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UniProtKB - O22241 (AROD4_ARATH)
Protein
Arogenate dehydratase 4, chloroplastic
Gene
ADT4
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Converts the prephenate produced from the shikimate-chorismate pathway into phenylalanine.
1 PublicationMiscellaneous
Has no detectable prehenate dehydratase activity.1 Publication
Catalytic activityi
Kineticsi
- KM=10.08 mM for arogenate1 Publication
- Vmax=52.32 pmol/sec/µg enzyme with arogenate as substrate1 Publication
: L-phenylalanine biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes L-phenylalanine from L-arogenate.Curated This subpathway is part of the pathway L-phenylalanine biosynthesis, which is itself part of Amino-acid biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-phenylalanine from L-arogenate, the pathway L-phenylalanine biosynthesis and in Amino-acid biosynthesis.
GO - Molecular functioni
- arogenate dehydratase activity Source: TAIR
- prephenate dehydratase activity Source: InterPro
GO - Biological processi
- defense response Source: TAIR
- L-phenylalanine biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Lyase |
Biological process | Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Phenylalanine biosynthesis |
Enzyme and pathway databases
BioCyci | ARA:AT3G44720-MONOMER |
BRENDAi | 4.2.1.91, 399 |
SABIO-RKi | O22241 |
UniPathwayi | UPA00121;UER00344 |
Names & Taxonomyi
Protein namesi | Recommended name: Arogenate dehydratase 4, chloroplastic1 Publication (EC:4.2.1.911 Publication)Short name: AtADT41 Publication |
Gene namesi | Name:ADT41 Publication Ordered Locus Names:At3g44720Imported ORF Names:T32N15.11Imported |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT3G44720 |
TAIRi | locus:2101630, AT3G44720 |
Subcellular locationi
Chloroplast
- chloroplast stroma 1 Publication
Chloroplast
- chloroplast Source: TAIR
- chloroplast stroma Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
Chloroplast, PlastidPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 34 | ChloroplastSequence analysisAdd BLAST | 34 | |
ChainiPRO_0000373793 | 35 – 424 | Arogenate dehydratase 4, chloroplasticAdd BLAST | 390 |
Proteomic databases
PaxDbi | O22241 |
PRIDEi | O22241 |
ProteomicsDBi | 246959 |
Expressioni
Tissue specificityi
Expressed in roots, leaves, stems, flowers and siliques. More abundant in stems and roots.1 Publication
Gene expression databases
ExpressionAtlasi | O22241, baseline and differential |
Genevisiblei | O22241, AT |
Interactioni
Protein-protein interaction databases
BioGRIDi | 8921, 10 interactors |
IntActi | O22241, 13 interactors |
STRINGi | 3702.AT3G44720.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 126 – 303 | Prephenate dehydratasePROSITE-ProRule annotationAdd BLAST | 178 | |
Domaini | 319 – 410 | ACTPROSITE-ProRule annotationAdd BLAST | 92 |
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG2797, Eukaryota |
HOGENOMi | CLU_035008_4_1_1 |
InParanoidi | O22241 |
OMAi | SHAIPKR |
OrthoDBi | 1090069at2759 |
PhylomeDBi | O22241 |
Family and domain databases
InterProi | View protein in InterPro IPR045865, ACT-like_dom_sf IPR002912, ACT_dom IPR001086, Preph_deHydtase IPR018528, Preph_deHydtase_CS |
Pfami | View protein in Pfam PF00800, PDT, 1 hit |
SUPFAMi | SSF55021, SSF55021, 1 hit |
PROSITEi | View protein in PROSITE PS51671, ACT, 1 hit PS00857, PREPHENATE_DEHYDR_1, 1 hit PS00858, PREPHENATE_DEHYDR_2, 1 hit PS51171, PREPHENATE_DEHYDR_3, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
O22241-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQAATSCDLK FRSTDPTSRN KCFSHAIPKR VAVTCGYRSE SFSFPNGVSV
60 70 80 90 100
SRSDWQSSCA ILSSKVASVE NTGGLADKIA AVNGHTNGSV NLGLVAVEST
110 120 130 140 150
NGKLAPAQPL TITDLSPAPL HGSSLRVAYQ GVPGAYSEAA AGKAYPNCDA
160 170 180 190 200
IPCDQFDVAF QAVELWIADR AVLPVENSLG GSIHRNYDLL LRHRLHIVGE
210 220 230 240 250
VQIPVHHCLL ALPGVRTDCV SRVISHPQAL AQTEHSLDVL TPHAAREAFH
260 270 280 290 300
DTAAAAEYIS ANDLHDTAAV ASARAAELYN LQILADGIQD DPGNVTRFLM
310 320 330 340 350
LAREPIIPRT DRPFKTSIVF AAQEHKGTSV LFKVLSAFAF RDISLTKIES
360 370 380 390 400
RPHHNRPLRV VGDGSFGTSK NFEYMFYVDF EASMAEPRAQ NALAEVQEYT
410 420
SFLRVLGSYP MDMTPWSMTS TEEA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ411467 mRNA Translation: ABD67753.1 AC002534 Genomic DNA Translation: AAB70035.1 CP002686 Genomic DNA Translation: AEE77939.1 AY062692 mRNA Translation: AAL32770.1 BT008862 mRNA Translation: AAP68301.1 |
RefSeqi | NP_190058.1, NM_114340.4 |
Genome annotation databases
EnsemblPlantsi | AT3G44720.1; AT3G44720.1; AT3G44720 |
GeneIDi | 823601 |
Gramenei | AT3G44720.1; AT3G44720.1; AT3G44720 |
KEGGi | ath:AT3G44720 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ411467 mRNA Translation: ABD67753.1 AC002534 Genomic DNA Translation: AAB70035.1 CP002686 Genomic DNA Translation: AEE77939.1 AY062692 mRNA Translation: AAL32770.1 BT008862 mRNA Translation: AAP68301.1 |
RefSeqi | NP_190058.1, NM_114340.4 |
3D structure databases
AlphaFoldDBi | O22241 |
SMRi | O22241 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 8921, 10 interactors |
IntActi | O22241, 13 interactors |
STRINGi | 3702.AT3G44720.1 |
Proteomic databases
PaxDbi | O22241 |
PRIDEi | O22241 |
ProteomicsDBi | 246959 |
Genome annotation databases
EnsemblPlantsi | AT3G44720.1; AT3G44720.1; AT3G44720 |
GeneIDi | 823601 |
Gramenei | AT3G44720.1; AT3G44720.1; AT3G44720 |
KEGGi | ath:AT3G44720 |
Organism-specific databases
Araporti | AT3G44720 |
TAIRi | locus:2101630, AT3G44720 |
Phylogenomic databases
eggNOGi | KOG2797, Eukaryota |
HOGENOMi | CLU_035008_4_1_1 |
InParanoidi | O22241 |
OMAi | SHAIPKR |
OrthoDBi | 1090069at2759 |
PhylomeDBi | O22241 |
Enzyme and pathway databases
UniPathwayi | UPA00121;UER00344 |
BioCyci | ARA:AT3G44720-MONOMER |
BRENDAi | 4.2.1.91, 399 |
SABIO-RKi | O22241 |
Miscellaneous databases
PROi | PR:O22241 |
Gene expression databases
ExpressionAtlasi | O22241, baseline and differential |
Genevisiblei | O22241, AT |
Family and domain databases
InterProi | View protein in InterPro IPR045865, ACT-like_dom_sf IPR002912, ACT_dom IPR001086, Preph_deHydtase IPR018528, Preph_deHydtase_CS |
Pfami | View protein in Pfam PF00800, PDT, 1 hit |
SUPFAMi | SSF55021, SSF55021, 1 hit |
PROSITEi | View protein in PROSITE PS51671, ACT, 1 hit PS00857, PREPHENATE_DEHYDR_1, 1 hit PS00858, PREPHENATE_DEHYDR_2, 1 hit PS51171, PREPHENATE_DEHYDR_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AROD4_ARATH | |
Accessioni | O22241Primary (citable) accession number: O22241 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 5, 2009 |
Last sequence update: | January 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 123 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways