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UniProtKB - O18635 (C12A2_MUSDO)
Protein
Cytochrome P450 CYP12A2
Gene
CYP12A2
Organism
Musca domestica (House fly)
Status
Functioni
Cofactori
hemeBy similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 483 | Iron (heme axial ligand)By similarity | 1 |
GO - Molecular functioni
- heme binding Source: InterPro
- iron ion binding Source: InterPro
- monooxygenase activity Source: UniProtKB-KW
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
Keywordsi
Molecular function | Monooxygenase, Oxidoreductase |
Ligand | Heme, Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:CYP12A2 |
Organismi | Musca domestica (House fly) |
Taxonomic identifieri | 7370 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Muscoidea › Muscidae › Musca › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | VectorBase:MDOA006998 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051923 | 1 – 537 | Cytochrome P450 CYP12A2Add BLAST | 537 |
Proteomic databases
PRIDEi | O18635 |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Phylogenomic databases
eggNOGi | KOG0159, Eukaryota |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
i Sequence
Sequence statusi: Complete.
O18635-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLKTKQQIIA LNRFRCWTSN LPGLQQQCRN QSTVTAASSE WEQAKPLSEM
60 70 80 90 100
PTISPFQLLR HFLPGGKYTN LDTTQLMLAF RRDFGPIVYF KGSLGKPDVV
110 120 130 140 150
MTNNPHDFEK ALHNQGIWPM RPGMEYLSYH RQVHRKDIFQ GVEGLLGSQG
160 170 180 190 200
EAWGSFRSAV NPVLMQPKNV HLYFNKMSEV NKEFMERIRK IRDPQTLEVP
210 220 230 240 250
DNFEEEINRW TLESVSVVAL DKQLGLITKN RDDPTPKRLF KALTDFFEAS
260 270 280 290 300
GDLEFQPSIW KYIKTPTFKK AIRSLDEITD ITKMYVDEAF ERIEAENKNR
310 320 330 340 350
NVEKPENEKS VLEKLVKIDK QIAMVMAMDM LMAGVDTTSS TFTGLLLCLA
360 370 380 390 400
KNPEKQKKLR EEIMQLLPQK DSEFNEAVFK NMPYLRACIK ESLRVYPLTV
410 420 430 440 450
GNARTQANDV VISGYRVPKG TLISMNSVTL IKDDAHYPRA SEFLPERWLR
460 470 480 490 500
ASKENEKSAE CPHALKASSP FVYLPFGFGS RSCIGRRIAE MELELGIARL
510 520 530
IRNFHVEFNY PTDNAFKSLL ISVPNIPLKF KFTDVDN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U94698 mRNA Translation: AAC98527.1 |
RefSeqi | NP_001295932.1, NM_001309003.1 |
Genome annotation databases
GeneIDi | 101889857 |
KEGGi | mde:101889857 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U94698 mRNA Translation: AAC98527.1 |
RefSeqi | NP_001295932.1, NM_001309003.1 |
3D structure databases
SMRi | O18635 |
ModBasei | Search... |
Proteomic databases
PRIDEi | O18635 |
Genome annotation databases
GeneIDi | 101889857 |
KEGGi | mde:101889857 |
Organism-specific databases
CTDi | 101889857 |
VEuPathDBi | VectorBase:MDOA006998 |
Phylogenomic databases
eggNOGi | KOG0159, Eukaryota |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | C12A2_MUSDO | |
Accessioni | O18635Primary (citable) accession number: O18635 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | January 1, 1998 | |
Last modified: | June 2, 2021 | |
This is version 79 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |