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Protein

Probable 26S proteasome regulatory subunit 10B

Gene

rpt-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi191 – 198ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

  • positive regulation of RNA polymerase II transcriptional preinitiation complex assembly Source: GO_Central
  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
  • regulation of protein stability Source: UniProtKB
  • ubiquitin-dependent ERAD pathway Source: GO_Central

Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-CEL-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-CEL-174113 SCF-beta-TrCP mediated degradation of Emi1
R-CEL-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-CEL-4608870 Asymmetric localization of PCP proteins
R-CEL-5632684 Hedgehog 'on' state
R-CEL-5668541 TNFR2 non-canonical NF-kB pathway
R-CEL-5689603 UCH proteinases
R-CEL-5689880 Ub-specific processing proteases
R-CEL-68949 Orc1 removal from chromatin
R-CEL-69229 Ubiquitin-dependent degradation of Cyclin D1
R-CEL-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-CEL-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-CEL-8939902 Regulation of RUNX2 expression and activity
R-CEL-8941858 Regulation of RUNX3 expression and activity
R-CEL-8948751 Regulation of PTEN stability and activity
R-CEL-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 26S proteasome regulatory subunit 10B
Alternative name(s):
26S proteasome AAA-ATPase subunit rpt-4
Proteasome regulatory particle ATPase-like protein 4
Gene namesi
Name:rpt-4
ORF Names:F23F1.8
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiF23F1.8a ; CE29280 ; WBGene00004504 ; rpt-4
F23F1.8b ; CE09608 ; WBGene00004504 ; rpt-4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000847351 – 406Probable 26S proteasome regulatory subunit 10BAdd BLAST406

Proteomic databases

EPDiO17071
PaxDbiO17071
PeptideAtlasiO17071
PRIDEiO17071

PTM databases

iPTMnetiO17071

Expressioni

Gene expression databases

BgeeiWBGene00004504

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • TBP-class protein binding Source: GO_Central

Protein-protein interaction databases

BioGridi38764, 8 interactors
IntActiO17071, 9 interactors
STRINGi6239.F23F1.8a

Structurei

3D structure databases

ProteinModelPortaliO17071
SMRiO17071
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

eggNOGiKOG0651 Eukaryota
COG1222 LUCA
GeneTreeiENSGT00550000074826
HOGENOMiHOG000225143
InParanoidiO17071
KOiK03064
OMAiHIELPNE
OrthoDBiEOG091G096W
PhylomeDBiO17071

Family and domain databases

InterProiView protein in InterPro
IPR005937 26S_Psome_P45-like
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR027417 P-loop_NTPase
IPR035263 PSMC6
PANTHERiPTHR23073:SF59 PTHR23073:SF59, 1 hit
PfamiView protein in Pfam
PF00004 AAA, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01242 26Sp45, 1 hit
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform a (identifier: O17071-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLLQFSNMV EPTGPAIVED ERTKALNSYR RKLAECRDIE QKLKDLRKKE
60 70 80 90 100
SEMTKQFDKS ENDIKSLQSV GQIVGEVLKQ LSEEKFIVKA TNGPRYVVGC
110 120 130 140 150
RRSINKEELK QGTRVSLDMT TLTIMRQLPR EVDPLVYKMS HEDPGNISYS
160 170 180 190 200
DVGGLAEQIR ELREVVELPL INPELFKRVG ITPPKGCLLF GPPGTGKTLL
210 220 230 240 250
ARAVASQLDC NFLKVVSSAI VDKYIGESAR MIREMFNYAR DHQPCIVFMD
260 270 280 290 300
EIDAIGGRRF SEGTSADREI QRTLMELLNQ LDGFDSLGKV KVIMATNRPD
310 320 330 340 350
TLDPALLRPG RLDRKIEIGL PNEQSRLEIL KIHSNKITKH GEIDFEAVVK
360 370 380 390 400
LSDGFSAADL RNVCTEAGMF AIRAEREFVI DEDFMKAVRK VGDAKRLETK

LDYKPV
Note: No experimental confirmation available.
Length:406
Mass (Da):45,859
Last modified:May 27, 2002 - v2
Checksum:iDCD706704840F529
GO
Isoform b (identifier: O17071-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: Missing.

Note: No experimental confirmation available.
Show »
Length:398
Mass (Da):44,912
Checksum:i77204F8C9668F324
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0155581 – 8Missing in isoform b. Curated8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080251 Genomic DNA Translation: CCD62357.1
FO080251 Genomic DNA Translation: CCD62358.1
PIRiT32268
RefSeqiNP_001022113.1, NM_001026942.3 [O17071-1]
NP_001022114.1, NM_001026943.3 [O17071-2]
UniGeneiCel.7235

Genome annotation databases

EnsemblMetazoaiF23F1.8a; F23F1.8a; WBGene00004504 [O17071-1]
GeneIDi173384
KEGGicel:CELE_F23F1.8
UCSCiF23F1.8a c. elegans [O17071-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPRS10_CAEEL
AccessioniPrimary (citable) accession number: O17071
Secondary accession number(s): Q5F4U7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 27, 2002
Last modified: May 23, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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