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Protein

60S ribosomal protein L3

Gene

RpL3

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The L3 protein is a component of the large subunit of cytoplasmic ribosomes.

GO - Molecular functioni

  • RNA binding Source: GO_Central
  • structural constituent of ribosome Source: FlyBase

GO - Biological processi

  • cytoplasmic translation Source: FlyBase
  • ribosomal large subunit assembly Source: GO_Central

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-DME-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-DME-1799339 SRP-dependent cotranslational protein targeting to membrane
R-DME-72689 Formation of a pool of free 40S subunits
R-DME-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-DME-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-DME-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L3
Gene namesi
Name:RpL3
ORF Names:CG4863
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0020910 RpL3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000772372 – 41660S ribosomal protein L3Add BLAST415

Proteomic databases

PaxDbiO16797
PeptideAtlasiO16797
PRIDEiO16797

Expressioni

Gene expression databases

BgeeiFBgn0020910
ExpressionAtlasiO16797 baseline and differential
GenevisibleiO16797 DM

Interactioni

Protein-protein interaction databases

BioGridi66481, 53 interactors
DIPiDIP-17151N
IntActiO16797, 52 interactors
MINTiO16797
STRINGi7227.FBpp0081822

Structurei

3D structure databases

ProteinModelPortaliO16797
SMRiO16797
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0746 Eukaryota
COG0087 LUCA
GeneTreeiENSGT00390000017606
InParanoidiO16797
KOiK02925
OMAiHQRTEYN
OrthoDBiEOG091G086T
PhylomeDBiO16797

Family and domain databases

InterProiView protein in InterPro
IPR000597 Ribosomal_L3
IPR019926 Ribosomal_L3_CS
IPR009000 Transl_B-barrel_sf
PfamiView protein in Pfam
PF00297 Ribosomal_L3, 1 hit
SUPFAMiSSF50447 SSF50447, 1 hit
PROSITEiView protein in PROSITE
PS00474 RIBOSOMAL_L3, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: O16797-1) [UniParc]FASTAAdd to basket
Also known as: H

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSHRKFSAPR HGSMAFYPKK RSARHRGKVK AFPKDDASKP VHLTCFIGYK
60 70 80 90 100
AGMTHIVREA DRPGSKINKK EVVEAVTVLE TPPMIVVGAV GYIETPFGLR
110 120 130 140 150
ALVNVWAQHL SEECRRRFYK NWYKSKKKAF TKASKKWTDD LGKKSIENDF
160 170 180 190 200
RKMLRYCKVI RVIAHSQIRL IKQRQKKAHV MEIQLNGGSI EDKVKWAREH
210 220 230 240 250
LEKPIQVSNV FGQDEMIDCV GVTKGKGFKG VTSRWHTKKL PRKTHKGLRK
260 270 280 290 300
VACIGAWHPS RVSTTVARAG QKGYHHRTEI NKKIYRIGAG IHTKDGKVIK
310 320 330 340 350
NNASTEYDLT DKSITPMGGF PHYGEVNNDF VMIKGCCIGS KKRIITLRKS
360 370 380 390 400
LLKHTKRSAL EQIKLKFIDT SSKMGHGRFQ TPADKLAFMG PLKKDRLKEE
410
AAATTAAAAA ATTTSA
Length:416
Mass (Da):46,916
Last modified:January 23, 2007 - v3
Checksum:i779D843982334AA5
GO
Isoform G (identifier: O16797-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     122-138: WYKSKKKAFTKASKKWT → CSSISLLRELFKSLNVV
     139-416: Missing.

Note: No experimental confirmation available.
Show »
Length:138
Mass (Da):15,611
Checksum:i2CB26B658A5BEE98
GO
Isoform D (identifier: O16797-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     124-161: KSKKKAFTKA...KMLRYCKVIR → VSEDHVVVLP...ADTCFLLESG
     162-416: Missing.

Note: No experimental confirmation available.
Show »
Length:161
Mass (Da):18,136
Checksum:i03925456CDC7AED2
GO

Sequence cautioni

The sequence AAR96131 differs from that shown. Reason: Frameshift at position 403.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005714122 – 138WYKSK…SKKWT → CSSISLLRELFKSLNVV in isoform G. CuratedAdd BLAST17
Alternative sequenceiVSP_005715124 – 161KSKKK…CKVIR → VSEDHVVVLPTPFVAIFFAP GVHTHKMAADTCFLLESG in isoform D. CuratedAdd BLAST38
Alternative sequenceiVSP_005716139 – 416Missing in isoform G. CuratedAdd BLAST278
Alternative sequenceiVSP_005717162 – 416Missing in isoform D. CuratedAdd BLAST255

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF016835 mRNA Translation: AAC26144.1
AE014297 Genomic DNA Translation: AAF54610.2
AE014297 Genomic DNA Translation: AAF54611.2
AE014297 Genomic DNA Translation: AAF54612.2
AE014297 Genomic DNA Translation: AAN13496.2
BT011339 mRNA Translation: AAR96131.1 Frameshift.
RefSeqiNP_524316.1, NM_079592.3 [O16797-1]
NP_731547.1, NM_169377.2 [O16797-2]
NP_731548.2, NM_169378.2 [O16797-1]
NP_731550.2, NM_169380.2 [O16797-5]
UniGeneiDm.6703

Genome annotation databases

EnsemblMetazoaiFBtr0082346; FBpp0081822; FBgn0020910 [O16797-1]
FBtr0082347; FBpp0081823; FBgn0020910 [O16797-2]
FBtr0302586; FBpp0291742; FBgn0020910 [O16797-5]
FBtr0336783; FBpp0307759; FBgn0020910 [O16797-1]
GeneIDi41347
KEGGidme:Dmel_CG4863

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRL3_DROME
AccessioniPrimary (citable) accession number: O16797
Secondary accession number(s): Q0KI83
, Q6NNE9, Q9VGR4, Q9VGR5, Q9VGR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 155 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

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