daf-16

Functionⁱ

Forkhead-type transcription factor (PubMed:9360933). Binds to the promoters of genes that contain the daf-16 binding element (DBE), TTGTTTAC, in their regulatory region (PubMed:10880363, PubMed:23770237). Functions in the Insulin/IGF-1-like signaling (IIS) mediated pathway which affects lipogenesis, lifespan, starvation survival, heat shock and oxidative stress responses, and dauer formation (PubMed:9360933, PubMed:8247153, PubMed:11747821, PubMed:11747825, PubMed:11381260, PubMed:14622602, PubMed:12750521, PubMed:17900900, PubMed:18358814, PubMed:18762027, PubMed:18832074, PubMed:19103192, PubMed:21531333, PubMed:22081913). Longevity signaling predominantly arises from expression in the intestine (PubMed:14622602). Daf-16 transcriptional activity is negatively regulated by cytoplasmic sequestration by association with ftt-2 (PubMed:11381260, PubMed:21531333). Inhibition is required for the carbon dioxide (CO2) avoidance response (PubMed:18524954). Upon loss of inhibition, daf-16 translocates to the nucleus to regulate genes that result in delayed reproduction and growth while increasing stress resistance starvation tolerance and longevity (PubMed:11747825, PubMed:21531333). Association with arginine methyltransferase prmt-1 prevents phosphorylation and allows for translocation to the nucleus and the subsequent transcription of longevity-related genes (PubMed:21531333). Modulation of its activity by cGMP levels in sensory neurons regulates lifespan (PubMed:19489741). Has a protective role against muscle dystrophy (PubMed:18397876). Involved in mediating protection against aberrant protein aggregation proteotoxicity (PubMed:16902091). Influences transcription of genes that code for proteins involved in immunity as part of a general stress response (PubMed:17096597, PubMed:18245330). Targets genes that inhibit and stimulate tumor growth (PubMed:17934462). Targets kinases, phosphatases and transcription factors that are primarily involved in signaling and gene regulation (PubMed:24516399). Thought to regulate ins-7 in FOXO-to-FOXO signaling, which coordinates daf-16 expression (PubMed:18025456). Activity is positively regulated by shc-1-mediated inhibition of daf-2 and activation of JNK pathway (PubMed:18832074). Functions by indirect interaction with jnk-1 of the mitogen-activated protein kinase (MAPK) pathway (PubMed:17894411). Involved in increased proteasome activity by activating expression of rpn-6.1 in response to proteotoxic stress, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity (PubMed:22922647). Also regulates proteasome activity in the intestine by preventing expression of deubiquitinase ubh-4 (PubMed:23770237). Represses transcription of natc-1 (PubMed:25330323). Involved in regulation of srh-234 expression (PubMed:25357003). Binds to the promoter of the AMPK-gamma regulatory subunit, aakg-4, and activates its transcription (PubMed:24516399). Also activates transcription of AMPK-gamma regulatory subunit, aakg-1 (PubMed:24516399). Maintains endoplasmic reticulum (ER) function by inducing protein degradation and elimination to remove misfolded secretory proteins from the ER independently of the ire-1/xbp-1 unfolded protein response pathway (PubMed:25448701). Regulates epidermal innate immunity to nematophagous fungal infection and physical wounding which trigger bli-3 induced ROS release, leading to daf-16 activation independently of daf-2 signaling (PubMed:24146615). May negatively regulate resistance to stress caused by oxidized cholesterol adducts by preventing the activation of daf-9 and nuclear hormone receptor daf-12, two members of the steroid signaling pathway (PubMed:24957743). Promotes apoptosis during embryonic development (PubMed:25383666).33 Publications

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	175 – 268	Fork-headPROSITE-ProRule annotationAdd BLAST		94

GO - Molecular functionⁱ

14-3-3 protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 21531333
activating transcription factor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19103192
beta-catenin binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 15905404
DEAD/H-box RNA helicase binding
Source: WormBase
Inferred from physical interactionⁱ
- 26195740
DNA-binding transcription factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 22922647
DNA-binding transcription factor activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
enzyme binding
Source: WormBase
Inferred from physical interactionⁱ
- 23028355
RNA polymerase II regulatory region sequence-specific DNA binding
Source: WormBase
Inferred from direct assayⁱ
- 19506556
sequence-specific DNA binding
Source: WormBase
Inferred from direct assayⁱ
- 11124266
transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ubiquitin protein ligase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 17276341
ubiquitin-specific protease binding
Source: WormBase
Inferred from physical interactionⁱ
- 26154057

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

aging
Source: UniProtKB
Inferred from direct assayⁱ
- 19103192
cellular response to DNA damage stimulus
Source: UniProtKB
Inferred from direct assayⁱ
- 22922647
cellular response to heat
Source: UniProtKB
Inferred from direct assayⁱ
- 11381260
- 11747825
cellular response to oxidative stress
Source: ParkinsonsUK-UCL
Inferred from genetic interactionⁱ
- 15905404
dauer larval development
Source: WormBase
Inferred from genetic interactionⁱ
- 11381260
defense response to Gram-negative bacterium
Source: WormBase
Inferred from mutant phenotypeⁱ
- 19454349
defense response to Gram-positive bacterium
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24972867
determination of adult lifespan
Source: UniProtKB
Inferred from direct assayⁱ
- 19103192
- 22922647
glucose homeostasis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
heat acclimation
Source: UniProtKB
Inferred from genetic interactionⁱ
- 21531333
innate immune response
Source: WormBase
Inferred from mutant phenotypeⁱ
- 19454349
insulin receptor signaling pathway
Source: WormBase
Inferred from direct assayⁱ
- 11124266
muscle tissue development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18397876
negative regulation of multicellular organism growth
Source: WormBase
Inferred from mutant phenotypeⁱ
- 12571101
negative regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23770237
nematode larval development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 11747821
positive regulation of adaptive immune response
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17096597
- 18245330
positive regulation of apoptotic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17934462
positive regulation of dauer larval development
Source: WormBase
Inferred from mutant phenotypeⁱ
- 6583682
positive regulation of defense response to bacterium
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22554143
positive regulation of gene expression
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 17526726
- 21531333
positive regulation of neuromuscular synaptic transmission
Source: UniProtKB
Inferred from genetic interactionⁱ
- 23665919
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23770237
positive regulation of synaptic growth at neuromuscular junction
Source: UniProtKB
Inferred from genetic interactionⁱ
- 23665919
positive regulation of transcription by RNA polymerase II
Source: WormBase
Inferred from direct assayⁱ
- 11124266
regulation of cell cycle process
Source: UniProtKB
Inferred from expression patternⁱ
- 17934462
regulation of dauer entry
Source: UniProtKB
Inferred from genetic interactionⁱ
- 21531333
- 24671950
regulation of dauer larval development
Source: UniProtKB
Inferred from genetic interactionⁱ
- 1732156
- 21124868
regulation of DNA-templated transcription in response to stress
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 12750521
regulation of gene expression
Source: UniProtKB
Inferred from genetic interactionⁱ
- 21531333
regulation of lipid biosynthetic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18762027
regulation of lipid storage
Source: UniProtKB
Inferred from genetic interactionⁱ
- 21531333
regulation of synaptic growth at neuromuscular junction
Source: UniProtKB
Inferred from genetic interactionⁱ
- 23665919
regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 17096597
- 17894411
response to oxidative stress
Source: UniProtKB
Inferred from genetic interactionⁱ
- 21531333
response to starvation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23352664
response to UV
Source: UniProtKB
Inferred from direct assayⁱ
- 11747825
short-term memory
Source: WormBase
Inferred from genetic interactionⁱ
- 26675724

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental protein, DNA-binding, Repressor
Biological process	Growth regulation, Immunity, Innate immunity, Stress response, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-CEL-156711 Polo-like kinase mediated events R-CEL-198693 AKT phosphorylates targets in the nucleus R-CEL-211163 AKT-mediated inactivation of FOXO1A R-CEL-5687128 MAPK6/MAPK4 signaling R-CEL-5689880 Ub-specific processing proteases R-CEL-69273 Cyclin A/B1/B2 associated events during G2/M transition
SignaLinkⁱ	O16850

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Forkhead box protein OCurated Short name: FOXO1 Publication Alternative name(s): Abnormal dauer formation protein 16Imported
Gene namesⁱ	Name:daf-16Imported ORF Names:R13H8.1Imported
Organismⁱ	Caenorhabditis elegans
Taxonomic identifierⁱ	6239 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Nematoda › Chromadorea › Rhabditida › Rhabditina › Rhabditomorpha › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis
Proteomesⁱ	UP000001940 Componentⁱ: Chromosome I

Organism-specific databases

WormBase More...WormBaseⁱ	R13H8.1a ; CE28771 ; WBGene00000912 ; daf-16 R13H8.1b ; CE28772 ; WBGene00000912 ; daf-16 R13H8.1c ; CE28773 ; WBGene00000912 ; daf-16 R13H8.1d ; CE38722 ; WBGene00000912 ; daf-16 R13H8.1e ; CE33160 ; WBGene00000912 ; daf-16 R13H8.1f ; CE44821 ; WBGene00000912 ; daf-16 R13H8.1g ; CE44935 ; WBGene00000912 ; daf-16 R13H8.1h ; CE45185 ; WBGene00000912 ; daf-16

WormBaseⁱ

R13H8.1a ; CE28771 ; WBGene00000912 ; daf-16
R13H8.1b ; CE28772 ; WBGene00000912 ; daf-16
R13H8.1c ; CE28773 ; WBGene00000912 ; daf-16
R13H8.1d ; CE38722 ; WBGene00000912 ; daf-16
R13H8.1e ; CE33160 ; WBGene00000912 ; daf-16
R13H8.1f ; CE44821 ; WBGene00000912 ; daf-16
R13H8.1g ; CE44935 ; WBGene00000912 ; daf-16
R13H8.1h ; CE45185 ; WBGene00000912 ; daf-16

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Dauer defective phenotype in larvae and a reduced stress phenotype in adults (PubMed:9360933). Increased carbonyl accumulation and increased sensitivity to starvation (PubMed:18025456). Increased expression of the srh-234 chemoreceptor during starvation (PubMed:25357003). Increased sensitivity to physical injury and more susceptible to death by nematophagous fungal infection (PubMed:24146615). Increased lifespan (PubMed:23805378). Causes a delay in apoptosis during embryonic development (PubMed:25383666). RNAi-mediated knock-down reduces expression of daf-16 target genes and genes up-regulated in response to nematophagous fungal infection such as sod-3 (PubMed:24146615). RNAi-mediated knockdown causes reduced ability of dietary restriction to extend lifespan (PubMed:17900900). Simultaneous RNAi-mediated knockdown of metalloproteinase zmp-2 restores normal survival upon heat stress and prevents increased susceptibility to heat stress in a daf-9 or daf-12 mutant background (PubMed:24957743). RNAi-mediated knockdown in a daf-2 (e1370) mutant background restores expression of deubiquitinase ubh-4 in the intestine (PubMed:23770237).9 Publications

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	266	R → K: Decreases methylation by prmt-1; when associated with K-268 and K-270. 1 Publication	1
Mutagenesisⁱ	268	R → K: Decreases methylation by prmt-1; when associated with K-266 and K-270. Prevents phosphorylation by akt 1 and/or 2; when associated with K-270. 1 Publication	1
Mutagenesisⁱ	270	R → K: Decreases methylation by prmt-1; when associated with K-266 and K-268. Prevents phosphorylation by akt 1 and/or 2; when associated with K-268. 1 Publication	1
Mutagenesisⁱ	271	S → A: Prevents phosphorylation and results in strong nuclear localization. Reduces phosphorylation; when associated with A-273. 2 Publications	1
Mutagenesisⁱ	273	T → A: Prevents phosphorylation and results in strong nuclear localization. 1 Publication	1
Mutagenesisⁱ	273	T → A: Reduces phosphorylation in normal and starved conditions. Reduces phosphorylation; when associated with A-271. 1 Publication	1
Mutagenesisⁱ	319	S → A: Prevents phosphorylation and results in cytoplasmic localization in unc-43 n498 gain-of-function or tax-6 mutant backgrounds. 1 Publication	1
Mutagenesisⁱ	319	S → D: Phosphomimetic mutant which causes constitutive nuclear localization. 1 Publication	1
Mutagenesisⁱ	345	S → A: Prevents phosphorylation and results in strong nuclear localization. 1 Publication	1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000414886	1 – 541	Forkhead box protein OCuratedAdd BLAST		541

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	273	Phosphothreonine1 Publication		1
Modified residueⁱ	319	Phosphoserine; by CaMK21 Publication		1

Post-translational modificationⁱ

Phosphorylated by akt-1 and/or akt-2 (PubMed:18358814, PubMed:21531333). Phosphorylated by sgk-1 (PubMed:18358814). Phosphorylated by unc-43 (PubMed:23805378). Phosphorylated by jnk-1 (PubMed:15767565). Dephosphorylated by tax-6 in vitro (PubMed:23805378).4 Publications

Ubiquitinated. Ubiquitination by rle-1 leads to proteasome-mediated degradation.1 Publication

Methylation by prmt-1 prevents phosphorylation and promotes translocation to the nucleus to allow for daf-16-dependent transcription.1 Publication

Keywords - PTMⁱ

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	O16850
PeptideAtlas More...PeptideAtlasⁱ	O16850
PRIDEⁱ	O16850

PTM databases

iPTMnetⁱ	O16850

iPTMnetⁱ

O16850

Expressionⁱ

Tissue specificityⁱ

Isoform b and isoform c are expressed in ectoderm, muscles, intestine and neurons (PubMed:9353126, PubMed:11747825, PubMed:14622602, PubMed:17894411). Isoform b is also expressed in the pharynx (PubMed:11747821). The intestine appears to be the primary site of longevity function (PubMed:14622602).5 Publications

Developmental stageⁱ

Expressed in embryos, larvae, dauer larvae and adults.1 Publication

Inductionⁱ

Induced by quinic acid.1 Publication

Gene expression databases

Bgeeⁱ	WBGene00000912 Expressed in 6 organ(s), highest expression level in adult organism

Bgeeⁱ

WBGene00000912 Expressed in 6 organ(s), highest expression level in adult organism

Interactionⁱ

Subunit structureⁱ

Interacts with rle-1 (PubMed:17276341). Interacts with unc-43 and tax-6 (PubMed:23805378). Interacts with jnk-1 (PubMed:15767565). Interacts with ftt-2 (PubMed:16777605, PubMed:21531333). Interacts with prmt-1 (PubMed:21531333).4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
akt-1	Q17941	3	EBI-324028,EBI-1770718
akt-2	Q9XTG7	3	EBI-324028,EBI-320656
sgk-1	Q2PJ68	3	EBI-324028,EBI-1770776
sir-2.1	Q21921	2	EBI-324028,EBI-966082

GO - Molecular functionⁱ

14-3-3 protein binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 21531333
activating transcription factor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 19103192
beta-catenin binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 15905404
DEAD/H-box RNA helicase binding
Source: WormBase
Inferred from physical interactionⁱ
- 26195740
enzyme binding
Source: WormBase
Inferred from physical interactionⁱ
- 23028355
transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ubiquitin protein ligase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 17276341
ubiquitin-specific protease binding
Source: WormBase
Inferred from physical interactionⁱ
- 26154057

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	38392, 5 interactors
Database of interacting proteins More...DIPⁱ	DIP-25581N
IntActⁱ	O16850, 23 interactors
STRINGⁱ	6239.R13H8.1h

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O16850
SMRⁱ	O16850
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Phylogenomic databases

eggNOGⁱ	KOG2294 Eukaryota COG5025 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000149005
HOGENOMⁱ	HOG000019698
InParanoidⁱ	O16850
KEGG Orthology (KO) More...KOⁱ	K09408
OMAⁱ	SASSGNC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06K3

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00059 FH, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR001766 Fork_head_dom IPR030456 TF_fork_head_CS_2 IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00250 Forkhead, 1 hit
PRINTSⁱ	PR00053 FORKHEAD
SMARTⁱ	View protein in SMART SM00339 FH, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS00658 FORK_HEAD_2, 1 hit PS50039 FORK_HEAD_3, 1 hit

Sequences (8+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 8 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 8 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform hImported (identifier: O16850-8) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQLEQKSSLH CSKCRNFLQK FSQDMQAWNC RELDSPLPSD ITLHNLEPAR 
        60         70         80         90        100
PDSGMSFSTD FDDDFFNLDL HQQERSASFG GVTQYSQQFL REKCSFSPYF 
       110        120        130        140        150
HTSLETVDSG RTSLYGSNEQ CGQLGGASSN GSTAMLHTPD GSNSHQTSFP 
       160        170        180        190        200
SDFRMSESPD DTVSGKKTTT RRNAWGNMSY AELITTAIMA SPEKRLTLAQ 
       210        220        230        240        250
VYEWMVQNVP YFRDKGDSNS SAGWKNSIRH NLSLHSRFMR IQNEGAGKSS 
       260        270        280        290        300
WWVINPDAKP GRNPRRTRER SNTIETTTKA QLEKSRRGAK KRIKERALMG 
       310        320        330        340        350
SLHSTLNGNS IAGSIQTISH DLYDDDSMQG AFDNVPSSFR PRTQSNLSIP 
       360        370        380        390        400
GSSSRVSPAI GSDIYDDLEF PSWVGESVPA IPSDIVDRTD QMRIDATTHI 
       410        420        430        440        450
GGVQIKQESK PIKTEPIAPP PSYHELNSVR GSCAQNPLLR NPIVPSTNFK 
       460        470        480        490        500
PMPLPGAYGN YQNGGITPIN WLSTSNSSPL PGIQSCGIVA AQHTVASSSA 
       510        520        530        540 
LPIDLENLTL PDQPLMDTMD VDALIRHELS QAGGQHIHFD L

Note: No experimental confirmation available.Curated

Length:541

Mass (Da):59,732

Last modified:January 25, 2012 - v3

Checksum:ⁱ8A36A86311A32CBB

GO

Isoform aImported (identifier: O16850-2) [UniParc]FASTA Add to basket

Also known as: b1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
1-221: MQLEQKSSLH...FRDKGDSNSS → MNDSIDDDFP...FGERSSPEEA

« Hide

        10         20         30         40         50
MNDSIDDDFP PEPRGRCYTW PMQQYIYQES SATIPHHHLN QHNNPYHPMH 
        60         70         80         90        100
PHHQLPHMQQ LPQPLLNLNM TTLTSSGSSV ASSIGGGAQC SPCASGSSTA 
       110        120        130        140        150
ATNSSQQQQT VGQMLAASVP CSSSGMTLGM SLNLSQGGGP MPAKKKRCRK 
       160        170        180        190        200
KPTDQLAQKK PNPWGEESYS DIIAKALESA PDGRLKLNEI YQWFSDNIPY 
       210        220        230        240        250
FGERSSPEEA AGWKNSIRHN LSLHSRFMRI QNEGAGKSSW WVINPDAKPG 
       260        270        280        290        300
RNPRRTRERS NTIETTTKAQ LEKSRRGAKK RIKERALMGS LHSTLNGNSI 
       310        320        330        340        350
AGSIQTISHD LYDDDSMQGA FDNVPSSFRP RTQSNLSIPG SSSRVSPAIG 
       360        370        380        390        400
SDIYDDLEFP SWVGESVPAI PSDIVDRTDQ MRIDATTHIG GVQIKQESKP 
       410        420        430        440        450
IKTEPIAPPP SYHELNSVRG SCAQNPLLRN PIVPSTNFKP MPLPGAYGNY 
       460        470        480        490        500
QNGGITPINW LSTSNSSPLP GIQSCGIVAA QHTVASSSAL PIDLENLTLP 
       510        520        530
DQPLMDTMDV DALIRHELSQ AGGQHIHFDL

Show »

Length:530

Mass (Da):57,899

Checksum:ⁱ8665FBDB428039D6

GO

Isoform bImported (identifier: O16850-4) [UniParc]FASTA Add to basket

Also known as: a21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
1-113: MQLEQKSSLH...LETVDSGRTS → MMEMLVDQGT...HEQIPEEDAD
152-154: DFR → E

« Hide

        10         20         30         40         50
MMEMLVDQGT DASSSASTST SSVSRFGADT FMNTPDDVMM NDDMEPIPRD 
        60         70         80         90        100
RCNTWPMRRP QLEPPLNSSP IIHEQIPEED ADLYGSNEQC GQLGGASSNG 
       110        120        130        140        150
STAMLHTPDG SNSHQTSFPS EMSESPDDTV SGKKTTTRRN AWGNMSYAEL 
       160        170        180        190        200
ITTAIMASPE KRLTLAQVYE WMVQNVPYFR DKGDSNSSAG WKNSIRHNLS 
       210        220        230        240        250
LHSRFMRIQN EGAGKSSWWV INPDAKPGRN PRRTRERSNT IETTTKAQLE 
       260        270        280        290        300
KSRRGAKKRI KERALMGSLH STLNGNSIAG SIQTISHDLY DDDSMQGAFD 
       310        320        330        340        350
NVPSSFRPRT QSNLSIPGSS SRVSPAIGSD IYDDLEFPSW VGESVPAIPS 
       360        370        380        390        400
DIVDRTDQMR IDATTHIGGV QIKQESKPIK TEPIAPPPSY HELNSVRGSC 
       410        420        430        440        450
AQNPLLRNPI VPSTNFKPMP LPGAYGNYQN GGITPINWLS TSNSSPLPGI 
       460        470        480        490        500
QSCGIVAAQH TVASSSALPI DLENLTLPDQ PLMDTMDVDA LIRHELSQAG 

GQHIHFDL

Show »

Length:508

Mass (Da):55,578

Checksum:ⁱ2C0CF97657CD6350

GO

Isoform cImported (identifier: O16850-3) [UniParc]FASTA Add to basket

Also known as: a11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
1-113: MQLEQKSSLH...LETVDSGRTS → MMEMLVDQGT...HEQIPEEDAD

« Hide

        10         20         30         40         50
MMEMLVDQGT DASSSASTST SSVSRFGADT FMNTPDDVMM NDDMEPIPRD 
        60         70         80         90        100
RCNTWPMRRP QLEPPLNSSP IIHEQIPEED ADLYGSNEQC GQLGGASSNG 
       110        120        130        140        150
STAMLHTPDG SNSHQTSFPS DFRMSESPDD TVSGKKTTTR RNAWGNMSYA 
       160        170        180        190        200
ELITTAIMAS PEKRLTLAQV YEWMVQNVPY FRDKGDSNSS AGWKNSIRHN 
       210        220        230        240        250
LSLHSRFMRI QNEGAGKSSW WVINPDAKPG RNPRRTRERS NTIETTTKAQ 
       260        270        280        290        300
LEKSRRGAKK RIKERALMGS LHSTLNGNSI AGSIQTISHD LYDDDSMQGA 
       310        320        330        340        350
FDNVPSSFRP RTQSNLSIPG SSSRVSPAIG SDIYDDLEFP SWVGESVPAI 
       360        370        380        390        400
PSDIVDRTDQ MRIDATTHIG GVQIKQESKP IKTEPIAPPP SYHELNSVRG 
       410        420        430        440        450
SCAQNPLLRN PIVPSTNFKP MPLPGAYGNY QNGGITPINW LSTSNSSPLP 
       460        470        480        490        500
GIQSCGIVAA QHTVASSSAL PIDLENLTLP DQPLMDTMDV DALIRHELSQ 
       510
AGGQHIHFDL

Show »

Length:510

Mass (Da):55,867

Checksum:ⁱ52574F3F979B3583

GO

Isoform dImported (identifier: O16850-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-54: Missing.

« Hide

        10         20         30         40         50
MSFSTDFDDD FFNLDLHQQE RSASFGGVTQ YSQQFLREKC SFSPYFHTSL 
        60         70         80         90        100
ETVDSGRTSL YGSNEQCGQL GGASSNGSTA MLHTPDGSNS HQTSFPSDFR 
       110        120        130        140        150
MSESPDDTVS GKKTTTRRNA WGNMSYAELI TTAIMASPEK RLTLAQVYEW 
       160        170        180        190        200
MVQNVPYFRD KGDSNSSAGW KNSIRHNLSL HSRFMRIQNE GAGKSSWWVI 
       210        220        230        240        250
NPDAKPGRNP RRTRERSNTI ETTTKAQLEK SRRGAKKRIK ERALMGSLHS 
       260        270        280        290        300
TLNGNSIAGS IQTISHDLYD DDSMQGAFDN VPSSFRPRTQ SNLSIPGSSS 
       310        320        330        340        350
RVSPAIGSDI YDDLEFPSWV GESVPAIPSD IVDRTDQMRI DATTHIGGVQ 
       360        370        380        390        400
IKQESKPIKT EPIAPPPSYH ELNSVRGSCA QNPLLRNPIV PSTNFKPMPL 
       410        420        430        440        450
PGAYGNYQNG GITPINWLST SNSSPLPGIQ SCGIVAAQHT VASSSALPID 
       460        470        480 
LENLTLPDQP LMDTMDVDAL IRHELSQAGG QHIHFDL

Note: No experimental confirmation available.Curated

Show »

Length:487

Mass (Da):53,518

Checksum:ⁱ6998CD8BF98A5747

GO

Isoform eImported (identifier: O16850-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-238: Missing.

« Hide

        10         20         30         40         50
MRIQNEGAGK SSWWVINPDA KPGRNPRRTR ERSNTIETTT KAQLEKSRRG 
        60         70         80         90        100
AKKRIKERAL MGSLHSTLNG NSIAGSIQTI SHDLYDDDSM QGAFDNVPSS 
       110        120        130        140        150
FRPRTQSNLS IPGSSSRVSP AIGSDIYDDL EFPSWVGESV PAIPSDIVDR 
       160        170        180        190        200
TDQMRIDATT HIGGVQIKQE SKPIKTEPIA PPPSYHELNS VRGSCAQNPL 
       210        220        230        240        250
LRNPIVPSTN FKPMPLPGAY GNYQNGGITP INWLSTSNSS PLPGIQSCGI 
       260        270        280        290        300
VAAQHTVASS SALPIDLENL TLPDQPLMDT MDVDALIRHE LSQAGGQHIH 

FDL

Note: No experimental confirmation available. Derived from EST data.Curated

Show »

Length:303

Mass (Da):32,933

Checksum:ⁱDD1DEB2F8E1BCCAD

GO

Isoform fImported (identifier: O16850-1) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-24: Missing.

« Hide

        10         20         30         40         50
MQAWNCRELD SPLPSDITLH NLEPARPDSG MSFSTDFDDD FFNLDLHQQE 
        60         70         80         90        100
RSASFGGVTQ YSQQFLREKC SFSPYFHTSL ETVDSGRTSL YGSNEQCGQL 
       110        120        130        140        150
GGASSNGSTA MLHTPDGSNS HQTSFPSDFR MSESPDDTVS GKKTTTRRNA 
       160        170        180        190        200
WGNMSYAELI TTAIMASPEK RLTLAQVYEW MVQNVPYFRD KGDSNSSAGW 
       210        220        230        240        250
KNSIRHNLSL HSRFMRIQNE GAGKSSWWVI NPDAKPGRNP RRTRERSNTI 
       260        270        280        290        300
ETTTKAQLEK SRRGAKKRIK ERALMGSLHS TLNGNSIAGS IQTISHDLYD 
       310        320        330        340        350
DDSMQGAFDN VPSSFRPRTQ SNLSIPGSSS RVSPAIGSDI YDDLEFPSWV 
       360        370        380        390        400
GESVPAIPSD IVDRTDQMRI DATTHIGGVQ IKQESKPIKT EPIAPPPSYH 
       410        420        430        440        450
ELNSVRGSCA QNPLLRNPIV PSTNFKPMPL PGAYGNYQNG GITPINWLST 
       460        470        480        490        500
SNSSPLPGIQ SCGIVAAQHT VASSSALPID LENLTLPDQP LMDTMDVDAL 
       510 
IRHELSQAGG QHIHFDL

Note: No experimental confirmation available.Curated

Show »

Length:517

Mass (Da):56,864

Checksum:ⁱ884488D4F43DB8D5

GO

Isoform gImported (identifier: O16850-7) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-217: Missing.
218-225: SNSSAGWK → MREMSTKN

« Hide

        10         20         30         40         50
MREMSTKNNS IRHNLSLHSR FMRIQNEGAG KSSWWVINPD AKPGRNPRRT 
        60         70         80         90        100
RERSNTIETT TKAQLEKSRR GAKKRIKERA LMGSLHSTLN GNSIAGSIQT 
       110        120        130        140        150
ISHDLYDDDS MQGAFDNVPS SFRPRTQSNL SIPGSSSRVS PAIGSDIYDD 
       160        170        180        190        200
LEFPSWVGES VPAIPSDIVD RTDQMRIDAT THIGGVQIKQ ESKPIKTEPI 
       210        220        230        240        250
APPPSYHELN SVRGSCAQNP LLRNPIVPST NFKPMPLPGA YGNYQNGGIT 
       260        270        280        290        300
PINWLSTSNS SPLPGIQSCG IVAAQHTVAS SSALPIDLEN LTLPDQPLMD 
       310        320 
TMDVDALIRH ELSQAGGQHI HFDL

Note: No experimental confirmation available.Curated

Show »

Length:324

Mass (Da):35,474

Checksum:ⁱB1E79F5EB916A3C3

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0K3AR63	A0A0K3AR63_CAEEL	Forkhead box protein O Forkhead box protein O	daf-16 CELE_R13H8.1, R13H8.1	485	Annotation score:
A0A0K3AR95	A0A0K3AR95_CAEEL	Forkhead box protein O Forkhead box protein O	daf-16 CELE_R13H8.1, R13H8.1	407	Annotation score:
A0A0K3ATP5	A0A0K3ATP5_CAEEL	Forkhead box protein O Forkhead box protein O	daf-16 CELE_R13H8.1, R13H8.1	405	Annotation score:
A0A0K3AWG6	A0A0K3AWG6_CAEEL	Forkhead box protein O Forkhead box protein O	daf-16 CELE_R13H8.1, R13H8.1	515	Annotation score:

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_053105	1 – 238	Missing in isoform e. CuratedAdd BLAST	238
Alternative sequenceⁱVSP_053106	1 – 221	MQLEQ…DSNSS → MNDSIDDDFPPEPRGRCYTW PMQQYIYQESSATIPHHHLN QHNNPYHPMHPHHQLPHMQQ LPQPLLNLNMTTLTSSGSSV ASSIGGGAQCSPCASGSSTA ATNSSQQQQTVGQMLAASVP CSSSGMTLGMSLNLSQGGGP MPAKKKRCRKKPTDQLAQKK PNPWGEESYSDIIAKALESA PDGRLKLNEIYQWFSDNIPY FGERSSPEEA in isoform a. 1 PublicationAdd BLAST	221
Alternative sequenceⁱVSP_042147	1 – 217	Missing in isoform g. CuratedAdd BLAST	217
Alternative sequenceⁱVSP_053107	1 – 113	MQLEQ…SGRTS → MMEMLVDQGTDASSSASTST SSVSRFGADTFMNTPDDVMM NDDMEPIPRDRCNTWPMRRP QLEPPLNSSPIIHEQIPEED AD in isoform b and isoform c. 2 PublicationsAdd BLAST	113
Alternative sequenceⁱVSP_053108	1 – 54	Missing in isoform d. CuratedAdd BLAST	54
Alternative sequenceⁱVSP_042148	1 – 24	Missing in isoform f. CuratedAdd BLAST	24
Alternative sequenceⁱVSP_053109	152 – 154	DFR → E in isoform b. 1 Publication	3
Alternative sequenceⁱVSP_042149	218 – 225	SNSSAGWK → MREMSTKN in isoform g. Curated	8

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF020342 mRNA Translation: AAB84390.1 AF020343 mRNA Translation: AAB84391.1 AF020344 mRNA Translation: AAB84392.1 AF032112 mRNA Translation: AAC47803.1 FO081472 Genomic DNA Translation: CCD71850.1 FO081472 Genomic DNA Translation: CCD71851.1 FO081472 Genomic DNA Translation: CCD71852.1 FO081472 Genomic DNA Translation: CCD71853.1 FO081472 Genomic DNA Translation: CCD71854.1 FO081472, FO080113 Genomic DNA Translation: CCD71855.1 FO081472, FO080113 Genomic DNA Translation: CCD71856.1 FO081472, FO080113 Genomic DNA Translation: CCD71857.1
PIRⁱ	T42234 T42255
NCBI Reference Sequences More...RefSeqⁱ	NP_001021593.1, NM_001026422.4 [O16850-2] NP_001021594.1, NM_001026423.4 [O16850-4] NP_001021595.1, NM_001026424.4 [O16850-3] NP_001021596.1, NM_001026425.3 [O16850-5] NP_001021597.1, NM_001026426.2 [O16850-6] NP_001021598.2, NM_001026427.4 [O16850-1] NP_001251490.1, NM_001264561.1 [O16850-8] NP_001251492.1, NM_001264563.1 [O16850-7]
UniGeneⁱ	Cel.18378

Genome annotation databases

EnsemblMetazoaⁱ	R13H8.1a; R13H8.1a; WBGene00000912 [O16850-2] R13H8.1b.1; R13H8.1b.1; WBGene00000912 [O16850-4] R13H8.1b.2; R13H8.1b.2; WBGene00000912 [O16850-4] R13H8.1c.1; R13H8.1c.1; WBGene00000912 [O16850-3] R13H8.1c.2; R13H8.1c.2; WBGene00000912 [O16850-3] R13H8.1d; R13H8.1d; WBGene00000912 [O16850-5] R13H8.1e; R13H8.1e; WBGene00000912 [O16850-6] R13H8.1f; R13H8.1f; WBGene00000912 [O16850-1] R13H8.1g; R13H8.1g; WBGene00000912 [O16850-7] R13H8.1h; R13H8.1h; WBGene00000912 [O16850-8]
GeneIDⁱ	172981
KEGGⁱ	cel:CELE_R13H8.1
UCSC genome browser More...UCSCⁱ	R13H8.1c c. elegans

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O16850	Isoform e of Forkhead box protein O		CAEEL		303	UniRef100_O16850
Isoform f of Forkhead box protein O		CAEEL		517
Isoform d of Forkhead box protein O		CAEEL		487
Forkhead box protein O		CAEEL		407

Protein	Similar proteins		Species	Score	Length	Source
O16850	Isoform e of Forkhead box protein O		CAEEL		303	UniRef90_O16850
Isoform f of Forkhead box protein O		CAEEL		517
Isoform d of Forkhead box protein O		CAEEL		487
Forkhead box protein O		CAEEL		407
Forkhead box protein O		CAEEL		515
+2

Protein	Similar proteins		Species	Score	Length	Source
O16850	Isoform e of Forkhead box protein O		CAEEL		303	UniRef50_O16850
Uncharacterized protein		Caenorhabditis tropicalis		674
DAF-16 transcription factor (Fragment)		HAECO		48
Uncharacterized protein (Fragment)		Caenorhabditis latens		541
Uncharacterized protein (Fragment)		CAERE		543
+15
O16850-2	Uncharacterized protein		CAEBE		483	UniRef50_O16850-2
Protein CBR-DAF-16		CAEBR		497
Uncharacterized protein		Caenorhabditis nigoni		86
Uncharacterized protein		HAEPC		484
Uncharacterized protein		ANGCS		496
+3
O16850-4	Isoform a of Forkhead box protein O		CAEEL		530	UniRef50_O16850-2
Uncharacterized protein		CAEBE		483
Protein CBR-DAF-16		CAEBR		497
Uncharacterized protein		Caenorhabditis nigoni		86
Uncharacterized protein		HAEPC		484
+3
O16850-3	Isoform a of Forkhead box protein O		CAEEL		530	UniRef50_O16850-2
Uncharacterized protein		CAEBE		483
Protein CBR-DAF-16		CAEBR		497
Uncharacterized protein		Caenorhabditis nigoni		86
Uncharacterized protein		HAEPC		484
+3

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF020342 mRNA Translation: AAB84390.1 AF020343 mRNA Translation: AAB84391.1 AF020344 mRNA Translation: AAB84392.1 AF032112 mRNA Translation: AAC47803.1 FO081472 Genomic DNA Translation: CCD71850.1 FO081472 Genomic DNA Translation: CCD71851.1 FO081472 Genomic DNA Translation: CCD71852.1 FO081472 Genomic DNA Translation: CCD71853.1 FO081472 Genomic DNA Translation: CCD71854.1 FO081472, FO080113 Genomic DNA Translation: CCD71855.1 FO081472, FO080113 Genomic DNA Translation: CCD71856.1 FO081472, FO080113 Genomic DNA Translation: CCD71857.1
PIRⁱ	T42234 T42255
RefSeqⁱ	NP_001021593.1, NM_001026422.4 [O16850-2] NP_001021594.1, NM_001026423.4 [O16850-4] NP_001021595.1, NM_001026424.4 [O16850-3] NP_001021596.1, NM_001026425.3 [O16850-5] NP_001021597.1, NM_001026426.2 [O16850-6] NP_001021598.2, NM_001026427.4 [O16850-1] NP_001251490.1, NM_001264561.1 [O16850-8] NP_001251492.1, NM_001264563.1 [O16850-7]
UniGeneⁱ	Cel.18378

3D structure databases

ProteinModelPortalⁱ	O16850
SMRⁱ	O16850
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	38392, 5 interactors
DIPⁱ	DIP-25581N
IntActⁱ	O16850, 23 interactors
STRINGⁱ	6239.R13H8.1h

PTM databases

iPTMnetⁱ	O16850

iPTMnetⁱ

O16850

Proteomic databases

PaxDbⁱ	O16850
PeptideAtlasⁱ	O16850
PRIDEⁱ	O16850

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblMetazoaⁱ	R13H8.1a; R13H8.1a; WBGene00000912 [O16850-2] R13H8.1b.1; R13H8.1b.1; WBGene00000912 [O16850-4] R13H8.1b.2; R13H8.1b.2; WBGene00000912 [O16850-4] R13H8.1c.1; R13H8.1c.1; WBGene00000912 [O16850-3] R13H8.1c.2; R13H8.1c.2; WBGene00000912 [O16850-3] R13H8.1d; R13H8.1d; WBGene00000912 [O16850-5] R13H8.1e; R13H8.1e; WBGene00000912 [O16850-6] R13H8.1f; R13H8.1f; WBGene00000912 [O16850-1] R13H8.1g; R13H8.1g; WBGene00000912 [O16850-7] R13H8.1h; R13H8.1h; WBGene00000912 [O16850-8]
GeneIDⁱ	172981
KEGGⁱ	cel:CELE_R13H8.1
UCSCⁱ	R13H8.1c c. elegans

Organism-specific databases

CTDⁱ	172981
WormBaseⁱ	R13H8.1a ; CE28771 ; WBGene00000912 ; daf-16 R13H8.1b ; CE28772 ; WBGene00000912 ; daf-16 R13H8.1c ; CE28773 ; WBGene00000912 ; daf-16 R13H8.1d ; CE38722 ; WBGene00000912 ; daf-16 R13H8.1e ; CE33160 ; WBGene00000912 ; daf-16 R13H8.1f ; CE44821 ; WBGene00000912 ; daf-16 R13H8.1g ; CE44935 ; WBGene00000912 ; daf-16 R13H8.1h ; CE45185 ; WBGene00000912 ; daf-16

Phylogenomic databases

eggNOGⁱ	KOG2294 Eukaryota COG5025 LUCA
GeneTreeⁱ	ENSGT00920000149005
HOGENOMⁱ	HOG000019698
InParanoidⁱ	O16850
KOⁱ	K09408
OMAⁱ	SASSGNC
OrthoDBⁱ	EOG091G06K3

Enzyme and pathway databases

Reactomeⁱ	R-CEL-156711 Polo-like kinase mediated events R-CEL-198693 AKT phosphorylates targets in the nucleus R-CEL-211163 AKT-mediated inactivation of FOXO1A R-CEL-5687128 MAPK6/MAPK4 signaling R-CEL-5689880 Ub-specific processing proteases R-CEL-69273 Cyclin A/B1/B2 associated events during G2/M transition
SignaLinkⁱ	O16850

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:O16850

PROⁱ

PR:O16850

Gene expression databases

Bgeeⁱ	WBGene00000912 Expressed in 6 organ(s), highest expression level in adult organism

Bgeeⁱ

WBGene00000912 Expressed in 6 organ(s), highest expression level in adult organism

Family and domain databases

CDDⁱ	cd00059 FH, 1 hit
Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR001766 Fork_head_dom IPR030456 TF_fork_head_CS_2 IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF00250 Forkhead, 1 hit
PRINTSⁱ	PR00053 FORKHEAD
SMARTⁱ	View protein in SMART SM00339 FH, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS00658 FORK_HEAD_2, 1 hit PS50039 FORK_HEAD_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FOXO_CAEEL
Accessionⁱ	O16850Primary (citable) accession number: O16850 Secondary accession number(s): F3NWW7 Q86S42
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 16, 2009
	Last sequence update:	January 25, 2012
	Last modified:	November 7, 2018
	This is version 158 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Caenorhabditis annotation project

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Caenorhabditis elegans
Caenorhabditis elegans: entries, gene names and cross-references to WormBase

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Help

UniRef

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Supporting data

UniProtKB - O16850 (FOXO_CAEEL)

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Forkhead box protein O

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

Family and domain databases

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ