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Protein

Peroxidase 19

Gene

PER19

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Removal of H2O2, oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.

Miscellaneous

There are 73 peroxidase genes in A.thaliana.

Catalytic activityi

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • heme bPROSITE-ProRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.PROSITE-ProRule annotation
  • Ca2+PROSITE-ProRule annotationNote: Binds 2 calcium ions per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei78Transition state stabilizerPROSITE-ProRule annotation1
Active sitei82Proton acceptorPROSITE-ProRule annotation1
Metal bindingi83Calcium 1PROSITE-ProRule annotation1
Metal bindingi86Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi88Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi90Calcium 1PROSITE-ProRule annotation1
Metal bindingi92Calcium 1PROSITE-ProRule annotation1
Binding sitei182Substrate; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi212Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi213Calcium 2PROSITE-ProRule annotation1
Metal bindingi265Calcium 2PROSITE-ProRule annotation1
Metal bindingi268Calcium 2PROSITE-ProRule annotation1
Metal bindingi273Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandCalcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT2G34060-MONOMER

Protein family/group databases

PeroxiBasei100 AtPrx19

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxidase 19 (EC:1.11.1.7)
Short name:
Atperox P19
Alternative name(s):
ATP51
Gene namesi
Name:PER19
Synonyms:P19
Ordered Locus Names:At2g34060
ORF Names:T14G11.18
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G34060
TAIRilocus:2055501 AT2G34060

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000002368532 – 346Peroxidase 19Add BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51 ↔ 134PROSITE-ProRule annotation
Disulfide bondi84 ↔ 89PROSITE-ProRule annotation
Disulfide bondi140 ↔ 342PROSITE-ProRule annotation
Glycosylationi185N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi219 ↔ 251PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO22959
PRIDEiO22959

PTM databases

iPTMnetiO22959

Expressioni

Gene expression databases

ExpressionAtlasiO22959 baseline and differential
GenevisibleiO22959 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT2G34060.1

Structurei

3D structure databases

ProteinModelPortaliO22959
SMRiO22959
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHK0 Eukaryota
ENOG410YCA9 LUCA
HOGENOMiHOG000237556
InParanoidiO22959
KOiK00430
OMAiPRVERDM
OrthoDBiEOG09360IU3
PhylomeDBiO22959

Family and domain databases

CDDicd00693 secretory_peroxidase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR000823 Peroxidase_pln
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
IPR033905 Secretory_peroxidase
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PRINTSiPR00458 PEROXIDASE
PR00461 PLPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O22959-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHVISLSLSS IFFFLFLTST ILISPVQPTT SKPPAPRPHR ELSADYYSKK
60 70 80 90 100
CPQLETLVGS VTSQRFKEVP ISAPATIRLF FHDCFVEGCD GSILIETKKG
110 120 130 140 150
SKKLAEREAY ENKELREEGF DSIIKAKALV ESHCPSLVSC SDILAIAARD
160 170 180 190 200
FIHLAGGPYY QVKKGRWDGK RSTAKNVPPN IPRSNSTVDQ LIKLFASKGL
210 220 230 240 250
TVEELVVLSG SHTIGFAHCK NFLGRLYDYK GTKRPDPSLD QRLLKELRMS
260 270 280 290 300
CPFSGGSSGV VLPLDATTPF VFDNGYFTGL GTNMGLLGSD QALFLDPRTK
310 320 330 340
PIALEMARDK QKFLKAFGDA MDKMGSIGVK RGKRHGEIRT DCRVFL
Length:346
Mass (Da):38,228
Last modified:January 1, 1998 - v1
Checksum:i85D43E7B4C17A814
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002341 Genomic DNA Translation: AAB67624.1
CP002685 Genomic DNA Translation: AEC08912.1
AY080602 mRNA Translation: AAL86286.1
BT002341 mRNA Translation: AAN86174.1
PIRiH84751
RefSeqiNP_180953.1, NM_128957.4
UniGeneiAt.37862

Genome annotation databases

EnsemblPlantsiAT2G34060.1; AT2G34060.1; AT2G34060
GeneIDi817967
GrameneiAT2G34060.1; AT2G34060.1; AT2G34060
KEGGiath:AT2G34060

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002341 Genomic DNA Translation: AAB67624.1
CP002685 Genomic DNA Translation: AEC08912.1
AY080602 mRNA Translation: AAL86286.1
BT002341 mRNA Translation: AAN86174.1
PIRiH84751
RefSeqiNP_180953.1, NM_128957.4
UniGeneiAt.37862

3D structure databases

ProteinModelPortaliO22959
SMRiO22959
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT2G34060.1

Protein family/group databases

PeroxiBasei100 AtPrx19

PTM databases

iPTMnetiO22959

Proteomic databases

PaxDbiO22959
PRIDEiO22959

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G34060.1; AT2G34060.1; AT2G34060
GeneIDi817967
GrameneiAT2G34060.1; AT2G34060.1; AT2G34060
KEGGiath:AT2G34060

Organism-specific databases

AraportiAT2G34060
TAIRilocus:2055501 AT2G34060

Phylogenomic databases

eggNOGiENOG410IHK0 Eukaryota
ENOG410YCA9 LUCA
HOGENOMiHOG000237556
InParanoidiO22959
KOiK00430
OMAiPRVERDM
OrthoDBiEOG09360IU3
PhylomeDBiO22959

Enzyme and pathway databases

BioCyciARA:AT2G34060-MONOMER

Miscellaneous databases

PROiPR:O22959

Gene expression databases

ExpressionAtlasiO22959 baseline and differential
GenevisibleiO22959 AT

Family and domain databases

CDDicd00693 secretory_peroxidase, 1 hit
InterProiView protein in InterPro
IPR010255 Haem_peroxidase
IPR002016 Haem_peroxidase_pln/fun/bac
IPR000823 Peroxidase_pln
IPR019794 Peroxidases_AS
IPR019793 Peroxidases_heam-ligand_BS
IPR033905 Secretory_peroxidase
PfamiView protein in Pfam
PF00141 peroxidase, 1 hit
PRINTSiPR00458 PEROXIDASE
PR00461 PLPEROXIDASE
SUPFAMiSSF48113 SSF48113, 1 hit
PROSITEiView protein in PROSITE
PS00435 PEROXIDASE_1, 1 hit
PS00436 PEROXIDASE_2, 1 hit
PS50873 PEROXIDASE_4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPER19_ARATH
AccessioniPrimary (citable) accession number: O22959
Secondary accession number(s): Q8RXZ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: January 1, 1998
Last modified: April 25, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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Main funding by: National Institutes of Health

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