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UniProtKB - O17562 (O17562_CAEEL)

Entry version 125 (25 May 2022)
Sequence version 2 (15 Jan 2008)
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Protein
Submitted name:

C-type LECtin

Gene

clec-223

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandLectinImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
C-type LECtinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:clec-223Imported
ORF Names:C03E10.5Imported, CELE_C03E10.5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...WormBasei		C03E10.5 ; CE41608 ; WBGene00007282 ; clec-223

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500415745920 – 1034Sequence analysisAdd BLAST1015

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O17562

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O17562

PeptideAtlas

More...PeptideAtlasi		O17562

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		WBGene00007282, Expressed in adult organism and 4 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		6239.C03E10.5

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		O17562

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini378 – 552C-type lectinInterPro annotationAdd BLAST175
Domaini640 – 805C-type lectinInterPro annotationAdd BLAST166
Domaini856 – 1011C-type lectinInterPro annotationAdd BLAST156

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni44 – 368DisorderedSequence analysisAdd BLAST325
Regioni588 – 632DisorderedSequence analysisAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi59 – 91Pro residuesSequence analysisAdd BLAST33
Compositional biasi92 – 368Polar residuesSequence analysisAdd BLAST277

Keywords - Domaini

SignalSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4297, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01030000237609

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003739_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O17562

Identification of Orthologs from Complete Genome Data

More...OMAi		HDEICIP

Database of Orthologous Groups

More...OrthoDBi		962918at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.10.100.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR016187, CTDL_fold

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00034, CLECT, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF56436, SSF56436, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O17562-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKLLVLFIL SLYISPVESN FYKNYNKQYK PIYNYPPPPN VYYPPDYIYE 
        60         70         80         90        100
DYSPEDDYYQ GPPGPPGLEG PPGPNGPPGP DGPPGPPGPP AEKSTSTTTV 
       110        120        130        140        150
SPTTESTAAP STSTETPTTE STAAPSTSTE TPTTESTAAP STSTETPTTE 
       160        170        180        190        200
STAAPSTSTE TPTTESTAAP STSTETPTTE STAAPSTSTE TPTTESTAAP 
       210        220        230        240        250
STSTETPTTE STAAPSTSTE TPTTESTAAP STSTETPTTE STAAPSTSTE 
       260        270        280        290        300
TPTTESTAAP STSTETPTTE STAAPSTSTE TPTTESTAAP STSTETPTTE 
       310        320        330        340        350
STAAPSTSTE TPTTESTAAP STSTETPTTE STAAPSTSTE TPTTESTAAP 
       360        370        380        390        400
STSTETPTTK TTIGSTSTIS QSCIETECDD GWIKTLRGNN PQKTLCMKLF 
       410        420        430        440        450
SHDTSSYDDA SMYCYDSHQA FLTGPDSNDE YDKIMEQALN ISDQVSDSQS 
       460        470        480        490        500
MILIGLKRTT ECTTDSGEQD QNSICRRPKG FIWQDGLGET SNTLINQHFN 
       510        520        530        540        550
DDPGVETSPD HVRACTGIII VKGATNNKNV YSLDCSNGEK SSGEKSKMVV 
       560        570        580        590        600
CGKLGKCPAT TPSTISTTSG ASSSTASVSS TILSSTATTM VTSTPTTEKS 
       610        620        630        640        650
STTTTSTPTS EATSTTTAMI TTTSGTTENP TTTDCPTKVC RYGFHPTIRN 
       660        670        680        690        700
GKVWCIRVFF HFVLNYQDGS DYCWNYFHST LSGPADENEY NVLLDQTKTD 
       710        720        730        740        750
PSLVQSLTKY TKVFMVLGAQ RTPACLYESS SAQCEKPSGY QWLDNVTDTT 
       760        770        780        790        800
YAFTKFNEDQ PDTSPEQPEG CVGVLVYTDP TKRDKELVWS LSCNDAQSAH 
       810        820        830        840        850
QVVLKLVVCG HEGVCPEEST IPPPSTQSTT TMKSTTTATT SMSTTKKVCA 
       860        870        880        890        900
KSDLKCANGW TSFNRTSTNP FCFKVISSYN QSYEQSEALC AASGGYLSGV 
       910        920        930        940        950
ENITEYQFAV ELAKAAVDYS TSFNEKILVT IALKRKVICL QTDSTESCIT 
       960        970        980        990       1000
FKAYEFVDDK TKYVAILQHY SLWADNQPVI ISDQPHGCVG IMVTQSTSTS 
      1010       1020       1030 
GDSKLFSTRC ETGTQTYGMS NAAYCARVPD VCPP
Length:1,034
Mass (Da):109,733
Last modified:January 15, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2FC42E4FBE2771DB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BX284605 Genomic DNA Translation: CAB03824.2

NCBI Reference Sequences

More...RefSeqi		NP_505863.2, NM_073462.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		C03E10.5.1; C03E10.5.1; WBGene00007282

Database of genes from NCBI RefSeq genomes

More...GeneIDi		179561

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		cel:CELE_C03E10.5

UCSC genome browser

More...UCSCi		C03E10.5, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CAB03824.2
RefSeqiNP_505863.2, NM_073462.4

3D structure databases

AlphaFoldDBiO17562
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

STRINGi6239.C03E10.5

Proteomic databases

EPDiO17562
PaxDbiO17562
PeptideAtlasiO17562

Genome annotation databases

EnsemblMetazoaiC03E10.5.1; C03E10.5.1; WBGene00007282
GeneIDi179561
KEGGicel:CELE_C03E10.5
UCSCiC03E10.5, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		179561
WormBaseiC03E10.5 ; CE41608 ; WBGene00007282 ; clec-223

Phylogenomic databases

eggNOGiKOG4297, Eukaryota
GeneTreeiENSGT01030000237609
HOGENOMiCLU_003739_0_0_1
InParanoidiO17562
OMAiHDEICIP
OrthoDBi962918at2759

Gene expression databases

BgeeiWBGene00007282, Expressed in adult organism and 4 other tissues

Family and domain databases

Gene3Di3.10.100.10, 2 hits
InterProiView protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR016187, CTDL_fold
SMARTiView protein in SMART
SM00034, CLECT, 3 hits
SUPFAMiSSF56436, SSF56436, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO17562_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O17562
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 15, 2008
Last modified: May 25, 2022
This is version 125 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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