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Protein

Probable 26S proteasome regulatory subunit 4

Gene

rpt-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity). May play a role in the degradation of microtubule severing protein mei-1 (PubMed:22621901).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi229 – 236ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 26S proteasome regulatory subunit 4
Gene namesi
Name:rpt-2
ORF Names:F29G9.5
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF29G9.5 ; CE09799 ; WBGene00004502 ; rpt-2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Proteasome

Pathology & Biotechi

Disruption phenotypei

RNAi-mediated knockdown at the L1 larval stage, causes 20 percent increase in mei-1 protein levels.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000846811 – 443Probable 26S proteasome regulatory subunit 4Add BLAST443

Proteomic databases

EPDiO16368
PaxDbiO16368
PeptideAtlasiO16368
PRIDEiO16368

Expressioni

Gene expression databases

BgeeiWBGene00004502

Interactioni

GO - Molecular functioni

  • TBP-class protein binding Source: GO_Central
  • ubiquitin protein ligase binding Source: WormBase

Protein-protein interaction databases

BioGridi44036, 2 interactors
IntActiO16368, 3 interactors
STRINGi6239.F29G9.5.1

Structurei

3D structure databases

ProteinModelPortaliO16368
SMRiO16368
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

eggNOGiKOG0726 Eukaryota
COG1222 LUCA
GeneTreeiENSGT00550000074818
HOGENOMiHOG000225143
InParanoidiO16368
KOiK03062
OMAiNATFIRV
OrthoDBiEOG091G07NC
PhylomeDBiO16368

Family and domain databases

InterProiView protein in InterPro
IPR005937 26S_Psome_P45-like
IPR035244 26S_subunit_4
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR027417 P-loop_NTPase
PANTHERiPTHR23073:SF24 PTHR23073:SF24, 1 hit
PfamiView protein in Pfam
PF00004 AAA, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01242 26Sp45, 1 hit
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit

Sequencei

Sequence statusi: Complete.

O16368-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGQQQSGFGG RGNDRGAGDG EKKEKKKYEA PIPSRIGKKK KGSKGPDAAS
60 70 80 90 100
KLPAVTPHAR CRLKLLKSER IKDYLLMEQE FIQNQERLKP QEERQEEERA
110 120 130 140 150
KVDELRGTPM AVGSLEEIID DQHAIVSTNV GSEHYVNIMS FVDKEQLEPG
160 170 180 190 200
CSVLLNHKNH AVIGVLSDDT DPMVSVMKLE KAPQETYADV GGLDQQIQEI
210 220 230 240 250
KEAVELPLTH PEYYEEMGIR PPKGVILYGC PGTGKTLLAK AVANQTSATF
260 270 280 290 300
LRIVGSELIQ KYLGDGPKMV RELFRVAEEN APSIVFIDEI DAVGTKRYDS
310 320 330 340 350
NSGGEREIQR TMLELLNQLD GFDSRGDVKV LMATNRIESL DPALIRPGRI
360 370 380 390 400
DRKIEFPLPD EKTKRRIFQI HTSRMTLGKE VNLEEFITAK DELSGADIKA
410 420 430 440
MCTEAGLLAL RERRMRVTME DFQKSKENVL YRKKEGAPEE LYL
Length:443
Mass (Da):49,723
Last modified:January 1, 1998 - v1
Checksum:i6908E4AB5C15C642
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO080494 Genomic DNA Translation: CCD64135.1
PIRiT31800
RefSeqiNP_504558.1, NM_072157.6
UniGeneiCel.2745

Genome annotation databases

EnsemblMetazoaiF29G9.5; F29G9.5; WBGene00004502
GeneIDi178988
KEGGicel:CELE_F29G9.5
UCSCiF29G9.5 c. elegans

Similar proteinsi

Entry informationi

Entry nameiPRS4_CAEEL
AccessioniPrimary (citable) accession number: O16368
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 1, 1998
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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