UniProtKB - O19011 (TGFB1_HORSE)
Transforming growth factor beta-1 proprotein
TGFB1
Functioni
GO - Molecular functioni
- antigen binding Source: AgBase
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
- protein serine/threonine kinase activator activity Source: Ensembl
- type III transforming growth factor beta receptor binding Source: AgBase
- type II transforming growth factor beta receptor binding Source: UniProtKB
- type I transforming growth factor beta receptor binding Source: AgBase
GO - Biological processi
- adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains Source: Ensembl
- aortic valve morphogenesis Source: Ensembl
- ATP biosynthetic process Source: UniProtKB
- BMP signaling pathway Source: GO_Central
- branch elongation involved in mammary gland duct branching Source: Ensembl
- cell-cell junction organization Source: UniProtKB
- cell cycle arrest Source: UniProtKB
- cell migration Source: UniProtKB
- cellular calcium ion homeostasis Source: Ensembl
- cellular response to organic cyclic compound Source: UniProtKB
- cellular response to transforming growth factor beta stimulus Source: AgBase
- chondrocyte differentiation Source: UniProtKB
- common-partner SMAD protein phosphorylation Source: UniProtKB
- embryonic liver development Source: Ensembl
- endoderm development Source: Ensembl
- epidermal growth factor receptor signaling pathway Source: UniProtKB
- epithelial to mesenchymal transition Source: UniProtKB
- extracellular matrix assembly Source: UniProtKB
- extrinsic apoptotic signaling pathway Source: BHF-UCL
- face morphogenesis Source: Ensembl
- germ cell migration Source: Ensembl
- hematopoietic progenitor cell differentiation Source: UniProtKB
- hyaluronan catabolic process Source: UniProtKB
- inflammatory response Source: AgBase
- lens fiber cell differentiation Source: Ensembl
- lipopolysaccharide-mediated signaling pathway Source: UniProtKB
- lymph node development Source: Ensembl
- mammary gland branching involved in thelarche Source: Ensembl
- MAPK cascade Source: UniProtKB
- membrane protein intracellular domain proteolysis Source: UniProtKB
- mitotic cell cycle checkpoint Source: UniProtKB
- mononuclear cell proliferation Source: Ensembl
- muscle cell cellular homeostasis Source: Ensembl
- myeloid dendritic cell differentiation Source: Ensembl
- negative regulation of biomineral tissue development Source: Ensembl
- negative regulation of blood vessel endothelial cell migration Source: UniProtKB
- negative regulation of cell-cell adhesion Source: UniProtKB
- negative regulation of cell cycle Source: UniProtKB
- negative regulation of cell growth Source: UniProtKB
- negative regulation of cell population proliferation Source: UniProtKB
- negative regulation of epithelial cell proliferation Source: UniProtKB
- negative regulation of fat cell differentiation Source: UniProtKB
- negative regulation of gene expression Source: BHF-UCL
- negative regulation of hyaluronan biosynthetic process Source: UniProtKB
- negative regulation of interleukin-17 production Source: Ensembl
- negative regulation of macrophage cytokine production Source: AgBase
- negative regulation of mitotic cell cycle Source: UniProtKB
- negative regulation of myoblast differentiation Source: UniProtKB
- negative regulation of ossification Source: Ensembl
- negative regulation of protein phosphorylation Source: UniProtKB
- negative regulation of skeletal muscle tissue development Source: UniProtKB
- negative regulation of T cell proliferation Source: Ensembl
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- neural tube closure Source: Ensembl
- Notch signaling pathway Source: Ensembl
- oligodendrocyte development Source: Ensembl
- ossification involved in bone remodeling Source: AgBase
- osteoclast differentiation Source: Ensembl
- pathway-restricted SMAD protein phosphorylation Source: UniProtKB
- phosphate-containing compound metabolic process Source: UniProtKB
- positive regulation of blood vessel endothelial cell migration Source: UniProtKB
- positive regulation of bone mineralization Source: AgBase
- positive regulation of cell cycle arrest Source: Ensembl
- positive regulation of cell division Source: UniProtKB-KW
- positive regulation of cell migration Source: BHF-UCL
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of cellular protein metabolic process Source: UniProtKB
- positive regulation of chemotaxis Source: UniProtKB
- positive regulation of collagen biosynthetic process Source: UniProtKB
- positive regulation of epithelial to mesenchymal transition Source: UniProtKB
- positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
- positive regulation of fibroblast migration Source: UniProtKB
- positive regulation of fibroblast proliferation Source: Ensembl
- positive regulation of gene expression Source: UniProtKB
- positive regulation of histone acetylation Source: Ensembl
- positive regulation of histone deacetylation Source: Ensembl
- positive regulation of interleukin-17 production Source: UniProtKB
- positive regulation of isotype switching to IgA isotypes Source: AgBase
- positive regulation of MAP kinase activity Source: UniProtKB
- positive regulation of microglia differentiation Source: UniProtKB
- positive regulation of NAD+ ADP-ribosyltransferase activity Source: UniProtKB
- positive regulation of odontogenesis Source: Ensembl
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: UniProtKB
- positive regulation of peptidyl-serine phosphorylation Source: UniProtKB
- positive regulation of peptidyl-threonine phosphorylation Source: UniProtKB
- positive regulation of phosphatidylinositol 3-kinase activity Source: UniProtKB
- positive regulation of protein-containing complex assembly Source: UniProtKB
- positive regulation of protein dephosphorylation Source: UniProtKB
- positive regulation of protein import into nucleus Source: AgBase
- positive regulation of protein kinase B signaling Source: UniProtKB
- positive regulation of protein phosphorylation Source: UniProtKB
- positive regulation of protein secretion Source: UniProtKB
- positive regulation of receptor clustering Source: Ensembl
- positive regulation of regulatory T cell differentiation Source: Ensembl
- positive regulation of SMAD protein signal transduction Source: AgBase
- positive regulation of superoxide anion generation Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: AgBase
- positive regulation of transcription regulatory region DNA binding Source: UniProtKB
- protein export from nucleus Source: UniProtKB
- protein kinase B signaling Source: UniProtKB
- receptor catabolic process Source: UniProtKB
- regulation of actin cytoskeleton reorganization Source: Ensembl
- regulation of branching involved in mammary gland duct morphogenesis Source: Ensembl
- regulation of cartilage development Source: Ensembl
- regulation of cell population proliferation Source: GO_Central
- regulation of interleukin-23 production Source: Ensembl
- regulation of SMAD protein signal transduction Source: UniProtKB
- regulation of sodium ion transport Source: Ensembl
- regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
- regulatory T cell differentiation Source: Ensembl
- response to cholesterol Source: UniProtKB
- response to estradiol Source: UniProtKB
- response to progesterone Source: UniProtKB
- response to wounding Source: AgBase
- salivary gland morphogenesis Source: AgBase
- SMAD protein complex assembly Source: UniProtKB
- SMAD protein signal transduction Source: GO_Central
- T cell homeostasis Source: Ensembl
- tolerance induction to self antigen Source: Ensembl
- transforming growth factor beta receptor signaling pathway Source: UniProtKB
- transforming growth factor beta receptor signaling pathway involved in heart development Source: Ensembl
- ureteric bud development Source: Ensembl
- vasculogenesis Source: Ensembl
- ventricular cardiac muscle tissue morphogenesis Source: Ensembl
Keywordsi
Molecular function | Growth factor, Mitogen |
Names & Taxonomyi
Protein namesi | Recommended name: Transforming growth factor beta-1 proproteinCleaved into the following 2 chains: |
Gene namesi | Name:TGFB1 |
Organismi | Equus caballus (Horse) |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:24051, TGFB1 |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix By similarity
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- blood microparticle Source: AgBase
- extracellular matrix Source: Ensembl
- extracellular space Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Other locations
- cell surface Source: BHF-UCL
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Extracellular matrix, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | By similarityAdd BLAST | 29 | |
ChainiPRO_0000033764 | 30 – 278 | Latency-associated peptideBy similarityAdd BLAST | 249 | |
ChainiPRO_0000033765 | 279 – 390 | Transforming growth factor beta-1By similarityAdd BLAST | 112 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 33 | Interchain (with C-1359 or C-1384 in LTBP1); in inactive formBy similarity | ||
Glycosylationi | 82 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 136 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 176 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 223 | Interchain (with C-225)By similarity | ||
Disulfide bondi | 225 | Interchain (with C-223)By similarity | ||
Disulfide bondi | 285 ↔ 294 | By similarity | ||
Disulfide bondi | 293 ↔ 356 | By similarity | ||
Disulfide bondi | 322 ↔ 387 | By similarity | ||
Disulfide bondi | 326 ↔ 389 | By similarity | ||
Disulfide bondi | 355 | InterchainBy similarity |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 278 – 279 | Cleavage; by FURINBy similarity | 2 |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, GlycoproteinProteomic databases
PaxDbi | O19011 |
Expressioni
Gene expression databases
Bgeei | ENSECAG00000011671, Expressed in blood and 20 other tissues |
ExpressionAtlasi | O19011, baseline |
Interactioni
Subunit structurei
Homodimer; disulfide-linked (By similarity).
Interacts with the serine proteases, HTRA1 and HTRA3: the interaction with either inhibits TGFB1-mediated signaling. The HTRA protease activity is required for this inhibition. May interact with THSD4; this interaction may lead to sequestration by FBN1 microfibril assembly and attenuation of TGFB signaling (By similarity).
Interacts with CD109, DPT and ASPN. Latency-associated peptide: Homodimer; disulfide-linked. Latency-associated peptide:
Interacts with Transforming growth factor beta-1 (TGF-beta-1) chain; interaction is non-covalent and maintains (TGF-beta-1) in a latent state; each Latency-associated peptide (LAP) monomer interacts with TGF-beta-1 in the other monomer. Latency-associated peptide:
Interacts with LTBP1; leading to regulate activation of TGF-beta-1. Latency-associated peptide:
Interacts with LRRC32/GARP; leading to regulate activation of TGF-beta-1 on the surface of activated regulatory T-cells (Tregs).
Interacts with LRRC33/NRROS; leading to regulate activation of TGF-beta-1 in macrophages and microglia. Latency-associated peptide:
Interacts (via cell attachment site) with integrins ITGAV and ITGB6 (ITGAV:ITGB6), leading to release of the active TGF-beta-1 (By similarity). Latency-associated peptide:
Interacts with NREP; the interaction results in a decrease in TGFB1 autoinduction (By similarity). Latency-associated peptide:
Interacts with HSP90AB1; inhibits latent TGFB1 activation. Transforming growth factor beta-1: Homodimer; disulfide-linked. Transforming growth factor beta-1:
Interacts with TGF-beta receptors (TGFBR1 and TGFBR2), leading to signal transduction (By similarity).
By similarityGO - Molecular functioni
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
- type III transforming growth factor beta receptor binding Source: AgBase
- type II transforming growth factor beta receptor binding Source: UniProtKB
- type I transforming growth factor beta receptor binding Source: AgBase
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 30 – 74 | Straightjacket domainBy similarityAdd BLAST | 45 | |
Regioni | 75 – 271 | Arm domainBy similarityAdd BLAST | 197 | |
Regioni | 226 – 252 | Bowtie tailBy similarityAdd BLAST | 27 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 244 – 246 | Cell attachment siteSequence analysis | 3 |
Domaini
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
GeneTreei | ENSGT00940000160457 |
HOGENOMi | CLU_039840_0_0_1 |
InParanoidi | O19011 |
OMAi | FSAHCSC |
OrthoDBi | 643840at2759 |
TreeFami | TF318514 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR016319, TGF-beta IPR015615, TGF-beta-rel IPR003939, TGFb1 IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
PIRSFi | PIRSF001787, TGF-beta, 1 hit |
PRINTSi | PR01423, TGFBETA PR01424, TGFBETA1 |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MPPSGLRLLP LLLPLLWLLV LTPGRPAAGL STCKTIDMEL VKRKRIEAIR
60 70 80 90 100
GQILSKLRLA SPPSQGEVPP GPLPEAVLAL YNSTRAQVAG ESAETEPEPE
110 120 130 140 150
ADYYAKEVTR VLMVEKENEI YKTVETGSHS IYMFFNTSEL RAAVPDPMLL
160 170 180 190 200
SRAELRLLRL KLSVEQHVEL YQKYSNNSWR YLSNRLLTPS DSPEWLSFDV
210 220 230 240 250
TGVVRQWLSQ GGAMEGFRLS AHCSCDSKDN TLRVGINGFS SSRRGDLATI
260 270 280 290 300
DGMNRPFLLL MATPLERAQQ LHSSRHRRAL DTNYCFSSTE KNCCVRQLYI
310 320 330 340 350
DFRKDLGWKW IHEPKGYHAN FCLGPCPYIW SLDTQYSKVL ALYNQHNPGA
360 370 380 390
SAAPCCVPQV LEPLPIVYYV GRKPKVEQLS NMIVRSCKCS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 137 | T → A in AAD49431 (Ref. 2) Curated | 1 | |
Sequence conflicti | 217 | F → L in AAD49431 (Ref. 2) Curated | 1 | |
Sequence conflicti | 224 | S → P in AAD49431 (Ref. 2) Curated | 1 | |
Sequence conflicti | 286 | F → S in AAD49431 (Ref. 2) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X99438 mRNA Translation: CAA67801.1 AF175709 mRNA Translation: AAD49431.1 |
RefSeqi | NP_001075318.1, NM_001081849.1 |
Genome annotation databases
Ensembli | ENSECAT00000012048; ENSECAP00000009480; ENSECAG00000011671 |
GeneIDi | 100033900 |
KEGGi | ecb:100033900 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X99438 mRNA Translation: CAA67801.1 AF175709 mRNA Translation: AAD49431.1 |
RefSeqi | NP_001075318.1, NM_001081849.1 |
3D structure databases
SMRi | O19011 |
ModBasei | Search... |
Proteomic databases
PaxDbi | O19011 |
Genome annotation databases
Ensembli | ENSECAT00000012048; ENSECAP00000009480; ENSECAG00000011671 |
GeneIDi | 100033900 |
KEGGi | ecb:100033900 |
Organism-specific databases
CTDi | 7040 |
VGNCi | VGNC:24051, TGFB1 |
Phylogenomic databases
GeneTreei | ENSGT00940000160457 |
HOGENOMi | CLU_039840_0_0_1 |
InParanoidi | O19011 |
OMAi | FSAHCSC |
OrthoDBi | 643840at2759 |
TreeFami | TF318514 |
Gene expression databases
Bgeei | ENSECAG00000011671, Expressed in blood and 20 other tissues |
ExpressionAtlasi | O19011, baseline |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR016319, TGF-beta IPR015615, TGF-beta-rel IPR003939, TGFb1 IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
PIRSFi | PIRSF001787, TGF-beta, 1 hit |
PRINTSi | PR01423, TGFBETA PR01424, TGFBETA1 |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TGFB1_HORSE | |
Accessioni | O19011Primary (citable) accession number: O19011 Secondary accession number(s): Q9TUM8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | January 1, 1998 | |
Last modified: | December 2, 2020 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families