Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Long-wave-sensitive opsin 1

Gene

OPN1LW

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal.

GO - Molecular functioni

  • G protein-coupled photoreceptor activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Photoreceptor protein, Receptor, Retinal protein, Transducer
Biological processSensory transduction, Vision
LigandChromophore

Names & Taxonomyi

Protein namesi
Recommended name:
Long-wave-sensitive opsin 1
Alternative name(s):
Red cone photoreceptor pigment
Red-sensitive opsin
Gene namesi
Name:OPN1LW
Synonyms:RCP
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 58ExtracellularSequence analysisAdd BLAST58
Transmembranei59 – 79Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini80 – 90CytoplasmicSequence analysisAdd BLAST11
Transmembranei91 – 111Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini112 – 126ExtracellularSequence analysisAdd BLAST15
Transmembranei127 – 147Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini148 – 168CytoplasmicSequence analysisAdd BLAST21
Transmembranei169 – 189Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini190 – 219ExtracellularSequence analysisAdd BLAST30
Transmembranei220 – 240Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini241 – 269CytoplasmicSequence analysisAdd BLAST29
Transmembranei270 – 290Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini291 – 301ExtracellularSequence analysisAdd BLAST11
Transmembranei302 – 324Helical; Name=7Sequence analysisAdd BLAST23
Topological domaini325 – 364CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001977981 – 364Long-wave-sensitive opsin 1Add BLAST364

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi126 ↔ 203PROSITE-ProRule annotation
Modified residuei312N6-(retinylidene)lysineBy similarity1

Post-translational modificationi

Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO18914

Expressioni

Tissue specificityi

The three color pigments are found in the cone photoreceptor cells.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000028751

Structurei

3D structure databases

ProteinModelPortaliO18914
SMRiO18914
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOGENOMiHOG000253932
HOVERGENiHBG107442
InParanoidiO18914
KOiK04251

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001760 Opsin
IPR000378 Opsin_red/grn
IPR027430 Retinal_BS
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00238 OPSIN
PR00575 OPSINREDGRN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
PS00238 OPSIN, 1 hit

Sequencei

Sequence statusi: Complete.

O18914-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTQRWGPQRL AGGQPQAGLE ESTQASIFTY TNSNATRDPF EGPNYHIAPR
60 70 80 90 100
WVYHLTSAWM IFVVIASVFT NGLVLVATMR FKKLRHPLNW ILVNLAIADL
110 120 130 140 150
AETIIASTIS VVNQIYGYFV LGHPLCVVEG YTVSLCGITG LWSLAIISWE
160 170 180 190 200
RWLVVCKPFG NVRFDAKLAI AGIAFSWIWA AVWTAPPIFG WSRYWPHGLK
210 220 230 240 250
TSCGPDVFSG SSYPGVQSYM IVLMTTCCII PLSVIILCYL QVWLAIRAVA
260 270 280 290 300
KQQKESESTQ KAEKEVTRMV VVMVLAYCLC WGPYTFFACF AAAHPGYAFH
310 320 330 340 350
PLVAALPAYF AKSATIYNPI IYVFMNRQFR NCILQLFGKK VDDSSELSSA
360
SRTEASSVSS VSPA
Length:364
Mass (Da):40,447
Last modified:November 30, 2010 - v2
Checksum:iAE9FE6DA70286555
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti192S → G in AAB86633 (PubMed:9580985).Curated1
Sequence conflicti230I → N in AAB86633 (PubMed:9580985).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX02003750 Genomic DNA No translation available.
AF031533 mRNA Translation: AAB86633.1
RefSeqiNP_001184001.1, NM_001197072.1
UniGeneiCfa.3642

Genome annotation databases

GeneIDi403778
KEGGicfa:403778

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAEX02003750 Genomic DNA No translation available.
AF031533 mRNA Translation: AAB86633.1
RefSeqiNP_001184001.1, NM_001197072.1
UniGeneiCfa.3642

3D structure databases

ProteinModelPortaliO18914
SMRiO18914
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000028751

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiO18914

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi403778
KEGGicfa:403778

Organism-specific databases

CTDi5956

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
HOGENOMiHOG000253932
HOVERGENiHBG107442
InParanoidiO18914
KOiK04251

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001760 Opsin
IPR000378 Opsin_red/grn
IPR027430 Retinal_BS
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00238 OPSIN
PR00575 OPSINREDGRN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
PS00238 OPSIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOPSR_CANLF
AccessioniPrimary (citable) accession number: O18914
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 30, 2010
Last modified: November 7, 2018
This is version 108 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again