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Protein

Sodium- and chloride-dependent creatine transporter 1

Gene

SLC6A8

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for the uptake of creatine. Plays an important role in supplying creatine to the brain via the blood-brain barrier (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandSodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium- and chloride-dependent creatine transporter 1
Short name:
CT1
Short name:
Creatine transporter 1
Alternative name(s):
Solute carrier family 6 member 8
Gene namesi
Name:SLC6A8
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 60CytoplasmicSequence analysisAdd BLAST60
Transmembranei61 – 81HelicalSequence analysisAdd BLAST21
Topological domaini82 – 87ExtracellularSequence analysis6
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109 – 138CytoplasmicSequence analysisAdd BLAST30
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Topological domaini160 – 230ExtracellularSequence analysisAdd BLAST71
Transmembranei231 – 251HelicalSequence analysisAdd BLAST21
Topological domaini252 – 269CytoplasmicSequence analysisAdd BLAST18
Transmembranei270 – 290HelicalSequence analysisAdd BLAST21
Topological domaini291 – 304ExtracellularSequence analysisAdd BLAST14
Transmembranei305 – 325HelicalSequence analysisAdd BLAST21
Topological domaini326 – 341CytoplasmicSequence analysisAdd BLAST16
Transmembranei342 – 362HelicalSequence analysisAdd BLAST21
Topological domaini363 – 394ExtracellularSequence analysisAdd BLAST32
Transmembranei395 – 415HelicalSequence analysisAdd BLAST21
Topological domaini416 – 444CytoplasmicSequence analysisAdd BLAST29
Transmembranei445 – 465HelicalSequence analysisAdd BLAST21
Topological domaini466 – 479ExtracellularSequence analysisAdd BLAST14
Transmembranei480 – 500HelicalSequence analysisAdd BLAST21
Topological domaini501 – 520CytoplasmicSequence analysisAdd BLAST20
Transmembranei521 – 541HelicalSequence analysisAdd BLAST21
Topological domaini542 – 560ExtracellularSequence analysisAdd BLAST19
Transmembranei561 – 581HelicalSequence analysisAdd BLAST21
Topological domaini582 – 635CytoplasmicSequence analysisAdd BLAST54

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002147731 – 635Sodium- and chloride-dependent creatine transporter 1Add BLAST635

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi197N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi548N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei617PhosphothreonineBy similarity1
Modified residuei620PhosphothreonineBy similarity1
Modified residuei623PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiO18875
PRIDEiO18875

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000013141

Structurei

3D structure databases

ProteinModelPortaliO18875
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3659 Eukaryota
COG0733 LUCA
HOGENOMiHOG000116406
HOVERGENiHBG071421
InParanoidiO18875
KOiK05039

Family and domain databases

InterProiView protein in InterPro
IPR000175 Na/ntran_symport
IPR002984 Na/ntran_symport_creatine
IPR037272 SNS_sf
PANTHERiPTHR11616 PTHR11616, 1 hit
PfamiView protein in Pfam
PF00209 SNF, 1 hit
PRINTSiPR01199 CRTTRANSPORT
PR00176 NANEUSMPORT
SUPFAMiSSF161070 SSF161070, 2 hits
PROSITEiView protein in PROSITE
PS00610 NA_NEUROTRAN_SYMP_1, 1 hit
PS00754 NA_NEUROTRAN_SYMP_2, 1 hit
PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

Sequencei

Sequence statusi: Complete.

O18875-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANKSTENGI YSVSGEEKKG PLIAPGPDGA PAKGDGPAAL GAPGSLLAVP
60 70 80 90 100
PRETWTRQMD FIMSCVGFAV GLGNVWRFPY LCYKNGGGVF LIPYILIALI
110 120 130 140 150
GGIPIFFLEI SLGQFMKAGS INVWNICPLF KGLGYASMVI VFYCNTYYIM
160 170 180 190 200
VLAWGFYYLV KSFTTTLPWA TCGHTWNTPD CVEIFRHEDC ANATMANLTC
210 220 230 240 250
DQLADRRSPV IEFWENKVLR LSEGLEVPGA LNWEVTLCLL TCWVLVYFCV
260 270 280 290 300
WKGVKSTGKI VYFTATFPYV VLVVLLVRGV LLPGALDGII YYLKPDWSKL
310 320 330 340 350
ASPQVWIDAG TQIFFSYAIG LGALTALGSY NRFNNNCYKD AIILALINSG
360 370 380 390 400
TSFFAGFVVF SILGFMATEQ GVHISKVAES GPGLAFIAYP RAVTLMPVAP
410 420 430 440 450
LWAALFFFML LLLGLDSQFV GVEGFITGLL DLLPASYYFR FQREISVALC
460 470 480 490 500
CTICFVIDLS MVTDGGMYVF QLFDYYSASG TTLLWQAFWE CVVVAWVYGA
510 520 530 540 550
DRFMDDVACM IGYRPCPWMK WCWSFFTPLV CMGIFIFNVV YHEPLVYNNT
560 570 580 590 600
YVYPWWGEAV GWAFALSSML CVPLHLLGCL LRAKGTMAER WQHLTQPIWG
610 620 630
LHHLEYRAQD SDVRGLTTLT PVSESSKVVV VESVM
Length:635
Mass (Da):70,676
Last modified:January 1, 1998 - v1
Checksum:i6DE9A04790FE4825
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027197 mRNA Translation: AAB84029.1
RefSeqiNP_777036.1, NM_174611.2
UniGeneiBt.88817

Genome annotation databases

GeneIDi282367
KEGGibta:282367

Similar proteinsi

Entry informationi

Entry nameiSC6A8_BOVIN
AccessioniPrimary (citable) accession number: O18875
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: April 25, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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