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UniProtKB - O17646 (O17646_CAEEL)

Entry version 139 (10 Feb 2021)
Sequence version 1 (01 Jan 1998)
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Protein
Submitted name:

USP domain-containing protein

Gene

C34F6.9

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
USP domain-containing proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:C34F6.9Imported, CELE_C34F6.9Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...WormBasei		C34F6.9 ; CE15678 ; WBGene00007943

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O17646

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O17646

PeptideAtlas

More...PeptideAtlasi		O17646

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		WBGene00007943, Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Database of interacting proteins

More...DIPi		DIP-27141N

Protein interaction database and analysis system

More...IntActi		O17646, 2 interactors

STRING: functional protein association networks

More...STRINGi		6239.C34F6.9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini869 – 1149USPInterPro annotationAdd BLAST281

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni280 – 304DisorderedSequence analysisAdd BLAST25
Regioni317 – 343DisorderedSequence analysisAdd BLAST27
Regioni608 – 683DisorderedSequence analysisAdd BLAST76
Regioni700 – 831DisorderedSequence analysisAdd BLAST132

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi629 – 654PolarSequence analysisAdd BLAST26
Compositional biasi730 – 749PolyampholyteSequence analysisAdd BLAST20
Compositional biasi771 – 793PolyampholyteSequence analysisAdd BLAST23
Compositional biasi794 – 819PolarSequence analysisAdd BLAST26

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1867, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00970000196546

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_273016_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O17646

Database of Orthologous Groups

More...OrthoDBi		1566037at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR028881, PAN2_dom
IPR038765, Papain-like_cys_pep_sf
IPR018200, USP_CS
IPR028889, USP_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13423, UCH_1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54001, SSF54001, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00973, USP_2, 1 hit
PS50235, USP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O17646-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGADPTQTV GEVLKRLHQK HLDGVSLTTL QRDDIHSIFP AVHVQHSIGQ 
        60         70         80         90        100
TSYDYQMTES YFTSRLSEVL TETHNLKAEE ASKIVNGQYT KATPSSQFLS 
       110        120        130        140        150
SIPSSMQEFV GKIGLPDPKT NAPAFYIDNL LANQLKSLKG IITKDSFNSE 
       160        170        180        190        200
KSLASFSYAD SFFLKMKGVH NNNEVASPDE KVQEKSSVSP VIPNEAVVSK 
       210        220        230        240        250
MNEYLDETGS AKNLEAHVKP VSDPPASPGR VISSKMLSSR SNDENKLLEN 
       260        270        280        290        300
AVETLPTVLP QTDYAENEKF LNDIQVETNN SISDHTRQPS NEPVEKVSES 
       310        320        330        340        350
AHDLTSQISQ CTDLLKDHPE SSETTSNTSA GVASATTDQT PPDVVADQKY 
       360        370        380        390        400
NVTTPIDPSH IVLTSPHSEF DKKEESSEQI HNNNMENDAL HNSTFPKQND 
       410        420        430        440        450
VVMLELFKAS EISEVPLSIL VVVPISEPSS VSTTDVSTTL DDALQDLPIS 
       460        470        480        490        500
QVVESSQNPV EEKTMSSETA VSLNLPCVNT LITEADEVKL RDALWEKRKR 
       510        520        530        540        550
EQEKLHNKTI IWSRTVTYPP IHTFPKTKKY VKQAAKIPQP AVLKEDPQAV 
       560        570        580        590        600
KPRPPKKDVL AGYSVETIFL ALTGETVLCR SHSLEDLVRL KQEELDAVTS 
       610        620        630        640        650
ILNNGVQKSQ CDSGVMSNTL KSQDRKESEG VQLNSPLPEN HAVNQTVNQS 
       660        670        680        690        700
MIRKGRPKRS TKTKSGSETE NESMSEDNDD FSEHDEDFDI EQAVQAIDNV 
       710        720        730        740        750
HHKAKRERKS RSSITVSEDG YPPETVSPQE LHSLKRKSLP DDNTTPSKQR 
       760        770        780        790        800
RSSRLKNSTA KTADFVYEPA VTDRSEQDKS PSLPREKNIG KDSGKSRLAS 
       810        820        830        840        850
QRSSSRRSSA PFSEESPSTK KTRFSTRVEQ YSRRVSNETI KSLLQQVLTP 
       860        870        880        890        900
KAADECDIQD HFPSPIVRRA IVNRNTLCYA ISMVQLLMRV PQVYSIVRSH 
       910        920        930        940        950
SHKKQKANRS ECFLCMLTNL ISERPRADDT PAFVALLKSN WKNIEDEGMQ 
       960        970        980        990       1000
CVMEAMQYFF NKFDEEYMHA HPPIRSYFEI EMFIAYECKS CKHVSNAPDK 
      1010       1020       1030       1040       1050
AIYVSIDLSS KTKGTMQSMV DKMANPIPVV GMNCKSCGQE TLCSTTRFTK 
      1060       1070       1080       1090       1100
LPEVLLYFVP RVKDQQRGKD MTVLNVQRQL ILKDDNNAHN YELCSFIAHC 
      1110       1120       1130       1140       1150
GKNGDNGHYK SFEVDRTNEF QYNEYDDAKV VLDSKLSSDI TIVLAMFRKQ 
      1160       1170       1180 
EAVAKDAATD IIFDGRGNIV FANEKHCQSI Q
Length:1,181
Mass (Da):132,194
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i310959CB250ED3F2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BX284606 Genomic DNA Translation: CAB03946.1

Protein sequence database of the Protein Information Resource

More...PIRi		T19736

NCBI Reference Sequences

More...RefSeqi		NP_509876.1, NM_077475.6

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		C34F6.9.1; C34F6.9.1; WBGene00007943

UCSC genome browser

More...UCSCi		C34F6.9, c. elegans

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA Translation: CAB03946.1
PIRiT19736
RefSeqiNP_509876.1, NM_077475.6

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

DIPiDIP-27141N
IntActiO17646, 2 interactors
STRINGi6239.C34F6.9

Proteomic databases

EPDiO17646
PaxDbiO17646
PeptideAtlasiO17646

Genome annotation databases

EnsemblMetazoaiC34F6.9.1; C34F6.9.1; WBGene00007943
UCSCiC34F6.9, c. elegans

Organism-specific databases

WormBaseiC34F6.9 ; CE15678 ; WBGene00007943

Phylogenomic databases

eggNOGiKOG1867, Eukaryota
GeneTreeiENSGT00970000196546
HOGENOMiCLU_273016_0_0_1
InParanoidiO17646
OrthoDBi1566037at2759

Gene expression databases

BgeeiWBGene00007943, Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR028881, PAN2_dom
IPR038765, Papain-like_cys_pep_sf
IPR018200, USP_CS
IPR028889, USP_dom
PfamiView protein in Pfam
PF13423, UCH_1, 1 hit
SUPFAMiSSF54001, SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00973, USP_2, 1 hit
PS50235, USP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO17646_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O17646
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: February 10, 2021
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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