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Entry version 151 (12 Aug 2020)
Sequence version 1 (01 Jan 1998)
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Protein

Pyruvate carboxylase 1

Gene

pyc-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei147ATPSequence analysis1
Binding sitei231ATPSequence analysis1
Binding sitei266ATPSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei323Sequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi568Divalent metal cationBy similarity1
Binding sitei640SubstrateBy similarity1
Metal bindingi737Divalent metal cation; via carbamate groupBy similarity1
Metal bindingi767Divalent metal cationBy similarity1
Metal bindingi769Divalent metal cationBy similarity1
Binding sitei904SubstrateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase, Multifunctional enzyme
Biological processGluconeogenesis
LigandATP-binding, Biotin, Metal-binding, Nucleotide-binding, Pyruvate, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
6.4.1.1, 1045

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-196780, Biotin transport and metabolism
R-CEL-70263, Gluconeogenesis

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00138

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pyruvate carboxylase 1 (EC:6.4.1.1)
Alternative name(s):
Pyruvic carboxylase 1
Short name:
PCB 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pyc-1Imported
ORF Names:D2023.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
D2023.2a ; CE09072 ; WBGene00004258 ; pyc-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002399371 – 1175Pyruvate carboxylase 1Add BLAST1175

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei737N6-carboxylysineBy similarity1
Modified residuei1140N6-biotinyllysinePROSITE-ProRule annotationBy similarity1

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O17732

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O17732

PeptideAtlas

More...
PeptideAtlasi
O17732

PRoteomics IDEntifications database

More...
PRIDEi
O17732

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O17732

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00004258, Expressed in multi-cellular organism and 5 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O17732, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with sir-2.2 and sir-2.3.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
44641, 7 interactors

Database of interacting proteins

More...
DIPi
DIP-25614N

Protein interaction database and analysis system

More...
IntActi
O17732, 2 interactors

STRING: functional protein association networks

More...
STRINGi
6239.D2023.2a.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O17732

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 481Biotin carboxylationSequence analysisAdd BLAST451
Domaini151 – 348ATP-graspPROSITE-ProRule annotationAdd BLAST198
Domaini559 – 828Pyruvate carboxyltransferasePROSITE-ProRule annotationAdd BLAST270
Domaini1099 – 1174Biotinyl-bindingPROSITE-ProRule annotationAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni567 – 571Substrate bindingBy similarity5

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0369, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00900000141164

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000395_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O17732

KEGG Orthology (KO)

More...
KOi
K01958

Identification of Orthologs from Complete Genome Data

More...
OMAi
YAIQSRV

Database of Orthologous Groups

More...
OrthoDBi
254436at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O17732

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.20.70, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013785, Aldolase_TIM
IPR011761, ATP-grasp
IPR005481, BC-like_N
IPR011764, Biotin_carboxylation_dom
IPR005482, Biotin_COase_C
IPR000089, Biotin_lipoyl
IPR003379, Carboxylase_cons_dom
IPR005479, CbamoylP_synth_lsu-like_ATP-bd
IPR016185, PreATP-grasp_dom_sf
IPR000891, PYR_CT
IPR005930, Pyruv_COase
IPR011054, Rudment_hybrid_motif
IPR011053, Single_hybrid_motif

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02785, Biotin_carb_C, 1 hit
PF00289, Biotin_carb_N, 1 hit
PF00364, Biotin_lipoyl, 1 hit
PF02786, CPSase_L_D2, 1 hit
PF00682, HMGL-like, 1 hit
PF02436, PYC_OADA, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF001594, Pyruv_carbox, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00878, Biotin_carb_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51230, SSF51230, 1 hit
SSF51246, SSF51246, 1 hit
SSF52440, SSF52440, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01235, pyruv_carbox, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50975, ATP_GRASP, 1 hit
PS50979, BC, 1 hit
PS50968, BIOTINYL_LIPOYL, 1 hit
PS00867, CPSASE_2, 1 hit
PS50991, PYR_CT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O17732-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRFSRIPPIF ANVVRQTHYR NYANGVIKPR EFNKVMVANR GEIAIRVFRA
60 70 80 90 100
LTELNKTSVA IYAEQDKNSM HRLKADEAYL VGKGLPPVAA YLTIDQIIET
110 120 130 140 150
ALKHNIDAIH PGYGFLSERS DFAAACQNAG IVFIGPSPDV MARMGDKVAA
160 170 180 190 200
RQAAIEAGVQ VVPGTPGPIT TADEAVEFAK QYGTPIILKA AYGGGGRGIR
210 220 230 240 250
RVDKLEEVEE AFRRSYSEAQ AAFGDGSLFV EKFVERPRHI EVQLLGDHHG
260 270 280 290 300
NIVHLYERDC SVQRRHQKVV EIAPAPALPE GVREKILADA LRLARHVGYQ
310 320 330 340 350
NAGTVEFLVD QKGNYYFIEV NARLQVEHTV TEEITGVDLV QAQIRIAEGK
360 370 380 390 400
SLDDLKLSQE TIQTTGSAIQ CRVTTEDPAK GFQPDSGRIE VFRSGEGMGI
410 420 430 440 450
RLDSASAFAG SVISPHYDSL MVKVIASARN HPNAAAKMIR ALKKFRIRGV
460 470 480 490 500
KTNIPFLLNV LRQPSFLDAS VDTYFIDEHP ELFQFKPSQN RAQKLLNYLG
510 520 530 540 550
EVKVNGPTTP LATDLKPAVV SPPIPYIPAG AKPPTGLRDV LVQRGPTEFA
560 570 580 590 600
KEVRSRPGCM ITDTTFRDAH QSLLATRVRT YDMAAISPFV AQSFNGLFSL
610 620 630 640 650
ENWGGATFDV SMRFLHECPW ERLQTLRKLI PNIPFQCLLR GANAMGYSNY
660 670 680 690 700
PDNVIYKFCE LAVKNGMDVF RVFDSLNYLP NLLVGMEAVG KAGGVVEAAI
710 720 730 740 750
AYTGDVTDKS RDKYDLKYYL NLADQLVKAQ AHILSIKDMA GVLKPEAAKL
760 770 780 790 800
LIGALRDKFP DIPIHVHTHD TSGAGVAAML ECAKAGADVV DAAVDSMSGM
810 820 830 840 850
TSQPSMGAIV ASLQGTKHDT GLSLDDISKY SAYWESTRQL YAPFECATTM
860 870 880 890 900
KSGNADVYKH EIPGGQYTNL QFQAFSLGLG PQFDEVKRMY REANLVLGDI
910 920 930 940 950
IKVTPSSKIV GDLAQFMVQN NLTRETLVDR ADDLSFPKSV VDFMQGNVGQ
960 970 980 990 1000
PPYGFPEPLR TKVLRGKPKV DGRPGENAKP VDLDAVKVEL EEKHGRTLSE
1010 1020 1030 1040 1050
EDVMSYSMFP TVFDEFETFR QQYGPVDKLP TRLFLTGLEI AEEVDVEIES
1060 1070 1080 1090 1100
GKTLAIQLLA EGKLNKRGER EVFFDLNGQM RSIFVVDKEA SKEIVTRPRA
1110 1120 1130 1140 1150
LPGVRGHIGA PMPGDVLELK IKEGDKVTKK QPLFVLSAMK MEMVIDSPIA
1160 1170
GTVKAIHAPQ GTKCSAGDLV VEVEP
Length:1,175
Mass (Da):129,285
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDE3D21194C21E6AF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H2L2E4H2L2E4_CAEEL
Pyruvate carboxylase 1
pyc-1 CELE_D2023.2, D2023.2
616Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF237467 mRNA Translation: AAF60326.1
Z81052 Genomic DNA Translation: CAB02872.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T20346

NCBI Reference Sequences

More...
RefSeqi
NP_001256376.1, NM_001269447.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
D2023.2a.1; D2023.2a.1; WBGene00004258
D2023.2a.2; D2023.2a.2; WBGene00004258

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_D2023.2

UCSC genome browser

More...
UCSCi
D2023.2.1, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237467 mRNA Translation: AAF60326.1
Z81052 Genomic DNA Translation: CAB02872.1
PIRiT20346
RefSeqiNP_001256376.1, NM_001269447.1

3D structure databases

SMRiO17732
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi44641, 7 interactors
DIPiDIP-25614N
IntActiO17732, 2 interactors
STRINGi6239.D2023.2a.1

PTM databases

iPTMnetiO17732

Proteomic databases

EPDiO17732
PaxDbiO17732
PeptideAtlasiO17732
PRIDEiO17732

Genome annotation databases

EnsemblMetazoaiD2023.2a.1; D2023.2a.1; WBGene00004258
D2023.2a.2; D2023.2a.2; WBGene00004258
KEGGicel:CELE_D2023.2
UCSCiD2023.2.1, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
179616
WormBaseiD2023.2a ; CE09072 ; WBGene00004258 ; pyc-1

Phylogenomic databases

eggNOGiKOG0369, Eukaryota
GeneTreeiENSGT00900000141164
HOGENOMiCLU_000395_0_1_1
InParanoidiO17732
KOiK01958
OMAiYAIQSRV
OrthoDBi254436at2759
PhylomeDBiO17732

Enzyme and pathway databases

UniPathwayiUPA00138
BRENDAi6.4.1.1, 1045
ReactomeiR-CEL-196780, Biotin transport and metabolism
R-CEL-70263, Gluconeogenesis

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O17732

Gene expression databases

BgeeiWBGene00004258, Expressed in multi-cellular organism and 5 other tissues
ExpressionAtlasiO17732, baseline and differential

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785, Aldolase_TIM
IPR011761, ATP-grasp
IPR005481, BC-like_N
IPR011764, Biotin_carboxylation_dom
IPR005482, Biotin_COase_C
IPR000089, Biotin_lipoyl
IPR003379, Carboxylase_cons_dom
IPR005479, CbamoylP_synth_lsu-like_ATP-bd
IPR016185, PreATP-grasp_dom_sf
IPR000891, PYR_CT
IPR005930, Pyruv_COase
IPR011054, Rudment_hybrid_motif
IPR011053, Single_hybrid_motif
PfamiView protein in Pfam
PF02785, Biotin_carb_C, 1 hit
PF00289, Biotin_carb_N, 1 hit
PF00364, Biotin_lipoyl, 1 hit
PF02786, CPSase_L_D2, 1 hit
PF00682, HMGL-like, 1 hit
PF02436, PYC_OADA, 1 hit
PIRSFiPIRSF001594, Pyruv_carbox, 1 hit
SMARTiView protein in SMART
SM00878, Biotin_carb_C, 1 hit
SUPFAMiSSF51230, SSF51230, 1 hit
SSF51246, SSF51246, 1 hit
SSF52440, SSF52440, 1 hit
TIGRFAMsiTIGR01235, pyruv_carbox, 1 hit
PROSITEiView protein in PROSITE
PS50975, ATP_GRASP, 1 hit
PS50979, BC, 1 hit
PS50968, BIOTINYL_LIPOYL, 1 hit
PS00867, CPSASE_2, 1 hit
PS50991, PYR_CT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPYC1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O17732
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: January 1, 1998
Last modified: August 12, 2020
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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