Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 144 (10 Apr 2019)
Sequence version 4 (25 Oct 2017)
Previous versions | rss
Other tutorials and videosHelp videoFeedback
Protein
Submitted name:

Protein-tyrosine-phosphatase

Gene

CELE_K09F6.3

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1217Phosphocysteine intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphataseSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Protein-tyrosine-phosphataseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CELE_K09F6.3Imported, K09F6.3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome II

Organism-specific databases

WormBase

More...
WormBasei
K09F6.3 ; CE52038 ; WBGene00019586

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 31HelicalSequence analysisAdd BLAST20
Transmembranei850 – 874HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O16728

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O16728

PeptideAtlas

More...
PeptideAtlasi
O16728

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00019586 Expressed in 3 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.K09F6.3

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O16728

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1014 – 1282Tyrosine-protein phosphataseInterPro annotationAdd BLAST269
Domaini1198 – 1273TYR_PHOSPHATASE_2InterPro annotationAdd BLAST76

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili157 – 177Sequence analysisAdd BLAST21
Coiled coili890 – 947Sequence analysisAdd BLAST58

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0789 Eukaryota
COG5599 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O16728

Database of Orthologous Groups

More...
OrthoDBi
411281at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O16728

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
IPR003125 WSN

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02206 WSN, 1 hit
PF00102 Y_phosphatase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00700 PRTYPHPHTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SM00453 WSN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52799 SSF52799, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O16728-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRQRKEKYCA MDWRIVLILT VLAIIPCIYG FNSIETISST TDRMSPHRVD
60 70 80 90 100
RQTTDDPLGF SINRMQKISR IVNSIYLTAE LTAGTANTYD LIAEFFNFGP
110 120 130 140 150
DSYNKLQSID MKELKSGLEE IVSIHSELTY TDIDKRAEQR FRHLIEIRKE
160 170 180 190 200
VEGVGSLEDI KDAQANYKSE LETFKKTTFD TAGIEEFQNA VKNFIGAAAD
210 220 230 240 250
VEKYSNLEKL TDVDIMYARP LIYTLKTSIE NLAKSYSSIN SFDDFEKIRN
260 270 280 290 300
PSEFVDPISK IVSGYKKYNA SRTTIERDGN FAKGMQSNAN NMKRLENVAS
310 320 330 340 350
VFEGLGSFVK NLQAVIDVRQ TMHLPKYTVG FIDGTFDPKK VVTDLEDDWV
360 370 380 390 400
QSVTHEMDLN RTINLLLPIG DHVSAIEASF LSSSSKQSKF FTGFKSSETE
410 420 430 440 450
VSPVDGSIDS IISTSKKVSE CIIAPLTYLE SIKEVEILLQ AIESLKKTVD
460 470 480 490 500
TLVGTKELVN WVKTNDVVLK EVEALCSYTD EEKKDFESSV PIKLKGLKSS
510 520 530 540 550
ENYTSLIKTL NQSSLFADAV FSEKLSTTGQ ETAYILGGLQ SLDAFYNSAT
560 570 580 590 600
DHIAFFDCLL NVAYYDLIPL AIDTLNKVRK MDVQPIRDGI DVVNDLFNVS
610 620 630 640 650
NQLDELKTKL RELNDPNFSI AETPLSNPSL HTTTIGLSVR GVIRMKDEID
660 670 680 690 700
HRSDFDVVIE NAEMVDQEMK NTGKKAINMV EFGSRLKKLK SELEGWKSNI
710 720 730 740 750
TVGGAHRIRR STPSLADYAH IFQNALKVGG VDDDLKKLMD AVKDFEKTGK
760 770 780 790 800
DAATKVKLKE VIASLNSLNS IGLQLSSFAT PFTAIGQSFS ALDAFFVSNG
810 820 830 840 850
KIITTPAPIV SSSGASQEGQ KSAGGSMTLQ PSQTVSVTTT EEPMDESTNL
860 870 880 890 900
MIFIGIGCGI VLVSALIVAV VCFYKRNKIA NDDMEQGTKI EKEKIARELA
910 920 930 940 950
AQEAQNIEAE KKKKEIKDLE AKVDYEKQKG EKIKEEAEKE IQDHRKKVED
960 970 980 990 1000
DKLPKFYDIR SPTIEDATAL EGDKGATNNG KLPLKAMYQF CKSILRIANL
1010 1020 1030 1040 1050
APNNAIVESE KYSEQDRYSD VLCGMDNRIL IDEDVCRRCY FKDQYINANY
1060 1070 1080 1090 1100
LELPNGNRMI LTQAPMSRTE HFKPEKDKKR KNLYSLSDEE EEISYLVQTV
1110 1120 1130 1140 1150
DKFYQTIVQT GTEVVAMLCD FNEEGVEKCS SYFPLEKDGK QKFHNVNVCT
1160 1170 1180 1190 1200
TNVQHPSADV VLRTLVITSY LGEKKKTHTV KHYSYKGWIE KNAPELPREI
1210 1220 1230 1240 1250
LNIFRVARNS KSLVVHCSNG IGRSAAFVFA EFVYQKMIRS LDTTSTVNLD
1260 1270 1280 1290 1300
FLSLLTELRH SRPRAIHTPM QLAFSIMMVL DFVMNNFPKG EMEAKYQEIR
1310 1320 1330 1340 1350
KSYLHARQMM HKDLEFDGSD GKTVDIALDE DGHGIPEKKG KKKTNKKAAQ
1360 1370 1380 1390
QASVKKDEKS KKKSKKDSKK GSKMDMKTAE EGMKSLQKKA A
Length:1,391
Mass (Da):156,370
Last modified:October 25, 2017 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i718E8CCBFA8F5744
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284602 Genomic DNA Translation: CCD61659.2

Genome annotation databases

UCSC genome browser

More...
UCSCi
K09F6.3 c. elegans

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA Translation: CCD61659.2

3D structure databases

ProteinModelPortaliO16728
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.K09F6.3

Proteomic databases

EPDiO16728
PaxDbiO16728
PeptideAtlasiO16728

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiK09F6.3 c. elegans

Organism-specific databases

WormBaseiK09F6.3 ; CE52038 ; WBGene00019586

Phylogenomic databases

eggNOGiKOG0789 Eukaryota
COG5599 LUCA
InParanoidiO16728
OrthoDBi411281at2759
PhylomeDBiO16728

Gene expression databases

BgeeiWBGene00019586 Expressed in 3 organ(s), highest expression level in multi-cellular organism

Family and domain databases

InterProiView protein in InterPro
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
IPR003125 WSN
PfamiView protein in Pfam
PF02206 WSN, 1 hit
PF00102 Y_phosphatase, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SM00453 WSN, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiO16728_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O16728
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: October 25, 2017
Last modified: April 10, 2019
This is version 144 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again