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Entry version 187 (12 Aug 2020)
Sequence version 1 (01 Jan 1998)
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Protein
Submitted name:

HLA class I antigen

Gene

HLA-C

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
HLA class I antigenImported
Submitted name:
HLA class I histocompatibility antigenImported
Submitted name:
HLA class I histocompatibility antigen, C alpha chainImported
Submitted name:
HLA-C proteinImported
Submitted name:
MHC class I antigenImported
Submitted name:
MHC class I histocompatibility antigenImported
Submitted name:
MHC class I proteinImported
Submitted name:
Major histocompatibility complex, class I, CImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HLA-CImported
Synonyms:HLA-CwImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4933, HLA-C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei308 – 331HelicalSequence analysisAdd BLAST24

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membraneARBA annotation, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 24Sequence analysisAdd BLAST24
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501509674325 – 366Sequence analysisAdd BLAST342

Keywords - PTMi

Disulfide bondARBA annotation, GlycoproteinARBA annotation

Proteomic databases

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
48758

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini209 – 297Ig-likeInterPro annotationAdd BLAST89

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotation

Keywords - Domaini

SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
1390181at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
3.30.500.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003597, Ig_C1-set
IPR011161, MHC_I-like_Ag-recog
IPR037055, MHC_I-like_Ag-recog_sf
IPR011162, MHC_I/II-like_Ag-recog
IPR001039, MHC_I_a_a1/a2
IPR010579, MHC_I_a_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07654, C1-set, 1 hit
PF00129, MHC_I, 1 hit
PF06623, MHC_I_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01638, MHCCLASSI

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00407, IGc1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726, SSF48726, 1 hit
SSF54452, SSF54452, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835, IG_LIKE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 45 potential isoforms that are computationally mapped.Show allAlign All

O19617-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRVMAPRALL LLLSGGLALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG
60 70 80 90 100
YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQN YKRQAQADRV
110 120 130 140 150
SLRNLRGYYN QSEDGSHTLQ RMYGCDLGPD GRLLRGYDQS AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DTAAQITQRK LEAARAAEQL RAYLEGTCVE WLRRYLENGK
210 220 230 240 250
ETLQRAEPPK THVTHHPLSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHMQHEGL QEPLTLSWEP
310 320 330 340 350
SSQPTIPIMG IVAGLAVLVV LAVLGAVVTA MMCRRKSSGG KGGSCSQAAC
360
SNSAQGSDES LITCKA
Length:366
Mass (Da):40,711
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0B9518E6AA77A609
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 45 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P10321HLAC_HUMAN
HLA class I histocompatibility anti...
HLA-C HLAC
366Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5QT33Q5QT33_HUMAN
HLA class I antigen
HLA-C HLA-Cw, HLAC
366Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
O78179O78179_HUMAN
HLA class I histocompatibility anti...
HLA-C HLA-Cw
366Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q53YP1Q53YP1_HUMAN
HLA class I histocompatibility anti...
HLA-C HLA-Cw
366Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5RIP0Q5RIP0_HUMAN
HLA class I histocompatibility anti...
HLA-C HLA-Cw
366Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JH50A0A0G2JH50_HUMAN
HLA class I histocompatibility anti...
HLA-C
372Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T9J9A0A140T9J9_HUMAN
HLA class I histocompatibility anti...
HLA-C
372Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PRU9A0A1W2PRU9_HUMAN
HLA class I histocompatibility anti...
HLA-C
244Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A2AEA2A2AEA2_HUMAN
HLA class I histocompatibility anti...
HLA-C
372Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PNZ7A0A1W2PNZ7_HUMAN
HLA class I histocompatibility anti...
HLA-C
244Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL662833 Genomic DNA No translation available.
BC033293 mRNA Translation: AAH33293.1
GQ472838 Genomic DNA Translation: ACV91118.1
GQ472839 Genomic DNA Translation: ACV91119.1
KU528607 Genomic DNA Translation: ALZ40822.1
KU319188 Genomic DNA Translation: ANG08604.1
KU319189 Genomic DNA Translation: ANG08605.1
KX649950 Genomic DNA Translation: ANZ73061.1
KY622045 Genomic DNA Translation: ASE99681.1
KY626050 Genomic DNA Translation: ASE99686.1
KY419402 Genomic DNA Translation: ASU50293.1
KY419403 Genomic DNA Translation: ASU50294.1
KY419404 Genomic DNA Translation: ASU50295.1
KY419405 Genomic DNA Translation: ASU50296.1
MF981006 Genomic DNA Translation: ATV81380.1
KY499646 Genomic DNA Translation: AUN50126.1
MG584060 Genomic DNA Translation: AUQ33504.1
MG701558 Genomic DNA Translation: AUQ33562.1
MG769793 Genomic DNA Translation: AUQ33682.1
MG747476 Genomic DNA Translation: AUZ98368.1
MG779942 Genomic DNA Translation: AVC68922.1
MG930617 Genomic DNA Translation: AVV62703.1
MG930622 Genomic DNA Translation: AVV62708.1
MG944953 Genomic DNA Translation: AVV63103.1
MG911201 Genomic DNA Translation: AWC68084.1
MH173509 Genomic DNA Translation: AWM62556.1
MH374096 Genomic DNA Translation: AWM63100.1
MH814709 Genomic DNA Translation: AXU24216.1
MH537760 Genomic DNA Translation: AXU93754.1
MH537761 Genomic DNA Translation: AXU93755.1
MH758989 Genomic DNA Translation: AZL48746.1
MH913462 Genomic DNA Translation: AZL48802.1
MH974085 Genomic DNA Translation: AZL48922.1
MH974089 Genomic DNA Translation: AZL48926.1
MK005653 Genomic DNA Translation: AZL48959.1
MK143732 Genomic DNA Translation: AZU90312.1
MK143758 Genomic DNA Translation: AZU90334.1
MK165858 Genomic DNA Translation: AZU90357.1
MK257843 Genomic DNA Translation: AZU90399.1
MK257872 Genomic DNA Translation: AZU90428.1
MK257898 Genomic DNA Translation: AZU90454.1
MK309015 Genomic DNA Translation: AZU90541.1
MK309016 Genomic DNA Translation: AZU90542.1
MK309044 Genomic DNA Translation: AZU90563.1
D83957 Genomic DNA Translation: BAA22206.1
BA000025 Genomic DNA Translation: BAB63310.1
AB774946 Genomic DNA Translation: BAN59792.1
LR777901 Genomic DNA Translation: CAB1055262.1
HE793165 Genomic DNA Translation: CCG58319.1
HF565303 Genomic DNA Translation: CCP37718.1
HG794375 Genomic DNA Translation: CDK41184.1
HG794378 Genomic DNA Translation: CDK41187.1
LK021963 Genomic DNA Translation: CDQ51644.1
LN600112 Genomic DNA Translation: CEF48102.2
LN624510 Genomic DNA Translation: CEH11580.1
LN811470 Genomic DNA Translation: CEP25297.1
LN832568 Genomic DNA Translation: CQR91446.1
LN877368 Genomic DNA Translation: CUA55111.1
LN912841 Genomic DNA Translation: CUU97168.1
LN912851 Genomic DNA Translation: CUU97178.1
LN912882 Genomic DNA Translation: CUU97209.1
LN912964 Genomic DNA Translation: CUU97291.1
LN912965 Genomic DNA Translation: CUU97292.1
LN912966 Genomic DNA Translation: CUU97293.1
LN912967 Genomic DNA Translation: CUU97294.1
LN912968 Genomic DNA Translation: CUU97295.1
MH269357 Genomic DNA Translation: QAX33617.1
MH269358 Genomic DNA Translation: QAX33618.1
MH269359 Genomic DNA Translation: QAX33619.1
MH269360 Genomic DNA Translation: QAX33620.1
MK500629 Genomic DNA Translation: QBM15724.1
MK616623 Genomic DNA Translation: QBM15763.1
MK650293 Genomic DNA Translation: QCQ66938.1
MK844029 Genomic DNA Translation: QCQ66960.1
MK844039 Genomic DNA Translation: QCQ66970.1
MK780765 Genomic DNA Translation: QCW64097.1
MK225295 Genomic DNA Translation: QDC33380.1
MK442082 Genomic DNA Translation: QDC33418.1
MK938201 Genomic DNA Translation: QDK63355.1
MK938226 Genomic DNA Translation: QDK63378.1
MK938239 Genomic DNA Translation: QDK63390.1
MK938240 Genomic DNA Translation: QDK63391.1
MK938247 Genomic DNA Translation: QDK63398.1
MK938258 Genomic DNA Translation: QDK63409.1
MK938280 Genomic DNA Translation: QDK63431.1
MK938292 Genomic DNA Translation: QDK63443.1
MK954471 Genomic DNA Translation: QDK63451.1
MK954478 Genomic DNA Translation: QDK63458.1
MK954488 Genomic DNA Translation: QDK63468.1
MK954506 Genomic DNA Translation: QDK63486.1
MK954547 Genomic DNA Translation: QDK63527.1
MK954551 Genomic DNA Translation: QDK63531.1
MK954557 Genomic DNA Translation: QDK63537.1
MK954560 Genomic DNA Translation: QDK63540.1
MK954579 Genomic DNA Translation: QDK63559.1
MK954594 Genomic DNA Translation: QDK63574.1
MK954603 Genomic DNA Translation: QDK63583.1
MK954620 Genomic DNA Translation: QDK63599.1
MK954623 Genomic DNA Translation: QDK63602.1
MK954634 Genomic DNA Translation: QDK63612.1
MK954699 Genomic DNA Translation: QDK63674.1
MK954713 Genomic DNA Translation: QDK63688.1
MK954714 Genomic DNA Translation: QDK63689.1
MK954725 Genomic DNA Translation: QDK63700.1
MK954732 Genomic DNA Translation: QDK63707.1
MK954746 Genomic DNA Translation: QDK63720.1
MK954755 Genomic DNA Translation: QDK63729.1
MK954761 Genomic DNA Translation: QDK63735.1
MK954764 Genomic DNA Translation: QDK63737.1
MK954771 Genomic DNA Translation: QDK63744.1
MK954781 Genomic DNA Translation: QDK63754.1
MK954797 Genomic DNA Translation: QDK63770.1
MK954816 Genomic DNA Translation: QDK63789.1
MK954818 Genomic DNA Translation: QDK63791.1
MK954821 Genomic DNA Translation: QDK63794.1
MK954839 Genomic DNA Translation: QDK63812.1
MN016547 Genomic DNA Translation: QDK63822.1
MN016592 Genomic DNA Translation: QDK63867.1
MN016606 Genomic DNA Translation: QDK63881.1
MN016622 Genomic DNA Translation: QDK63897.1
MN016632 Genomic DNA Translation: QDK63907.1
MN016638 Genomic DNA Translation: QDK63913.1
MN016641 Genomic DNA Translation: QDK63916.1
MN016689 Genomic DNA Translation: QDK63963.1
MN016705 Genomic DNA Translation: QDK63979.1
MN016735 Genomic DNA Translation: QDK64008.1
MN016758 Genomic DNA Translation: QDK64031.1
MN016761 Genomic DNA Translation: QDK64034.1
MN016774 Genomic DNA Translation: QDK64047.1
MN016783 Genomic DNA Translation: QDK64056.1
MN016784 Genomic DNA Translation: QDK64057.1
MN016788 Genomic DNA Translation: QDK64061.1
MN016792 Genomic DNA Translation: QDK64065.1
MN016800 Genomic DNA Translation: QDK64073.1
MN016808 Genomic DNA Translation: QDK64081.1
MN016821 Genomic DNA Translation: QDK64094.1
MN016833 Genomic DNA Translation: QDK64106.1
MN016847 Genomic DNA Translation: QDK64120.1
MN016849 Genomic DNA Translation: QDK64122.1
MN016857 Genomic DNA Translation: QDK64130.1
MN016865 Genomic DNA Translation: QDK64138.1
MN016867 Genomic DNA Translation: QDK64140.1
MN016871 Genomic DNA Translation: QDK64144.1
MN016872 Genomic DNA Translation: QDK64145.1
MN016879 Genomic DNA Translation: QDK64152.1
MN016890 Genomic DNA Translation: QDK64163.1
MN016909 Genomic DNA Translation: QDK64182.1
MN016915 Genomic DNA Translation: QDK64188.1
MN016923 Genomic DNA Translation: QDK64196.1
MN115516 Genomic DNA Translation: QDK64245.1
MN115525 Genomic DNA Translation: QDK64254.1
MN115529 Genomic DNA Translation: QDK64258.1
MN115537 Genomic DNA Translation: QDK64266.1
MN115545 Genomic DNA Translation: QDK64274.1
MN166928 Genomic DNA Translation: QEQ28568.1
MN380617 Genomic DNA Translation: QEQ28596.1
MN380625 Genomic DNA Translation: QEQ28604.1
MN176141 Genomic DNA Translation: QGY93927.1
MN783627 Genomic DNA Translation: QHD25631.1
MN783628 Genomic DNA Translation: QHD25632.1
MN640674 Genomic DNA Translation: QHQ71334.1
MN815925 Genomic DNA Translation: QHQ72383.1
MN154524 Genomic DNA Translation: QIA58958.1
MN296486 Genomic DNA Translation: QID88817.1
MN984347 Genomic DNA Translation: QIJ58240.1
LT575524 Genomic DNA Translation: SBL08196.1
LT599302 Genomic DNA Translation: SBW38523.1
LT599310 Genomic DNA Translation: SBW38531.1
LT599317 Genomic DNA Translation: SBW38538.1
LT599328 Genomic DNA Translation: SBW38549.1
LT618799 Genomic DNA Translation: SCQ83615.1
LT627695 Genomic DNA Translation: SFV42124.1
LT898183 Genomic DNA Translation: SNQ25993.1
LT962592 Genomic DNA Translation: SOQ60063.1
LT962607 Genomic DNA Translation: SOQ60078.1
LT962613 Genomic DNA Translation: SOQ60084.1
LT962617 Genomic DNA Translation: SOQ70040.1
LT963220 Genomic DNA Translation: SOR74764.1
LT963259 Genomic DNA Translation: SOR74803.1
LT964794 Genomic DNA Translation: SOT92898.1
LT964813 Genomic DNA Translation: SOT92917.1
LT964820 Genomic DNA Translation: SOT92924.1
LT964841 Genomic DNA Translation: SOT92945.1
LT964849 Genomic DNA Translation: SOT92953.1
LT964853 Genomic DNA Translation: SOT92957.1
LT966226 Genomic DNA Translation: SOU90380.1
LT966290 Genomic DNA Translation: SOU90444.1
LT966291 Genomic DNA Translation: SOU90445.1
LT970872 Genomic DNA Translation: SOX29787.1
LT990031 Genomic DNA Translation: SPI58569.1
LS453233 Genomic DNA Translation: SPS67918.1
LS453256 Genomic DNA Translation: SPS67946.1
LS453267 Genomic DNA Translation: SPS67963.1
LS992350 Genomic DNA Translation: SYY42650.1
LS992433 Genomic DNA Translation: SYY42733.1
LR027063 Genomic DNA Translation: VCU43103.1
LR596415 Genomic DNA Translation: VUE12350.1

NCBI Reference Sequences

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RefSeqi
NP_001229971.1, NM_001243042.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000424832; ENSP00000414063; ENSG00000233841

Database of genes from NCBI RefSeq genomes

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GeneIDi
3107

UCSC genome browser

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UCSCi
uc011fcf.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662833 Genomic DNA No translation available.
BC033293 mRNA Translation: AAH33293.1
GQ472838 Genomic DNA Translation: ACV91118.1
GQ472839 Genomic DNA Translation: ACV91119.1
KU528607 Genomic DNA Translation: ALZ40822.1
KU319188 Genomic DNA Translation: ANG08604.1
KU319189 Genomic DNA Translation: ANG08605.1
KX649950 Genomic DNA Translation: ANZ73061.1
KY622045 Genomic DNA Translation: ASE99681.1
KY626050 Genomic DNA Translation: ASE99686.1
KY419402 Genomic DNA Translation: ASU50293.1
KY419403 Genomic DNA Translation: ASU50294.1
KY419404 Genomic DNA Translation: ASU50295.1
KY419405 Genomic DNA Translation: ASU50296.1
MF981006 Genomic DNA Translation: ATV81380.1
KY499646 Genomic DNA Translation: AUN50126.1
MG584060 Genomic DNA Translation: AUQ33504.1
MG701558 Genomic DNA Translation: AUQ33562.1
MG769793 Genomic DNA Translation: AUQ33682.1
MG747476 Genomic DNA Translation: AUZ98368.1
MG779942 Genomic DNA Translation: AVC68922.1
MG930617 Genomic DNA Translation: AVV62703.1
MG930622 Genomic DNA Translation: AVV62708.1
MG944953 Genomic DNA Translation: AVV63103.1
MG911201 Genomic DNA Translation: AWC68084.1
MH173509 Genomic DNA Translation: AWM62556.1
MH374096 Genomic DNA Translation: AWM63100.1
MH814709 Genomic DNA Translation: AXU24216.1
MH537760 Genomic DNA Translation: AXU93754.1
MH537761 Genomic DNA Translation: AXU93755.1
MH758989 Genomic DNA Translation: AZL48746.1
MH913462 Genomic DNA Translation: AZL48802.1
MH974085 Genomic DNA Translation: AZL48922.1
MH974089 Genomic DNA Translation: AZL48926.1
MK005653 Genomic DNA Translation: AZL48959.1
MK143732 Genomic DNA Translation: AZU90312.1
MK143758 Genomic DNA Translation: AZU90334.1
MK165858 Genomic DNA Translation: AZU90357.1
MK257843 Genomic DNA Translation: AZU90399.1
MK257872 Genomic DNA Translation: AZU90428.1
MK257898 Genomic DNA Translation: AZU90454.1
MK309015 Genomic DNA Translation: AZU90541.1
MK309016 Genomic DNA Translation: AZU90542.1
MK309044 Genomic DNA Translation: AZU90563.1
D83957 Genomic DNA Translation: BAA22206.1
BA000025 Genomic DNA Translation: BAB63310.1
AB774946 Genomic DNA Translation: BAN59792.1
LR777901 Genomic DNA Translation: CAB1055262.1
HE793165 Genomic DNA Translation: CCG58319.1
HF565303 Genomic DNA Translation: CCP37718.1
HG794375 Genomic DNA Translation: CDK41184.1
HG794378 Genomic DNA Translation: CDK41187.1
LK021963 Genomic DNA Translation: CDQ51644.1
LN600112 Genomic DNA Translation: CEF48102.2
LN624510 Genomic DNA Translation: CEH11580.1
LN811470 Genomic DNA Translation: CEP25297.1
LN832568 Genomic DNA Translation: CQR91446.1
LN877368 Genomic DNA Translation: CUA55111.1
LN912841 Genomic DNA Translation: CUU97168.1
LN912851 Genomic DNA Translation: CUU97178.1
LN912882 Genomic DNA Translation: CUU97209.1
LN912964 Genomic DNA Translation: CUU97291.1
LN912965 Genomic DNA Translation: CUU97292.1
LN912966 Genomic DNA Translation: CUU97293.1
LN912967 Genomic DNA Translation: CUU97294.1
LN912968 Genomic DNA Translation: CUU97295.1
MH269357 Genomic DNA Translation: QAX33617.1
MH269358 Genomic DNA Translation: QAX33618.1
MH269359 Genomic DNA Translation: QAX33619.1
MH269360 Genomic DNA Translation: QAX33620.1
MK500629 Genomic DNA Translation: QBM15724.1
MK616623 Genomic DNA Translation: QBM15763.1
MK650293 Genomic DNA Translation: QCQ66938.1
MK844029 Genomic DNA Translation: QCQ66960.1
MK844039 Genomic DNA Translation: QCQ66970.1
MK780765 Genomic DNA Translation: QCW64097.1
MK225295 Genomic DNA Translation: QDC33380.1
MK442082 Genomic DNA Translation: QDC33418.1
MK938201 Genomic DNA Translation: QDK63355.1
MK938226 Genomic DNA Translation: QDK63378.1
MK938239 Genomic DNA Translation: QDK63390.1
MK938240 Genomic DNA Translation: QDK63391.1
MK938247 Genomic DNA Translation: QDK63398.1
MK938258 Genomic DNA Translation: QDK63409.1
MK938280 Genomic DNA Translation: QDK63431.1
MK938292 Genomic DNA Translation: QDK63443.1
MK954471 Genomic DNA Translation: QDK63451.1
MK954478 Genomic DNA Translation: QDK63458.1
MK954488 Genomic DNA Translation: QDK63468.1
MK954506 Genomic DNA Translation: QDK63486.1
MK954547 Genomic DNA Translation: QDK63527.1
MK954551 Genomic DNA Translation: QDK63531.1
MK954557 Genomic DNA Translation: QDK63537.1
MK954560 Genomic DNA Translation: QDK63540.1
MK954579 Genomic DNA Translation: QDK63559.1
MK954594 Genomic DNA Translation: QDK63574.1
MK954603 Genomic DNA Translation: QDK63583.1
MK954620 Genomic DNA Translation: QDK63599.1
MK954623 Genomic DNA Translation: QDK63602.1
MK954634 Genomic DNA Translation: QDK63612.1
MK954699 Genomic DNA Translation: QDK63674.1
MK954713 Genomic DNA Translation: QDK63688.1
MK954714 Genomic DNA Translation: QDK63689.1
MK954725 Genomic DNA Translation: QDK63700.1
MK954732 Genomic DNA Translation: QDK63707.1
MK954746 Genomic DNA Translation: QDK63720.1
MK954755 Genomic DNA Translation: QDK63729.1
MK954761 Genomic DNA Translation: QDK63735.1
MK954764 Genomic DNA Translation: QDK63737.1
MK954771 Genomic DNA Translation: QDK63744.1
MK954781 Genomic DNA Translation: QDK63754.1
MK954797 Genomic DNA Translation: QDK63770.1
MK954816 Genomic DNA Translation: QDK63789.1
MK954818 Genomic DNA Translation: QDK63791.1
MK954821 Genomic DNA Translation: QDK63794.1
MK954839 Genomic DNA Translation: QDK63812.1
MN016547 Genomic DNA Translation: QDK63822.1
MN016592 Genomic DNA Translation: QDK63867.1
MN016606 Genomic DNA Translation: QDK63881.1
MN016622 Genomic DNA Translation: QDK63897.1
MN016632 Genomic DNA Translation: QDK63907.1
MN016638 Genomic DNA Translation: QDK63913.1
MN016641 Genomic DNA Translation: QDK63916.1
MN016689 Genomic DNA Translation: QDK63963.1
MN016705 Genomic DNA Translation: QDK63979.1
MN016735 Genomic DNA Translation: QDK64008.1
MN016758 Genomic DNA Translation: QDK64031.1
MN016761 Genomic DNA Translation: QDK64034.1
MN016774 Genomic DNA Translation: QDK64047.1
MN016783 Genomic DNA Translation: QDK64056.1
MN016784 Genomic DNA Translation: QDK64057.1
MN016788 Genomic DNA Translation: QDK64061.1
MN016792 Genomic DNA Translation: QDK64065.1
MN016800 Genomic DNA Translation: QDK64073.1
MN016808 Genomic DNA Translation: QDK64081.1
MN016821 Genomic DNA Translation: QDK64094.1
MN016833 Genomic DNA Translation: QDK64106.1
MN016847 Genomic DNA Translation: QDK64120.1
MN016849 Genomic DNA Translation: QDK64122.1
MN016857 Genomic DNA Translation: QDK64130.1
MN016865 Genomic DNA Translation: QDK64138.1
MN016867 Genomic DNA Translation: QDK64140.1
MN016871 Genomic DNA Translation: QDK64144.1
MN016872 Genomic DNA Translation: QDK64145.1
MN016879 Genomic DNA Translation: QDK64152.1
MN016890 Genomic DNA Translation: QDK64163.1
MN016909 Genomic DNA Translation: QDK64182.1
MN016915 Genomic DNA Translation: QDK64188.1
MN016923 Genomic DNA Translation: QDK64196.1
MN115516 Genomic DNA Translation: QDK64245.1
MN115525 Genomic DNA Translation: QDK64254.1
MN115529 Genomic DNA Translation: QDK64258.1
MN115537 Genomic DNA Translation: QDK64266.1
MN115545 Genomic DNA Translation: QDK64274.1
MN166928 Genomic DNA Translation: QEQ28568.1
MN380617 Genomic DNA Translation: QEQ28596.1
MN380625 Genomic DNA Translation: QEQ28604.1
MN176141 Genomic DNA Translation: QGY93927.1
MN783627 Genomic DNA Translation: QHD25631.1
MN783628 Genomic DNA Translation: QHD25632.1
MN640674 Genomic DNA Translation: QHQ71334.1
MN815925 Genomic DNA Translation: QHQ72383.1
MN154524 Genomic DNA Translation: QIA58958.1
MN296486 Genomic DNA Translation: QID88817.1
MN984347 Genomic DNA Translation: QIJ58240.1
LT575524 Genomic DNA Translation: SBL08196.1
LT599302 Genomic DNA Translation: SBW38523.1
LT599310 Genomic DNA Translation: SBW38531.1
LT599317 Genomic DNA Translation: SBW38538.1
LT599328 Genomic DNA Translation: SBW38549.1
LT618799 Genomic DNA Translation: SCQ83615.1
LT627695 Genomic DNA Translation: SFV42124.1
LT898183 Genomic DNA Translation: SNQ25993.1
LT962592 Genomic DNA Translation: SOQ60063.1
LT962607 Genomic DNA Translation: SOQ60078.1
LT962613 Genomic DNA Translation: SOQ60084.1
LT962617 Genomic DNA Translation: SOQ70040.1
LT963220 Genomic DNA Translation: SOR74764.1
LT963259 Genomic DNA Translation: SOR74803.1
LT964794 Genomic DNA Translation: SOT92898.1
LT964813 Genomic DNA Translation: SOT92917.1
LT964820 Genomic DNA Translation: SOT92924.1
LT964841 Genomic DNA Translation: SOT92945.1
LT964849 Genomic DNA Translation: SOT92953.1
LT964853 Genomic DNA Translation: SOT92957.1
LT966226 Genomic DNA Translation: SOU90380.1
LT966290 Genomic DNA Translation: SOU90444.1
LT966291 Genomic DNA Translation: SOU90445.1
LT970872 Genomic DNA Translation: SOX29787.1
LT990031 Genomic DNA Translation: SPI58569.1
LS453233 Genomic DNA Translation: SPS67918.1
LS453256 Genomic DNA Translation: SPS67946.1
LS453267 Genomic DNA Translation: SPS67963.1
LS992350 Genomic DNA Translation: SYY42650.1
LS992433 Genomic DNA Translation: SYY42733.1
LR027063 Genomic DNA Translation: VCU43103.1
LR596415 Genomic DNA Translation: VUE12350.1
RefSeqiNP_001229971.1, NM_001243042.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

ProteomicsDBi48758

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
3107

Genome annotation databases

EnsembliENST00000424832; ENSP00000414063; ENSG00000233841
GeneIDi3107
UCSCiuc011fcf.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3107
HGNCiHGNC:4933, HLA-C

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

OrthoDBi1390181at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
3107, 284 hits in 843 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
HLA-C, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3107

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003597, Ig_C1-set
IPR011161, MHC_I-like_Ag-recog
IPR037055, MHC_I-like_Ag-recog_sf
IPR011162, MHC_I/II-like_Ag-recog
IPR001039, MHC_I_a_a1/a2
IPR010579, MHC_I_a_C
PfamiView protein in Pfam
PF07654, C1-set, 1 hit
PF00129, MHC_I, 1 hit
PF06623, MHC_I_C, 1 hit
PRINTSiPR01638, MHCCLASSI
SMARTiView protein in SMART
SM00407, IGc1, 1 hit
SUPFAMiSSF48726, SSF48726, 1 hit
SSF54452, SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO19617_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O19617
Secondary accession number(s): A0A090KMD8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: August 12, 2020
This is version 187 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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