UniProtKB - O22131 (LBD18_ARATH)
Protein
LOB domain-containing protein 18
Gene
LBD18
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Involved in the positive regulation of tracheary element (TE) differentiation. Involved in a positive feedback loop that maintains or promotes NAC030/VND7 expression that regulates TE differentiation-related genes (PubMed:19088331). Functions in the initiation and emergence of lateral roots, in conjunction with LBD16, downstream of ARF7 and ARF19 (PubMed:19717544, PubMed:23749813). Transcriptional activator that directly regulates EXPA14, a gene encoding a cell wall-loosening factor that promotes lateral root emergence. Activates EXPA14 by directly binding to a specific region of its promoter (PubMed:22974309). Transcriptional activator that directly regulates EXPA17, a gene encoding a cell wall-loosening factor that promotes lateral root emergence (PubMed:23872272). Acts downstream of the auxin influx carriers AUX1 and LAX1 in the regulation of lateral root initiation and development (PubMed:26059335).6 Publications
Miscellaneous
Plants over-expressing LBD18 have a dwarf and bushy phenotype, with short petioles, curled downward leaves, ectopic shoots from the adaxial side of cotyledons, shrunken root tips and disorganized columella cells.1 Publication
GO - Biological processi
- hormone-mediated signaling pathway Source: GO_Central
- lateral root formation Source: TAIR
- positive regulation of transcription, DNA-templated Source: UniProtKB
- xylem development Source: TAIR
Names & Taxonomyi
Protein namesi | Recommended name: LOB domain-containing protein 18Alternative name(s): ASYMMETRIC LEAVES 2-like protein 20 Short name: AS2-like protein 20 |
Gene namesi | Name:LBD18 Synonyms:ASL20 Ordered Locus Names:At2g45420 ORF Names:F4L23.7 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT2G45420 |
TAIRi | locus:2050951, AT2G45420 |
Subcellular locationi
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
Reduced number of lateral roots.1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 109 | P → L: Loss of function in lateral root formation. Abolishes DNA-binding activity. Abolishes interaction with GIP1. 2 Publications | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000132269 | 1 – 262 | LOB domain-containing protein 18Add BLAST | 262 |
Proteomic databases
PaxDbi | O22131 |
PRIDEi | O22131 |
ProteomicsDBi | 237150 |
Expressioni
Tissue specificityi
Expressed in roots, stems, leaves and flowers (PubMed:12068116, PubMed:24484953). Expressed in vascular tissues of hypocotyls, leaves, roots, developing floral organs and siliques (PubMed:19088331).3 Publications
Developmental stagei
During lateral root formation, expressed in the lateral root primordia, and the developing, emerged, and mature lateral roots.1 Publication
Inductioni
By auxin.3 Publications
Gene expression databases
ExpressionAtlasi | O22131, baseline and differential |
Genevisiblei | O22131, AT |
Interactioni
Subunit structurei
Binary interactionsi
O22131
With | #Exp. | IntAct |
---|---|---|
LBD23 [P59467] | 3 | EBI-15212656,EBI-15193845 |
Protein-protein interaction databases
BioGRIDi | 4486, 6 interactors |
IntActi | O22131, 2 interactors |
STRINGi | 3702.AT2G45420.1 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 36 – 138 | LOBPROSITE-ProRule annotationAdd BLAST | 103 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 3 – 39 | Gly-richAdd BLAST | 37 | |
Compositional biasi | 144 – 180 | Pro-richAdd BLAST | 37 |
Sequence similaritiesi
Belongs to the LOB domain-containing protein family.Curated
Phylogenomic databases
eggNOGi | ENOG502QR68, Eukaryota |
HOGENOMi | CLU_058353_3_5_1 |
InParanoidi | O22131 |
OMAi | PQPLFFT |
OrthoDBi | 1304135at2759 |
PhylomeDBi | O22131 |
Family and domain databases
InterProi | View protein in InterPro IPR004883, LOB IPR017394, LOB_18/20 |
Pfami | View protein in Pfam PF03195, LOB, 1 hit |
PIRSFi | PIRSF038127, UCP038127_LOB, 1 hit |
PROSITEi | View protein in PROSITE PS50891, LOB, 1 hit |
i Sequence
Sequence statusi: Complete.
O22131-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGGGNTITA VGGGGGGCGG GGSSGGGGSS GGGGGGPCGA CKFLRRKCVP
60 70 80 90 100
GCIFAPYFDS EQGSAYFAAV HKVFGASNVS KLLLHIPVHR RSDAVVTICY
110 120 130 140 150
EAQARIRDPI YGCVAHIFAL QQQVVNLQAE VSYLQAHLAS LELPQPQTRP
160 170 180 190 200
QPMPQPQPLF FTPPPPLAIT DLPASVSPLP STYDLASIFD QTTSSSAWAT
210 220 230 240 250
QQRRFIDPRH QYGVSSSSSS VAVGLGGENS HDLQALAHEL LHRQGSPPPA
260
ATDHSPSRTM SR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF447891 mRNA Translation: AAL38036.1 AB473853 mRNA Translation: BAH10564.1 AC002387 Genomic DNA Translation: AAB82622.2 CP002685 Genomic DNA Translation: AEC10551.1 BT025716 mRNA Translation: ABF82619.1 |
PIRi | C84890 |
RefSeqi | NP_850436.1, NM_180105.2 |
Genome annotation databases
EnsemblPlantsi | AT2G45420.1; AT2G45420.1; AT2G45420 |
GeneIDi | 819150 |
Gramenei | AT2G45420.1; AT2G45420.1; AT2G45420 |
KEGGi | ath:AT2G45420 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF447891 mRNA Translation: AAL38036.1 AB473853 mRNA Translation: BAH10564.1 AC002387 Genomic DNA Translation: AAB82622.2 CP002685 Genomic DNA Translation: AEC10551.1 BT025716 mRNA Translation: ABF82619.1 |
PIRi | C84890 |
RefSeqi | NP_850436.1, NM_180105.2 |
3D structure databases
SMRi | O22131 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4486, 6 interactors |
IntActi | O22131, 2 interactors |
STRINGi | 3702.AT2G45420.1 |
Proteomic databases
PaxDbi | O22131 |
PRIDEi | O22131 |
ProteomicsDBi | 237150 |
Genome annotation databases
EnsemblPlantsi | AT2G45420.1; AT2G45420.1; AT2G45420 |
GeneIDi | 819150 |
Gramenei | AT2G45420.1; AT2G45420.1; AT2G45420 |
KEGGi | ath:AT2G45420 |
Organism-specific databases
Araporti | AT2G45420 |
TAIRi | locus:2050951, AT2G45420 |
Phylogenomic databases
eggNOGi | ENOG502QR68, Eukaryota |
HOGENOMi | CLU_058353_3_5_1 |
InParanoidi | O22131 |
OMAi | PQPLFFT |
OrthoDBi | 1304135at2759 |
PhylomeDBi | O22131 |
Miscellaneous databases
PROi | PR:O22131 |
Gene expression databases
ExpressionAtlasi | O22131, baseline and differential |
Genevisiblei | O22131, AT |
Family and domain databases
InterProi | View protein in InterPro IPR004883, LOB IPR017394, LOB_18/20 |
Pfami | View protein in Pfam PF03195, LOB, 1 hit |
PIRSFi | PIRSF038127, UCP038127_LOB, 1 hit |
PROSITEi | View protein in PROSITE PS50891, LOB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LBD18_ARATH | |
Accessioni | O22131Primary (citable) accession number: O22131 Secondary accession number(s): B7XG74, Q1ECL8, Q8W1D7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 17, 2003 |
Last sequence update: | June 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 118 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families