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Protein

Nuclear hormone receptor family member nhr-169

Gene

nhr-169

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Orphan nuclear receptor.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi16 – 90Nuclear receptorPROSITE-ProRule annotationAdd BLAST75
Zinc fingeri19 – 40NR C4-typePROSITE-ProRule annotationAdd BLAST22
Zinc fingeri56 – 72NR C4-typePROSITE-ProRule annotationAdd BLAST17

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear hormone receptor family member nhr-169
Gene namesi
Name:nhr-169
ORF Names:C54C8.1
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiC54C8.1 ; CE36114 ; WBGene00008289 ; nhr-169

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002236011 – 356Nuclear hormone receptor family member nhr-169Add BLAST356

Proteomic databases

PaxDbiO17706
PRIDEiO17706

Expressioni

Gene expression databases

BgeeiWBGene00008289 Expressed in 1 organ(s), highest expression level in multi-cellular organism

Interactioni

Protein-protein interaction databases

IntActiO17706, 1 interactor
STRINGi6239.C54C8.1

Structurei

3D structure databases

ProteinModelPortaliO17706
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini144 – 356NR LBDPROSITE-ProRule annotationAdd BLAST213

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri19 – 40NR C4-typePROSITE-ProRule annotationAdd BLAST22
Zinc fingeri56 – 72NR C4-typePROSITE-ProRule annotationAdd BLAST17

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00390000015766
HOGENOMiHOG000016336
InParanoidiO17706
OrthoDBiEOG09370JB6
PhylomeDBiO17706

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

O17706-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLSTSLEMP FRESTDPICS VCNFSSLIAP HFGGLVCSAC ASFFRRTVAL
60 70 80 90 100
NIHYLCKKDN QCKGMRKNCR ACRFESCVKI AGMKRSLVKE RKNLNNIPLY
110 120 130 140 150
ILNRRNETGN QGVVRAFVSS NQNRLENRLS LSPLTELPIN DEMDVSKILK
160 170 180 190 200
TTPSSLLKYY VEQVSHGKQF YMNTLNIRTK EELFEIVSYQ SKVAAETCRT
210 220 230 240 250
CPGVDLLDNR DILILRKYFQ FSNIWIESTW KYWFSNDFSN DTEKFDIKLM
260 270 280 290 300
EFIGQVKSTL LISLSRLKFN IFEFTAFKAI CIWKLVYHET SRAMKIVAQE
310 320 330 340 350
HYEGVTKALI SYYQTYTLLD SMEIAIRVGE ITLLVSSVFQ MYHDMAKLYL

HMGLPF
Length:356
Mass (Da):41,272
Last modified:July 5, 2004 - v2
Checksum:iD09769DBB4B0B2D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83102 Genomic DNA Translation: CAB05462.2
PIRiT20200
RefSeqiNP_493156.2, NM_060755.2
UniGeneiCel.19068

Genome annotation databases

EnsemblMetazoaiC54C8.1; C54C8.1; WBGene00008289
GeneIDi183768
KEGGicel:CELE_C54C8.1
UCSCiC54C8.1 c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z83102 Genomic DNA Translation: CAB05462.2
PIRiT20200
RefSeqiNP_493156.2, NM_060755.2
UniGeneiCel.19068

3D structure databases

ProteinModelPortaliO17706
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO17706, 1 interactor
STRINGi6239.C54C8.1

Proteomic databases

PaxDbiO17706
PRIDEiO17706

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC54C8.1; C54C8.1; WBGene00008289
GeneIDi183768
KEGGicel:CELE_C54C8.1
UCSCiC54C8.1 c. elegans

Organism-specific databases

CTDi183768
WormBaseiC54C8.1 ; CE36114 ; WBGene00008289 ; nhr-169

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00390000015766
HOGENOMiHOG000016336
InParanoidiO17706
OrthoDBiEOG09370JB6
PhylomeDBiO17706

Miscellaneous databases

PROiPR:O17706

Gene expression databases

BgeeiWBGene00008289 Expressed in 1 organ(s), highest expression level in multi-cellular organism

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNH169_CAEEL
AccessioniPrimary (citable) accession number: O17706
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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Main funding by: National Institutes of Health

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