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Protein

Major allergen Can f 1

Gene
N/A
Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Major allergen Can f 1
Alternative name(s):
Allergen Dog 1
Allergen: Can f 1
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei174 Can f 1
3169 Can f 1.0101

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001798019 – 174Major allergen Can f 1Add BLAST156

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi78 ↔ 169By similarity
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO18873

Expressioni

Tissue specificityi

Tongue epithelial tissue.

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000029242

Structurei

3D structure databases

ProteinModelPortaliO18873
SMRiO18873
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calycin superfamily. Lipocalin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1KM Eukaryota
ENOG4111BH9 LUCA
HOGENOMiHOG000231562
HOVERGENiHBG101411

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR002345 Lipocalin
IPR000566 Lipocln_cytosolic_FA-bd_dom
IPR002450 von_Ebner_gland
PANTHERiPTHR11430 PTHR11430, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR01175 VNEBNERGLAND
SUPFAMiSSF50814 SSF50814, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O18873-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTLLLTIGF SLIAILQAQD TPALGKDTVA VSGKWYLKAM TADQEVPEKP
60 70 80 90 100
DSVTPMILKA QKGGNLEAKI TMLTNGQCQN ITVVLHKTSE PGKYTAYEGQ
110 120 130 140 150
RVVFIQPSPV RDHYILYCEG ELHGRQIRMA KLLGRDPEQS QEALEDFREF
160 170
SRAKGLNQEI LELAQSETCS PGGQ
Length:174
Mass (Da):19,248
Last modified:January 1, 1998 - v1
Checksum:i091A3025660806D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027177 mRNA Translation: AAC48794.1
RefSeqiNP_001003190.1, NM_001003190.1
UniGeneiCfa.3693

Genome annotation databases

GeneIDi403830
KEGGicfa:403830

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF027177 mRNA Translation: AAC48794.1
RefSeqiNP_001003190.1, NM_001003190.1
UniGeneiCfa.3693

3D structure databases

ProteinModelPortaliO18873
SMRiO18873
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000029242

Protein family/group databases

Allergomei174 Can f 1
3169 Can f 1.0101

Proteomic databases

PaxDbiO18873

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi403830
KEGGicfa:403830

Organism-specific databases

CTDi29989

Phylogenomic databases

eggNOGiENOG410J1KM Eukaryota
ENOG4111BH9 LUCA
HOGENOMiHOG000231562
HOVERGENiHBG101411

Family and domain databases

Gene3Di2.40.128.20, 1 hit
InterProiView protein in InterPro
IPR012674 Calycin
IPR002345 Lipocalin
IPR000566 Lipocln_cytosolic_FA-bd_dom
IPR002450 von_Ebner_gland
PANTHERiPTHR11430 PTHR11430, 1 hit
PfamiView protein in Pfam
PF00061 Lipocalin, 1 hit
PRINTSiPR01175 VNEBNERGLAND
SUPFAMiSSF50814 SSF50814, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiALL1_CANLF
AccessioniPrimary (citable) accession number: O18873
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: February 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Allergens
    Nomenclature of allergens and list of entries
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