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Protein

Chymotrypsin-like elastase family member 3B

Gene

CELA3B

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Efficient protease with alanine specificity but only little elastolytic activity.By similarity

Catalytic activityi

Preferential cleavage: Ala-|-Xaa. Does not hydrolyze elastin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei60Charge relay systemBy similarity1
Active sitei110Charge relay systemBy similarity1
Active sitei204Charge relay systemBy similarity1

GO - Molecular functioni

  • serine-type endopeptidase activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS01.154

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsin-like elastase family member 3B (EC:3.4.21.70)
Alternative name(s):
Elastase IIIB
Elastase-3B
Protease E
Gene namesi
Name:CELA3B
Synonyms:ELA3B
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei‹1 – 2Or 3Sequence analysis›2
PropeptideiPRO_00000277013 – 15Activation peptideSequence analysisAdd BLAST13
ChainiPRO_000002770216 – ›257Chymotrypsin-like elastase family member 3BAdd BLAST›242

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi45 ↔ 61PROSITE-ProRule annotation
Disulfide bondi104 ↔ 107PROSITE-ProRule annotation
Disulfide bondi144 ↔ 210PROSITE-ProRule annotation
Disulfide bondi175 ↔ 191PROSITE-ProRule annotation
Disulfide bondi200 ↔ 231PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PRIDEiO19023

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000005184

Structurei

3D structure databases

ProteinModelPortaliO19023
SMRiO19023
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 255Peptidase S1PROSITE-ProRule annotationAdd BLAST240

Sequence similaritiesi

Belongs to the peptidase S1 family. Elastase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
InParanoidiO19023

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

O19023-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
VASGYGPPSS HPSSRVVNGE DAVPYSWPWQ VSLQYEKNGS FHHTCGGSLI
60 70 80 90 100
APDWVVTAGH CISSSLTYQV ALGDYNLAVK EGPEQVIPIN SGDLFVHPLW
110 120 130 140 150
NRLCVACGND IALIKLSRSA QLGDAVQLAS LPPAGDILPN ETPCYITGWG
160 170 180 190 200
RLYTNGPLPD KLQRALLPVV DYEHCSKWNW WGSTVKKTMV CAGGDIRSGC
210 220 230 240 250
NGDSGGPLNC PTDDGGWQVH GVTSFVSSFG CNTQRKPTVF TRVSAFIDWI

EETIASH
Length:257
Mass (Da):27,687
Last modified:January 1, 1998 - v1
Checksum:i4D443DB67233D8DC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei2571

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000067 mRNA Translation: CAA03899.1
UniGeneiMmu.3417

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ000067 mRNA Translation: CAA03899.1
UniGeneiMmu.3417

3D structure databases

ProteinModelPortaliO19023
SMRiO19023
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000005184

Protein family/group databases

MEROPSiS01.154

Proteomic databases

PRIDEiO19023

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
InParanoidiO19023

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCEL3B_MACMU
AccessioniPrimary (citable) accession number: O19023
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
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