UniProtKB - O17919 (DKC1_CAEEL)
Protein
Putative H/ACA ribonucleoprotein complex subunit 4
Gene
K01G5.5
Organism
Caenorhabditis elegans
Status
Functioni
Plays a central role in ribosomal RNA processing. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs (By similarity).By similarity
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 113 | NucleophileBy similarity | 1 |
GO - Molecular functioni
- pseudouridine synthase activity Source: GO_Central
- RNA binding Source: UniProtKB-KW
GO - Biological processi
- box H/ACA RNA 3'-end processing Source: GO_Central
- mRNA pseudouridine synthesis Source: GO_Central
- rRNA pseudouridine synthesis Source: GO_Central
- snRNA pseudouridine synthesis Source: GO_Central
Keywordsi
Molecular function | Isomerase, Ribonucleoprotein, RNA-binding |
Biological process | Ribosome biogenesis, rRNA processing |
Enzyme and pathway databases
Reactomei | R-CEL-171319, Telomere Extension By Telomerase |
Names & Taxonomyi
Protein namesi | |
Gene namesi | ORF Names:K01G5.5 |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | K01G5.5 ; CE16195 ; WBGene00010478 |
Subcellular locationi
Nucleus
- nucleolus By similarity
Nucleus
- box H/ACA snoRNP complex Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000121988 | 1 – 445 | Putative H/ACA ribonucleoprotein complex subunit 4Add BLAST | 445 |
Proteomic databases
EPDi | O17919 |
PaxDbi | O17919 |
PeptideAtlasi | O17919 |
PTM databases
iPTMneti | O17919 |
Expressioni
Gene expression databases
Bgeei | WBGene00010478, Expressed in multi-cellular organism and 5 other tissues |
Interactioni
Subunit structurei
Component of the small nucleolar ribonucleoprotein particle containing H/ACA-type snoRNAs (H/ACA snoRNPs).
By similarityProtein-protein interaction databases
BioGRIDi | 41691, 33 interactors |
DIPi | DIP-25862N |
IntActi | O17919, 1 interactor |
STRINGi | 6239.K01G5.5 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 284 – 359 | PUAPROSITE-ProRule annotationAdd BLAST | 76 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 421 – 425 | Poly-Glu | 5 |
Sequence similaritiesi
Belongs to the pseudouridine synthase TruB family.Curated
Phylogenomic databases
eggNOGi | KOG2529, Eukaryota |
GeneTreei | ENSGT00510000047092 |
HOGENOMi | CLU_032087_3_2_1 |
InParanoidi | O17919 |
OMAi | PRRWGMG |
OrthoDBi | 1070373at2759 |
PhylomeDBi | O17919 |
Family and domain databases
InterProi | View protein in InterPro IPR012960, Dyskerin-like IPR020103, PsdUridine_synth_cat_dom_sf IPR002501, PsdUridine_synth_N IPR002478, PUA IPR015947, PUA-like_sf IPR004802, tRNA_PsdUridine_synth_B_fam IPR032819, TruB_C IPR004521, Uncharacterised_CHP00451 |
PANTHERi | PTHR23127, PTHR23127, 1 hit |
Pfami | View protein in Pfam PF08068, DKCLD, 1 hit PF01472, PUA, 1 hit PF16198, TruB_C_2, 1 hit PF01509, TruB_N, 1 hit |
SMARTi | View protein in SMART SM01136, DKCLD, 1 hit SM00359, PUA, 1 hit |
SUPFAMi | SSF55120, SSF55120, 1 hit SSF88697, SSF88697, 1 hit |
TIGRFAMsi | TIGR00425, CBF5, 1 hit TIGR00451, unchar_dom_2, 1 hit |
PROSITEi | View protein in PROSITE PS50890, PUA, 1 hit |
i Sequence
Sequence statusi: Complete.
O17919-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGKKDKRSKL EGDDLAEAQQ KGSFQLPSSN ETAKLDASQW PLLLKNYDKL
60 70 80 90 100
NVRTNHYTPH VEGVSPLKRD IKNYISSGFF NLDKPSNPSS HEVVSWIKRI
110 120 130 140 150
LRCEKTGHSG TLDPKVSGCL IVCIDRTTRL AKSQQGAGKE YICIFKLHEE
160 170 180 190 200
VEDDRKVKQA LEKLTGALFQ RPPLISAVKR QLRIRTVYEN KFIEYDPAQQ
210 220 230 240 250
MGIFNCICES GTYVRTICVH LGLILGCGGQ MQELRRNRSG ICDENENMVT
260 270 280 290 300
MHDVLDAQYL LDTQKDESYM RHIVRPLEAL LTQHKRVVVK DSCINAICYG
310 320 330 340 350
AKILIPGILR YDDDIEVGKE IVIMSTKGEA ICIAIAQMNT STIASVDHGV
360 370 380 390 400
VAKSKRVIME RDVYGRKWGL GPVASKKKQM VKDGLLDKFG KPNDTTPKSW
410 420 430 440
AKEYVQTSTK KEVKKEETPD EEEEEAPKKK SKKSKKQESS DSDSD
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z92803 Genomic DNA Translation: CAB07244.1 |
PIRi | T23199 |
RefSeqi | NP_499370.1, NM_066969.4 |
Genome annotation databases
EnsemblMetazoai | K01G5.5.1; K01G5.5.1; WBGene00010478 |
GeneIDi | 176504 |
KEGGi | cel:CELE_K01G5.5 |
UCSCi | K01G5.5.1, c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z92803 Genomic DNA Translation: CAB07244.1 |
PIRi | T23199 |
RefSeqi | NP_499370.1, NM_066969.4 |
3D structure databases
SMRi | O17919 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 41691, 33 interactors |
DIPi | DIP-25862N |
IntActi | O17919, 1 interactor |
STRINGi | 6239.K01G5.5 |
PTM databases
iPTMneti | O17919 |
Proteomic databases
EPDi | O17919 |
PaxDbi | O17919 |
PeptideAtlasi | O17919 |
Genome annotation databases
EnsemblMetazoai | K01G5.5.1; K01G5.5.1; WBGene00010478 |
GeneIDi | 176504 |
KEGGi | cel:CELE_K01G5.5 |
UCSCi | K01G5.5.1, c. elegans |
Organism-specific databases
CTDi | 176504 |
WormBasei | K01G5.5 ; CE16195 ; WBGene00010478 |
Phylogenomic databases
eggNOGi | KOG2529, Eukaryota |
GeneTreei | ENSGT00510000047092 |
HOGENOMi | CLU_032087_3_2_1 |
InParanoidi | O17919 |
OMAi | PRRWGMG |
OrthoDBi | 1070373at2759 |
PhylomeDBi | O17919 |
Enzyme and pathway databases
Reactomei | R-CEL-171319, Telomere Extension By Telomerase |
Miscellaneous databases
PROi | PR:O17919 |
Gene expression databases
Bgeei | WBGene00010478, Expressed in multi-cellular organism and 5 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR012960, Dyskerin-like IPR020103, PsdUridine_synth_cat_dom_sf IPR002501, PsdUridine_synth_N IPR002478, PUA IPR015947, PUA-like_sf IPR004802, tRNA_PsdUridine_synth_B_fam IPR032819, TruB_C IPR004521, Uncharacterised_CHP00451 |
PANTHERi | PTHR23127, PTHR23127, 1 hit |
Pfami | View protein in Pfam PF08068, DKCLD, 1 hit PF01472, PUA, 1 hit PF16198, TruB_C_2, 1 hit PF01509, TruB_N, 1 hit |
SMARTi | View protein in SMART SM01136, DKCLD, 1 hit SM00359, PUA, 1 hit |
SUPFAMi | SSF55120, SSF55120, 1 hit SSF88697, SSF88697, 1 hit |
TIGRFAMsi | TIGR00425, CBF5, 1 hit TIGR00451, unchar_dom_2, 1 hit |
PROSITEi | View protein in PROSITE PS50890, PUA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DKC1_CAEEL | |
Accessioni | O17919Primary (citable) accession number: O17919 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | January 1, 1998 | |
Last modified: | April 7, 2021 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - SIMILARITY comments
Index of protein domains and families