AAL66993.1
AY117238 mRNA Translation: AAM51313.1
PIRiA85430
RefSeqiNP_195361.1, NM_119806.3
UniGeneiAt.4607

Genome annotation databases

EnsemblPlantsiAT4G36430.1; AT4G36430.1; AT4G36430
GeneIDi829795
GrameneiAT4G36430.1; AT4G36430.1; AT4G36430
KEGGiath:AT4G36430

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ286345 mRNA Translation: CAB71009.1
AF452384 mRNA Translation: AAL40848.1
Z99708 Genomic DNA Translation: CAB16848.1
AL161589 Genomic DNA Translation: CAB80309.1
CP002687 Genomic DNA Translation: AEE86655.1
AY074296 mRNA Translation: AAL66993.1
AY117238 mRNA Translation: AAM51313.1
PIRiA85430
RefSeqiNP_195361.1, NM_119806.3
UniGeneiAt.4607

3D structure databases

ProteinModelPortaliO23237
SMRiO23237
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT4G36430.1

Protein family/group databases

PeroxiBasei215 AtPrx49

PTM databases

SwissPalmiO23237

Proteomic databases

PaxDbiO23237
PRIDEiO23237

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G36430.1; AT4G36430.1; AT4G36430
GeneIDi829795
GrameneiAT4G36430.1; AT4G36430.1; AT4G36430
KEGGiath:AT4G36430

Organism-specific databases

AraportiAT4G36430
TAIRilocus:2115335 AT4G36430

Phylogenomic databases

eggNOGiENOG410IIQM Eukaryota
ENOG410YA1B LUCA
HOGENOMiHOG000237557
InParanoidiO23237
KOiK00430
OMAiSPGFYAH
OrthoDBiEOG09360H0D
PhylomeDBiO23237

Enzyme and pathway databases

BioCyciARA:AT4G36430-MONOMER

Miscellaneous databases

PROiPR:O23237

Gene expression databases

ExpressionAtlasiO23237 baseline and differential
GenevisibleiO23237 AT

Family and domain databases

CDDicd00693 secretory_peroxidase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR000823 Peroxidase_pln
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
IPR033905 Secretory_peroxidase
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PRINTSiPR00458 PEROXIDASE
PR00461 PLPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPER49_ARATH
AccessioniPrimary (citable) accession number: O23237
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: May 1, 1999
Last modified: April 25, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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Main funding by: National Institutes of Health

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