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Protein

Pyruvate kinase

Gene

pyk-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase 2 (gpd-2), Glyceraldehyde-3-phosphate dehydrogenase 4 (gpd-4), Glyceraldehyde-3-phosphate dehydrogenase 3 (gpd-3), Glyceraldehyde-3-phosphate dehydrogenase 1 (gpd-1)
  2. Probable phosphoglycerate kinase (pgk-1)
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (ipgm-1)
  4. Enolase (enol-1)
  5. Pyruvate kinase (pyk-1), Pyruvate kinase (pyk-1), Pyruvate kinase (pyk-2), Pyruvate kinase (pyk-2), Pyruvate kinase (pyk-1), Pyruvate kinase (pyk-2), Pyruvate kinase (pyk-1), Pyruvate kinase (pyk-1)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processGlycolysisUniRule annotation
LigandMagnesiumUniRule annotation, PyruvateImported

Enzyme and pathway databases

ReactomeiR-CEL-6798695 Neutrophil degranulation
R-CEL-70171 Glycolysis
UniPathwayiUPA00109; UER00188

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinaseUniRule annotation (EC:2.7.1.40UniRule annotation)
Gene namesi
Name:pyk-1Imported
ORF Names:CELE_F25H5.3Imported, F25H5.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiF25H5.3a ; CE15898 ; WBGene00009126 ; pyk-1

PTM / Processingi

Proteomic databases

EPDiO17836
PeptideAtlasiO17836

Expressioni

Gene expression databases

BgeeiWBGene00009126
ExpressionAtlasiO17836 baseline and differential

Interactioni

Protein-protein interaction databases

DIPiDIP-25767N
IntActiO17836, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliO17836
SMRiO17836
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 425PKInterPro annotationAdd BLAST348
Domaini442 – 559PK_CInterPro annotationAdd BLAST118

Sequence similaritiesi

Belongs to the pyruvate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2323 Eukaryota
COG0469 LUCA
GeneTreeiENSGT00390000008859
HOGENOMiHOG000021559
KOiK00873

Family and domain databases

Gene3Di2.40.33.10, 1 hit
3.40.1380.20, 2 hits
InterProiView protein in InterPro
IPR001697 Pyr_Knase
IPR015813 Pyrv/PenolPyrv_Kinase-like_dom
IPR011037 Pyrv_Knase-like_insert_dom_sf
IPR018209 Pyrv_Knase_AS
IPR015793 Pyrv_Knase_brl
IPR015795 Pyrv_Knase_C
IPR036918 Pyrv_Knase_C_sf
IPR015806 Pyrv_Knase_insert_dom_sf
PANTHERiPTHR11817 PTHR11817, 1 hit
PfamiView protein in Pfam
PF00224 PK, 1 hit
PF02887 PK_C, 1 hit
PRINTSiPR01050 PYRUVTKNASE
SUPFAMiSSF50800 SSF50800, 1 hit
SSF51621 SSF51621, 2 hits
SSF52935 SSF52935, 1 hit
TIGRFAMsiTIGR01064 pyruv_kin, 1 hit
PROSITEiView protein in PROSITE
PS00110 PYRUVATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

O17836-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSQVQDVE LAEAGDTINE VKASSASGRG RLARRMTIEE EHAGDYFKQE
60 70 80 90 100
QKLAAVPATT HMEHLCRLDI REAPHLVRQT GIICTIGPAC ASVEMLQKLI
110 120 130 140 150
LNGMNIARLN FSHGSHEYHA GTIANVREAA DSFSDKRVIG IALDTKGPEI
160 170 180 190 200
RTGLLAGGAS AEIELARGAS IRLTTDPHFS ESGTAVNLFV DYKNIAKVLS
210 220 230 240 250
VGSRVYIDDG LISLIVEELQ TDAVICSVEN GGMLGSRKGV NLPGTIVDLP
260 270 280 290 300
AVSEKDCKDL QFGVEQGVDI IFASFIRNAE GIRTIRKVLG EKGKKIKIIA
310 320 330 340 350
KIENQEGVDN ADEIISESDG VMVARGDLGI EIPAEKVFLA QKMLISKCNR
360 370 380 390 400
AGKPVICATQ MLESMVHKPR PTRAEGSDVA NAVLDGADCV MLSGETAKGE
410 420 430 440 450
YPVDALKIMH YICKEAEAAV YHRRLFDELL QNTQKPTDMS HTIAIAATSA
460 470 480 490 500
AASCHASAIL LITTTGRSAI QCSRYKPAVP ILTISRDVAV CRQLHLYRGV
510 520 530 540 550
FPVHYPAERA ADWPTDVDNR INHAIAIGKD RGFIHKGDFL VVVTGWRQGA
560
GATNTLRIIT AE
Length:562
Mass (Da):60,664
Last modified:January 1, 1998 - v1
Checksum:i6865EC68BBCAD9A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA Translation: CAB02984.1
PIRiT21361
RefSeqiNP_492458.1, NM_060057.4
UniGeneiCel.17414

Genome annotation databases

EnsemblMetazoaiF25H5.3a; F25H5.3a; WBGene00009126
GeneIDi172744
KEGGicel:CELE_F25H5.3
UCSCiF25H5.3d c. elegans

Similar proteinsi

Entry informationi

Entry nameiO17836_CAEEL
AccessioniPrimary (citable) accession number: O17836
Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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