UniProtKB - O17894 (HM35_CAEEL)
Protein
Homeobox protein unc-39
Gene
unc-39
Organism
Caenorhabditis elegans
Status
Functioni
Probable transcription factor required for differentiation and migration of neuronal cells, such as RID and CAN neurons (PubMed:2361334, PubMed:15282156). Specifically, plays a role in the terminal differentiation of RID peptidergic neurons (PubMed:27855782). Also required for CAN neuron axon guidance (PubMed:15282156).3 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 225 – 277 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 53 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- axon guidance Source: UniProtKB
- locomotion Source: WormBase
- mesodermal cell migration Source: WormBase
- neuron migration Source: UniProtKB
- oviposition Source: WormBase
- positive regulation of locomotion Source: UniProtKB
- regulation of cell migration Source: WormBase
- regulation of nematode male tail tip morphogenesis Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Homeobox protein unc-39CuratedAlternative name(s): Homeobox protein ceh-35Imported Uncoordinated protein 39Imported |
Gene namesi | ORF Names:F56A12.1Imported |
Organismi | Caenorhabditis elegansImported |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | F56A12.1 ; CE37921 ; WBGene00006775 ; unc-39 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation1 Publication
Nucleus
- nucleus Source: WormBase
Other locations
- transcription regulator complex Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
RNAi-mediated knockdown results in 60% larval lethality (PubMed:15282156). Surviving animals display uncoordinated locomotion, withered tail morphology, and defects in both CAN neuronal cell migration and axon guidance (PubMed:15282156).1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 203 | R → Q in e257; uncoordinated locomotion, withered tail morphology, egg-laying defects, protruding vulvae and multiple vulvae. Defective pharyngeal development, which results in animals appearing starved. Mesodermal lineage and neuronal cell migration and specification defects. Abolishes differentiation of RID peptidergic neurons. 2 Publications | 1 | |
Mutagenesisi | 220 | I → IQF in ct73; uncoordinated locomotion, withered tail morphology, egg-laying defects, protruding vulvae and multiple vulvae. Defective pharyngeal development, which results in animals appearing starved. Mesodermal lineage and neuronal cell migration and specification defects. 2 Publications | 1 | |
Mutagenesisi | 283 | P → L in rh72; uncoordinated locomotion, withered tail morphology, egg-laying defects, protruding vulvae and multiple vulvae. Defective pharyngeal development, which results in animals appearing starved. Mesodermal lineage and neuronal cell migration and specification defects. 1 Publication | 1 | |
Mutagenesisi | 298 | P → L in hp701; abolishes differentiation of RID peptidergic neurons. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000446110 | 1 – 335 | Homeobox protein unc-39Add BLAST | 335 |
Proteomic databases
PaxDbi | O17894 |
Expressioni
Developmental stagei
Expressed in muscles and neurons from embryogenesis to adulthood (PubMed:15282156, PubMed:27855782). First expressed post-fertilization, then accumulates in anterior cells of the embryo that give rise to neuronal and mesodermal tissues and body wall muscle cells, where expression persists and increases (PubMed:15282156). Also expressed in posterior nuclei post-fertilization (PubMed:15282156). At the 2-fold stage of embryogenesis, expression is restricted to fewer cells (PubMed:15282156).2 Publications
Gene expression databases
Bgeei | WBGene00006775, Expressed in multi-cellular organism and 4 other tissues |
Interactioni
Binary interactionsi
O17894
With | #Exp. | IntAct |
---|---|---|
eya-1 [O17670] | 5 | EBI-317698,EBI-311862 |
Protein-protein interaction databases
DIPi | DIP-24571N |
IntActi | O17894, 8 interactors |
STRINGi | 6239.F56A12.1 |
Family & Domainsi
Sequence similaritiesi
Belongs to the SIX/Sine oculis homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0775, Eukaryota |
GeneTreei | ENSGT00940000167410 |
HOGENOMi | CLU_872206_0_0_1 |
InParanoidi | O17894 |
OMAi | RYKESQL |
OrthoDBi | 1360664at2759 |
PhylomeDBi | O17894 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR031701, SIX1_SD |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF16878, SIX1_SD, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
O17894-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTDHPPIDTS SYFDCYQQHQ LPLQYTFTSS SNSNTSNSST SPSHISDQFS
60 70 80 90 100
SSGGPPYELS SHILTPSSVI PTPSPSVASA SISSPTIPAF GCTMSEYSME
110 120 130 140 150
QMEAISTSLF QARDGDRLVA FFKQLESLYG PNAVDHLRSE AIIVAYTYAL
160 170 180 190 200
YHSNEFETLF HLLSNRHFQQ RHYNDLQDIW HHARYKESQL KRGKELNPVE
210 220 230 240 250
KYRLRRKFPA PKTIWDGEEI VYSFKDSSRK FLKQFFRNVS EYPTQEQKRE
260 270 280 290 300
ISRATGLKIV QISNWFKNRR QRDKSNNSAK CSPPSSSSST NGGSDFLPII
310 320 330
TPQSFNLAAA PFNMNMIYGT LRDSQSDNDQ FTFNP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX284605 Genomic DNA Translation: CAB04483.2 |
PIRi | T22761 |
RefSeqi | NP_506563.2, NM_074162.2 |
Genome annotation databases
EnsemblMetazoai | F56A12.1.1; F56A12.1.1; WBGene00006775 |
GeneIDi | 191623 |
KEGGi | cel:CELE_F56A12.1 |
UCSCi | F56A12.1, c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX284605 Genomic DNA Translation: CAB04483.2 |
PIRi | T22761 |
RefSeqi | NP_506563.2, NM_074162.2 |
3D structure databases
SMRi | O17894 |
ModBasei | Search... |
Protein-protein interaction databases
DIPi | DIP-24571N |
IntActi | O17894, 8 interactors |
STRINGi | 6239.F56A12.1 |
Proteomic databases
PaxDbi | O17894 |
Genome annotation databases
EnsemblMetazoai | F56A12.1.1; F56A12.1.1; WBGene00006775 |
GeneIDi | 191623 |
KEGGi | cel:CELE_F56A12.1 |
UCSCi | F56A12.1, c. elegans |
Organism-specific databases
CTDi | 191623 |
WormBasei | F56A12.1 ; CE37921 ; WBGene00006775 ; unc-39 |
Phylogenomic databases
eggNOGi | KOG0775, Eukaryota |
GeneTreei | ENSGT00940000167410 |
HOGENOMi | CLU_872206_0_0_1 |
InParanoidi | O17894 |
OMAi | RYKESQL |
OrthoDBi | 1360664at2759 |
PhylomeDBi | O17894 |
Miscellaneous databases
PROi | PR:O17894 |
Gene expression databases
Bgeei | WBGene00006775, Expressed in multi-cellular organism and 4 other tissues |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR031701, SIX1_SD |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit PF16878, SIX1_SD, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HM35_CAEEL | |
Accessioni | O17894Primary (citable) accession number: O17894 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 16, 2019 |
Last sequence update: | March 1, 2005 | |
Last modified: | April 7, 2021 | |
This is version 153 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - SIMILARITY comments
Index of protein domains and families