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Entry version 113 (07 Oct 2020)
Sequence version 1 (01 Jan 1998)
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Protein

Coagulation factor VIII

Gene

F8

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAcute phase, Blood coagulation, Hemostasis
LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coagulation factor VIII
Alternative name(s):
Procoagulant component
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:F8
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9615 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002254 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000296620 – 2343Coagulation factor VIIIAdd BLAST2324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi233N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi253N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei359SulfotyrosineBy similarity1
Modified residuei408SulfotyrosineBy similarity1
Glycosylationi595N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei731SulfotyrosineBy similarity1
Modified residuei732SulfotyrosineBy similarity1
Modified residuei736SulfotyrosineBy similarity1
Glycosylationi877N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi921N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi937N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi938N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi956N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1007N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1019N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1037N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1062N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1069N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1080N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1179N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1193N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1275N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1290N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1308N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1341N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1391N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1419N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1429N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1453N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1547N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1618N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1675SulfotyrosineBy similarity1
Modified residuei1691SulfotyrosineBy similarity1
Glycosylationi1821N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi2032 ↔ 2180PROSITE-ProRule annotation
Glycosylationi2129N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2185 ↔ 2337PROSITE-ProRule annotation
Glycosylationi2281N-linked (GlcNAc...) asparagineSequence analysis1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei385 – 386Cleavage; by thrombinBy similarity2
Sitei753 – 754Cleavage; by thrombinBy similarity2
Sitei1320 – 1321Cleavage (activation)By similarity2
Sitei1659 – 1660Cleavage (activation)By similarity2
Sitei1700 – 1701Cleavage; by thrombinBy similarity2

Keywords - PTMi

Disulfide bond, Glycoprotein, Sulfation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O18806

PRoteomics IDEntifications database

More...
PRIDEi
O18806

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with vWF. vWF binding is essential for the stabilization of F8 in circulation (By similarity).

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9612.ENSCAFP00000029035

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 343F5/8 type A 1Add BLAST324
Domaini20 – 199Plastocyanin-like 1Add BLAST180
Domaini207 – 343Plastocyanin-like 2Add BLAST137
Domaini393 – 724F5/8 type A 2Add BLAST332
Domaini393 – 567Plastocyanin-like 3Add BLAST175
Domaini577 – 724Plastocyanin-like 4Add BLAST148
Domaini1705 – 2032F5/8 type A 3Add BLAST328
Domaini1705 – 1869Plastocyanin-like 5Add BLAST165
Domaini1879 – 2032Plastocyanin-like 6Add BLAST154
Domaini2032 – 2180F5/8 type C 1PROSITE-ProRule annotationAdd BLAST149
Domaini2185 – 2337F5/8 type C 2PROSITE-ProRule annotationAdd BLAST153

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni754 – 1659BAdd BLAST906

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QSFZ, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O18806

KEGG Orthology (KO)

More...
KOi
K03899

Database of Orthologous Groups

More...
OrthoDBi
454773at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00057, FA58C, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.260, 2 hits
2.60.40.420, 6 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001117, Cu-oxidase
IPR011706, Cu-oxidase_2
IPR011707, Cu-oxidase_3
IPR033138, Cu_oxidase_CS
IPR008972, Cupredoxin
IPR000421, FA58C
IPR024715, Factor_5/8-like
IPR014707, Factor_8
IPR008979, Galactose-bd-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR24543:SF249, PTHR24543:SF249, 5 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00394, Cu-oxidase, 1 hit
PF07731, Cu-oxidase_2, 1 hit
PF07732, Cu-oxidase_3, 2 hits
PF00754, F5_F8_type_C, 2 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000354, Factors_V_VIII, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00231, FA58C, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49503, SSF49503, 6 hits
SSF49785, SSF49785, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01285, FA58C_1, 2 hits
PS01286, FA58C_2, 2 hits
PS50022, FA58C_3, 2 hits
PS00079, MULTICOPPER_OXIDASE1, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

O18806-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQVELYTCCF LCLLPFSLSA TRKYYLGAVE LSWDYMQSDL LSALHADTSF
60 70 80 90 100
SSRVPGSLPL TTSVTYRKTV FVEFTDDLFN IAKPRPPWMG LLGPTIQAEV
110 120 130 140 150
YDTVVIVLKN MASHPVSLHA VGVSYWKASE GAEYEDQTSQ KEKEDDNVIP
160 170 180 190 200
GESHTYVWQV LKENGPMASD PPCLTYSYFS HVDLVKDLNS GLIGALLVCK
210 220 230 240 250
EGSLAKERTQ TLQEFVLLFA VFDEGKSWHS ETNASLTQAE AQHELHTING
260 270 280 290 300
YVNRSLPGLT VCHKRSVYWH VIGMGTTPEV HSIFLEGHTF LVRNHRQASL
310 320 330 340 350
EISPITFLTA QTFLMDLGQF LLFCHIPSHQ HDGMEAYVKV DSCPEEPQLR
360 370 380 390 400
MKNNEDKDYD DGLYDSDMDV VSFDDDSSSP FIQIRSVAKK HPKTWVHYIA
410 420 430 440 450
AEEEDWDYAP SGPTPNDRSH KNLYLNNGPQ RIGKKYKKVR FVAYTDETFK
460 470 480 490 500
TREAIQYESG ILGPLLYGEV GDTLLIIFKN QASRPYNIYP HGINYVTPLH
510 520 530 540 550
TGRLPKGVKH LKDMPILPGE IFKYKWTVTV EDGPTKSDPR CLTRYYSSFI
560 570 580 590 600
NLERDLASGL IGPLLICYKE SVDQRGNQMM SDKRNVILFS VFDENRSWYL
610 620 630 640 650
TENMQRFLPN ADVVQPHDPE FQLSNIMHSI NGYVFDNLQL SVCLHEVAYW
660 670 680 690 700
YILSVGAQTD FLSVFFSGYT FKHKMVYEDT LTLFPFSGET VFMSMENPGL
710 720 730 740 750
WVLGCHNSDF RNRGMTALLK VSSCNRNIDD YYEDTYEDIP TPLLNENNVI
760 770 780 790 800
KPRSFSQNSR HPSTKEKQLK ATTTPENDIE KIDLQSGERT QLIKAQSVSS
810 820 830 840 850
SDLLMLLGQN PTPRGLFLSD LREATDRADD HSRGAIERNK GPPEVASLRP
860 870 880 890 900
ELRHSEDREF TPEPELQLRL NENLGTNTTV ELKKLDLKIS SSSDSLMTSP
910 920 930 940 950
TIPSDKLAAA TEKTGSLGPP NMSVHFNSHL GTIVFGNNSS HLIQSGVPLE
960 970 980 990 1000
LSEEDNDSKL LEAPLMNIQE SSLRENVLSM ESNRLFKEER IRGPASLIKD
1010 1020 1030 1040 1050
NALFKVNISS VKTNRAPVNL TTNRKTRVAI PTLLIENSTS VWQDIMLERN
1060 1070 1080 1090 1100
TEFKEVTSLI HNETFMDRNT TALGLNHVSN KTTLSKNVEM AHQKKEDPVP
1110 1120 1130 1140 1150
LRAENPDLSS SKIPFLPDWI KTHGKNSLSS EQRPSPKQLT SLGSEKSVKD
1160 1170 1180 1190 1200
QNFLSEEKVV VGEDEFTKDT ELQEIFPNNK SIFFANLANV QENDTYNQEK
1210 1220 1230 1240 1250
KSPEEIERKE KLTQENVALP QAHTMIGTKN FLKNLFLLST KQNVAGLEEQ
1260 1270 1280 1290 1300
PYTPILQDTR SLNDSPHSEG IHMANFSKIR EEANLEGLGN QTNQMVERFP
1310 1320 1330 1340 1350
STTRMSSNAS QHVITQRGKR SLKQPRLSQG EIKFERKVIA NDTSTQWSKN
1360 1370 1380 1390 1400
MNYLAQGTLT QIEYNEKEKR AITQSPLSDC SMRNHVTIQM NDSALPVAKE
1410 1420 1430 1440 1450
SASPSVRHTD LTKIPSQHNS SHLPASACNY TFRERTSGVQ EGSHFLQEAK
1460 1470 1480 1490 1500
RNNLSLAFVT LGITEGQGKF SSLGKSATNQ PMYKKLENTV LLQPGLSETS
1510 1520 1530 1540 1550
DKVELLSQVH VDQEDSFPTK TSNDSPGHLD LMGKIFLQKT QGPVKMNKTN
1560 1570 1580 1590 1600
SPGKVPFLKW ATESSEKIPS KLLGVLAWDN HYDTQIPSEE WKSQKKSQTN
1610 1620 1630 1640 1650
TAFKRKDTIL PLGPCENNDS TAAINEGQDK PQREAMWAKQ GEPGRLCSQN
1660 1670 1680 1690 1700
PPVSKHHQRE ITVTTLQPEE DKFEYDDTFS IEMKREDFDI YGDYENQGLR
1710 1720 1730 1740 1750
SFQKKTRHYF IAAVERLWDY GMSRSPHILR NRAQSGDVQQ FKKVVFQEFT
1760 1770 1780 1790 1800
DGSFTQPLYR GELNEHLGLL GPYIRAEVED NIVVTFKNQA SRPYSFYSSL
1810 1820 1830 1840 1850
ISYDEDEGQG AEPRRKFVNP NETKIYFWKV QHHMAPTKDE FDCKAWAYFS
1860 1870 1880 1890 1900
DVDLEKDVHS GLIGPLLICR SNTLNPAHGR QVTVQEFALV FTIFDETKSW
1910 1920 1930 1940 1950
YFTENLERNC RAPCNVQKED PTLKENFRFH AINGYVKDTL PGLVMAQDQK
1960 1970 1980 1990 2000
VRWYLLSMGS NENIHSIHFS GHVFTVRKKE EYKMAVYNLY PGVFETVEML
2010 2020 2030 2040 2050
PSQVGIWRIE CLIGEHLQAG MSTLFLVYSK KCQTPLGMAS GHIRDFQITA
2060 2070 2080 2090 2100
SGQYGQWAPK LARLHYSGSI NAWSTKDPFS WIKVDLLAPM IIHGIMTQGA
2110 2120 2130 2140 2150
RQKFSSLYVS QFIIMYSLDG NKWHSYRGNS TGTLMVFFGN VDSSGIKHNI
2160 2170 2180 2190 2200
FNPPIIAQYI RLHPTHYSIR STLRMELLGC DFNSCSMPLG MESKAISDAQ
2210 2220 2230 2240 2250
ITASSYLSSM LATWSPSQAR LHLQGRTNAW RPQANNPKEW LQVDFRKTMK
2260 2270 2280 2290 2300
VTGITTQGVK SLLISMYVKE FLISSSQDGH NWTLFLQNGK VKVFQGNRDS
2310 2320 2330 2340
STPVRNRLEP PLVARYVRLH PQSWAHHIAL RLEVLGCDTQ QPA
Length:2,343
Mass (Da):265,831
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA854FAE571C3B399
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti293R → G in AAC05384 (Ref. 2) Curated1
Sequence conflicti365D → G in AAC05384 (Ref. 2) Curated1
Sequence conflicti480N → K in AAC05384 (Ref. 2) Curated1
Sequence conflicti592F → L in AAC05384 (Ref. 2) Curated1
Sequence conflicti603N → D in AAC05384 (Ref. 2) Curated1
Sequence conflicti928S → G in AAC05384 (Ref. 2) Curated1
Sequence conflicti1203P → L in AAC05384 (Ref. 2) Curated1
Sequence conflicti1696N → D in AAC05384 (Ref. 2) Curated1
Sequence conflicti2289G → D in AAC05384 (Ref. 2) Curated1
Sequence conflicti2307R → A in AAC05384 (Ref. 2) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF016234 mRNA Translation: AAB87412.1
AF049489 mRNA Translation: AAC05384.1

NCBI Reference Sequences

More...
RefSeqi
NP_001003212.1, NM_001003212.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
403875

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cfa:403875

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016234 mRNA Translation: AAB87412.1
AF049489 mRNA Translation: AAC05384.1
RefSeqiNP_001003212.1, NM_001003212.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
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Protein-protein interaction databases

STRINGi9612.ENSCAFP00000029035

Proteomic databases

PaxDbiO18806
PRIDEiO18806

Genome annotation databases

GeneIDi403875
KEGGicfa:403875

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
2157

Phylogenomic databases

eggNOGiENOG502QSFZ, Eukaryota
InParanoidiO18806
KOiK03899
OrthoDBi454773at2759

Family and domain databases

CDDicd00057, FA58C, 2 hits
Gene3Di2.60.120.260, 2 hits
2.60.40.420, 6 hits
InterProiView protein in InterPro
IPR001117, Cu-oxidase
IPR011706, Cu-oxidase_2
IPR011707, Cu-oxidase_3
IPR033138, Cu_oxidase_CS
IPR008972, Cupredoxin
IPR000421, FA58C
IPR024715, Factor_5/8-like
IPR014707, Factor_8
IPR008979, Galactose-bd-like_sf
PANTHERiPTHR24543:SF249, PTHR24543:SF249, 5 hits
PfamiView protein in Pfam
PF00394, Cu-oxidase, 1 hit
PF07731, Cu-oxidase_2, 1 hit
PF07732, Cu-oxidase_3, 2 hits
PF00754, F5_F8_type_C, 2 hits
PIRSFiPIRSF000354, Factors_V_VIII, 1 hit
SMARTiView protein in SMART
SM00231, FA58C, 2 hits
SUPFAMiSSF49503, SSF49503, 6 hits
SSF49785, SSF49785, 2 hits
PROSITEiView protein in PROSITE
PS01285, FA58C_1, 2 hits
PS01286, FA58C_2, 2 hits
PS50022, FA58C_3, 2 hits
PS00079, MULTICOPPER_OXIDASE1, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFA8_CANLF
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O18806
Secondary accession number(s): O62730
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: January 1, 1998
Last modified: October 7, 2020
This is version 113 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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