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Entry version 150 (12 Aug 2020)
Sequence version 1 (01 Jan 1998)
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Protein

Probable S-adenosylmethionine synthase 1

Gene

sams-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: S-adenosyl-L-methionine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes S-adenosyl-L-methionine from L-methionine.By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Probable S-adenosylmethionine synthase 3 (sams-3), Probable S-adenosylmethionine synthase 1 (sams-1), Probable S-adenosylmethionine synthase 4 (sams-4), Probable S-adenosylmethionine synthase 5 (sams-5)
This subpathway is part of the pathway S-adenosyl-L-methionine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes S-adenosyl-L-methionine from L-methionine, the pathway S-adenosyl-L-methionine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi10MagnesiumBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei16ATPBy similarity1
Metal bindingi44PotassiumBy similarity1
Binding sitei57MethionineBy similarity1
Binding sitei100MethionineBy similarity1
Binding sitei245ATPBy similarity1
Binding sitei245Methionine; shared with neighboring subunitBy similarity1
Binding sitei268ATP; via amide nitrogen; shared with neighboring subunitBy similarity1
Binding sitei272ATP; shared with neighboring subunitBy similarity1
Binding sitei276ATP; shared with neighboring subunitBy similarity1
Binding sitei276MethionineBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi166 – 168ATPBy similarity3
Nucleotide bindingi234 – 237ATPBy similarity4
Nucleotide bindingi251 – 252ATPBy similarity2

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processOne-carbon metabolism
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-156581, Methylation
R-CEL-1614635, Sulfur amino acid metabolism
R-CEL-2408508, Metabolism of ingested SeMet, Sec, MeSec into H2Se

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00315;UER00080

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable S-adenosylmethionine synthase 1 (EC:2.5.1.6By similarity)
Short name:
AdoMet synthase 1
Alternative name(s):
Methionine adenosyltransferase 1
Short name:
MAT 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sams-1
ORF Names:C49F5.1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...
WormBasei
C49F5.1 ; CE08852 ; WBGene00008205 ; sams-1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001744441 – 403Probable S-adenosylmethionine synthase 1Add BLAST403

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O17680

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O17680

PeptideAtlas

More...
PeptideAtlasi
O17680

PRoteomics IDEntifications database

More...
PRIDEi
O17680

2D gel databases

The World-2DPAGE database

More...
World-2DPAGEi
0011:O17680
0020:O17680

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00008205, Expressed in multi-cellular organism and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
46276, 34 interactors

Protein interaction database and analysis system

More...
IntActi
O17680, 4 interactors

Molecular INTeraction database

More...
MINTi
O17680

STRING: functional protein association networks

More...
STRINGi
6239.C49F5.1.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O17680

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AdoMet synthase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1506, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183185

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_041802_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O17680

KEGG Orthology (KO)

More...
KOi
K00789

Identification of Orthologs from Complete Genome Data

More...
OMAi
DGTIPWL

Database of Orthologous Groups

More...
OrthoDBi
685006at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O17680

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_00086, S_AdoMet_synth1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022631, ADOMET_SYNTHASE_CS
IPR022630, S-AdoMet_synt_C
IPR022629, S-AdoMet_synt_central
IPR022628, S-AdoMet_synt_N
IPR002133, S-AdoMet_synthetase
IPR022636, S-AdoMet_synthetase_sfam

The PANTHER Classification System

More...
PANTHERi
PTHR11964, PTHR11964, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02773, S-AdoMet_synt_C, 1 hit
PF02772, S-AdoMet_synt_M, 1 hit
PF00438, S-AdoMet_synt_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000497, MAT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55973, SSF55973, 3 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01034, metK, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00376, ADOMET_SYNTHASE_1, 1 hit
PS00377, ADOMET_SYNTHASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O17680-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSKFLFTSE SVSEGHPDKM CDQISDAVLD AHLKQDPNAK VACETVTKTG
60 70 80 90 100
MVMLCGEITS KAVVDYQVLV RRVIEKIGFT DSSIGFDHKT CNVLVALEQQ
110 120 130 140 150
SPEIAAGVHV NKDGEDVGAG DQGIMFGYAT DETEETMPLT LILSHKINAE
160 170 180 190 200
LHKLRRNGTL PWVRPDSKSQ VTIEYESRHG ATIPLRVHTV VVSTQHSPDV
210 220 230 240 250
TLEKLRETIL ADVIKKVIPA SLLDESTVFH INPCGTFIVG GPMGDAGVTG
260 270 280 290 300
RKIIVDTYGG WGAHGGGAFS GKDPTKVDRS AAYAARWVAT SLVKAGLAKR
310 320 330 340 350
VLVQLSYAIG IAKPISVLVY AFGTSPLTDE ELHQIVEDSF DLTPGKIIKE
360 370 380 390 400
LDLKRPIYEK TAENGHFGHS EFPWEQPKAL KISPALLEKA KGNPIPATSA

IAH
Length:403
Mass (Da):43,582
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i81A54B625BC7D96B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z81485 Genomic DNA Translation: CAB03975.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T20070

NCBI Reference Sequences

More...
RefSeqi
NP_510002.1, NM_077601.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C49F5.1.1; C49F5.1.1; WBGene00008205
C49F5.1.2; C49F5.1.2; WBGene00008205
C49F5.1.3; C49F5.1.3; WBGene00008205

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C49F5.1

UCSC genome browser

More...
UCSCi
C49F5.1.1, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z81485 Genomic DNA Translation: CAB03975.1
PIRiT20070
RefSeqiNP_510002.1, NM_077601.3

3D structure databases

SMRiO17680
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi46276, 34 interactors
IntActiO17680, 4 interactors
MINTiO17680
STRINGi6239.C49F5.1.1

2D gel databases

World-2DPAGEi0011:O17680
0020:O17680

Proteomic databases

EPDiO17680
PaxDbiO17680
PeptideAtlasiO17680
PRIDEiO17680

Genome annotation databases

EnsemblMetazoaiC49F5.1.1; C49F5.1.1; WBGene00008205
C49F5.1.2; C49F5.1.2; WBGene00008205
C49F5.1.3; C49F5.1.3; WBGene00008205
KEGGicel:CELE_C49F5.1
UCSCiC49F5.1.1, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
181370
WormBaseiC49F5.1 ; CE08852 ; WBGene00008205 ; sams-1

Phylogenomic databases

eggNOGiKOG1506, Eukaryota
GeneTreeiENSGT00950000183185
HOGENOMiCLU_041802_1_1_1
InParanoidiO17680
KOiK00789
OMAiDGTIPWL
OrthoDBi685006at2759
PhylomeDBiO17680

Enzyme and pathway databases

UniPathwayiUPA00315;UER00080
ReactomeiR-CEL-156581, Methylation
R-CEL-1614635, Sulfur amino acid metabolism
R-CEL-2408508, Metabolism of ingested SeMet, Sec, MeSec into H2Se

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O17680

Gene expression databases

BgeeiWBGene00008205, Expressed in multi-cellular organism and 5 other tissues

Family and domain databases

HAMAPiMF_00086, S_AdoMet_synth1, 1 hit
InterProiView protein in InterPro
IPR022631, ADOMET_SYNTHASE_CS
IPR022630, S-AdoMet_synt_C
IPR022629, S-AdoMet_synt_central
IPR022628, S-AdoMet_synt_N
IPR002133, S-AdoMet_synthetase
IPR022636, S-AdoMet_synthetase_sfam
PANTHERiPTHR11964, PTHR11964, 1 hit
PfamiView protein in Pfam
PF02773, S-AdoMet_synt_C, 1 hit
PF02772, S-AdoMet_synt_M, 1 hit
PF00438, S-AdoMet_synt_N, 1 hit
PIRSFiPIRSF000497, MAT, 1 hit
SUPFAMiSSF55973, SSF55973, 3 hits
TIGRFAMsiTIGR01034, metK, 1 hit
PROSITEiView protein in PROSITE
PS00376, ADOMET_SYNTHASE_1, 1 hit
PS00377, ADOMET_SYNTHASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMETK1_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O17680
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: August 12, 2020
This is version 150 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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