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Entry version 106 (31 Jul 2019)
Sequence version 1 (01 Jan 1998)
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Protein

Protein NLP8

Gene

NLP8

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable transcription factor.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein NLP8
Short name:
AtNLP8
Alternative name(s):
NIN-like protein 8
Nodule inception protein-like protein 8
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NLP8
Ordered Locus Names:At2g43500
ORF Names:T1O24.24
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT2G43500

The Arabidopsis Information Resource

More...
TAIRi
locus:2058244 AT2G43500

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004014931 – 947Protein NLP8Add BLAST947

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O22864

PRoteomics IDEntifications database

More...
PRIDEi
O22864

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O22864 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O22864 AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT2G43500.2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini577 – 671RWP-RKPROSITE-ProRule annotationAdd BLAST95
Domaini847 – 929PB1PROSITE-ProRule annotationAdd BLAST83

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili646 – 666Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi794 – 845Ser-richAdd BLAST52

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IKM4 Eukaryota
ENOG410YA7W LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000237689

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O22864

Database of Orthologous Groups

More...
OrthoDBi
100342at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O22864

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06407 PB1_NLP, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000270 PB1_dom
IPR034891 PB1_NLP
IPR003035 RWP-RK_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00564 PB1, 1 hit
PF02042 RWP-RK, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00666 PB1, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51745 PB1, 1 hit
PS51519 RWP_RK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O22864-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MENPFASREK GFGNYSDFPT EQMDGLSSNF GSGVRNLISD DMFNPSSELM
60 70 80 90 100
NFDSLAAWCN SPSATDILFA QYGLSNSQPM PFGAFTSFHV ADPKATSLTR
110 120 130 140 150
SFYDLESSYY GEERSSAQEM NSQFHRSSDS DELSGKRRKV VNQKIGFPNV
160 170 180 190 200
LNCTIPRSLS HSLDEKMLKA LSLFMESSGS GEGILAQVWT PIKTGDQYLL
210 220 230 240 250
STCDQAYLLD PRFSQYREVS RRFTFAAEAN QCSFPGLPGR VFISGVPEWT
260 270 280 290 300
SNVMYYKTDE YLRMKHAIDN EVRGSIAIPI LEASGTSCCA VMELVTSKEK
310 320 330 340 350
PNFDMEMDSV CRALQAVNLR TAAIPRPQYL SSSQRDALAE IQDVLRTVCH
360 370 380 390 400
AHKLPLALAW IPCRKDQSIR VSGQKSGENC ILCIEETACY VNDMEMEGFV
410 420 430 440 450
HACLEHCLRE KEGIVGKAFI SNQPFFSSDV KAYDISEYPI VQHARKYGLN
460 470 480 490 500
AAVAIKLRST YTGEDDYILE LFLPVSMKGS LEQQLLLDSL SGTMQRICRT
510 520 530 540 550
LRTVSEVGST KKEGTKPGFR SSDMSNFPQT TSSENFQTIS LDSEFNSTRS
560 570 580 590 600
MFSGMSSDKE NSITVSQGTL EQDVSKARTP EKKKSTTEKN VSLSALQQHF
610 620 630 640 650
SGSLKDAAKS LGGETSAYFQ AWVYFFCPTT LKRICRQHGI MRWPSRKINK
660 670 680 690 700
VNRSLRKIQT VLDSVQGVEG GLKFDSATGE FIAVRPFIQE IDTQKGLSSL
710 720 730 740 750
DNDAHARRSQ EDMPDDTSFK LQEAKSVDNA IKLEEDTTMN QARPGSFMEV
760 770 780 790 800
NASGQPWAWM AKESGLNGSE GIKSVCNLSS VEISDGMDPT IRCSGSIVEP
810 820 830 840 850
NQSMSCSISD SSNGSGAVLR GSSSTSMEDW NQMRTHNSNS SESGSTTLIV
860 870 880 890 900
KASYREDTVR FKFEPSVGCP QLYKEVGKRF KLQDGSFQLK YLDDEEEWVM
910 920 930 940
LVTDSDLQEC LEILHGMGKH SVKFLVRDLS APLGSSGGSN GYLGTGL
Note: Derived from EST data. No experimental confirmation available.
Length:947
Mass (Da):104,884
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i158218E64E17CD69
GO
Isoform 2 (identifier: O22864-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     316-348: AVNLRTAAIPRPQYLSSSQRDALAEIQDVLRTV → VDTLFSPSLSFCFVLFFCLYVCLRVLLSPARLL
     349-947: Missing.

Show »
Length:348
Mass (Da):38,921
Checksum:i5CB0838146730B5D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1P8B2Q9A0A1P8B2Q9_ARATH
Plant regulator RWP-RK family prote...
NIN-like protein 8 NLP8, At2g43500, T1O24.24
934Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1P8B2R8A0A1P8B2R8_ARATH
Plant regulator RWP-RK family prote...
NIN-like protein 8 NLP8, At2g43500, T1O24.24
947Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_040195316 – 348AVNLR…VLRTV → VDTLFSPSLSFCFVLFFCLY VCLRVLLSPARLL in isoform 2. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_040196349 – 947Missing in isoform 2. 1 PublicationAdd BLAST599

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC002335 Genomic DNA Translation: AAB64326.1
CP002685 Genomic DNA Translation: AEC10283.1
AY649251 Genomic DNA Translation: AAT69168.1
AY102562 mRNA Translation: AAM76767.1
AY102563 mRNA Translation: AAM76768.1

Protein sequence database of the Protein Information Resource

More...
PIRi
H84866

NCBI Reference Sequences

More...
RefSeqi
NP_001154573.1, NM_001161101.2 [O22864-1]

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT2G43500.2; AT2G43500.2; AT2G43500 [O22864-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
818951

Gramene; a comparative resource for plants

More...
Gramenei
AT2G43500.2; AT2G43500.2; AT2G43500 [O22864-1]

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT2G43500

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002335 Genomic DNA Translation: AAB64326.1
CP002685 Genomic DNA Translation: AEC10283.1
AY649251 Genomic DNA Translation: AAT69168.1
AY102562 mRNA Translation: AAM76767.1
AY102563 mRNA Translation: AAM76768.1
PIRiH84866
RefSeqiNP_001154573.1, NM_001161101.2 [O22864-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi3702.AT2G43500.2

Proteomic databases

PaxDbiO22864
PRIDEiO22864

Genome annotation databases

EnsemblPlantsiAT2G43500.2; AT2G43500.2; AT2G43500 [O22864-1]
GeneIDi818951
GrameneiAT2G43500.2; AT2G43500.2; AT2G43500 [O22864-1]
KEGGiath:AT2G43500

Organism-specific databases

AraportiAT2G43500
TAIRilocus:2058244 AT2G43500

Phylogenomic databases

eggNOGiENOG410IKM4 Eukaryota
ENOG410YA7W LUCA
HOGENOMiHOG000237689
InParanoidiO22864
OrthoDBi100342at2759
PhylomeDBiO22864

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O22864

Gene expression databases

ExpressionAtlasiO22864 baseline and differential
GenevisibleiO22864 AT

Family and domain databases

CDDicd06407 PB1_NLP, 1 hit
InterProiView protein in InterPro
IPR000270 PB1_dom
IPR034891 PB1_NLP
IPR003035 RWP-RK_dom
PfamiView protein in Pfam
PF00564 PB1, 1 hit
PF02042 RWP-RK, 1 hit
SMARTiView protein in SMART
SM00666 PB1, 1 hit
PROSITEiView protein in PROSITE
PS51745 PB1, 1 hit
PS51519 RWP_RK, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNLP8_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O22864
Secondary accession number(s): Q8L4P4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: January 1, 1998
Last modified: July 31, 2019
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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