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Entry version 144 (12 Aug 2020)
Sequence version 1 (01 Jan 1998)
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Protein

DNA topoisomerase 1

Gene

top-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Required for normal spermatogenesis and oogenesis (PubMed:16943775).By similarity1 Publication

Miscellaneous

Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.PROSITE-ProRule annotation EC:5.6.2.1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei761O-(3'-phospho-DNA)-tyrosine intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Isomerase, Topoisomerase

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-4615885, SUMOylation of DNA replication proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA topoisomerase 1 (EC:5.6.2.1PROSITE-ProRule annotation)
Alternative name(s):
DNA topoisomerase I
Short name:
topoI
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:top-1
ORF Names:M01E5.5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
M01E5.5a ; CE12282 ; WBGene00006595 ; top-1
M01E5.5b ; CE12284 ; WBGene00006595 ; top-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown causes abnormal gonad morphology, enlarged sperm nuclei and aberrant progression through meiosis. Oocytes appear to have undergone endomitotic reduplication.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003304821 – 806DNA topoisomerase 1Add BLAST806

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O17966

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O17966

PeptideAtlas

More...
PeptideAtlasi
O17966

PRoteomics IDEntifications database

More...
PRIDEi
O17966

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in male germ cells and in mature sperm.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Isoform a: only expressed in embryos (PubMed:9540836). Isoform b: present at all developmental stages (PubMed:9540836). Not expressed during spermatocyte meiosis (PubMed:16943775).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00006595, Expressed in multi-cellular organism and 6 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei358Interaction with DNABy similarity1
Sitei406Interaction with DNABy similarity1
Sitei454Interaction with DNABy similarity1
Sitei485Interaction with DNABy similarity1
Sitei543Interaction with DNABy similarity1
Sitei581Interaction with DNABy similarity1
Sitei623Interaction with DNABy similarity1
Sitei681Interaction with DNABy similarity1
Sitei699Interaction with DNABy similarity1

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
57335, 11 interactors

STRING: functional protein association networks

More...
STRINGi
6239.M01E5.5a

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O17966

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni467 – 468Interaction with DNABy similarity2
Regioni530 – 535Interaction with DNABy similarity6
Regioni634 – 636Interaction with DNABy similarity3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the type IB topoisomerase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0981, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000167650

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009193_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O17966

KEGG Orthology (KO)

More...
KOi
K03163

Identification of Orthologs from Complete Genome Data

More...
OMAi
CSLKYEH

Database of Orthologous Groups

More...
OrthoDBi
303947at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O17966

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00659, Topo_IB_C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.41, 1 hit
1.10.132.10, 1 hit
2.170.11.10, 1 hit
3.90.15.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011010, DNA_brk_join_enz
IPR013034, DNA_topo_DNA_db_N_dom1
IPR013030, DNA_topo_DNA_db_N_dom2
IPR001631, TopoI
IPR018521, TopoI_AS
IPR025834, TopoI_C_dom
IPR014711, TopoI_cat_a-hlx-sub_euk
IPR014727, TopoI_cat_a/b-sub_euk
IPR013500, TopoI_cat_euk
IPR008336, TopoI_DNA-bd_euk
IPR036202, TopoI_DNA-bd_euk_N_sf
IPR013499, TopoI_euk

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14370, Topo_C_assoc, 1 hit
PF01028, Topoisom_I, 1 hit
PF02919, Topoisom_I_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00416, EUTPISMRASEI

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00435, TOPEUc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56349, SSF56349, 1 hit
SSF56741, SSF56741, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00176, TOPOISOMERASE_I_EUK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform a (identifier: O17966-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVVSNHHSN GNGNSTVYDT NGNDEIKKEV KDEPMASDSE VPFGELMKRD
60 70 80 90 100
KKEKKQKKRK AESGSDEDDY KPEKRKSSAK NGKKKDVGSD SEDDYKPEKK
110 120 130 140 150
KSKKNNKKKA QESSEDDDEE SEGDVSEEDV KPQIHSDDEL EEEDEAPTTD
160 170 180 190 200
DEEEQKRKEK ERRKKEKREK KERKEKKRLE KENRKIKEED DEDSDDEDDE
210 220 230 240 250
KAKKKKRKSK GAEKSKPSTS KKDAGGKKEP PKKKVKKEED IEDIWEWWKE
260 270 280 290 300
EKKPAGVKWN SLQHCGPLFA PPYIPLPSHV HFKYGGEKMK LTLETEEIAQ
310 320 330 340 350
FYAGVLDHEY STKEAFNKNF MKDWRKVMTV EERERIHDLK KCDFRAIDAY
360 370 380 390 400
QKEQREIRKA MTKEEKLKIK EEKEAEVKIY GIAIIDGHRQ KVANFRIEPP
410 420 430 440 450
GVFRGRGGHP KMGLIKKRIM PEDVIINCGK DTEIPKPPPG HKWKEVRHDN
460 470 480 490 500
TVTWLCSWTE SVLGQNKYIM LNPSSKIKGE KDFEKYETAR RLKKKIGGIR
510 520 530 540 550
ERYTDDFKSK EMRVRQRATA LYFIDKLALR AGNEKDVDEA ADTVGCCSLR
560 570 580 590 600
VEHIKLFDSA KLNEDDKKEK EFVVEFDFLG KDSIRYFNRV SVEKRVYKNL
610 620 630 640 650
KIFMEGKAPS DDLFDRLDTA TLNDHLRSLM DGLTVKVFRT YNASITLQEQ
660 670 680 690 700
LIKLTNPKDN VAAKILSYNR ANRQVAILCN HQRAVSKGFD ESMQKLEQKI
710 720 730 740 750
KDKKKEVKEA EAALKSARGA EKEKAQKKYD RLKEQLKKLK ISRTDKDENK
760 770 780 790 800
QIALGTSKLN YIDPRITVAW CKKFEVPLEK VFTKTHREKF RWAIDMTNSS

DEEYVF
Length:806
Mass (Da):94,030
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5979AD386DEBD004
GO
Isoform b (identifier: O17966-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     134-205: Missing.

Note: Predominant isoform.Curated
Show »
Length:734
Mass (Da):85,089
Checksum:i1BE2C2FA8E492FF4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti172E → K in CAA65537 (PubMed:8647074).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_033045134 – 205Missing in isoform b. CuratedAdd BLAST72

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X96762 mRNA Translation: CAA65537.1
Z93385 Genomic DNA Translation: CAB07639.1
Z93385 Genomic DNA Translation: CAB07640.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S65469
T23647
T23648

NCBI Reference Sequences

More...
RefSeqi
NP_001021578.1, NM_001026407.5 [O17966-2]
NP_493337.1, NM_060936.5 [O17966-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
M01E5.5a.1; M01E5.5a.1; WBGene00006595 [O17966-1]
M01E5.5a.2; M01E5.5a.2; WBGene00006595 [O17966-1]
M01E5.5b.1; M01E5.5b.1; WBGene00006595 [O17966-2]
M01E5.5b.2; M01E5.5b.2; WBGene00006595 [O17966-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
266847

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_M01E5.5

UCSC genome browser

More...
UCSCi
M01E5.5b, c. elegans [O17966-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X96762 mRNA Translation: CAA65537.1
Z93385 Genomic DNA Translation: CAB07639.1
Z93385 Genomic DNA Translation: CAB07640.1
PIRiS65469
T23647
T23648
RefSeqiNP_001021578.1, NM_001026407.5 [O17966-2]
NP_493337.1, NM_060936.5 [O17966-1]

3D structure databases

SMRiO17966
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi57335, 11 interactors
STRINGi6239.M01E5.5a

Proteomic databases

EPDiO17966
PaxDbiO17966
PeptideAtlasiO17966
PRIDEiO17966

Genome annotation databases

EnsemblMetazoaiM01E5.5a.1; M01E5.5a.1; WBGene00006595 [O17966-1]
M01E5.5a.2; M01E5.5a.2; WBGene00006595 [O17966-1]
M01E5.5b.1; M01E5.5b.1; WBGene00006595 [O17966-2]
M01E5.5b.2; M01E5.5b.2; WBGene00006595 [O17966-2]
GeneIDi266847
KEGGicel:CELE_M01E5.5
UCSCiM01E5.5b, c. elegans [O17966-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
266847
WormBaseiM01E5.5a ; CE12282 ; WBGene00006595 ; top-1
M01E5.5b ; CE12284 ; WBGene00006595 ; top-1

Phylogenomic databases

eggNOGiKOG0981, Eukaryota
GeneTreeiENSGT00940000167650
HOGENOMiCLU_009193_0_1_1
InParanoidiO17966
KOiK03163
OMAiCSLKYEH
OrthoDBi303947at2759
PhylomeDBiO17966

Enzyme and pathway databases

ReactomeiR-CEL-4615885, SUMOylation of DNA replication proteins

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O17966

Gene expression databases

BgeeiWBGene00006595, Expressed in multi-cellular organism and 6 other tissues

Family and domain databases

CDDicd00659, Topo_IB_C, 1 hit
Gene3Di1.10.10.41, 1 hit
1.10.132.10, 1 hit
2.170.11.10, 1 hit
3.90.15.10, 1 hit
InterProiView protein in InterPro
IPR011010, DNA_brk_join_enz
IPR013034, DNA_topo_DNA_db_N_dom1
IPR013030, DNA_topo_DNA_db_N_dom2
IPR001631, TopoI
IPR018521, TopoI_AS
IPR025834, TopoI_C_dom
IPR014711, TopoI_cat_a-hlx-sub_euk
IPR014727, TopoI_cat_a/b-sub_euk
IPR013500, TopoI_cat_euk
IPR008336, TopoI_DNA-bd_euk
IPR036202, TopoI_DNA-bd_euk_N_sf
IPR013499, TopoI_euk
PfamiView protein in Pfam
PF14370, Topo_C_assoc, 1 hit
PF01028, Topoisom_I, 1 hit
PF02919, Topoisom_I_N, 1 hit
PRINTSiPR00416, EUTPISMRASEI
SMARTiView protein in SMART
SM00435, TOPEUc, 1 hit
SUPFAMiSSF56349, SSF56349, 1 hit
SSF56741, SSF56741, 1 hit
PROSITEiView protein in PROSITE
PS00176, TOPOISOMERASE_I_EUK, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTOP1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O17966
Secondary accession number(s): O17965, Q27529
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: January 1, 1998
Last modified: August 12, 2020
This is version 144 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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