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Protein

Metallothionein

Gene
N/A
Organism
Balaena mysticetus (Bowhead whale)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Metallothioneins have a high content of cysteine residues that bind various heavy metals.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi5Divalent metal cation; cluster BBy similarity1
Metal bindingi7Divalent metal cation; cluster BBy similarity1
Metal bindingi13Divalent metal cation; cluster BBy similarity1
Metal bindingi15Divalent metal cation; cluster BBy similarity1
Metal bindingi19Divalent metal cation; cluster BBy similarity1
Metal bindingi21Divalent metal cation; cluster BBy similarity1
Metal bindingi24Divalent metal cation; cluster BBy similarity1
Metal bindingi26Divalent metal cation; cluster BBy similarity1
Metal bindingi29Divalent metal cation; cluster BBy similarity1
Metal bindingi33Divalent metal cation; cluster ABy similarity1
Metal bindingi34Divalent metal cation; cluster ABy similarity1
Metal bindingi36Divalent metal cation; cluster ABy similarity1
Metal bindingi37Divalent metal cation; cluster ABy similarity1
Metal bindingi41Divalent metal cation; cluster ABy similarity1
Metal bindingi44Divalent metal cation; cluster ABy similarity1
Metal bindingi48Divalent metal cation; cluster ABy similarity1
Metal bindingi50Divalent metal cation; cluster ABy similarity1
Metal bindingi57Divalent metal cation; cluster ABy similarity1
Metal bindingi59Divalent metal cation; cluster ABy similarity1
Metal bindingi60Divalent metal cation; cluster ABy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Metal-thiolate cluster

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein
Short name:
MT
OrganismiBalaena mysticetus (Bowhead whale)
Taxonomic identifieri27602 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaCetaceaMysticetiBalaenidaeBalaena

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001972571 – 61MetallothioneinAdd BLAST61

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiO18842

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliO18842
SMRiO18842
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 29BetaAdd BLAST29
Regioni30 – 61AlphaAdd BLAST32

Domaini

Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG009063

Family and domain databases

Gene3Di4.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003019 Metalthion
IPR017854 Metalthion_dom_sf
IPR023587 Metalthion_dom_sf_vert
IPR000006 Metalthion_vert
IPR018064 Metalthion_vert_metal_BS
PANTHERiPTHR23299 PTHR23299, 1 hit
PfamiView protein in Pfam
PF00131 Metallothio, 1 hit
PRINTSiPR00860 MTVERTEBRATE
SUPFAMiSSF57868 SSF57868, 1 hit
PROSITEiView protein in PROSITE
PS00203 METALLOTHIONEIN_VRT, 1 hit

Sequencei

Sequence statusi: Complete.

O18842-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPNCSCAAG GSCTCAGSCK CKECKCTSCK KSCCSCCPPG CTKCAQGCVC
60
KGASDKCNCC A
Length:61
Mass (Da):6,025
Last modified:January 1, 1998 - v1
Checksum:i4D0A7C5E1D23A4A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022117 mRNA Translation: AAB72006.1

Similar proteinsi

Entry informationi

Entry nameiMT_BALMY
AccessioniPrimary (citable) accession number: O18842
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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