UniProtKB - O18739 (CCN2_BOVIN)
Protein
CCN family member 2
Gene
CCN2
Organism
Bos taurus (Bovine)
Status
Functioni
Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity).By similarity
GO - Molecular functioni
- heparin binding Source: GO_Central
- insulin-like growth factor binding Source: InterPro
- integrin binding Source: GO_Central
GO - Biological processi
- cell adhesion Source: GO_Central
- DNA biosynthetic process Source: UniProtKB-KW
- negative regulation of cell death Source: GO_Central
- signal transduction Source: GO_Central
Keywordsi
Molecular function | Heparin-binding |
Biological process | Cell adhesion, DNA synthesis |
Names & Taxonomyi
Protein namesi | Recommended name: CCN family member 2CuratedAlternative name(s): Cellular communication network factor 2 Connective tissue growth factor |
Gene namesi | Name:CCN2 Synonyms:CTGF |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Artiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Organism-specific databases
VGNCi | VGNC:27794, CCN2 |
Subcellular locationi
Extracellular region or secreted
- extracellular matrix By similarity
- Secreted By similarity
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Other locations
- extracellular matrix Source: GO_Central
Keywords - Cellular componenti
Extracellular matrix, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_0000014401 | 27 – 349 | CCN family member 2Add BLAST | 323 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 256 ↔ 293 | By similarity | ||
Disulfide bondi | 273 ↔ 307 | By similarity | ||
Disulfide bondi | 284 ↔ 323 | By similarity | ||
Disulfide bondi | 287 ↔ 325 | By similarity | ||
Disulfide bondi | 292 ↔ 329 | By similarity |
Keywords - PTMi
Disulfide bondProteomic databases
PaxDbi | O18739 |
PRIDEi | O18739 |
Expressioni
Gene expression databases
Bgeei | ENSBTAG00000006367, Expressed in lung and 19 other tissues |
ExpressionAtlasi | O18739, baseline and differential |
Interactioni
Subunit structurei
Monomer.
Interacts with TSKU.
By similarityGO - Molecular functioni
- insulin-like growth factor binding Source: InterPro
- integrin binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000008357 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 98 | IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST | 72 | |
Domaini | 101 – 167 | VWFCPROSITE-ProRule annotationAdd BLAST | 67 | |
Domaini | 198 – 243 | TSP type-1PROSITE-ProRule annotationAdd BLAST | 46 | |
Domaini | 256 – 330 | CTCKPROSITE-ProRule annotationAdd BLAST | 75 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 247 – 349 | Heparin-bindingBy similarityAdd BLAST | 103 |
Sequence similaritiesi
Belongs to the CCN family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QQDX, Eukaryota |
GeneTreei | ENSGT00940000155019 |
HOGENOMi | CLU_063247_1_0_1 |
InParanoidi | O18739 |
OMAi | QDCGGQC |
OrthoDBi | 999958at2759 |
TreeFami | TF326070 |
Family and domain databases
Gene3Di | 2.20.100.10, 1 hit |
InterProi | View protein in InterPro IPR006207, Cys_knot_C IPR006208, Glyco_hormone_CN IPR009030, Growth_fac_rcpt_cys_sf IPR000867, IGFBP-like IPR012395, IGFBP_CNN IPR017891, Insulin_GF-bd_Cys-rich_CS IPR043973, TSP1_CCN IPR000884, TSP1_rpt IPR036383, TSP1_rpt_sf IPR001007, VWF_dom |
Pfami | View protein in Pfam PF00007, Cys_knot, 1 hit PF00219, IGFBP, 1 hit PF19035, TSP1_CCN, 1 hit PF00093, VWC, 1 hit |
PIRSFi | PIRSF036495, IGFBP_rP_CNN, 1 hit |
SMARTi | View protein in SMART SM00041, CT, 1 hit SM00121, IB, 1 hit SM00209, TSP1, 1 hit SM00214, VWC, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF82895, SSF82895, 1 hit |
PROSITEi | View protein in PROSITE PS01185, CTCK_1, 1 hit PS01225, CTCK_2, 1 hit PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS50092, TSP1, 1 hit PS01208, VWFC_1, 1 hit PS50184, VWFC_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
O18739-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSATGLGPVR CAFVLLLALC SRPASSQDCS APCQCPAGPA PRCPAGVSLV
60 70 80 90 100
LDGCGCCRVC AKQLSELCTE RDPCDPHKGL FCDFGSPANR KIGVCTAKDG
110 120 130 140 150
APCVFGGTVY QSGESFQSSC KYQCTCLDGS VGCVPLCSVD VRLPSPDCPF
160 170 180 190 200
PRRVKLPGKC CEEWVCDEPK EHTVVGPALA AYRPEDTFGP DPTMIRANCL
210 220 230 240 250
VQTTEWSACS KTCGMGISTR VTNDNAFCRL EKQSRLCMVR PCEADLEENI
260 270 280 290 300
KKGKKCIRTP KISKPIKFEL SGCTSMKTYR AKFCGVCTDG RCCTPHRTTT
310 320 330 340
LPVEFKCPDG EVMKKSMMFI KTCACHYNCP GDNDIFESLY YRKMYGDMA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q1MPB2 | A0A3Q1MPB2_BOVIN | CCN family member 2 | CCN2 | 364 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 28 | D → DC in AAB66596 (Ref. 1) Curated | 1 | |
Sequence conflicti | 58 | Missing in AAB66596 (Ref. 1) Curated | 1 | |
Sequence conflicti | 88 | A → T in AAB66596 (Ref. 1) Curated | 1 | |
Sequence conflicti | 103 – 104 | CV → YI in AAB66596 (Ref. 1) Curated | 2 | |
Sequence conflicti | 166 – 169 | CDEP → SRDE in AAB66596 (Ref. 1) Curated | 4 | |
Sequence conflicti | 184 | P → L in AAB66596 (Ref. 1) Curated | 1 | |
Sequence conflicti | 200 | L → Q in AAB66596 (Ref. 1) Curated | 1 | |
Sequence conflicti | 209 | C → Y in AAB66596 (Ref. 1) Curated | 1 | |
Sequence conflicti | 269 | E → Q in AAB66596 (Ref. 1) Curated | 1 | |
Sequence conflicti | 284 | C → F in AAB66596 (Ref. 1) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF000137 mRNA Translation: AAB66596.1 AF309555 Genomic DNA Translation: AAG30290.1 BC113279 mRNA Translation: AAI13280.1 |
RefSeqi | NP_776455.1, NM_174030.2 |
Genome annotation databases
Ensembli | ENSBTAT00000008357; ENSBTAP00000008357; ENSBTAG00000006367 |
GeneIDi | 281103 |
KEGGi | bta:281103 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF000137 mRNA Translation: AAB66596.1 AF309555 Genomic DNA Translation: AAG30290.1 BC113279 mRNA Translation: AAI13280.1 |
RefSeqi | NP_776455.1, NM_174030.2 |
3D structure databases
SMRi | O18739 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000008357 |
Proteomic databases
PaxDbi | O18739 |
PRIDEi | O18739 |
Genome annotation databases
Ensembli | ENSBTAT00000008357; ENSBTAP00000008357; ENSBTAG00000006367 |
GeneIDi | 281103 |
KEGGi | bta:281103 |
Organism-specific databases
CTDi | 1490 |
VGNCi | VGNC:27794, CCN2 |
Phylogenomic databases
eggNOGi | ENOG502QQDX, Eukaryota |
GeneTreei | ENSGT00940000155019 |
HOGENOMi | CLU_063247_1_0_1 |
InParanoidi | O18739 |
OMAi | QDCGGQC |
OrthoDBi | 999958at2759 |
TreeFami | TF326070 |
Gene expression databases
Bgeei | ENSBTAG00000006367, Expressed in lung and 19 other tissues |
ExpressionAtlasi | O18739, baseline and differential |
Family and domain databases
Gene3Di | 2.20.100.10, 1 hit |
InterProi | View protein in InterPro IPR006207, Cys_knot_C IPR006208, Glyco_hormone_CN IPR009030, Growth_fac_rcpt_cys_sf IPR000867, IGFBP-like IPR012395, IGFBP_CNN IPR017891, Insulin_GF-bd_Cys-rich_CS IPR043973, TSP1_CCN IPR000884, TSP1_rpt IPR036383, TSP1_rpt_sf IPR001007, VWF_dom |
Pfami | View protein in Pfam PF00007, Cys_knot, 1 hit PF00219, IGFBP, 1 hit PF19035, TSP1_CCN, 1 hit PF00093, VWC, 1 hit |
PIRSFi | PIRSF036495, IGFBP_rP_CNN, 1 hit |
SMARTi | View protein in SMART SM00041, CT, 1 hit SM00121, IB, 1 hit SM00209, TSP1, 1 hit SM00214, VWC, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF82895, SSF82895, 1 hit |
PROSITEi | View protein in PROSITE PS01185, CTCK_1, 1 hit PS01225, CTCK_2, 1 hit PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS50092, TSP1, 1 hit PS01208, VWFC_1, 1 hit PS50184, VWFC_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCN2_BOVIN | |
Accessioni | O18739Primary (citable) accession number: O18739 Secondary accession number(s): Q2HJ71, Q9GL71 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | February 11, 2002 | |
Last modified: | April 7, 2021 | |
This is version 138 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families