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UniProtKB - O18875 (SC6A8_BOVIN)
Protein
Sodium- and chloride-dependent creatine transporter 1
Gene
SLC6A8
Organism
Bos taurus (Bovine)
Status
Functioni
Required for the uptake of creatine. Plays an important role in supplying creatine to the brain via the blood-brain barrier (By similarity).
By similarityGO - Molecular functioni
- creatine:sodium symporter activity Source: InterPro
GO - Biological processi
- creatine transmembrane transport Source: UniProtKB
- neurotransmitter transport Source: InterPro
- sodium ion transmembrane transport Source: GO_Central
Keywordsi
Biological process | Ion transport, Sodium transport, Symport, Transport |
Ligand | Sodium |
Names & Taxonomyi
Protein namesi | Recommended name: Sodium- and chloride-dependent creatine transporter 1Short name: CT1 Short name: Creatine transporter 1 Alternative name(s): Solute carrier family 6 member 8 |
Gene namesi | Name:SLC6A8 |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | HostDB:ENSBTAG00000009959 |
Subcellular locationi
Other locations
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 60 | CytoplasmicSequence analysisAdd BLAST | 60 | |
Transmembranei | 61 – 81 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 82 – 87 | ExtracellularSequence analysis | 6 | |
Transmembranei | 88 – 108 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 109 – 138 | CytoplasmicSequence analysisAdd BLAST | 30 | |
Transmembranei | 139 – 159 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 160 – 230 | ExtracellularSequence analysisAdd BLAST | 71 | |
Transmembranei | 231 – 251 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 252 – 269 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 270 – 290 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 291 – 304 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 305 – 325 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 326 – 341 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 342 – 362 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 363 – 394 | ExtracellularSequence analysisAdd BLAST | 32 | |
Transmembranei | 395 – 415 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 416 – 444 | CytoplasmicSequence analysisAdd BLAST | 29 | |
Transmembranei | 445 – 465 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 466 – 479 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 480 – 500 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 501 – 520 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 521 – 541 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 542 – 560 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 561 – 581 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 582 – 635 | CytoplasmicSequence analysisAdd BLAST | 54 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000214773 | 1 – 635 | Sodium- and chloride-dependent creatine transporter 1Add BLAST | 635 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 192 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 197 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 548 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 617 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 620 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 623 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | O18875 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 27 | DisorderedSequence analysisAdd BLAST | 27 |
Sequence similaritiesi
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A8 subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3660, Eukaryota |
GeneTreei | ENSGT00940000155869 |
HOGENOMi | CLU_006855_9_5_1 |
InParanoidi | O18875 |
OMAi | MLCLMAV |
OrthoDBi | 250396at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR000175, Na/ntran_symport IPR002984, Na/ntran_symport_creatine IPR037272, SNS_sf |
PANTHERi | PTHR11616, PTHR11616, 1 hit |
Pfami | View protein in Pfam PF00209, SNF, 1 hit |
PRINTSi | PR01199, CRTTRANSPORT PR00176, NANEUSMPORT |
SUPFAMi | SSF161070, SSF161070, 1 hit |
PROSITEi | View protein in PROSITE PS00610, NA_NEUROTRAN_SYMP_1, 1 hit PS00754, NA_NEUROTRAN_SYMP_2, 1 hit PS50267, NA_NEUROTRAN_SYMP_3, 1 hit |
i Sequence
Sequence statusi: Complete.
O18875-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MANKSTENGI YSVSGEEKKG PLIAPGPDGA PAKGDGPAAL GAPGSLLAVP
60 70 80 90 100
PRETWTRQMD FIMSCVGFAV GLGNVWRFPY LCYKNGGGVF LIPYILIALI
110 120 130 140 150
GGIPIFFLEI SLGQFMKAGS INVWNICPLF KGLGYASMVI VFYCNTYYIM
160 170 180 190 200
VLAWGFYYLV KSFTTTLPWA TCGHTWNTPD CVEIFRHEDC ANATMANLTC
210 220 230 240 250
DQLADRRSPV IEFWENKVLR LSEGLEVPGA LNWEVTLCLL TCWVLVYFCV
260 270 280 290 300
WKGVKSTGKI VYFTATFPYV VLVVLLVRGV LLPGALDGII YYLKPDWSKL
310 320 330 340 350
ASPQVWIDAG TQIFFSYAIG LGALTALGSY NRFNNNCYKD AIILALINSG
360 370 380 390 400
TSFFAGFVVF SILGFMATEQ GVHISKVAES GPGLAFIAYP RAVTLMPVAP
410 420 430 440 450
LWAALFFFML LLLGLDSQFV GVEGFITGLL DLLPASYYFR FQREISVALC
460 470 480 490 500
CTICFVIDLS MVTDGGMYVF QLFDYYSASG TTLLWQAFWE CVVVAWVYGA
510 520 530 540 550
DRFMDDVACM IGYRPCPWMK WCWSFFTPLV CMGIFIFNVV YHEPLVYNNT
560 570 580 590 600
YVYPWWGEAV GWAFALSSML CVPLHLLGCL LRAKGTMAER WQHLTQPIWG
610 620 630
LHHLEYRAQD SDVRGLTTLT PVSESSKVVV VESVM
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF027197 mRNA Translation: AAB84029.1 |
RefSeqi | NP_777036.1, NM_174611.2 |
Genome annotation databases
Ensembli | ENSBTAT00000013141; ENSBTAP00000013141; ENSBTAG00000009959 |
GeneIDi | 282367 |
KEGGi | bta:282367 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF027197 mRNA Translation: AAB84029.1 |
RefSeqi | NP_777036.1, NM_174611.2 |
3D structure databases
SMRi | O18875 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000013141 |
Proteomic databases
PaxDbi | O18875 |
Genome annotation databases
Ensembli | ENSBTAT00000013141; ENSBTAP00000013141; ENSBTAG00000009959 |
GeneIDi | 282367 |
KEGGi | bta:282367 |
Organism-specific databases
CTDi | 6535 |
VEuPathDBi | HostDB:ENSBTAG00000009959 |
Phylogenomic databases
eggNOGi | KOG3660, Eukaryota |
GeneTreei | ENSGT00940000155869 |
HOGENOMi | CLU_006855_9_5_1 |
InParanoidi | O18875 |
OMAi | MLCLMAV |
OrthoDBi | 250396at2759 |
Gene expression databases
ExpressionAtlasi | O18875, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000175, Na/ntran_symport IPR002984, Na/ntran_symport_creatine IPR037272, SNS_sf |
PANTHERi | PTHR11616, PTHR11616, 1 hit |
Pfami | View protein in Pfam PF00209, SNF, 1 hit |
PRINTSi | PR01199, CRTTRANSPORT PR00176, NANEUSMPORT |
SUPFAMi | SSF161070, SSF161070, 1 hit |
PROSITEi | View protein in PROSITE PS00610, NA_NEUROTRAN_SYMP_1, 1 hit PS00754, NA_NEUROTRAN_SYMP_2, 1 hit PS50267, NA_NEUROTRAN_SYMP_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SC6A8_BOVIN | |
Accessioni | O18875Primary (citable) accession number: O18875 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | January 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 115 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families