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Protein

Profilin-4

Gene

PRO4

Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Has a high affinity for poly-proline.

GO - Molecular functioni

  • actin monomer binding Source: AgBase
  • proline-rich region binding Source: AgBase

GO - Biological processi

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Profilin-4
Alternative name(s):
Pollen allergen Zea m 12
ZmPRO4
Allergen: Zea m 12
Gene namesi
Name:PRO4
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeTripsacinaeZea
Proteomesi
  • UP000007305 Componenti: Chromosome 6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3538 Zea m 12.0104
682 Zea m 12

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001996492 – 131Profilin-4Add BLAST130

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi13 ↔ 115Curated
Modified residuei111PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylated by MAP kinases.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiO22655
PRIDEiO22655

Expressioni

Tissue specificityi

Expressed predominantly in endosperm but is also found at low levels in all tissues examined, including mature and germinated pollen.

Gene expression databases

ExpressionAtlasiO22655 differential
GenevisibleiO22655 ZM

Interactioni

Subunit structurei

Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi4577.GRMZM2G108780_P01

Structurei

3D structure databases

ProteinModelPortaliO22655
SMRiO22655
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi81 – 97Involved in PIP2 interactionAdd BLAST17

Sequence similaritiesi

Belongs to the profilin family.Curated

Phylogenomic databases

eggNOGiKOG1755 Eukaryota
ENOG41126PD LUCA
HOGENOMiHOG000171591
KOiK05759
OMAiNETTDIM
OrthoDBiEOG09360WEB

Family and domain databases

CDDicd00148 PROF, 1 hit
InterProiView protein in InterPro
IPR005455 PFN
IPR036140 PFN_sf
IPR027310 Profilin_CS
PANTHERiPTHR11604 PTHR11604, 1 hit
PfamiView protein in Pfam
PF00235 Profilin, 1 hit
PRINTSiPR00392 PROFILIN
PR01640 PROFILINPLNT
SMARTiView protein in SMART
SM00392 PROF, 1 hit
SUPFAMiSSF55770 SSF55770, 1 hit
PROSITEiView protein in PROSITE
PS00414 PROFILIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

O22655-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSWQAYVDEH LMCEIEGQHL SAAAIVGHDG SVWAQSESFP ELKPEEVAGI
60 70 80 90 100
IKDFDEPGTL APTGLFVGGT KYMVIQGEPG VVIRGKKGTG GITIKKTGMS
110 120 130
LIIGVYDEPM TPGQCNMVVE RLGDYLIEQG F
Length:131
Mass (Da):14,101
Last modified:January 1, 1998 - v1
Checksum:iE0744573FAADBE85
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D6LL87A0A1D6LL87_MAIZE
Profilin
541662 ZEAMMB73_Zm00001d036213
161Annotation score:

Polymorphismi

Several isoforms of the allergen exist due to polymorphism.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF032370 mRNA Translation: AAB86960.1
PIRiT01328
RefSeqiNP_001104885.1, NM_001111415.1
UniGeneiZm.1859

Genome annotation databases

EnsemblPlantsiZm00001d036213_T001; Zm00001d036213_P001; Zm00001d036213
GeneIDi541662
GrameneiZm00001d036213_T001; Zm00001d036213_P001; Zm00001d036213
KEGGizma:541662

Similar proteinsi

Entry informationi

Entry nameiPROF4_MAIZE
AccessioniPrimary (citable) accession number: O22655
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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