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Entry version 161 (08 May 2019)
Sequence version 3 (16 Dec 2008)
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Protein

Phospholipid-transporting ATPase

Gene

tat-3

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-UniRule
  • magnesium ion binding Source: UniProtKB-UniRule
  • phospholipid-translocating ATPase activity Source: GO_Central

GO - Biological processi

  • phospholipid translocation Source: GO_Central
  • sterol metabolic process Source: WormBase

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.6.3.1 1045

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-936837 Ion transport by P-type ATPases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phospholipid-transporting ATPaseUniRule annotation (EC:7.6.2.1UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tat-3Imported
ORF Names:CELE_W09D10.2Imported, W09D10.2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

Organism-specific databases

WormBase

More...
WormBasei
W09D10.2 ; CE43310 ; WBGene00012360 ; tat-3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei131 – 148HelicalUniRule annotationAdd BLAST18
Transmembranei363 – 385HelicalUniRule annotationAdd BLAST23
Transmembranei426 – 448HelicalUniRule annotationAdd BLAST23
Transmembranei1139 – 1159HelicalUniRule annotationAdd BLAST21
Transmembranei1171 – 1191HelicalUniRule annotationAdd BLAST21
Transmembranei1221 – 1243HelicalUniRule annotationAdd BLAST23
Transmembranei1255 – 1273HelicalUniRule annotationAdd BLAST19
Transmembranei1285 – 1308HelicalUniRule annotationAdd BLAST24
Transmembranei1328 – 1346HelicalUniRule annotationAdd BLAST19

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O18182

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O18182

PeptideAtlas

More...
PeptideAtlasi
O18182

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00012360 Expressed in 5 organ(s), highest expression level in material anatomical entity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.W09D10.2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini97 – 151PhoLip_ATPase_NInterPro annotationAdd BLAST55
Domaini1107 – 1356PhoLip_ATPase_CInterPro annotationAdd BLAST250

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0206 Eukaryota
COG0474 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000167741

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000202528

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O18182

KEGG Orthology (KO)

More...
KOi
K01530

Identification of Orthologs from Complete Genome Data

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OMAi
PHRDLMN

Database of Orthologous Groups

More...
OrthoDBi
587717at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O18182

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1110.10, 2 hits
3.40.50.1000, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c

The PANTHER Classification System

More...
PANTHERi
PTHR24092 PTHR24092, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01652 ATPase-Plipid, 2 hits
TIGR01494 ATPase_P-type, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O18182-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKKSVDVEA STSNSSSALY DTTVTKGHHR RTSSLWVPPT RPIFSSPTQV
60 70 80 90 100
IKEKAENGGR ILKTHPVTRW LFPTQPMLPQ QRLVVPNNQK EPPPRYEQPN
110 120 130 140 150
RKYCGNRIST TKYSVLTFIP KNLFEQLHRA ANLYFIFIVI LNMIIGAFGK
160 170 180 190 200
YISVLPIAFV LGITAIKDAF EDYRRYKSDQ KINHSTCRVW DASQQRYRKL
210 220 230 240 250
EWQNILVGDF VHLSHDEIIP ADILLLRSSD VNGVCYVETC NLDGESNLKQ
260 270 280 290 300
RQAIRSMGKY HNANVPLEYS PAEFNYRIAC EQPTTDVYKF EGRLEAIEGG
310 320 330 340 350
PPLAREFTIL AKENVLLRGC VVKNTDFVEG IVLYAGKDTK AMLNNNGPRY
360 370 380 390 400
KRSSLEKMTN VDILWSVCTL LALCVIGAVL SGVWLRTFST PYIVPFLVFI
410 420 430 440 450
HPNSSYHNNN DSQYKYSPSY ESWFSFWSYI IVLQVMIPIS LYVSIEFIKI
460 470 480 490 500
FQVWFMSQDR NMYYDKVDKR LQCRALNITE ELGQIQYVMS DKTGTLTENQ
510 520 530 540 550
MVFRRCSVNG NDYGGRPVVD AVDSSLELVA STLRSDQPTE KKLQMAALAE
560 570 580 590 600
AAAKTRRLRP SRDPALESQL ASSVLKLGAD IDDPVFAFFL TMAICNTVVV
610 620 630 640 650
NAKPHEDLMD PDGDIVNSRF APEEVSPRRG SSLEDGFKYL ADVEEESPAS
660 670 680 690 700
TQASTPVMIT EENDGFEEIE LIEFPEVKTD ETQMTEKEET ISAEVAAKKS
710 720 730 740 750
GSDEKDNNYN GERKEGKGFG ILHRPSILSV PFAKLKGMKS PFRRSVDKRS
760 770 780 790 800
SSSTETAVAP PLHSFYDSES PDELALVEAA REYGIRLLRR RFDDVIVYLR
810 820 830 840 850
HSTSSVKYKV LHTLPFDADR KRMSVIIRES SGLKRIIVLT KGADATVIPV
860 870 880 890 900
LSEAFSTSAR GEEVIFKSQE HLTQYAKEGL RTLCLSMKIW TEEEYQGWKE
910 920 930 940 950
KHEEAELDMM DKETMLAEST LRAEQDLELL GVTAIEDRLQ DGVPECIHSL
960 970 980 990 1000
REAGIRVWVL TGDKIETAVN IAYSSRLFSP SMDLLNIGAN GVRAVSDLLT
1010 1020 1030 1040 1050
EHLKRIARAY EVSADAADSF GLVLNASTMS YCLDPHNLER FVKLLRGCRS
1060 1070 1080 1090 1100
VLCCRATPLQ KAQLVNLAKN HLKGKVLAIG DGANDVSMIQ GADVGIGLSG
1110 1120 1130 1140 1150
QEGMQAVMSS DFAMARFRFL SNLLLVHGHW NYYRLAQTIL YFFYKNAMLV
1160 1170 1180 1190 1200
FVIFWYQIFN GFSAQVPIDP VYLMVYNLIF TSVPPLLFGC LDQDASAELL
1210 1220 1230 1240 1250
LDCPRLYEQG RLGKRYRWYS FWINMLDAVW QSLVVFFICY FTYRGSNVDM
1260 1270 1280 1290 1300
WTFGHLLVTQ LIIVNTFHLA LFVQYWTWPM FWSMFLSVLL FFICALLYNG
1310 1320 1330 1340 1350
FVTANWTWTN VKDPPSMVSL KSFSSLEFWM ALIISVVLCL TPRYVLTTVV
1360 1370 1380 1390 1400
NTVSPSTTLR TRLGAEDGFK KKTESRFTAC AVGCLSAPFK CARMCCQKTK
1410
PADVHIEEVH H
Length:1,411
Mass (Da):159,945
Last modified:December 16, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i545C4F858FC225CD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284603 Genomic DNA Translation: CAB07859.3

NCBI Reference Sequences

More...
RefSeqi
NP_499363.3, NM_066962.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
W09D10.2; W09D10.2; WBGene00012360

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
176498

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_W09D10.2

UCSC genome browser

More...
UCSCi
W09D10.2 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284603 Genomic DNA Translation: CAB07859.3
RefSeqiNP_499363.3, NM_066962.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi6239.W09D10.2

Proteomic databases

EPDiO18182
PaxDbiO18182
PeptideAtlasiO18182

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiW09D10.2; W09D10.2; WBGene00012360
GeneIDi176498
KEGGicel:CELE_W09D10.2
UCSCiW09D10.2 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
176498
WormBaseiW09D10.2 ; CE43310 ; WBGene00012360 ; tat-3

Phylogenomic databases

eggNOGiKOG0206 Eukaryota
COG0474 LUCA
GeneTreeiENSGT00940000167741
HOGENOMiHOG000202528
InParanoidiO18182
KOiK01530
OMAiPHRDLMN
OrthoDBi587717at2759
PhylomeDBiO18182

Enzyme and pathway databases

BRENDAi3.6.3.1 1045
ReactomeiR-CEL-936837 Ion transport by P-type ATPases

Gene expression databases

BgeeiWBGene00012360 Expressed in 5 organ(s), highest expression level in material anatomical entity

Family and domain databases

Gene3Di3.40.1110.10, 2 hits
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR006539 P-type_ATPase_IV
IPR032631 P-type_ATPase_N
IPR001757 P_typ_ATPase
IPR032630 P_typ_ATPase_c
PANTHERiPTHR24092 PTHR24092, 1 hit
PfamiView protein in Pfam
PF16212 PhoLip_ATPase_C, 1 hit
PF16209 PhoLip_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 1 hit
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 1 hit
TIGRFAMsiTIGR01652 ATPase-Plipid, 2 hits
TIGR01494 ATPase_P-type, 1 hit
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO18182_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O18182
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: December 16, 2008
Last modified: May 8, 2019
This is version 161 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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