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Entry version 135 (18 Sep 2019)
Sequence version 1 (01 Jan 1998)
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Protein

Uncharacterized TPR repeat-containing protein At1g05150

Gene

At1g05150

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uncharacterized TPR repeat-containing protein At1g05150
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:At1g05150
ORF Names:YUP8H12.24
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G05150

The Arabidopsis Information Resource

More...
TAIRi
locus:2207255 AT1G05150

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003020471 – 808Uncharacterized TPR repeat-containing protein At1g05150Add BLAST808

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O23052

PRoteomics IDEntifications database

More...
PRIDEi
O23052

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O23052

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O23052

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O23052 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O23052 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
24547, 1 interactor

STRING: functional protein association networks

More...
STRINGi
3702.AT1G05150.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O23052

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 41EF-hand 1PROSITE-ProRule annotationAdd BLAST36
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati234 – 267TPR 1Add BLAST34
Repeati269 – 301TPR 2Add BLAST33
Repeati310 – 343TPR 3Add BLAST34
Repeati344 – 377TPR 4Add BLAST34
Repeati378 – 411TPR 5Add BLAST34
Repeati412 – 445TPR 6Add BLAST34
Repeati447 – 479TPR 7Add BLAST33
Domaini600 – 635EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili773 – 794Sequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi111 – 114Poly-Ser4
Compositional biasi173 – 177Poly-Asn5

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IQRB Eukaryota
ENOG41102AN LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000239938

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O23052

Identification of Orthologs from Complete Genome Data

More...
OMAi
LDLGMFF

Database of Orthologous Groups

More...
OrthoDBi
228087at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O23052

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028 TPR, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47473 SSF47473, 1 hit
SSF48452 SSF48452, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50222 EF_HAND_2, 2 hits
PS50005 TPR, 6 hits
PS50293 TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O23052-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATRGSRSEK VKRIFQQFDG NHDGGLNREE MAALVVAVNP RVKFSDEQIN
60 70 80 90 100
AILDEVFRTY AEFIDPNKGL TYDGLLRTYD DGAGDVDRDF DALGLELNAD
110 120 130 140 150
ETTIKGSEAA SSSSITDERA VEAQKKQRTA AWAVSPNHGI VFDETWKLVD
160 170 180 190 200
DLEILVKRLK SKQEKDGKLK ADNNNNNVDA FSDAGWSREL GPSSEISEKR
210 220 230 240 250
IYWEESSHDY GVFVKELGVL RSKADGARSR EEAFDGHMAI GRVLYEHQLF
260 270 280 290 300
KEALVSFKRA CELQPTDVRP HFKAGNCLYV LGKCKESKDE FLLALEAAES
310 320 330 340 350
GGNQWAYLLP QIYVNLGIAL EGEGMVLSAC EYYREAAILC PTHFRALKLL
360 370 380 390 400
GSALFGVGEY RAAVKALEEA IYLKPDYADA HCDLASSLHS MGEDERAIEV
410 420 430 440 450
FQRAIDLKPG HVDALYNLGG LYMDLGRFQR ASEMYTRVLT VWPNHWRAQL
460 470 480 490 500
NKAVSLLGAG ETEEAKRALK EALKLTNRVE LHDAISHLKH LQKKKGKNNG
510 520 530 540 550
NGNGGEGPFI VVEPSKFKTV GEKTTLRPDL ATALQIRAFQ RVTRLGKCDV
560 570 580 590 600
EAVRKEMRDN DVPVSYSGSG GPTKSIRKPN LEEILRRLLS SLKPDTFQGA
610 620 630 640 650
IKAINEKILA LLDDSGSGRV DMGMFYAVIA PLCGGHSDKR KRVAFDALLW
660 670 680 690 700
RPVNEGSSQI TKTDAVKYIK LLRAIYIPSH GMSEMLEVHG EEEAESSVTV
710 720 730 740 750
TFNQFLAMFD DPDWGFGIMS TILKLEANDR NRHGNQVCSV CRYPVIGSRF
760 770 780 790 800
KEVKARFSLC NQCYGEGKVP PSFKQEEYKF REYESEAEAM KAKCVCFSMQ

SHKKAIAT
Length:808
Mass (Da):90,169
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF4B8DA7AB620B86A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti526L → F in BAF01292 (Ref. 3) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC000098 Genomic DNA Translation: AAB71463.1
CP002684 Genomic DNA Translation: AEE27795.1
AK229432 mRNA Translation: BAF01292.1

Protein sequence database of the Protein Information Resource

More...
PIRi
G86185

NCBI Reference Sequences

More...
RefSeqi
NP_172007.1, NM_100393.3

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G05150.1; AT1G05150.1; AT1G05150

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
839312

Gramene; a comparative resource for plants

More...
Gramenei
AT1G05150.1; AT1G05150.1; AT1G05150

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G05150

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC000098 Genomic DNA Translation: AAB71463.1
CP002684 Genomic DNA Translation: AEE27795.1
AK229432 mRNA Translation: BAF01292.1
PIRiG86185
RefSeqiNP_172007.1, NM_100393.3

3D structure databases

SMRiO23052
ModBaseiSearch...

Protein-protein interaction databases

BioGridi24547, 1 interactor
STRINGi3702.AT1G05150.1

PTM databases

iPTMnetiO23052
SwissPalmiO23052

Proteomic databases

PaxDbiO23052
PRIDEiO23052

Genome annotation databases

EnsemblPlantsiAT1G05150.1; AT1G05150.1; AT1G05150
GeneIDi839312
GrameneiAT1G05150.1; AT1G05150.1; AT1G05150
KEGGiath:AT1G05150

Organism-specific databases

AraportiAT1G05150
TAIRilocus:2207255 AT1G05150

Phylogenomic databases

eggNOGiENOG410IQRB Eukaryota
ENOG41102AN LUCA
HOGENOMiHOG000239938
InParanoidiO23052
OMAiLDLGMFF
OrthoDBi228087at2759
PhylomeDBiO23052

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O23052

Gene expression databases

ExpressionAtlasiO23052 baseline and differential
GenevisibleiO23052 AT

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
SMARTiView protein in SMART
SM00028 TPR, 7 hits
SUPFAMiSSF47473 SSF47473, 1 hit
SSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 2 hits
PS50005 TPR, 6 hits
PS50293 TPR_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiY1515_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O23052
Secondary accession number(s): Q0WNK7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: January 1, 1998
Last modified: September 18, 2019
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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