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Protein

Probable phospholipase D F09G2.8

Gene

F09G2.8

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

A phosphatidylcholine + H2O = choline + a phosphatidate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei277PROSITE-ProRule annotation1
Active sitei279PROSITE-ProRule annotation1
Active sitei284PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-CEL-1855204 Synthesis of IP3 and IP4 in the cytosol
R-CEL-2029485 Role of phospholipids in phagocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phospholipase D F09G2.8 (EC:3.1.4.4)
Alternative name(s):
Choline phosphatase F09G2.8
Phosphatidylcholine-hydrolyzing phospholipase D F09G2.8
Gene namesi
ORF Names:F09G2.8
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF09G2.8a ; CE09303 ; WBGene00017316
F09G2.8b ; CE41221 ; WBGene00017316

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 123CytoplasmicSequence analysisAdd BLAST123
Transmembranei124 – 144Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini145 – 554ExtracellularSequence analysisAdd BLAST410

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002505831 – 554Probable phospholipase D F09G2.8Add BLAST554

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi181N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi208N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi244N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi266N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi333N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi350N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi468N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi513N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiO17405
PaxDbiO17405
PeptideAtlasiO17405
PRIDEiO17405

Expressioni

Gene expression databases

BgeeiWBGene00017316 Expressed in 5 organ(s), highest expression level in adult organism

Interactioni

Protein-protein interaction databases

STRINGi6239.F09G2.8b

Structurei

3D structure databases

ProteinModelPortaliO17405
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini272 – 299PLD phosphodiesterase 1PROSITE-ProRule annotationAdd BLAST28
Domaini492 – 518PLD phosphodiesterase 2PROSITE-ProRule annotationAdd BLAST27

Sequence similaritiesi

Belongs to the phospholipase D family.Curated

Keywords - Domaini

Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3603 Eukaryota
ENOG410XQZ4 LUCA
GeneTreeiENSGT00390000009798
HOGENOMiHOG000293407
InParanoidiO17405
KOiK16860
OMAiWHADARI
OrthoDBiEOG091G07LR
PhylomeDBiO17405

Family and domain databases

InterProiView protein in InterPro
IPR032803 PLDc_3
IPR001736 PLipase_D/transphosphatidylase
PfamiView protein in Pfam
PF13918 PLDc_3, 1 hit
SMARTiView protein in SMART
SM00155 PLDc, 2 hits
PROSITEiView protein in PROSITE
PS50035 PLD, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform b (identifier: O17405-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPLRLINFRQ QRRCRQSPSV ARLESIVLNR RELLLDHFQY SLFQNSSEIP
60 70 80 90 100
MTTILINDRP MRHTHDGRAD MTNFEMDLFD TRIEVPTSKN SGGDGMHSPY
110 120 130 140 150
YDEESSKKRC CKCGNSRNRI IKPACVPISI VSLFIIALVF LPLFNEEDLA
160 170 180 190 200
SPIKLTTGCS VDCKTFLVES IPIGLPFKTN NHTAEAWINI IDNSKQYLDI
210 220 230 240 250
SVMYWNLNTS DYKSSVYGRR VYEAIIRAGK RGVKIRIAQD GASNLSDNKE
260 270 280 290 300
SAYLVQEGLA EVREINVTRL IGSGIIHTKF ILSDIATLYI GSANMDWKSL
310 320 330 340 350
SEVKEVGVVF QECPCVASDL YKIFAAYWKL GENDSVIPEK WPISYRTPFN
360 370 380 390 400
FSSMAKLTMD GEPAEYFISS SPGPFNPKGR EHDLAAIQKI MKDARKSVCI
410 420 430 440 450
SVMDYIPSTL YMKKSNRFWP EIDDSIRDAA YRGVNVRMLI SHWDHSRKEM
460 470 480 490 500
IPFLKSLQTI TDGLPRYNRT EHGQVQVRIF TVPPNGKEKI PFTRVNHAKY
510 520 530 540 550
MVTEDIAYIG TSNWSGDYFI STAGVAMVVR QPSATKRLQN VFDRDWNSEY

SKDL
Note: No experimental confirmation available.
Length:554
Mass (Da):63,216
Last modified:February 22, 2012 - v2
Checksum:i27FC4B5F9C98B4A0
GO
Isoform a (identifier: O17405-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MPLRLINFRQQRRCRQSPSVARLES → MVSGRTYLTPHEKEENGERKNTRME
     26-63: Missing.

Note: No experimental confirmation available.
Show »
Length:516
Mass (Da):58,573
Checksum:i62747B31104FAE57
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0424091 – 25MPLRL…ARLES → MVSGRTYLTPHEKEENGERK NTRME in isoform a. CuratedAdd BLAST25
Alternative sequenceiVSP_04241026 – 63Missing in isoform a. CuratedAdd BLAST38

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080529 Genomic DNA Translation: CCD64428.1
FO080529 Genomic DNA Translation: CCD64430.1
PIRiT32489
RefSeqiNP_001122905.1, NM_001129433.2 [O17405-1]
NP_001256080.1, NM_001269151.1 [O17405-2]
UniGeneiCel.8908

Genome annotation databases

EnsemblMetazoaiF09G2.8a; F09G2.8a; WBGene00017316 [O17405-2]
F09G2.8b; F09G2.8b; WBGene00017316 [O17405-1]
GeneIDi179105
KEGGicel:CELE_F09G2.8
UCSCiF09G2.8b c. elegans [O17405-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080529 Genomic DNA Translation: CCD64428.1
FO080529 Genomic DNA Translation: CCD64430.1
PIRiT32489
RefSeqiNP_001122905.1, NM_001129433.2 [O17405-1]
NP_001256080.1, NM_001269151.1 [O17405-2]
UniGeneiCel.8908

3D structure databases

ProteinModelPortaliO17405
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F09G2.8b

Proteomic databases

EPDiO17405
PaxDbiO17405
PeptideAtlasiO17405
PRIDEiO17405

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF09G2.8a; F09G2.8a; WBGene00017316 [O17405-2]
F09G2.8b; F09G2.8b; WBGene00017316 [O17405-1]
GeneIDi179105
KEGGicel:CELE_F09G2.8
UCSCiF09G2.8b c. elegans [O17405-1]

Organism-specific databases

CTDi179105
WormBaseiF09G2.8a ; CE09303 ; WBGene00017316
F09G2.8b ; CE41221 ; WBGene00017316

Phylogenomic databases

eggNOGiKOG3603 Eukaryota
ENOG410XQZ4 LUCA
GeneTreeiENSGT00390000009798
HOGENOMiHOG000293407
InParanoidiO17405
KOiK16860
OMAiWHADARI
OrthoDBiEOG091G07LR
PhylomeDBiO17405

Enzyme and pathway databases

ReactomeiR-CEL-1855204 Synthesis of IP3 and IP4 in the cytosol
R-CEL-2029485 Role of phospholipids in phagocytosis

Miscellaneous databases

PROiPR:O17405

Gene expression databases

BgeeiWBGene00017316 Expressed in 5 organ(s), highest expression level in adult organism

Family and domain databases

InterProiView protein in InterPro
IPR032803 PLDc_3
IPR001736 PLipase_D/transphosphatidylase
PfamiView protein in Pfam
PF13918 PLDc_3, 1 hit
SMARTiView protein in SMART
SM00155 PLDc, 2 hits
PROSITEiView protein in PROSITE
PS50035 PLD, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPLDL_CAEEL
AccessioniPrimary (citable) accession number: O17405
Secondary accession number(s): G4RZL0, G8JY27
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: February 22, 2012
Last modified: November 7, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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