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UniProtKB - O17554 (ALKMO_CAEEL)
Protein
Alkylglycerol monooxygenase
Gene
agmo-1
Organism
Caenorhabditis elegans
Status
Functioni
Glyceryl-ether monooxygenase that cleaves the O-alkyl bond of ether lipids.
By similarityCatalytic activityi
- (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 1-O-(1,2-saturated-alkyl)-sn-glycerol + O2 = (6R)-L-erythro-6,7-dihydrobiopterin + a 1-(1-hydroxyalkyl)-sn-glycerol + H2OBy similarityEC:1.14.16.5By similarity
Cofactori
Fe cationBy similarity
GO - Molecular functioni
- glyceryl-ether monooxygenase activity Source: GO_Central
- iron ion binding Source: InterPro
GO - Biological processi
- lipid biosynthetic process Source: InterPro
- membrane lipid metabolic process Source: GO_Central
Keywordsi
Molecular function | Oxidoreductase |
Ligand | Iron |
Enzyme and pathway databases
Reactomei | R-CEL-75109, Triglyceride biosynthesis |
Names & Taxonomyi
Protein namesi | Recommended name: Alkylglycerol monooxygenaseImported (EC:1.14.16.5By similarity)Alternative name(s): Transmembrane protein 195 homolog |
Gene namesi | Name:agmo-1Imported ORF Names:BE10.2Imported |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | BE10.2 ; CE30592 ; WBGene00007210 ; agmo-1 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Multi-pass membrane protein By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 56 – 76 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 104 – 124 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 366 – 386 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 396 – 416 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 430 – 450 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 452 – 472 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000299305 | 1 – 505 | Alkylglycerol monooxygenaseAdd BLAST | 505 |
Proteomic databases
EPDi | O17554 |
PaxDbi | O17554 |
PRIDEi | O17554 |
Expressioni
Gene expression databases
Bgeei | WBGene00007210, Expressed in multi-cellular organism and 4 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 130 – 262 | Fatty acid hydroxylaseSequence analysisAdd BLAST | 133 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 145 – 149 | Histidine box-1 | 5 | |
Motifi | 158 – 162 | Histidine box-2 | 5 | |
Motifi | 234 – 238 | Histidine box-3 | 5 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0872, Eukaryota |
GeneTreei | ENSGT00440000033807 |
HOGENOMi | CLU_033631_2_1_1 |
InParanoidi | O17554 |
OMAi | GMLSQCF |
OrthoDBi | 1446475at2759 |
PhylomeDBi | O17554 |
Family and domain databases
InterProi | View protein in InterPro IPR006694, Fatty_acid_hydroxylase |
Pfami | View protein in Pfam PF04116, FA_hydroxylase, 1 hit |
i Sequence
Sequence statusi: Complete.
O17554-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNETAWLDRV FSNTSLGHRL LDRLTLTNLR HAFYLISPYE TTVESIDDVP
60 70 80 90 100
NYNAEVSAWW LVFLTAEFFI LFISGHEDRF ALNDSITSIC AGMLSQCFKF
110 120 130 140 150
GGRAVAIFLY VIVWDNWRIL ELPWDSPWTW IFCLFFQDFM YYLGHRAVHE
160 170 180 190 200
AGFFWGLHTI HHSSEYYNFS TALRQAAIQD AGLAIYDCIQ AFFIPPSIFL
210 220 230 240 250
VHRYFSEIFQ FIMHTSLVDT MGPLGLVFNT PSHHRVHHGR NPYCIDKNYG
260 270 280 290 300
GVFIIWDKMF NTFEAERHDD PPIYGLVTNE NTFNQIYLQF HALWDILIFK
310 320 330 340 350
GFTKDVKGEP MFPGVVNKLK ATVFPPGWFP GVPVTPFFHW MSMVNPAHGV
360 370 380 390 400
PEPEKPVLRY SPPARILVKV YVASSFLLLL AIFFHFEYDR NHLSYLDCTV
410 420 430 440 450
KIAYFVVTMQ CFGAFFDMKW YARYIEIARC CGVLIYYGVL MFDHIGAGTH
460 470 480 490 500
RLFVISLHIM AIALWTTDVL VEKLSQCCSK NQSINPEKGD LERAPEIASI
SKNVQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z93372 Genomic DNA Translation: CAB07547.2 |
PIRi | T18789 |
RefSeqi | NP_499664.2, NM_067263.5 |
Genome annotation databases
EnsemblMetazoai | BE10.2.1; BE10.2.1; WBGene00007210 |
GeneIDi | 176695 |
KEGGi | cel:CELE_BE10.2 |
UCSCi | BE10.2, c. elegans |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z93372 Genomic DNA Translation: CAB07547.2 |
PIRi | T18789 |
RefSeqi | NP_499664.2, NM_067263.5 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 6239.BE10.2 |
Proteomic databases
EPDi | O17554 |
PaxDbi | O17554 |
PRIDEi | O17554 |
Genome annotation databases
EnsemblMetazoai | BE10.2.1; BE10.2.1; WBGene00007210 |
GeneIDi | 176695 |
KEGGi | cel:CELE_BE10.2 |
UCSCi | BE10.2, c. elegans |
Organism-specific databases
CTDi | 176695 |
WormBasei | BE10.2 ; CE30592 ; WBGene00007210 ; agmo-1 |
Phylogenomic databases
eggNOGi | KOG0872, Eukaryota |
GeneTreei | ENSGT00440000033807 |
HOGENOMi | CLU_033631_2_1_1 |
InParanoidi | O17554 |
OMAi | GMLSQCF |
OrthoDBi | 1446475at2759 |
PhylomeDBi | O17554 |
Enzyme and pathway databases
Reactomei | R-CEL-75109, Triglyceride biosynthesis |
Miscellaneous databases
PROi | PR:O17554 |
Gene expression databases
Bgeei | WBGene00007210, Expressed in multi-cellular organism and 4 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR006694, Fatty_acid_hydroxylase |
Pfami | View protein in Pfam PF04116, FA_hydroxylase, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ALKMO_CAEEL | |
Accessioni | O17554Primary (citable) accession number: O17554 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 11, 2007 |
Last sequence update: | October 1, 2002 | |
Last modified: | December 2, 2020 | |
This is version 116 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase - SIMILARITY comments
Index of protein domains and families