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Entry version 143 (10 Feb 2021)
Sequence version 1 (01 Jan 1998)
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Protein

Probable 26S proteasome regulatory subunit 4

Gene

rpt-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). May play a role in the degradation of microtubule severing protein mei-1 (PubMed:22621901).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi229 – 236ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • negative regulation of gene expression Source: UniProtKB
  • protein catabolic process Source: InterPro

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-CEL-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-CEL-1236978, Cross-presentation of soluble exogenous antigens (endosomes)
R-CEL-187577, SCF(Skp2)-mediated degradation of p27/p21
R-CEL-195253, Degradation of beta-catenin by the destruction complex
R-CEL-349425, Autodegradation of the E3 ubiquitin ligase COP1
R-CEL-350562, Regulation of ornithine decarboxylase (ODC)
R-CEL-382556, ABC-family proteins mediated transport
R-CEL-4608870, Asymmetric localization of PCP proteins
R-CEL-4641258, Degradation of DVL
R-CEL-532668, N-glycan trimming in the ER and Calnexin/Calreticulin cycle
R-CEL-5632684, Hedgehog 'on' state
R-CEL-5687128, MAPK6/MAPK4 signaling
R-CEL-5689603, UCH proteinases
R-CEL-5689880, Ub-specific processing proteases
R-CEL-68949, Orc1 removal from chromatin
R-CEL-69017, CDK-mediated phosphorylation and removal of Cdc6
R-CEL-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-CEL-75815, Ubiquitin-dependent degradation of Cyclin D
R-CEL-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-CEL-8939902, Regulation of RUNX2 expression and activity
R-CEL-8941858, Regulation of RUNX3 expression and activity
R-CEL-8948751, Regulation of PTEN stability and activity
R-CEL-983168, Antigen processing: Ubiquitination & Proteasome degradation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable 26S proteasome regulatory subunit 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rpt-2
ORF Names:F29G9.5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegans
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome V

Organism-specific databases

WormBase

More...
WormBasei
F29G9.5 ; CE09799 ; WBGene00004502 ; rpt-2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown at the L1 larval stage, causes 20 percent increase in mei-1 protein levels.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000846811 – 443Probable 26S proteasome regulatory subunit 4Add BLAST443

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O16368

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O16368

PeptideAtlas

More...
PeptideAtlasi
O16368

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00004502, Expressed in multi-cellular organism and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
44036, 44 interactors

Protein interaction database and analysis system

More...
IntActi
O16368, 3 interactors

STRING: functional protein association networks

More...
STRINGi
6239.F29G9.5

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O16368

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0726, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00990000203571

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000688_2_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O16368

Identification of Orthologs from Complete Genome Data

More...
OMAi
ARCKLRY

Database of Orthologous Groups

More...
OrthoDBi
571919at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O16368

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005937, 26S_Psome_P45-like
IPR035244, 26S_subunit_4
IPR003593, AAA+_ATPase
IPR041569, AAA_lid_3
IPR003959, ATPase_AAA_core
IPR003960, ATPase_AAA_CS
IPR027417, P-loop_NTPase
IPR032501, Prot_ATP_ID_OB

The PANTHER Classification System

More...
PANTHERi
PTHR23073:SF77, PTHR23073:SF77, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00004, AAA, 1 hit
PF17862, AAA_lid_3, 1 hit
PF16450, Prot_ATP_ID_OB, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01242, 26Sp45, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00674, AAA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O16368-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGQQQSGFGG RGNDRGAGDG EKKEKKKYEA PIPSRIGKKK KGSKGPDAAS
60 70 80 90 100
KLPAVTPHAR CRLKLLKSER IKDYLLMEQE FIQNQERLKP QEERQEEERA
110 120 130 140 150
KVDELRGTPM AVGSLEEIID DQHAIVSTNV GSEHYVNIMS FVDKEQLEPG
160 170 180 190 200
CSVLLNHKNH AVIGVLSDDT DPMVSVMKLE KAPQETYADV GGLDQQIQEI
210 220 230 240 250
KEAVELPLTH PEYYEEMGIR PPKGVILYGC PGTGKTLLAK AVANQTSATF
260 270 280 290 300
LRIVGSELIQ KYLGDGPKMV RELFRVAEEN APSIVFIDEI DAVGTKRYDS
310 320 330 340 350
NSGGEREIQR TMLELLNQLD GFDSRGDVKV LMATNRIESL DPALIRPGRI
360 370 380 390 400
DRKIEFPLPD EKTKRRIFQI HTSRMTLGKE VNLEEFITAK DELSGADIKA
410 420 430 440
MCTEAGLLAL RERRMRVTME DFQKSKENVL YRKKEGAPEE LYL
Length:443
Mass (Da):49,723
Last modified:January 1, 1998 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6908E4AB5C15C642
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
FO080494 Genomic DNA Translation: CCD64135.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T31800

NCBI Reference Sequences

More...
RefSeqi
NP_504558.1, NM_072157.6

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
F29G9.5.1; F29G9.5.1; WBGene00004502

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
178988

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_F29G9.5

UCSC genome browser

More...
UCSCi
F29G9.5, c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080494 Genomic DNA Translation: CCD64135.1
PIRiT31800
RefSeqiNP_504558.1, NM_072157.6

3D structure databases

SMRiO16368
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi44036, 44 interactors
IntActiO16368, 3 interactors
STRINGi6239.F29G9.5

Proteomic databases

EPDiO16368
PaxDbiO16368
PeptideAtlasiO16368

Genome annotation databases

EnsemblMetazoaiF29G9.5.1; F29G9.5.1; WBGene00004502
GeneIDi178988
KEGGicel:CELE_F29G9.5
UCSCiF29G9.5, c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
178988
WormBaseiF29G9.5 ; CE09799 ; WBGene00004502 ; rpt-2

Phylogenomic databases

eggNOGiKOG0726, Eukaryota
GeneTreeiENSGT00990000203571
HOGENOMiCLU_000688_2_3_1
InParanoidiO16368
OMAiARCKLRY
OrthoDBi571919at2759
PhylomeDBiO16368

Enzyme and pathway databases

ReactomeiR-CEL-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-CEL-1236978, Cross-presentation of soluble exogenous antigens (endosomes)
R-CEL-187577, SCF(Skp2)-mediated degradation of p27/p21
R-CEL-195253, Degradation of beta-catenin by the destruction complex
R-CEL-349425, Autodegradation of the E3 ubiquitin ligase COP1
R-CEL-350562, Regulation of ornithine decarboxylase (ODC)
R-CEL-382556, ABC-family proteins mediated transport
R-CEL-4608870, Asymmetric localization of PCP proteins
R-CEL-4641258, Degradation of DVL
R-CEL-532668, N-glycan trimming in the ER and Calnexin/Calreticulin cycle
R-CEL-5632684, Hedgehog 'on' state
R-CEL-5687128, MAPK6/MAPK4 signaling
R-CEL-5689603, UCH proteinases
R-CEL-5689880, Ub-specific processing proteases
R-CEL-68949, Orc1 removal from chromatin
R-CEL-69017, CDK-mediated phosphorylation and removal of Cdc6
R-CEL-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-CEL-75815, Ubiquitin-dependent degradation of Cyclin D
R-CEL-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-CEL-8939902, Regulation of RUNX2 expression and activity
R-CEL-8941858, Regulation of RUNX3 expression and activity
R-CEL-8948751, Regulation of PTEN stability and activity
R-CEL-983168, Antigen processing: Ubiquitination & Proteasome degradation

Miscellaneous databases

Protein Ontology

More...
PROi
PR:O16368

Gene expression databases

BgeeiWBGene00004502, Expressed in multi-cellular organism and 5 other tissues

Family and domain databases

InterProiView protein in InterPro
IPR005937, 26S_Psome_P45-like
IPR035244, 26S_subunit_4
IPR003593, AAA+_ATPase
IPR041569, AAA_lid_3
IPR003959, ATPase_AAA_core
IPR003960, ATPase_AAA_CS
IPR027417, P-loop_NTPase
IPR032501, Prot_ATP_ID_OB
PANTHERiPTHR23073:SF77, PTHR23073:SF77, 1 hit
PfamiView protein in Pfam
PF00004, AAA, 1 hit
PF17862, AAA_lid_3, 1 hit
PF16450, Prot_ATP_ID_OB, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR01242, 26Sp45, 1 hit
PROSITEiView protein in PROSITE
PS00674, AAA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPRS4_CAEEL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O16368
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: February 10, 2021
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families
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