UniProtKB - O16850 (FOXO_CAEEL)
Forkhead box protein O
daf-16
Functioni
Forkhead-type transcription factor (PubMed:9360933).
Binds to the promoters of genes that contain the daf-16/FOXO binding element (DBE), TTGTTTAC, in their regulatory region (PubMed:10880363, PubMed:23770237, PubMed:26675724).
Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, sleep, associative memory, and dauer formation (PubMed:9360933, PubMed:8247153, PubMed:11747821, PubMed:11747825, PubMed:11381260, PubMed:14622602, PubMed:12750521, PubMed:17900900, PubMed:18358814, PubMed:18762027, PubMed:18832074, PubMed:19103192, PubMed:21531333, PubMed:22081913, PubMed:29523076, PubMed:26675724).
Longevity signaling predominantly arises from expression in the intestine (PubMed:14622602).
Transcriptional activity of daf-16/FOXO is negatively regulated by interaction with host cell factor homolog hcf-1; and by cytoplasmic sequestration by association with ftt-2 (PubMed:11381260, PubMed:21531333, PubMed:18828672).
Inhibition is required for the carbon dioxide (CO2) avoidance response (PubMed:18524954).
Upon loss of inhibition, daf-16 translocates to the nucleus to regulate genes that result in delayed reproduction and growth while increasing stress resistance starvation tolerance and longevity (PubMed:11747825, PubMed:21531333).
Association with arginine methyltransferase prmt-1 prevents phosphorylation and allows for translocation to the nucleus and the subsequent transcription of longevity-related genes (PubMed:21531333).
Modulation of its activity by cGMP levels in sensory neurons regulates lifespan (PubMed:19489741).
Has a protective role against muscle dystrophy (PubMed:18397876).
Involved in mediating protection against aberrant protein aggregation proteotoxicity (PubMed:16902091).
Influences transcription of genes that code for proteins involved in immunity as part of a general stress response (PubMed:17096597, PubMed:18245330).
Targets genes that inhibit and stimulate tumor growth (PubMed:17934462).
Targets kinases, phosphatases and transcription factors that are primarily involved in signaling and gene regulation (PubMed:24516399).
Thought to regulate ins-7 in FOXO-to-FOXO signaling, which coordinates daf-16 expression (PubMed:18025456).
Activity is positively regulated by shc-1-mediated inhibition of daf-2 and activation of JNK pathway (PubMed:18832074).
Functions by indirect interaction with jnk-1 of the mitogen-activated protein kinase (MAPK) pathway (PubMed:17894411).
Involved in increased proteasome activity by activating expression of rpn-6.1 in response to proteotoxic stress, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity (PubMed:22922647).
Also regulates proteasome activity in the intestine by preventing expression of deubiquitinase ubh-4 (PubMed:23770237).
Represses transcription of natc-1 (PubMed:25330323).
Involved in regulation of srh-234 expression (PubMed:25357003).
Binds to the promoter of the AMPK-gamma regulatory subunit, aakg-4, and activates its transcription (PubMed:24516399).
Also activates transcription of AMPK-gamma regulatory subunit, aakg-1 (PubMed:24516399).
Maintains endoplasmic reticulum (ER) function by inducing protein degradation and elimination to remove misfolded secretory proteins from the ER independently of the ire-1/xbp-1 unfolded protein response pathway (PubMed:25448701).
Regulates epidermal innate immunity to nematophagous fungal infection and physical wounding which trigger bli-3 induced ROS release, leading to daf-16 activation independently of daf-2 signaling (PubMed:24146615).
May negatively regulate resistance to stress caused by oxidized cholesterol adducts by preventing the activation of daf-9 and nuclear hormone receptor daf-12, two members of the steroid signaling pathway (PubMed:24957743).
Promotes apoptosis during embryonic development (PubMed:25383666).
Probably through the regulation of the autophagy genes atg-18 and atg-16.2, plays a role in regulating stem cell number in the germline during larval development (PubMed:28285998).
Plays a role in learning and memory; including associative memory, and aversive gustatory associated learning known as salt avoidance learning (PubMed:26675724, PubMed:30779740).
Plays a role in regulating gene transcription in response to white light exposure (PubMed:29500338).
Binds to the promoter of dex-1 to positively regulate its expression in seam cells during the dauer phase (PubMed:30409788).
37 PublicationsFunctions in the Insulin/IGF-1-like signaling (IIS) mediated pathway (PubMed:24834345).
May play a role in lifespan modulation, but less significant than that played by isoforms d and f (PubMed:24834345).
1 PublicationFunctions in the Insulin/IGF-1-like signaling (IIS) mediated pathway (PubMed:24834345).
Transcript level in the early adult may play a role in lifespan modulation, but effect is more significant than that played by isoform a (PubMed:24834345).
1 PublicationFunctions in the Insulin/IGF-1-like signaling (IIS) mediated pathway (PubMed:24834345).
Transcript level in the early adult may play a role in lifespan modulation, but effect is more significant than that played by isoform a (PubMed:24834345).
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 175 – 268 | Fork-headPROSITE-ProRule annotationAdd BLAST | 94 |
GO - Molecular functioni
- 14-3-3 protein binding Source: UniProtKB
- beta-catenin binding Source: ParkinsonsUK-UCL
- DEAD/H-box RNA helicase binding Source: WormBase
- DNA-binding transcription factor activity Source: UniProtKB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription factor binding Source: UniProtKB
- enzyme binding Source: WormBase
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: WormBase
- sequence-specific DNA binding Source: WormBase
- ubiquitin protein ligase binding Source: UniProtKB
- ubiquitin-specific protease binding Source: WormBase
GO - Biological processi
- aging Source: UniProtKB
- cellular response to DNA damage stimulus Source: UniProtKB
- cellular response to heat Source: UniProtKB
- cellular response to oxidative stress Source: ParkinsonsUK-UCL
- dauer larval development Source: WormBase
- defense response to Gram-negative bacterium Source: WormBase
- defense response to Gram-positive bacterium Source: UniProtKB
- determination of adult lifespan Source: UniProtKB
- heat acclimation Source: UniProtKB
- innate immune response Source: WormBase
- insulin receptor signaling pathway Source: WormBase
- muscle tissue development Source: UniProtKB
- negative regulation of multicellular organism growth Source: WormBase
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- nematode larval development Source: UniProtKB
- positive regulation of adaptive immune response Source: UniProtKB
- positive regulation of apoptotic process Source: UniProtKB
- positive regulation of dauer larval development Source: WormBase
- positive regulation of defense response to bacterium Source: UniProtKB
- positive regulation of gene expression Source: UniProtKB
- positive regulation of neuromuscular synaptic transmission Source: UniProtKB
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
- positive regulation of synaptic assembly at neuromuscular junction Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: WormBase
- regulation of cell cycle process Source: UniProtKB
- regulation of dauer entry Source: UniProtKB
- regulation of dauer larval development Source: UniProtKB
- regulation of DNA-templated transcription in response to stress Source: UniProtKB
- regulation of gene expression Source: UniProtKB
- regulation of lipid biosynthetic process Source: UniProtKB
- regulation of lipid storage Source: UniProtKB
- regulation of synaptic assembly at neuromuscular junction Source: UniProtKB
- regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- response to oxidative stress Source: UniProtKB
- response to starvation Source: UniProtKB
- response to UV Source: UniProtKB
- short-term memory Source: WormBase
- sleep Source: UniProtKB
Keywordsi
Molecular function | Developmental protein, DNA-binding, Repressor |
Biological process | Growth regulation, Immunity, Innate immunity, Stress response, Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-CEL-1181150, Signaling by NODAL R-CEL-198693, AKT phosphorylates targets in the nucleus R-CEL-211163, AKT-mediated inactivation of FOXO1A R-CEL-5687128, MAPK6/MAPK4 signaling R-CEL-5689880, Ub-specific processing proteases R-CEL-9607240, FLT3 Signaling R-CEL-9614399, Regulation of localization of FOXO transcription factors R-CEL-9615017, FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-CEL-9617629, Regulation of FOXO transcriptional activity by acetylation R-CEL-9617828, FOXO-mediated transcription of cell cycle genes R-CEL-9634638, Estrogen-dependent nuclear events downstream of ESR-membrane signaling |
SignaLinki | O16850 |
Names & Taxonomyi
Protein namesi | Recommended name: Forkhead box protein OCuratedShort name: FOXO1 Publication Alternative name(s): Abnormal dauer formation protein 16Imported |
Gene namesi | Name:daf-16Imported ORF Names:R13H8.1Imported |
Organismi | Caenorhabditis elegans |
Taxonomic identifieri | 6239 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Proteomesi |
|
Organism-specific databases
WormBasei | R13H8.1a ; CE28771 ; WBGene00000912 ; daf-16 R13H8.1b ; CE28772 ; WBGene00000912 ; daf-16 R13H8.1c ; CE28773 ; WBGene00000912 ; daf-16 R13H8.1d ; CE38722 ; WBGene00000912 ; daf-16 R13H8.1e ; CE33160 ; WBGene00000912 ; daf-16 R13H8.1f ; CE44821 ; WBGene00000912 ; daf-16 R13H8.1g ; CE44935 ; WBGene00000912 ; daf-16 R13H8.1h ; CE45185 ; WBGene00000912 ; daf-16 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 11 Publications
Nucleus
- Nucleus 11 Publications
Note: Shuttles between cytoplasm and nucleus (PubMed:11381260, PubMed:17894411). Nuclear translocation is inhibited by phosphorylation by AKT proteins (PubMed:11381260, PubMed:11747825, PubMed:21531333). Association with ftt-2 sequesters daf-16 in the cytoplasm (PubMed:21531333). Association with prmt-1 allows for translocation to the nucleus (PubMed:21531333). Nuclear translocation is promoted by phosphorylation by unc-43 and inhibited by dephosphorylation by tax-6 (PubMed:23805378). Nuclear translocation is promoted by jnk-1 upon heat stress and by sek-1 upon oxidative stress (PubMed:15888317, PubMed:15767565). Nucleocytoplasmic shuttling is induced by starvation, heat treatment, hypergravity, reactive oxygen species (generated by juglone), exposure to tributyltin or 4-hydroxy-E-globularinin (4-HEG) and the flavonoids kaempferol and fisetin (PubMed:11381260, PubMed:17551714, PubMed:18832074, PubMed:19252938, PubMed:21531333, PubMed:23805378). Nuclear localization induced by nematophagous fungal infection (PubMed:24146615).10 Publications
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Disruption phenotypei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 266 | R → K: Decreases methylation by prmt-1; when associated with K-268 and K-270. 1 Publication | 1 | |
Mutagenesisi | 268 | R → K: Decreases methylation by prmt-1; when associated with K-266 and K-270. Prevents phosphorylation by akt 1 and/or 2; when associated with K-270. 1 Publication | 1 | |
Mutagenesisi | 270 | R → K: Decreases methylation by prmt-1; when associated with K-266 and K-268. Prevents phosphorylation by akt 1 and/or 2; when associated with K-268. 1 Publication | 1 | |
Mutagenesisi | 271 | S → A: Prevents phosphorylation and results in strong nuclear localization. Reduces phosphorylation; when associated with A-273. 2 Publications | 1 | |
Mutagenesisi | 273 | T → A: Prevents phosphorylation and results in strong nuclear localization. 1 Publication | 1 | |
Mutagenesisi | 273 | T → A: Reduces phosphorylation in normal and starved conditions. Reduces phosphorylation; when associated with A-271. 1 Publication | 1 | |
Mutagenesisi | 319 | S → A: Prevents phosphorylation and results in cytoplasmic localization in unc-43 n498 gain-of-function or tax-6 mutant backgrounds. 1 Publication | 1 | |
Mutagenesisi | 319 | S → D: Phosphomimetic mutant which causes constitutive nuclear localization. 1 Publication | 1 | |
Mutagenesisi | 345 | S → A: Prevents phosphorylation and results in strong nuclear localization. 1 Publication | 1 | |
Mutagenesisi | 373 – 541 | Missing in m27; defective dauer phase entry, but animals are capable of entering a partial dauer state with some dauer morphological characteristics. Reduces dex-1 expression in seam cells during the dauer phase. 1 PublicationAdd BLAST | 169 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000414886 | 1 – 541 | Forkhead box protein OCuratedAdd BLAST | 541 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 273 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 319 | Phosphoserine; by CaMK21 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
PaxDbi | O16850 |
PeptideAtlasi | O16850 |
PTM databases
iPTMneti | O16850 |
Expressioni
Tissue specificityi
Developmental stagei
Inductioni
Gene expression databases
Bgeei | WBGene00000912, Expressed in adult organism and 6 other tissues |
ExpressionAtlasi | O16850, baseline and differential |
Interactioni
Subunit structurei
Binary interactionsi
O16850
With | #Exp. | IntAct |
---|---|---|
akt-1 [Q17941] | 3 | EBI-324028,EBI-1770718 |
akt-2 [Q9XTG7] | 3 | EBI-324028,EBI-320656 |
sgk-1 [Q2PJ68] | 3 | EBI-324028,EBI-1770776 |
sir-2.1 [Q21921] | 2 | EBI-324028,EBI-966082 |
GO - Molecular functioni
- 14-3-3 protein binding Source: UniProtKB
- beta-catenin binding Source: ParkinsonsUK-UCL
- DEAD/H-box RNA helicase binding Source: WormBase
- DNA-binding transcription factor binding Source: UniProtKB
- enzyme binding Source: WormBase
- ubiquitin protein ligase binding Source: UniProtKB
- ubiquitin-specific protease binding Source: WormBase
Protein-protein interaction databases
BioGRIDi | 38392, 70 interactors |
ComplexPortali | CPX-3882, daf-16-ftt-2 complex CPX-3883, daf-16-sir-2.1 complex CPX-3884, daf-16-par-5 complex |
DIPi | DIP-25581N |
IntActi | O16850, 23 interactors |
STRINGi | 6239.R13H8.1h |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 118 – 168 | DisorderedSequence analysisAdd BLAST | 51 | |
Regioni | 252 – 291 | DisorderedSequence analysisAdd BLAST | 40 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 118 – 158 | Polar residuesSequence analysisAdd BLAST | 41 |
Phylogenomic databases
eggNOGi | KOG2294, Eukaryota |
GeneTreei | ENSGT00940000170843 |
InParanoidi | O16850 |
OMAi | PCGANSA |
OrthoDBi | 1160384at2759 |
PhylomeDBi | O16850 |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit |
s (8+)i Sequence
Sequence statusi: Complete.
This entry describes 8 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 8 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MQLEQKSSLH CSKCRNFLQK FSQDMQAWNC RELDSPLPSD ITLHNLEPAR
60 70 80 90 100
PDSGMSFSTD FDDDFFNLDL HQQERSASFG GVTQYSQQFL REKCSFSPYF
110 120 130 140 150
HTSLETVDSG RTSLYGSNEQ CGQLGGASSN GSTAMLHTPD GSNSHQTSFP
160 170 180 190 200
SDFRMSESPD DTVSGKKTTT RRNAWGNMSY AELITTAIMA SPEKRLTLAQ
210 220 230 240 250
VYEWMVQNVP YFRDKGDSNS SAGWKNSIRH NLSLHSRFMR IQNEGAGKSS
260 270 280 290 300
WWVINPDAKP GRNPRRTRER SNTIETTTKA QLEKSRRGAK KRIKERALMG
310 320 330 340 350
SLHSTLNGNS IAGSIQTISH DLYDDDSMQG AFDNVPSSFR PRTQSNLSIP
360 370 380 390 400
GSSSRVSPAI GSDIYDDLEF PSWVGESVPA IPSDIVDRTD QMRIDATTHI
410 420 430 440 450
GGVQIKQESK PIKTEPIAPP PSYHELNSVR GSCAQNPLLR NPIVPSTNFK
460 470 480 490 500
PMPLPGAYGN YQNGGITPIN WLSTSNSSPL PGIQSCGIVA AQHTVASSSA
510 520 530 540
LPIDLENLTL PDQPLMDTMD VDALIRHELS QAGGQHIHFD L
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0K3AR63 | A0A0K3AR63_CAEEL | Fork-head domain-containing protein | daf-16 CELE_R13H8.1, R13H8.1 | 485 | Annotation score: | ||
A0A0K3AR95 | A0A0K3AR95_CAEEL | Fork-head domain-containing protein | daf-16 CELE_R13H8.1, R13H8.1 | 407 | Annotation score: | ||
A0A0K3ATP5 | A0A0K3ATP5_CAEEL | Fork-head domain-containing protein | daf-16 CELE_R13H8.1, R13H8.1 | 405 | Annotation score: | ||
A0A0K3AWG6 | A0A0K3AWG6_CAEEL | Fork-head domain-containing protein | daf-16 CELE_R13H8.1, R13H8.1 | 515 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_053105 | 1 – 238 | Missing in isoform e. CuratedAdd BLAST | 238 | |
Alternative sequenceiVSP_053106 | 1 – 221 | MQLEQ…DSNSS → MNDSIDDDFPPEPRGRCYTW PMQQYIYQESSATIPHHHLN QHNNPYHPMHPHHQLPHMQQ LPQPLLNLNMTTLTSSGSSV ASSIGGGAQCSPCASGSSTA ATNSSQQQQTVGQMLAASVP CSSSGMTLGMSLNLSQGGGP MPAKKKRCRKKPTDQLAQKK PNPWGEESYSDIIAKALESA PDGRLKLNEIYQWFSDNIPY FGERSSPEEA in isoform a. 1 PublicationAdd BLAST | 221 | |
Alternative sequenceiVSP_042147 | 1 – 217 | Missing in isoform g. CuratedAdd BLAST | 217 | |
Alternative sequenceiVSP_053107 | 1 – 113 | MQLEQ…SGRTS → MMEMLVDQGTDASSSASTST SSVSRFGADTFMNTPDDVMM NDDMEPIPRDRCNTWPMRRP QLEPPLNSSPIIHEQIPEED AD in isoform b and isoform c. 2 PublicationsAdd BLAST | 113 | |
Alternative sequenceiVSP_053108 | 1 – 54 | Missing in isoform d. CuratedAdd BLAST | 54 | |
Alternative sequenceiVSP_042148 | 1 – 24 | Missing in isoform f. CuratedAdd BLAST | 24 | |
Alternative sequenceiVSP_053109 | 152 – 154 | DFR → E in isoform b. 1 Publication | 3 | |
Alternative sequenceiVSP_042149 | 218 – 225 | SNSSAGWK → MREMSTKN in isoform g. Curated | 8 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF020342 mRNA Translation: AAB84390.1 AF020343 mRNA Translation: AAB84391.1 AF020344 mRNA Translation: AAB84392.1 AF032112 mRNA Translation: AAC47803.1 BX284601 Genomic DNA Translation: CCD71850.1 BX284601 Genomic DNA Translation: CCD71851.1 BX284601 Genomic DNA Translation: CCD71852.1 BX284601 Genomic DNA Translation: CCD71853.1 BX284601 Genomic DNA Translation: CCD71854.1 BX284601, FO080113 Genomic DNA Translation: CCD71855.1 BX284601, FO080113 Genomic DNA Translation: CCD71856.1 BX284601, FO080113 Genomic DNA Translation: CCD71857.1 |
PIRi | T42234 T42255 |
RefSeqi | NP_001021593.1, NM_001026422.4 [O16850-2] NP_001021594.1, NM_001026423.4 NP_001021595.1, NM_001026424.4 NP_001021596.1, NM_001026425.3 [O16850-5] NP_001021597.1, NM_001026426.2 NP_001021598.2, NM_001026427.4 [O16850-1] NP_001251490.1, NM_001264561.1 NP_001251492.1, NM_001264563.1 |
Genome annotation databases
EnsemblMetazoai | R13H8.1a.1; R13H8.1a.1; WBGene00000912 [O16850-2] R13H8.1b.1; R13H8.1b.1; WBGene00000912 [O16850-4] R13H8.1b.2; R13H8.1b.2; WBGene00000912 [O16850-4] R13H8.1c.1; R13H8.1c.1; WBGene00000912 [O16850-3] R13H8.1c.2; R13H8.1c.2; WBGene00000912 [O16850-3] R13H8.1d.1; R13H8.1d.1; WBGene00000912 [O16850-5] R13H8.1e.1; R13H8.1e.1; WBGene00000912 [O16850-6] R13H8.1f.1; R13H8.1f.1; WBGene00000912 [O16850-1] R13H8.1g.1; R13H8.1g.1; WBGene00000912 [O16850-7] R13H8.1h.1; R13H8.1h.1; WBGene00000912 [O16850-8] |
GeneIDi | 172981 |
UCSCi | R13H8.1c, c. elegans |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF020342 mRNA Translation: AAB84390.1 AF020343 mRNA Translation: AAB84391.1 AF020344 mRNA Translation: AAB84392.1 AF032112 mRNA Translation: AAC47803.1 BX284601 Genomic DNA Translation: CCD71850.1 BX284601 Genomic DNA Translation: CCD71851.1 BX284601 Genomic DNA Translation: CCD71852.1 BX284601 Genomic DNA Translation: CCD71853.1 BX284601 Genomic DNA Translation: CCD71854.1 BX284601, FO080113 Genomic DNA Translation: CCD71855.1 BX284601, FO080113 Genomic DNA Translation: CCD71856.1 BX284601, FO080113 Genomic DNA Translation: CCD71857.1 |
PIRi | T42234 T42255 |
RefSeqi | NP_001021593.1, NM_001026422.4 [O16850-2] NP_001021594.1, NM_001026423.4 NP_001021595.1, NM_001026424.4 NP_001021596.1, NM_001026425.3 [O16850-5] NP_001021597.1, NM_001026426.2 NP_001021598.2, NM_001026427.4 [O16850-1] NP_001251490.1, NM_001264561.1 NP_001251492.1, NM_001264563.1 |
3D structure databases
SMRi | O16850 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 38392, 70 interactors |
ComplexPortali | CPX-3882, daf-16-ftt-2 complex CPX-3883, daf-16-sir-2.1 complex CPX-3884, daf-16-par-5 complex |
DIPi | DIP-25581N |
IntActi | O16850, 23 interactors |
STRINGi | 6239.R13H8.1h |
PTM databases
iPTMneti | O16850 |
Proteomic databases
PaxDbi | O16850 |
PeptideAtlasi | O16850 |
Genome annotation databases
EnsemblMetazoai | R13H8.1a.1; R13H8.1a.1; WBGene00000912 [O16850-2] R13H8.1b.1; R13H8.1b.1; WBGene00000912 [O16850-4] R13H8.1b.2; R13H8.1b.2; WBGene00000912 [O16850-4] R13H8.1c.1; R13H8.1c.1; WBGene00000912 [O16850-3] R13H8.1c.2; R13H8.1c.2; WBGene00000912 [O16850-3] R13H8.1d.1; R13H8.1d.1; WBGene00000912 [O16850-5] R13H8.1e.1; R13H8.1e.1; WBGene00000912 [O16850-6] R13H8.1f.1; R13H8.1f.1; WBGene00000912 [O16850-1] R13H8.1g.1; R13H8.1g.1; WBGene00000912 [O16850-7] R13H8.1h.1; R13H8.1h.1; WBGene00000912 [O16850-8] |
GeneIDi | 172981 |
UCSCi | R13H8.1c, c. elegans |
Organism-specific databases
CTDi | 172981 |
WormBasei | R13H8.1a ; CE28771 ; WBGene00000912 ; daf-16 R13H8.1b ; CE28772 ; WBGene00000912 ; daf-16 R13H8.1c ; CE28773 ; WBGene00000912 ; daf-16 R13H8.1d ; CE38722 ; WBGene00000912 ; daf-16 R13H8.1e ; CE33160 ; WBGene00000912 ; daf-16 R13H8.1f ; CE44821 ; WBGene00000912 ; daf-16 R13H8.1g ; CE44935 ; WBGene00000912 ; daf-16 R13H8.1h ; CE45185 ; WBGene00000912 ; daf-16 |
Phylogenomic databases
eggNOGi | KOG2294, Eukaryota |
GeneTreei | ENSGT00940000170843 |
InParanoidi | O16850 |
OMAi | PCGANSA |
OrthoDBi | 1160384at2759 |
PhylomeDBi | O16850 |
Enzyme and pathway databases
Reactomei | R-CEL-1181150, Signaling by NODAL R-CEL-198693, AKT phosphorylates targets in the nucleus R-CEL-211163, AKT-mediated inactivation of FOXO1A R-CEL-5687128, MAPK6/MAPK4 signaling R-CEL-5689880, Ub-specific processing proteases R-CEL-9607240, FLT3 Signaling R-CEL-9614399, Regulation of localization of FOXO transcription factors R-CEL-9615017, FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes R-CEL-9617629, Regulation of FOXO transcriptional activity by acetylation R-CEL-9617828, FOXO-mediated transcription of cell cycle genes R-CEL-9634638, Estrogen-dependent nuclear events downstream of ESR-membrane signaling |
SignaLinki | O16850 |
Miscellaneous databases
PROi | PR:O16850 |
Gene expression databases
Bgeei | WBGene00000912, Expressed in adult organism and 6 other tissues |
ExpressionAtlasi | O16850, baseline and differential |
Family and domain databases
CDDi | cd00059, FH, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR001766, Fork_head_dom IPR030456, TF_fork_head_CS_2 IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00250, Forkhead, 1 hit |
PRINTSi | PR00053, FORKHEAD |
SMARTi | View protein in SMART SM00339, FH, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00658, FORK_HEAD_2, 1 hit PS50039, FORK_HEAD_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FOXO_CAEEL | |
Accessioni | O16850Primary (citable) accession number: O16850 Secondary accession number(s): F3NWW7 Q86S42 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 16, 2009 |
Last sequence update: | January 25, 2012 | |
Last modified: | February 23, 2022 | |
This is version 175 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Caenorhabditis annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase