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Protein

DNA replication licensing factor MCM7

Gene

mcm-7

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.UniRule annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • DNA replication initiation Source: InterPro
  • MCM complex assembly Source: WormBase

Keywordsi

Molecular functionDNA-bindingUniRule annotationSAAS annotation, HelicaseUniRule annotationSAAS annotation, Hydrolase
Biological processCell cycleUniRule annotation, DNA replicationUniRule annotationSAAS annotation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA replication licensing factor MCM7UniRule annotation (EC:3.6.4.12UniRule annotation)
Gene namesi
Name:mcm-7Imported
Synonyms:MCM7UniRule annotation
ORF Names:CELE_F32D1.10Imported, F32D1.10Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF32D1.10 ; CE09874 ; WBGene00003159 ; mcm-7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

PTM / Processingi

Proteomic databases

EPDiO16297
PaxDbiO16297
PeptideAtlasiO16297

Expressioni

Gene expression databases

BgeeiWBGene00003159 Expressed in 5 organ(s), highest expression level in material anatomical entity

Interactioni

Protein-protein interaction databases

IntActiO16297, 1 interactor
STRINGi6239.F32D1.10.1

Structurei

3D structure databases

ProteinModelPortaliO16297
SMRiO16297
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini341 – 546MCMInterPro annotationAdd BLAST206

Sequence similaritiesi

Belongs to the MCM family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0482 Eukaryota
COG1241 LUCA
GeneTreeiENSGT00930000151047
HOGENOMiHOG000224125
InParanoidiO16297
KOiK02210
OMAiVKIQEMA
OrthoDBiEOG091G02LB
PhylomeDBiO16297

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR031327 MCM
IPR008050 MCM7
IPR018525 MCM_CS
IPR001208 MCM_dom
IPR027925 MCM_N
IPR033762 MCM_OB
IPR012340 NA-bd_OB-fold
IPR027417 P-loop_NTPase
PANTHERiPTHR11630 PTHR11630, 1 hit
PTHR11630:SF26 PTHR11630:SF26, 1 hit
PfamiView protein in Pfam
PF00493 MCM, 1 hit
PF14551 MCM_N, 1 hit
PF17207 MCM_OB, 1 hit
PRINTSiPR01657 MCMFAMILY
PR01663 MCMPROTEIN7
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00350 MCM, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00847 MCM_1, 1 hit
PS50051 MCM_2, 1 hit

Sequencei

Sequence statusi: Complete.

O16297-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTTTYNTDW AAEKTKIRSF FDEYYVDNED GSGKAFPYRD QVFEIARRDK
60 70 80 90 100
QAIVVNVDHI KESDIPDALE LSEAITSNTK RYEVLFKDTI SDMIQDYLGD
110 120 130 140 150
KQAPVIDALD AYMFQRLHMD RNEGAANEEV SLQDKRKKYP PQLLQRFEVY
160 170 180 190 200
FTTDDAAHET CVRNIKATEI GHLVSMKGVV IRATEVKPCV EVMTYTCDTC
210 220 230 240 250
AAEVYQPVKG MQFTPPVNCP NKECVEAKAN GRLHMQLRGS KFVKFQELKI
260 270 280 290 300
QELSEQVPVG SIPRTMTVHV YGEMTRKCNT GNVVHVSGVF LPIMQSGFRP
310 320 330 340 350
TGGLVADTYL EAHYINNLDD NPTFNGVQSA ELEVLRRKGD NYETLAASIA
360 370 380 390 400
PEIFGHVDVK KCLLMALVGG NDNSSNGMKI RGCINVLMMG DPGVAKSQLL
410 420 430 440 450
GYVNRLAPRS QYTTGRGSSG VGLTAAVMKD PVTGEMSLEG GALVLADGGI
460 470 480 490 500
CCIDEFDKMM DHDRTAIHEV MEQQTISIAK AGIMTTLNAR TAIIAAANPA
510 520 530 540 550
YGRYNPNRSI EQNVDLPAAL LSRFDLILLM QDKADRENDK ILAEHITYVH
560 570 580 590 600
QHGCHPNREK KDLISLETLR EYISLCKTYT PTVDPALRER IVEAYVEMRR
610 620 630 640 650
DARYSSDPTF VSPRMILGIV RMATARAKLR LSTIVDESDV EEALRLMQFA
660 670 680 690 700
KDSLRPEQNK IEKRMAPVDA AFAVLRELYH ADNAPIAISN AIQRCARKGI
710 720 730
SEVALKKCLD QYTANGLLVM DRQNIVFAMN
Length:730
Mass (Da):81,617
Last modified:January 1, 1998 - v1
Checksum:iB286033F128809F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CCD68490.1
PIRiT03920
RefSeqiNP_504199.1, NM_071798.5
UniGeneiCel.17496

Genome annotation databases

EnsemblMetazoaiF32D1.10; F32D1.10; WBGene00003159
GeneIDi178831
KEGGicel:CELE_F32D1.10
UCSCiF32D1.10.1 c. elegans

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284605 Genomic DNA Translation: CCD68490.1
PIRiT03920
RefSeqiNP_504199.1, NM_071798.5
UniGeneiCel.17496

3D structure databases

ProteinModelPortaliO16297
SMRiO16297
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiO16297, 1 interactor
STRINGi6239.F32D1.10.1

Proteomic databases

EPDiO16297
PaxDbiO16297
PeptideAtlasiO16297

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF32D1.10; F32D1.10; WBGene00003159
GeneIDi178831
KEGGicel:CELE_F32D1.10
UCSCiF32D1.10.1 c. elegans

Organism-specific databases

CTDi178831
WormBaseiF32D1.10 ; CE09874 ; WBGene00003159 ; mcm-7

Phylogenomic databases

eggNOGiKOG0482 Eukaryota
COG1241 LUCA
GeneTreeiENSGT00930000151047
HOGENOMiHOG000224125
InParanoidiO16297
KOiK02210
OMAiVKIQEMA
OrthoDBiEOG091G02LB
PhylomeDBiO16297

Gene expression databases

BgeeiWBGene00003159 Expressed in 5 organ(s), highest expression level in material anatomical entity

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR031327 MCM
IPR008050 MCM7
IPR018525 MCM_CS
IPR001208 MCM_dom
IPR027925 MCM_N
IPR033762 MCM_OB
IPR012340 NA-bd_OB-fold
IPR027417 P-loop_NTPase
PANTHERiPTHR11630 PTHR11630, 1 hit
PTHR11630:SF26 PTHR11630:SF26, 1 hit
PfamiView protein in Pfam
PF00493 MCM, 1 hit
PF14551 MCM_N, 1 hit
PF17207 MCM_OB, 1 hit
PRINTSiPR01657 MCMFAMILY
PR01663 MCMPROTEIN7
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00350 MCM, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00847 MCM_1, 1 hit
PS50051 MCM_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiO16297_CAEEL
AccessioniPrimary (citable) accession number: O16297
Entry historyiIntegrated into UniProtKB/TrEMBL: January 1, 1998
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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