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Protein

Guanine nucleotide-binding protein subunit beta-like protein

Gene

Rack1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes (By similarity).By similarity

GO - Biological processi

  • cellular response to starvation Source: FlyBase
  • cuticle development Source: FlyBase
  • IRES-dependent viral translational initiation Source: FlyBase
  • locomotory behavior Source: FlyBase
  • mRNA splicing, via spliceosome Source: FlyBase
  • muscle cell cellular homeostasis Source: FlyBase
  • negative regulation of protein phosphorylation Source: UniProtKB
  • oogenesis Source: FlyBase
  • oviposition Source: FlyBase
  • positive regulation by host of viral genome replication Source: FlyBase
  • positive regulation of actin filament polymerization Source: UniProtKB
  • positive regulation of glycogen biosynthetic process Source: FlyBase
  • regulation of autophagosome size Source: FlyBase
  • wing disc development Source: FlyBase

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

SignaLinkiO18640

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit beta-like protein
Alternative name(s):
Receptor of activated protein kinase C homolog
Gene namesi
Name:Rack1
ORF Names:CG7111
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0020618 Rack1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001277401 – 318Guanine nucleotide-binding protein subunit beta-like proteinAdd BLAST318

Proteomic databases

PaxDbiO18640
PRIDEiO18640

Expressioni

Tissue specificityi

Highest expression in the mesodermal and endodermal lineages.1 Publication

Gene expression databases

BgeeiFBgn0020618
ExpressionAtlasiO18640 baseline and differential
GenevisibleiO18640 DM

Interactioni

Subunit structurei

Interacts with the 80S ribosome.1 Publication

Protein-protein interaction databases

BioGridi60209, 46 interactors
DIPiDIP-17169N
IntActiO18640, 29 interactors
STRINGi7227.FBpp0303680

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00Ag1-318[»]
ProteinModelPortaliO18640
SMRiO18640
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati13 – 44WD 1Add BLAST32
Repeati62 – 92WD 2Add BLAST31
Repeati104 – 134WD 3Add BLAST31
Repeati147 – 179WD 4Add BLAST33
Repeati191 – 221WD 5Add BLAST31
Repeati232 – 261WD 6Add BLAST30
Repeati282 – 312WD 7Add BLAST31

Sequence similaritiesi

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0279 Eukaryota
ENOG410XQGZ LUCA
GeneTreeiENSGT00910000144232
InParanoidiO18640
KOiK14753
OMAiQYGYPKR
OrthoDBiEOG091G0KZQ
PhylomeDBiO18640

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 7 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 4 hits
PS50082 WD_REPEATS_2, 6 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

O18640-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSETLQLRGT LIGHNGWVTQ IATNPKDPDT IISASRDKTL IVWKLTRDED
60 70 80 90 100
TNYGYPQKRL YGHSHFISDV VLSSDGNYAL SGSWDQTLRL WDLAAGKTTR
110 120 130 140 150
RFEGHTKDVL SVAFSADNRQ IVSGSRDKTI KLWNTLAECK FTIQEDGHTD
160 170 180 190 200
WVSCVRFSPN HSNPIIVSCG WDRTVKVWNL ANCKLKNNHH GHNGYLNTVT
210 220 230 240 250
VSPDGSLCTS GGKDSKALLW DLNDGKNLYT LEHNDIINAL CFSPNRYWLC
260 270 280 290 300
VAYGPSIKIW DLACKKTVEE LRPEVVSPTS KADQPQCLSL AWSTDGQTLF
310
AGYSDNTIRV WQVSVSAH
Length:318
Mass (Da):35,618
Last modified:June 1, 2001 - v2
Checksum:i202930BE51AEE822
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti104G → R in AAB72148 (PubMed:9296523).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U96491 mRNA Translation: AAB72148.1
AE014134 Genomic DNA Translation: AAF52566.1
AY071661 mRNA Translation: AAL49283.1
RefSeqiNP_001260218.1, NM_001273289.1
NP_001285723.1, NM_001298794.1
NP_477269.1, NM_057921.4
UniGeneiDm.6830

Genome annotation databases

EnsemblMetazoaiFBtr0079565; FBpp0079187; FBgn0020618
FBtr0331238; FBpp0303680; FBgn0020618
FBtr0345448; FBpp0311572; FBgn0020618
GeneIDi34070
KEGGidme:Dmel_CG7111

Similar proteinsi

Entry informationi

Entry nameiGBLP_DROME
AccessioniPrimary (citable) accession number: O18640
Secondary accession number(s): Q9VLW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

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