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Protein

Tyrosine 3-monooxygenase

Gene

TH

Organism
Schistosoma mansoni (Blood fluke)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

L-tyrosine + tetrahydrobiopterin + O2 = L-dopa + 4a-hydroxytetrahydrobiopterin.

Cofactori

Pathwayi: dopamine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes dopamine from L-tyrosine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Tyrosine 3-monooxygenase (TH)
  2. no protein annotated in this organism
This subpathway is part of the pathway dopamine biosynthesis, which is itself part of Catecholamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes dopamine from L-tyrosine, the pathway dopamine biosynthesis and in Catecholamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi294IronBy similarity1
Metal bindingi299IronBy similarity1
Metal bindingi339IronBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
Biological processCatecholamine biosynthesis, Neurotransmitter biosynthesis
LigandIron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00747; UER00733

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine 3-monooxygenase (EC:1.14.16.2)
Alternative name(s):
Tyrosine 3-hydroxylase
Short name:
TH
Gene namesi
Name:TH
OrganismiSchistosoma mansoni (Blood fluke)
Taxonomic identifieri6183 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002055671 – 465Tyrosine 3-monooxygenaseAdd BLAST465

Proteomic databases

PRIDEiO17446

Structurei

3D structure databases

ProteinModelPortaliO17446
SMRiO17446
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3820 Eukaryota
COG3186 LUCA
HOGENOMiHOG000233373

Family and domain databases

Gene3Di1.10.800.10, 1 hit
InterProiView protein in InterPro
IPR001273 ArAA_hydroxylase
IPR018301 ArAA_hydroxylase_Fe/CU_BS
IPR036951 ArAA_hydroxylase_sf
IPR036329 Aro-AA_hydroxylase_C_sf
IPR019774 Aromatic-AA_hydroxylase_C
IPR005962 Tyr_3_mOase
IPR019773 Tyrosine_3-monooxygenase-like
PANTHERiPTHR11473 PTHR11473, 1 hit
PfamiView protein in Pfam
PF00351 Biopterin_H, 1 hit
PIRSFiPIRSF000336 TH, 1 hit
PRINTSiPR00372 FYWHYDRXLASE
SUPFAMiSSF56534 SSF56534, 1 hit
TIGRFAMsiTIGR01269 Tyr_3_monoox, 1 hit
PROSITEiView protein in PROSITE
PS00367 BH4_AAA_HYDROXYL_1, 1 hit
PS51410 BH4_AAA_HYDROXYL_2, 1 hit

Sequencei

Sequence statusi: Complete.

O17446-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMTMMCDES IEENNKSSTV ELNHNEKDGR IHSIIINFHP ITHEQSNNQF
60 70 80 90 100
YIQTLHEILK YIIDKKLNLV HFETRPTLTL SNANRDVQYS CLITLEANEI
110 120 130 140 150
NMSLLYEELR GNSFISGINL LNNQESEDWY PKHISDLDKC QHLLRKFQPE
160 170 180 190 200
LQTDHPGFHD KVYRERREAI AKIAFQYKYG DRIPEVEYTK EEIETWGLVF
210 220 230 240 250
TKMKAVHASR ACREYIDGFQ LLEKYCNYNS ESIPQLQTIC EFMHRTSGFR
260 270 280 290 300
IRPVAGLVSP KDFLASLAFR VFQCTQYIRH HSRPMHTPEP DCIHELIGHM
310 320 330 340 350
PMLVNRQFAD FSQELGLASL GASEEEITRL STLYWFTVEF GLCNENGETR
360 370 380 390 400
ALGAGIMSSY GELENAFSDL SVKEPFNIND AAVQVYDDVG YQKIYFVTES
410 420 430 440 450
IESMKRELRN YINTSGKSTI PIYDPITETV HMKSRFSIRK ELLKHVKEEI
460
GQLDTLLNHS NYTLP
Length:465
Mass (Da):54,081
Last modified:January 1, 1998 - v1
Checksum:i0DE47B4A474665CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF030336 mRNA Translation: AAC62256.1

Similar proteinsi

Entry informationi

Entry nameiTY3H_SCHMA
AccessioniPrimary (citable) accession number: O17446
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

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