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Entry version 125 (29 Sep 2021)
Sequence version 3 (24 Jul 2013)
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Protein

Nucleolar complex protein 2 homolog

Gene

pro-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for normal somatic gonad development and for regulation of germline development and proliferation.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Gonadal differentiation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleolar complex protein 2 homolog
Short name:
Protein NOC2 homolog
Alternative name(s):
Proximal proliferation in germline protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pro-2
ORF Names:C07E3.2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
C07E3.2 ; CE47947 ; WBGene00007413 ; pro-2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Worms exhibit slow growth and sterility caused by germline proliferation defective phenotype (Glp) or proximal germ cell proliferation abnormal phenotype (Pro).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001210511 – 715Nucleolar complex protein 2 homologAdd BLAST715

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O17580

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O17580

PeptideAtlas

More...
PeptideAtlasi
O17580

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O17580

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00007413, Expressed in material anatomical entity and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
39917, 4 interactors

Protein interaction database and analysis system

More...
IntActi
O17580, 1 interactor

STRING: functional protein association networks

More...
STRINGi
6239.C07E3.2

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni17 – 71DisorderedSequence analysisAdd BLAST55
Regioni85 – 132DisorderedSequence analysisAdd BLAST48
Regioni638 – 715DisorderedSequence analysisAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi21 – 46Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi56 – 71Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi92 – 127Acidic residuesSequence analysisAdd BLAST36
Compositional biasi638 – 686Basic and acidic residuesSequence analysisAdd BLAST49

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NOC2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2256, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000010057

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_399139_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O17580

Identification of Orthologs from Complete Genome Data

More...
OMAi
INFMRRS

Database of Orthologous Groups

More...
OrthoDBi
1194328at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O17580

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR005343, Noc2

The PANTHER Classification System

More...
PANTHERi
PTHR12687, PTHR12687, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03715, Noc2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O17580-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLLKKPAGL KKRKVISKRI KIEKKPSSED EGSSDEEVPK LDGEGSLDGS
60 70 80 90 100
EDEDDGTVTV EKGGVKKHKL DLEKLKQSDP EFFKFLQQED ADLLNMEDDG
110 120 130 140 150
DDDEDDDEDD EDEEEEESDD DEDDEEDDDK TKIKKIRKPK IKSDNSGRLI
160 170 180 190 200
VDSNVYSYLQ QVLVLDDETS TPTNPSDVRM AVDVFVACVA RVGADIEAPK
210 220 230 240 250
YVINEQSIFE AVVRMCFQAM PDILKRLLKA KPEGDKVLFS KTAIKKYQTY
260 270 280 290 300
VRTYLHAMIV FLNEVQTTEV LIATIKAMTR LVDLYAHFSR MSKLLIKAVV
310 320 330 340 350
RIWSRKTLEC RLPAFVCMNL LVKNYPQHFV PLYKTAYVAF VANSKIVTNE
360 370 380 390 400
TWPLLQFMHR TFAELTILNP EQAYKYAFVY IRQTAVHLRN AMISKGRKDL
410 420 430 440 450
IFSIYNWQMM QCMYMWVRVI AKAHSVNGAE QIGELVYPLI QVIVGIFKLC
460 470 480 490 500
NAPTFLPLRL HCCQLLIQLQ ASCTNYIPIL QVSCDCLEEL ARELKSKPKP
510 520 530 540 550
VKGAVKLPDI ECTLKCSSQF SDLPQWRKVI SEHVFRTMMQ SAHLLASQAA
560 570 580 590 600
FPDVVLPINH RISAILETMK NGDHAHLFRG FQTKLKEHSR FVLDVLARKS
610 620 630 640 650
VDINDEMQVR AVRFDLNNPD SPIKTFYRQW EKVWKMKERS AVENSKKDDK
660 670 680 690 700
KKKKEEEAAA AKKRKPNETV EDEDDVKPEV SKAKRKRIKI GAAAKKADAS
710
VPDQFADMSM WSDED
Length:715
Mass (Da):81,954
Last modified:July 24, 2013 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i52F296EEA4D9DF52
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EU068465 mRNA Translation: ABU49430.1
Z49908, Z81573, Z99268 Genomic DNA Translation: CAA90103.2

Protein sequence database of the Protein Information Resource

More...
PIRi
T19060

NCBI Reference Sequences

More...
RefSeqi
NP_496224.2, NM_063823.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C07E3.2.1; C07E3.2.1; WBGene00007413

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
174598

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C07E3.2

UCSC genome browser

More...
UCSCi
C07E3.2.1, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU068465 mRNA Translation: ABU49430.1
Z49908, Z81573, Z99268 Genomic DNA Translation: CAA90103.2
PIRiT19060
RefSeqiNP_496224.2, NM_063823.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi39917, 4 interactors
IntActiO17580, 1 interactor
STRINGi6239.C07E3.2

PTM databases

iPTMnetiO17580

Proteomic databases

EPDiO17580
PaxDbiO17580
PeptideAtlasiO17580

Genome annotation databases

EnsemblMetazoaiC07E3.2.1; C07E3.2.1; WBGene00007413
GeneIDi174598
KEGGicel:CELE_C07E3.2
UCSCiC07E3.2.1, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
174598
WormBaseiC07E3.2 ; CE47947 ; WBGene00007413 ; pro-2

Phylogenomic databases

eggNOGiKOG2256, Eukaryota
GeneTreeiENSGT00390000010057
HOGENOMiCLU_399139_0_0_1
InParanoidiO17580
OMAiINFMRRS
OrthoDBi1194328at2759
PhylomeDBiO17580

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O17580

Gene expression databases

BgeeiWBGene00007413, Expressed in material anatomical entity and 5 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR005343, Noc2
PANTHERiPTHR12687, PTHR12687, 1 hit
PfamiView protein in Pfam
PF03715, Noc2, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNOC2L_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O17580
Secondary accession number(s): A7UGI7
, O17971, O18163, Q17785
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: July 24, 2013
Last modified: September 29, 2021
This is version 125 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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