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Entry version 143 (16 Jan 2019)
Sequence version 1 (01 Jan 1998)
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Protein

Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase wee-1.3

Gene

wee-1.3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase during oocyte maturation (PubMed:16338136, PubMed:16421191, PubMed:16466390). Required for oocyte maturation, embryonic development, germline proliferation and initiation of meiosis during spermatogenesis (PubMed:11702779, PubMed:12397109, PubMed:27104746). Required for chromosome structure during mitosis and negative regulation of nuclear envelope breakdown (PubMed:16421191).6 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei137ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei228Proton acceptorPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi233Magnesium; via carbonyl oxygenBy similarity1
Metal bindingi246Magnesium; via carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi114 – 122ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • cyclin-dependent protein serine/threonine kinase inhibitor activity Source: WormBase
  • metal ion binding Source: UniProtKB-KW
  • protein kinase activity Source: GO_Central
  • protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Kinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle, Differentiation, Oogenesis, Spermatogenesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-156711 Polo-like kinase mediated events
R-CEL-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-CEL-69478 G2/M DNA replication checkpoint

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
O18209

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase wee-1.3 (EC:2.7.11.1)
Alternative name(s):
Lethal protein 37
Myt1 kinase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:wee-1.3
Synonyms:let-37, myt-1, spe-37
ORF Names:Y53C12A.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
Y53C12A.1 ; CE14884 ; WBGene00006940 ; wee-1.3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Worms exhibit oocytes that mature prematurely (also known as the Emo phenotype) and chromosomes that appear condensed (PubMed:16421191). Subcellular defects include irregular perinuclear foci in oocytes (PubMed:16421191). RNAi-mediated knockdown results in an accumulation of damaged, compressed, polyploid oocytes in the uterus (PubMed:11702779). RNAi-mediated knockdown in a double oma-1 and oma-2 knockout background allows for the progression of meiosis beyond the prophase stage and oocyte maturation, but these oocytes cannot be fertilized (PubMed:11702779). RNAi-mediated knockdown in a cdc-25.2 mutant background suppresses the defect in intestinal cell divisions in the cdc-25.2 single mutant (PubMed:27104746).3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi103F → I in eb94; viable but induces male sterility due to abnormal sperm. 1 Publication1
Mutagenesisi160I → N in eb62; viable but induces male sterility due to abnormal sperm. 1 Publication1
Mutagenesisi163H → P in eb90; induces inviable embryos and larvae. 1 Publication1
Mutagenesisi245G → E in eb88; induces inviable embryos and larvae. 1 Publication1
Mutagenesisi558G → R in eb95; induces defects in spermatogenesis. 1 Publication1
Mutagenesisi560G → E in hc144; induces defects in spermatogenesis. 1 Publication1
Mutagenesisi560G → R in q89; dominant allele that induces an arrest of spermatogenesis at early stages. 1 Publication1
Mutagenesisi561D → N in hc145; induces defects in spermatogenesis. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000865761 – 677Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase wee-1.3Add BLAST677

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O18209

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O18209

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed during both germline and early embryonic development. In larvae, it is expressed in the distal region, germline, and in some neurons and hypodermal cells. Not expressed in distal region of the adult.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00006940 Expressed in 5 organ(s), highest expression level in adult organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
39853, 5 interactors

Database of interacting proteins

More...
DIPi
DIP-24649N

Protein interaction database and analysis system

More...
IntActi
O18209, 1 interactor

STRING: functional protein association networks

More...
STRINGi
6239.Y53C12A.1.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O18209

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O18209

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini108 – 355Protein kinasePROSITE-ProRule annotationAdd BLAST248

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0601 Eukaryota
ENOG410XS1M LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159427

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000115589

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O18209

KEGG Orthology (KO)

More...
KOi
K06633

Identification of Orthologs from Complete Genome Data

More...
OMAi
REAESHM

Database of Orthologous Groups

More...
OrthoDBi
1063695at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O18209

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069 Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O18209-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDDTEGNSSM DSIRNGQSSP LPQVTPRLPQ IPMMMRETPL STKRERQAIT
60 70 80 90 100
PRFRRPAPKM IKTMPPTRSI WSVRKESVPL LVTPQGPKPL ESPKYDHTNA
110 120 130 140 150
QSFFEQVFQI DEIIGRGSFG EVFAARCRED SQLYAVKVSL APIRQHSISK
160 170 180 190 200
YREAESHMII PPHKNLVKFY RAWEETGRLY IQTELCDQSL LKYCTEKHAL
210 220 230 240 250
PEDEIWNIFV DLLQAVHHLH SNDMIHDDIK PENIFLTKDM ICKLGDFGLV
260 270 280 290 300
INLKNPNDVK SAEEGDSKYL APEVLNGRPT KSSDIFSLGM TILEATTDLD
310 320 330 340 350
VPSNGDSWHQ IRNGQIPDRF FAGISTDLRS LIALMLDSDP RIRPTSRDLL
360 370 380 390 400
DHPVIKKKLM KRGTYVKCIS ILNGFFYAFS AVLVWVMAFF SVLFHPIVRF
410 420 430 440 450
HAAIKDRQSE ICAQFVNNQQ HTPIQTPETS KVYLESLTGV AVRQASQIVS
460 470 480 490 500
PFDFSDDENP PNAQRRLFTG AVPCRLNFDN DQDDDEEQAT CSSSNSSAIE
510 520 530 540 550
PQLDEPESPP RMNDVIDKLG KRGTPRSARR NLTFNRHRQV AASVAPKSSL
560 570 580 590 600
NHYNHHTGSG DGFSNNSLIP ISDQERTEKY LRMRLTEQQL DWADQNNVID
610 620 630 640 650
EAPPPMSCPP RIRRSIRDLP RMPVLNFNVL DEPSNKPTVD HHTILEQSES
660 670
PRRRLNRGAK PVPRNRMMSF GSSGDEV
Length:677
Mass (Da):76,967
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD1F35F551E30CEA9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z99277 Genomic DNA Translation: CAB16484.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T27127

NCBI Reference Sequences

More...
RefSeqi
NP_496095.1, NM_063694.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Cel.38644

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
Y53C12A.1; Y53C12A.1; WBGene00006940

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
174531

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_Y53C12A.1

UCSC genome browser

More...
UCSCi
Y53C12A.1 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z99277 Genomic DNA Translation: CAB16484.1
PIRiT27127
RefSeqiNP_496095.1, NM_063694.4
UniGeneiCel.38644

3D structure databases

ProteinModelPortaliO18209
SMRiO18209
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi39853, 5 interactors
DIPiDIP-24649N
IntActiO18209, 1 interactor
STRINGi6239.Y53C12A.1.1

Proteomic databases

EPDiO18209
PaxDbiO18209

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiY53C12A.1; Y53C12A.1; WBGene00006940
GeneIDi174531
KEGGicel:CELE_Y53C12A.1
UCSCiY53C12A.1 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
174531
WormBaseiY53C12A.1 ; CE14884 ; WBGene00006940 ; wee-1.3

Phylogenomic databases

eggNOGiKOG0601 Eukaryota
ENOG410XS1M LUCA
GeneTreeiENSGT00940000159427
HOGENOMiHOG000115589
InParanoidiO18209
KOiK06633
OMAiREAESHM
OrthoDBi1063695at2759
PhylomeDBiO18209

Enzyme and pathway databases

ReactomeiR-CEL-156711 Polo-like kinase mediated events
R-CEL-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-CEL-69478 G2/M DNA replication checkpoint
SignaLinkiO18209

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O18209

Gene expression databases

BgeeiWBGene00006940 Expressed in 5 organ(s), highest expression level in adult organism

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPMY13_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O18209
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: January 1, 1998
Last modified: January 16, 2019
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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