UniProtKB - O18840 (ACTB_CANLF)
Actin, cytoplasmic 1
ACTB
Functioni
Miscellaneous
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein kinase binding Source: GO_Central
- structural constituent of postsynaptic actin cytoskeleton Source: GO_Central
GO - Biological processi
- axonogenesis Source: GO_Central
- cell motility Source: GO_Central
Keywordsi
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-CFA-190873, Gap junction degradation R-CFA-196025, Formation of annular gap junctions R-CFA-2029482, Regulation of actin dynamics for phagocytic cup formation R-CFA-3928662, EPHB-mediated forward signaling R-CFA-3928665, EPH-ephrin mediated repulsion of cells R-CFA-4420097, VEGFA-VEGFR2 Pathway R-CFA-446353, Cell-extracellular matrix interactions R-CFA-5250924, B-WICH complex positively regulates rRNA expression R-CFA-5626467, RHO GTPases activate IQGAPs R-CFA-5663213, RHO GTPases Activate WASPs and WAVEs R-CFA-5674135, MAP2K and MAPK activation R-CFA-5689603, UCH proteinases R-CFA-5696394, DNA Damage Recognition in GG-NER R-CFA-8856828, Clathrin-mediated endocytosis |
Names & Taxonomyi
Protein namesi | Recommended name: Actin, cytoplasmic 1Alternative name(s): Beta-actin Cleaved into the following chain: |
Gene namesi | Name:ACTB |
Organismi | Canis lupus familiaris (Dog) (Canis familiaris) |
Taxonomic identifieri | 9615 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Caniformia › Canidae › Canis › |
Proteomesi |
|
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytoskeleton
- cytoskeleton By similarity
Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs.By similarity
Cytoskeleton
- actin cytoskeleton Source: UniProtKB
- actin filament Source: GO_Central
- cytoskeleton Source: AgBase
Nucleus
- NuA4 histone acetyltransferase complex Source: GO_Central
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: AgBase
Other locations
- axon Source: GO_Central
- cytoplasm Source: GO_Central
- dense body Source: AgBase
- focal adhesion Source: AgBase
- membrane Source: GO_Central
- protein-containing complex Source: UniProtKB
- synapse Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000000761 | 1 – 375 | Actin, cytoplasmic 1Add BLAST | 375 | |
Initiator methioninei | Removed; alternateBy similarity | |||
ChainiPRO_0000367068 | 2 – 375 | Actin, cytoplasmic 1, N-terminally processedAdd BLAST | 374 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 2 | N-acetylaspartate; in Actin, cytoplasmic 1, N-terminally processedBy similarity | 1 | |
Modified residuei | 44 | Methionine (R)-sulfoxideBy similarity | 1 | |
Modified residuei | 47 | Methionine (R)-sulfoxideBy similarity | 1 | |
Modified residuei | 73 | Tele-methylhistidineBy similarity | 1 | |
Modified residuei | 84 | N6-methyllysineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Methylation, Oxidation, Ubl conjugationProteomic databases
PaxDbi | O18840 |
PRIDEi | O18840 |
Expressioni
Gene expression databases
Bgeei | ENSCAFG00000016020, Expressed in lymph node and 51 other tissues |
Interactioni
Subunit structurei
Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.
Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs.
Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57 SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3.
Found in a complex with XPO6, Ran, ACTB and PFN1.
Interacts with XPO6 and EMD.
Interacts with ERBB2.
Interacts with GCSAM (By similarity).
Interacts with TBC1D21.
Interacts with CPNE1 (via VWFA domain) and CPNE4 (via VWFA domain) (By similarity).
Interacts with DHX9 (via C-terminus); this interaction is direct and mediates the attachment to nuclear ribonucleoprotein complexes.
Interacts with FAM107A (By similarity).
By similarityGO - Molecular functioni
- protein kinase binding Source: GO_Central
Protein-protein interaction databases
IntActi | O18840, 1 interactor |
MINTi | O18840 |
STRINGi | 9612.ENSCAFP00000023597 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0676, Eukaryota |
HOGENOMi | CLU_027965_0_2_1 |
InParanoidi | O18840 |
OMAi | FHTTAER |
OrthoDBi | 649708at2759 |
TreeFami | TF354237 |
Family and domain databases
InterProi | View protein in InterPro IPR004000, Actin IPR020902, Actin/actin-like_CS IPR004001, Actin_CS IPR043129, ATPase_NBD |
PANTHERi | PTHR11937, PTHR11937, 1 hit |
Pfami | View protein in Pfam PF00022, Actin, 1 hit |
PRINTSi | PR00190, ACTIN |
SMARTi | View protein in SMART SM00268, ACTIN, 1 hit |
SUPFAMi | SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00406, ACTINS_1, 1 hit PS00432, ACTINS_2, 1 hit PS01132, ACTINS_ACT_LIKE, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MDDDIAALVV DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH QGVMVGMGQK
60 70 80 90 100
DSYVGDEAQS KRGILTLKYP IEHGIVTNWD DMEKIWHHTF YNELRVAPEE
110 120 130 140 150
HPVLLTEAPL NPKANREKMT QIMFETFNTP AMYVAIQAVL SLYASGRTTG
160 170 180 190 200
IVMDSGDGVT HTVPIYEGYA LPHAILRLDL AGRDLTDYLM KILTERGYSF
210 220 230 240 250
TTTAEREIVR DIKEKLCYVA LDFEQEMATA ASSSSLEKSY ELPDGQVITI
260 270 280 290 300
GNERFRCPEA LFQPSFLGME SCGIHETTFN SIMKCDVDIR KDLYANTVLS
310 320 330 340 350
GGTTMYPGIA DRMQKEITAL APSTMKIKII APPERKYSVW IGGSILASLS
360 370
TFQQMWISKQ EYDESGPSIV HRKCF
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 4 | D → E in AAB71610 (Ref. 1) Curated | 1 | |
Sequence conflicti | 46 | G → R in AAB71610 (Ref. 1) Curated | 1 | |
Sequence conflicti | 101 | H → A in AAB71610 (Ref. 1) Curated | 1 | |
Sequence conflicti | 131 | A → T in CAA93907 (Ref. 3) Curated | 1 | |
Sequence conflicti | 215 – 230 | KLCYV…EMATA → EALLRRPGLRAGDGHG in AAB71610 (Ref. 1) CuratedAdd BLAST | 16 | |
Sequence conflicti | 259 | E → K in AAB71610 (Ref. 1) Curated | 1 | |
Sequence conflicti | 323 – 324 | ST → AR in AAB71610 (Ref. 1) Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF021873 mRNA Translation: AAB71610.2 AF484115 mRNA Translation: AAL92020.1 Z70044 mRNA Translation: CAA93907.1 U67202 mRNA Translation: AAC48640.1 |
RefSeqi | NP_001182774.2, NM_001195845.2 |
Genome annotation databases
Ensembli | ENSCAFT00030028371; ENSCAFP00030024748; ENSCAFG00030015381 ENSCAFT00040028964; ENSCAFP00040025226; ENSCAFG00040015695 |
GeneIDi | 403580 |
KEGGi | cfa:403580 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF021873 mRNA Translation: AAB71610.2 AF484115 mRNA Translation: AAL92020.1 Z70044 mRNA Translation: CAA93907.1 U67202 mRNA Translation: AAC48640.1 |
RefSeqi | NP_001182774.2, NM_001195845.2 |
3D structure databases
SMRi | O18840 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | O18840, 1 interactor |
MINTi | O18840 |
STRINGi | 9612.ENSCAFP00000023597 |
Proteomic databases
PaxDbi | O18840 |
PRIDEi | O18840 |
Genome annotation databases
Ensembli | ENSCAFT00030028371; ENSCAFP00030024748; ENSCAFG00030015381 ENSCAFT00040028964; ENSCAFP00040025226; ENSCAFG00040015695 |
GeneIDi | 403580 |
KEGGi | cfa:403580 |
Organism-specific databases
CTDi | 60 |
Phylogenomic databases
eggNOGi | KOG0676, Eukaryota |
HOGENOMi | CLU_027965_0_2_1 |
InParanoidi | O18840 |
OMAi | FHTTAER |
OrthoDBi | 649708at2759 |
TreeFami | TF354237 |
Enzyme and pathway databases
Reactomei | R-CFA-190873, Gap junction degradation R-CFA-196025, Formation of annular gap junctions R-CFA-2029482, Regulation of actin dynamics for phagocytic cup formation R-CFA-3928662, EPHB-mediated forward signaling R-CFA-3928665, EPH-ephrin mediated repulsion of cells R-CFA-4420097, VEGFA-VEGFR2 Pathway R-CFA-446353, Cell-extracellular matrix interactions R-CFA-5250924, B-WICH complex positively regulates rRNA expression R-CFA-5626467, RHO GTPases activate IQGAPs R-CFA-5663213, RHO GTPases Activate WASPs and WAVEs R-CFA-5674135, MAP2K and MAPK activation R-CFA-5689603, UCH proteinases R-CFA-5696394, DNA Damage Recognition in GG-NER R-CFA-8856828, Clathrin-mediated endocytosis |
Gene expression databases
Bgeei | ENSCAFG00000016020, Expressed in lymph node and 51 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR004000, Actin IPR020902, Actin/actin-like_CS IPR004001, Actin_CS IPR043129, ATPase_NBD |
PANTHERi | PTHR11937, PTHR11937, 1 hit |
Pfami | View protein in Pfam PF00022, Actin, 1 hit |
PRINTSi | PR00190, ACTIN |
SMARTi | View protein in SMART SM00268, ACTIN, 1 hit |
SUPFAMi | SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00406, ACTINS_1, 1 hit PS00432, ACTINS_2, 1 hit PS01132, ACTINS_ACT_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ACTB_CANLF | |
Accessioni | O18840Primary (citable) accession number: O18840 Secondary accession number(s): Q11209, Q8SPX4, Q95164 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2005 |
Last sequence update: | November 13, 2007 | |
Last modified: | February 10, 2021 | |
This is version 159 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families